Publication Date:
1991-10-25
Description:
The action of dopamine and other monoamine neurotransmitters at synapses is terminated predominantly by high-affinity reuptake into presynaptic terminals by specific sodium-dependent neurotransmitter transport proteins. A complementary DNA encoding a rat dopamine transporter has been isolated that exhibits high sequence similarity with the previously cloned norepinephrine and gamma-aminobutyric acid transporters. Transient expression of the complementary DNA in HeLa cells confirms the cocaine sensitivity of this transporter.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kilty, J E -- Lorang, D -- Amara, S G -- New York, N.Y. -- Science. 1991 Oct 25;254(5031):578-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Yale University, New Haven, CT 06510.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1948035" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
Base Sequence
;
Carrier Proteins/drug effects/*genetics/metabolism
;
Cloning, Molecular
;
Cocaine/*pharmacology
;
Dopamine/*metabolism
;
Dopamine Plasma Membrane Transport Proteins
;
Gene Expression
;
HeLa Cells
;
Humans
;
Kinetics
;
*Membrane Glycoproteins
;
*Membrane Transport Proteins
;
Molecular Sequence Data
;
*Nerve Tissue Proteins
;
Oligodeoxyribonucleotides
;
Polymerase Chain Reaction/methods
;
Rats
;
Sequence Homology, Nucleic Acid
;
Transfection
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
