Publication Date:
2002-11-02
Description:
beta-Defensins are small antimicrobial peptides of the innate immune system produced in response to microbial infection of mucosal tissue and skin. We demonstrate that murine beta-defensin 2 (mDF2beta) acts directly on immature dendritic cells as an endogenous ligand for Toll-like receptor 4 (TLR-4), inducing up-regulation of costimulatory molecules and dendritic cell maturation. These events, in turn, trigger robust, type 1 polarized adaptive immune responses in vivo, suggesting that mDF2beta may play an important role in immunosurveillance against pathogens and, possibly, self antigens or tumor antigens.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Biragyn, Arya -- Ruffini, Pier Adelchi -- Leifer, Cynthia A -- Klyushnenkova, Elena -- Shakhov, Alexander -- Chertov, Oleg -- Shirakawa, Aiko K -- Farber, Joshua M -- Segal, David M -- Oppenheim, Joost J -- Kwak, Larry W -- N0L-CO-12400/CO/NCI NIH HHS/ -- New York, N.Y. -- Science. 2002 Nov 1;298(5595):1025-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Experimental Transplantation and Immunology Branch, National Cancer Institute, Bethesda, MD 20892, USA. arya@mail.ncifcrf.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12411706" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigens, Neoplasm/immunology
;
Cancer Vaccines/immunology
;
Cell Line
;
Cytokines/biosynthesis
;
Dendritic Cells/*immunology
;
*Drosophila Proteins
;
Female
;
Humans
;
Interferon-alpha/physiology
;
Ligands
;
Lipopolysaccharides/immunology/pharmacology
;
Lymphocyte Culture Test, Mixed
;
Membrane Glycoproteins/genetics/*physiology
;
Mice
;
Mice, Inbred BALB C
;
Mice, Inbred C3H
;
Mice, Inbred C57BL
;
Neoplasms/immunology/therapy
;
Receptors, CCR6
;
Receptors, Cell Surface/genetics/*physiology
;
Receptors, Chemokine/metabolism
;
Recombinant Fusion Proteins/pharmacology
;
Signal Transduction
;
Toll-Like Receptor 4
;
Toll-Like Receptors
;
Transfection
;
beta-Defensins/pharmacology/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
