Publication Date:
1997-01-31
Description:
The relation between an antigenic peptide that can stimulate a mature T cell and the natural peptide that promoted selection of this cell in the thymus is still unknown. An experimental system was devised to address this issue in vivo-mice expressing neopeptides in thymic stromal cells after adenovirus-mediated delivery of invariant chain-peptide fusion proteins. In this system, selection of T cells capable of responding to a given antigenic peptide could be promoted by the peptide itself, by closely related analogs lacking agonist and antagonist activity, or by ostensibly unrelated peptides. However, the precise repertoire of T cells selected was dictated by the particular neopeptide expressed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nakano, N -- Rooke, R -- Benoist, C -- Mathis, D -- New York, N.Y. -- Science. 1997 Jan 31;275(5300):678-83.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut de Genetique et de Biologie Moleculaire et Cellulaire (INSERM, CNRS, Universite Louis Pasteur), 1 rue Laurent Fries, 67404 Illkirch, C.U. de Strasbourg, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9005856" target="_blank"〉PubMed〈/a〉
Keywords:
Adenoviridae/genetics
;
Amino Acid Sequence
;
Animals
;
Antigen-Presenting Cells/immunology
;
Antigens, Differentiation, B-Lymphocyte/genetics
;
Cells, Cultured
;
Cloning, Molecular
;
Cross Reactions
;
Cytochrome c Group/immunology
;
DNA, Complementary/genetics
;
Genetic Vectors
;
Histocompatibility Antigens Class II/genetics
;
Hybridomas
;
Interleukin-2/biosynthesis
;
*Lymphocyte Activation
;
Mice
;
Molecular Sequence Data
;
Peptides/chemistry/*immunology
;
Receptors, Antigen, T-Cell/*immunology
;
Recombinant Fusion Proteins
;
T-Lymphocytes/*immunology
;
Thymus Gland/cytology/*immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
