Publication Date:
2002-02-02
Description:
More than 2000 transcription factors are encoded in the human genome. Such proteins have often been classified according to common structural elements. But because transcription factors evolved in the service of biologic function, we propose an alternative grouping of eukaryotic transcription factors on the basis of characteristics that describe their roles within cellular regulatory circuits.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brivanlou, Ali H -- Darnell, James E Jr -- 1RO1EY12370-03/EY/NEI NIH HHS/ -- 2RO1HD/GM32105-06A1/HD/NICHD NIH HHS/ -- AI32489/AI/NIAID NIH HHS/ -- AI34420/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2002 Feb 1;295(5556):813-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Molecular Vertebrate Embryology, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11823631" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cell Nucleus/metabolism
;
Cytoplasm/metabolism
;
DNA/metabolism
;
DNA-Binding Proteins/metabolism
;
*Gene Expression Regulation
;
Phosphorylation
;
Phosphoserine/metabolism
;
Receptors, Cell Surface/metabolism
;
Second Messenger Systems
;
*Signal Transduction
;
Transcription Factors/chemistry/*classification/*metabolism
;
*Transcription, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
