Publication Date:
1979-12-21
Description:
The female hybrid hare (Lepus timidus x Lepus europaeus) is heterozygous for electrophoretically separable, X-linked isoenzymes of glucose-6-phosphate dehydrogenase. The isoenzymes of this animal have been used as cellular markers in the study of the clonal origins of experimentally induced atherosclerotic lesions. Aortic lesions produced in the hybrid hare by feeding cholesterol and injuring the aortic wall with a catheter have been shown to have polyclonal characteristics and in this way are fundamentally different from atherosclerotic fibrous plaques in man.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pearson, T A -- Dillman, J -- Williams, K J -- Wolff, J A -- Adams, R -- Solez, K -- Heptinstall, R H -- Malmros, H -- Sternby, N -- New York, N.Y. -- Science. 1979 Dec 21;206(4425):1423-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/505016" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Arteriosclerosis/enzymology/*pathology
;
Catheterization/methods
;
Clone Cells/enzymology/*pathology
;
Diet, Atherogenic
;
*Disease Models, Animal
;
Glucosephosphate Dehydrogenase/metabolism
;
Isoenzymes/metabolism
;
Rabbits
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
