Publication Date:
1978-04-21
Description:
A new antigenic determinant was discovered with a hemagglutination-inhibition assay system. Designated Hv(1), it is located in the variable region of human immunoglobulin heavy chains of the G, M, and A classes. Pedigree and population analyses suggest that it has an autosomal dominant mode of inheritance. This represents the first description of an allotypic determinant in the variable region of human immunoglobulins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wang, A C -- Mathur, S -- Pandey, J -- Siegel, F P -- Middaugh, C R -- Litman, G W -- New York, N.Y. -- Science. 1978 Apr 21;200(4339):327-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/416494" target="_blank"〉PubMed〈/a〉
Keywords:
*Binding Sites, Antibody
;
Genes
;
Hemagglutination Inhibition Tests
;
Humans
;
Immunoglobulin Fab Fragments/genetics
;
Immunoglobulin Fc Fragments/genetics
;
Immunoglobulin Heavy Chains/*genetics
;
*Immunoglobulin Variable Region
;
Pedigree
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
