Publication Date:
1988-01-08
Description:
The beta-adrenergic agonist isoproterenol and analogs of adenosine 3',5'-monophosphate (cAMP) induced a potassium current, M current, in freshly dissociated gastric smooth muscle cells. Muscarinic agonists suppress this current, apparently by acting at a locus downstream from regulation of cAMP levels by adenylate cyclase and phosphodiesterase. Thus, M current can be induced by an agent and regulated in antagonistic fashion by beta-adrenergic and muscarinic systems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sims, S M -- Singer, J J -- Walsh, J V Jr -- DK 31620/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 1988 Jan 8;239(4836):190-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology, University of Massachusetts Medical School Worcester 01655.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2827305" target="_blank"〉PubMed〈/a〉
Keywords:
Acetylcholine/pharmacology
;
Animals
;
Bufo marinus
;
Cyclic AMP/physiology
;
Electric Conductivity
;
In Vitro Techniques
;
Isoproterenol/pharmacology
;
Membrane Potentials/drug effects
;
Muscarine/pharmacology
;
Muscle, Smooth/*physiology
;
Potassium/*physiology
;
Receptors, Adrenergic, beta/*physiology
;
Receptors, Muscarinic/*physiology
;
Stomach/physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
