Publication Date:
1998-12-16
Description:
The trophoblast cell lineage is essential for the survival of the mammalian embryo in utero. This lineage is specified before implantation into the uterus and is restricted to form the fetal portion of the placenta. A culture of mouse blastocysts or early postimplantation trophoblasts in the presence of fibroblast growth factor 4 (FGF4) permitted the isolation of permanent trophoblast stem cell lines. These cell lines differentiated to other trophoblast subtypes in vitro in the absence of FGF4 and exclusively contributed to the trophoblast lineage in vivo in chimeras.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tanaka, S -- Kunath, T -- Hadjantonakis, A K -- Nagy, A -- Rossant, J -- New York, N.Y. -- Science. 1998 Dec 11;282(5396):2072-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9851926" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Blastocyst/cytology
;
Cell Differentiation
;
Cell Division
;
Cell Line
;
Cell Lineage
;
Chimera
;
Culture Media, Conditioned
;
Embryo, Mammalian/cytology
;
Female
;
Fibroblast Growth Factor 4
;
Fibroblast Growth Factors/*pharmacology/physiology
;
Fibroblasts/cytology
;
Gene Expression Regulation, Developmental
;
Genetic Markers
;
Karyotyping
;
Male
;
Mice
;
Models, Biological
;
Proto-Oncogene Proteins/*pharmacology/physiology
;
Signal Transduction
;
Stem Cells/*cytology/metabolism
;
Trophoblasts/*cytology/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
