Publication Date:
2008-05-03
Description:
The protozoan parasite Trypanosoma brucei is lysed by apolipoprotein L-I, a component of human high-density lipoprotein (HDL) particles that are also characterized by the presence of haptoglobin-related protein. We report that this process is mediated by a parasite glycoprotein receptor, which binds the haptoglobin-hemoglobin complex with high affinity for the uptake and incorporation of heme into intracellular hemoproteins. In mice, this receptor was required for optimal parasite growth and the resistance of parasites to the oxidative burst by host macrophages. In humans, the trypanosome receptor also recognized the complex between hemoglobin and haptoglobin-related protein, which explains its ability to capture trypanolytic HDLs. Thus, in humans the presence of haptoglobin-related protein has diverted the function of the trypanosome haptoglobin-hemoglobin receptor to elicit innate host immunity against the parasite.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vanhollebeke, Benoit -- De Muylder, Geraldine -- Nielsen, Marianne J -- Pays, Annette -- Tebabi, Patricia -- Dieu, Marc -- Raes, Martine -- Moestrup, Soren K -- Pays, Etienne -- New York, N.Y. -- Science. 2008 May 2;320(5876):677-81. doi: 10.1126/science.1156296.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Molecular Parasitology, Institute for Molecular Biology and Medicine, Universite Libre de Bruxelles, 12 rue des Profs Jeener et Brachet, B6041 Gosselies, Belgium.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18451305" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
Haptoglobins/metabolism
;
Hemoglobins/metabolism
;
Humans
;
Immunity, Innate
;
Lipoproteins, HDL/metabolism
;
Mice
;
Mice, Inbred Strains
;
Molecular Sequence Data
;
Receptors, Cell Surface/*immunology/metabolism
;
Trypanosoma brucei brucei/*immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
