Publication Date:
2014-09-27
Description:
Animal behaviors are reinforced by subsequent rewards following within a narrow time window. Such reward signals are primarily coded by dopamine, which modulates the synaptic connections of medium spiny neurons in the striatum. The mechanisms of the narrow timing detection, however, remain unknown. Here, we optically stimulated dopaminergic and glutamatergic inputs separately and found that dopamine promoted spine enlargement only during a narrow time window (0.3 to 2 seconds) after the glutamatergic inputs. The temporal contingency was detected by rapid regulation of adenosine 3',5'-cyclic monophosphate in thin distal dendrites, in which protein-kinase A was activated only within the time window because of a high phosphodiesterase activity. Thus, we describe a molecular basis of reinforcement plasticity at the level of single dendritic spines.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225776/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225776/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yagishita, Sho -- Hayashi-Takagi, Akiko -- Ellis-Davies, Graham C R -- Urakubo, Hidetoshi -- Ishii, Shin -- Kasai, Haruo -- DA035612/DA/NIDA NIH HHS/ -- GM53395/GM/NIGMS NIH HHS/ -- NS069720/NS/NINDS NIH HHS/ -- R01 GM053395/GM/NIGMS NIH HHS/ -- R01 NS069720/NS/NINDS NIH HHS/ -- R21 DA035612/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 2014 Sep 26;345(6204):1616-20. doi: 10.1126/science.1255514.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Structural Physiology, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan. Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan. ; Laboratory of Structural Physiology, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan. Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan. Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan. ; Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA. ; Integrated Systems Biology Laboratory, Department of Systems Science, Graduate School of Informatics, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan. ; Laboratory of Structural Physiology, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan. Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan. hkasai@m.u-tokyo.ac.jp.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25258080" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cyclic AMP/metabolism
;
Cyclic AMP-Dependent Protein Kinases/metabolism
;
Dendritic Spines/*drug effects/physiology
;
Dopamine/*pharmacology
;
Dopamine Plasma Membrane Transport Proteins/genetics/metabolism
;
Electrical Synapses/drug effects/physiology
;
Glutamic Acid/*physiology
;
Learning/drug effects/*physiology
;
Mice
;
Neuronal Plasticity/*drug effects
;
Phosphoric Diester Hydrolases/metabolism
;
*Reward
;
Time Factors
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
