Publication Date:
2014-08-12
Description:
Top-down modulation of sensory processing allows the animal to select inputs most relevant to current tasks. We found that the cingulate (Cg) region of the mouse frontal cortex powerfully influences sensory processing in the primary visual cortex (V1) through long-range projections that activate local gamma-aminobutyric acid-ergic (GABAergic) circuits. Optogenetic activation of Cg neurons enhanced V1 neuron responses and improved visual discrimination. Focal activation of Cg axons in V1 caused a response increase at the activation site but a decrease at nearby locations (center-surround modulation). Whereas somatostatin-positive GABAergic interneurons contributed preferentially to surround suppression, vasoactive intestinal peptide-positive interneurons were crucial for center facilitation. Long-range corticocortical projections thus act through local microcircuits to exert spatially specific top-down modulation of sensory processing.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zhang, Siyu -- Xu, Min -- Kamigaki, Tsukasa -- Hoang Do, Johnny Phong -- Chang, Wei-Cheng -- Jenvay, Sean -- Miyamichi, Kazunari -- Luo, Liqun -- Dan, Yang -- R01 EY018861/EY/NEI NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2014 Aug 8;345(6197):660-5. doi: 10.1126/science.1254126.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA. ; Department of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA. ; Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA. ydan@berkeley.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25104383" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Animals, Genetically Modified
;
Discrimination (Psychology)
;
GABAergic Neurons/chemistry/*physiology
;
Gyrus Cinguli/cytology/*physiology
;
Interneurons
;
Mice
;
Mice, Inbred C57BL
;
Neural Inhibition
;
Photic Stimulation
;
Somatostatin/analysis
;
Visual Cortex/cytology/*physiology
;
Visual Perception/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
