Publication Date:
2000-04-25
Description:
T cells from patients who had received chemotherapy for B-lineage acute lymphocytic leukemia were studied to determine whether genetic instability, a principal characteristic of cancer cells, can also occur in nonmalignant cells. Consistent with expectations for a genetic instability phenotype, multiple mutations were detected in the hypoxanthine-guanine phosphoribosyltransferase (HPRT) reporter gene in independently isolated mutant T cells expressing identical rearranged T cell receptor beta (TCRbeta) gene hypervariable regions. These results indicate that cancer treatment can lead to genetic instability in nonmalignant cells in some individuals. They also suggest a mechanistic paradigm for the induction of second malignancies and drug resistance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Finette, B A -- Homans, A C -- Albertini, R J -- 1K01CA77737/CA/NCI NIH HHS/ -- 1R29HD35309/HD/NICHD NIH HHS/ -- P30CA22435/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2000 Apr 21;288(5465):514-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pediatrics, Vermont Cancer Center, University of Vermont, Medical Alumni Building, Burlington, VT 05405, USA. finette@salus.med.uvm.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10775110" target="_blank"〉PubMed〈/a〉
Keywords:
Adolescent
;
Adult
;
Alleles
;
Antineoplastic Agents/*therapeutic use
;
Burkitt Lymphoma/blood/*drug therapy/*genetics
;
Cell Lineage
;
Cell Transformation, Neoplastic
;
Child
;
Child, Preschool
;
Clone Cells
;
Drug Resistance, Neoplasm
;
Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
;
Genes, Reporter
;
*Genes, T-Cell Receptor
;
Humans
;
Hypoxanthine Phosphoribosyltransferase/genetics
;
Infant
;
*Mutation
;
Neoplasms, Second Primary/etiology
;
Precursor Cell Lymphoblastic Leukemia-Lymphoma/blood/drug therapy/*genetics
;
Recurrence
;
*T-Lymphocytes
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
