Publication Date:
2010-01-16
Description:
NLR (nucleotide-binding domain, leucine-rich repeat-containing) proteins have rapidly emerged as central regulators of immunity and inflammation with demonstrated relevance to human diseases. Much attention has focused on the ability of several NLRs to activate the inflammasome complex and drive proteolytic processing of inflammatory cytokines; however, NLRs also regulate important inflammasome-independent functions in the immune system. We discuss several of these functions, including the regulation of canonical and noncanonical NF-kappaB activation, mitogen-activated protein kinase activation, cytokine and chemokine production, antimicrobial reactive oxygen species production, type I interferon production, and ribonuclease L activity. We also explore the mechanistic basis of these functions and describe current challenges in the field.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943909/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943909/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ting, Jenny P Y -- Duncan, Joseph A -- Lei, Yu -- AI031496/AI/NIAID NIH HHS/ -- AI057157/AI/NIAID NIH HHS/ -- AI063031/AI/NIAID NIH HHS/ -- CA131645/CA/NCI NIH HHS/ -- DE016326/DE/NIDCR NIH HHS/ -- DK38108/DK/NIDDK NIH HHS/ -- R01 AI063031/AI/NIAID NIH HHS/ -- R01 AI088255/AI/NIAID NIH HHS/ -- R01 DE016326/DE/NIDCR NIH HHS/ -- R21 CA131645/CA/NCI NIH HHS/ -- R37 AI029564/AI/NIAID NIH HHS/ -- U19 AI031496/AI/NIAID NIH HHS/ -- U19 AI077437/AI/NIAID NIH HHS/ -- U19AI077437/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2010 Jan 15;327(5963):286-90. doi: 10.1126/science.1184004.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology-Immunology, University of North Carolina, Chapel Hill, NC 27599, USA. jpyting@med.unc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20075243" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cytokines/metabolism
;
Endoribonucleases/metabolism
;
Humans
;
*Immunity, Innate
;
Inflammation
;
Interferon Type I/metabolism
;
Intracellular Signaling Peptides and Proteins/chemistry/*metabolism
;
Mitochondrial Proteins/metabolism
;
Mitogen-Activated Protein Kinases/metabolism
;
NF-kappa B/metabolism
;
Nod1 Signaling Adaptor Protein/metabolism
;
Nod2 Signaling Adaptor Protein/metabolism
;
Protein Interaction Domains and Motifs
;
Receptors, Pattern Recognition/chemistry/*metabolism
;
*Signal Transduction
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
