Publication Date:
1998-01-07
Description:
The inositol 1,4,5-trisphosphate (IP3) receptor is a calcium ion channel involved in the release of free Ca2+ from intracellular stores. For analysis of the role of IP3-induced Ca2+ release (IICR) on patterning of the embryonic body, monoclonal antibodies that inhibit IICR were produced. Injection of these blocking antibodies into the ventral part of early Xenopus embryos induced modest dorsal differentiation. A close correlation between IICR blocking potencies and ectopic dorsal axis induction frequency suggests that an active IP3-Ca2+ signal may participate in the modulation of ventral differentiation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kume, S -- Muto, A -- Inoue, T -- Suga, K -- Okano, H -- Mikoshiba, K -- New York, N.Y. -- Science. 1997 Dec 12;278(5345):1940-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Mikoshiba Calciosignal Net Project, Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Corporation (JST), 2-9-3 Shimo-Meguro, Meguro-ku, Tokyo 153, Japan. skume@ims.u-tokyo.ac.jp〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9395395" target="_blank"〉PubMed〈/a〉
Keywords:
Activins
;
Animals
;
Antibodies, Blocking
;
Antibodies, Monoclonal
;
*Body Patterning
;
Calcium/*metabolism
;
Calcium Channels/immunology/*metabolism
;
Cell Differentiation
;
Embryo, Nonmammalian/*metabolism
;
Embryonic Development
;
Embryonic Induction
;
Fibroblast Growth Factor 2/pharmacology
;
Gastrula/metabolism
;
Gene Expression Regulation, Developmental
;
Inhibins/pharmacology
;
Inositol 1,4,5-Trisphosphate/*metabolism
;
Inositol 1,4,5-Trisphosphate Receptors
;
Receptors, Cytoplasmic and Nuclear/immunology/*metabolism
;
*Signal Transduction
;
Xenopus
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
