Publication Date:
1978-09-15
Description:
Rebound insomnia followed the withdrawal of three benzodiazepine hypnotic drugs, each of which had been administered in a single nightly dose for only short-term periods. The intense worsening of sleep is attributed to the short duration of the action of these drugs. A hypothesis involving benzodiazepine receptors in the brain is proposed in which there is a delay or lag in replacement of endogenous benzodiazepine-like molecules after the abrupt withdrawal of exogenous drugs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kales, A -- Scharf, M B -- Kales, J D -- New York, N.Y. -- Science. 1978 Sep 15;201(4360):1039-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/684426" target="_blank"〉PubMed〈/a〉
Keywords:
Benzodiazepines/*adverse effects/metabolism
;
Brain/metabolism
;
Flunitrazepam/adverse effects/metabolism
;
Humans
;
Hypnotics and Sedatives/*adverse effects/metabolism
;
Nitrazepam/adverse effects/metabolism
;
Receptors, Drug/drug effects/metabolism
;
Sleep Initiation and Maintenance Disorders/*etiology/metabolism
;
*Substance Withdrawal Syndrome/metabolism
;
Syndrome
;
Time Factors
;
Triazolam/adverse effects/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
