Publication Date:
1997-12-31
Description:
A lymphocyte subpopulation, the Valpha14 natural killer T (NKT) cells, expresses both NK1.1 and a single invariant T cell receptor encoded by the Valpha14 and Jalpha281 gene segments. Mice with a deletion of the Jalpha281 gene segment were found to exclusively lack this subpopulation. The Valpha14 NKT cell-deficient mice could no longer mediate the interleukin-12 (IL-12)-induced rejection of tumors. Although the antitumor effect of IL-12 was thought to be mediated through natural killer cells and T cells, Valpha14 NKT cells were found to be an essential target of IL-12, and they mediated their cytotoxicity by an NK-like effector mechanism after activation with IL-12.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cui, J -- Shin, T -- Kawano, T -- Sato, H -- Kondo, E -- Toura, I -- Kaneko, Y -- Koseki, H -- Kanno, M -- Taniguchi, M -- New York, N.Y. -- Science. 1997 Nov 28;278(5343):1623-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Core Research for Evolutional Science and Technology (CREST) Project, Japan Science and Technology Corporation (JST), 1-8-1 Inohana, Chuo-ku, Chiba, Japan 260.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9374462" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Anti-Bacterial Agents/pharmacology
;
*Cytotoxicity, Immunologic
;
Gene Deletion
;
Gene Targeting
;
Genes, RAG-1
;
Genes, T-Cell Receptor alpha
;
Interferon-gamma/immunology
;
Interleukin-12/*immunology
;
Killer Cells, Natural/*immunology
;
*Macrolides
;
Melanoma, Experimental/immunology
;
Mice
;
Mice, Inbred C57BL
;
Mice, Transgenic
;
Neoplasms, Experimental/*immunology
;
Poly I-C/pharmacology
;
Proton-Translocating ATPases/antagonists & inhibitors
;
Receptors, Antigen, T-Cell, alpha-beta/genetics/*immunology
;
T-Lymphocyte Subsets/*immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
