Publication Date:
1989-08-18
Description:
Keratinocyte growth factor (KGF) is a human mitogen that is specific for epithelial cells. The complementary DNA sequence of KGF demonstrates that it is a member of the fibroblast growth factor family. The KGF transcript was present in stromal cells derived from epithelial tissues. By comparison with the expression of other epithelial cell mitogens, only KGF, among known human growth factors, has the properties of a stromal mediator of epithelial cell proliferation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Finch, P W -- Rubin, J S -- Miki, T -- Ron, D -- Aaronson, S A -- New York, N.Y. -- Science. 1989 Aug 18;245(4919):752-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, MD 20892.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2475908" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
Base Sequence
;
Cell Division
;
Codon
;
DNA/genetics/isolation & purification
;
Epithelial Cells
;
Epithelium/analysis/metabolism
;
Fibroblast Growth Factor 10
;
Fibroblast Growth Factor 7
;
*Fibroblast Growth Factors/genetics
;
Fibroblasts/metabolism
;
Gene Expression Regulation
;
Growth Substances/*genetics/physiology
;
Humans
;
Mesoderm/metabolism
;
Mice
;
Molecular Sequence Data
;
Nucleic Acid Hybridization
;
Oligonucleotide Probes
;
RNA/analysis
;
Sequence Homology, Nucleic Acid
;
Skin/analysis
;
Tissue Distribution
;
Transcription, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
