Publication Date:
2018-10-31
Description:
The hydroxy amino acids have its unique effects in the biotechnology and molecular biology, and all sorts of synthetic hydroxy amino acids have also been developed. The hydroxy amino acids have been proved to be valuable for antifungal, antibacterial, antiviral and anticancer properties and known as a constituent of pharmaceutical intermediates. In addition to these fundamental researches, the hydroxy amino acids are applied widely to the synthesis of chiral drugs, such as (2 S , 3 R , 4 S )-4-hydroxyisoleucine (4-HIL) is proved to be worthy in medical treatment, cis -4-hydroxy-L-proline (C4LHyp) and trans-4-hydroxy-L-proline (T4LHyp) are applied to build the chiral intermediates in pharmaceutical synthesis. Through comparisons chemical synthesis with biological catalysis to form hydroxy amino acids, enantioselective biocatalysts will undoubtedly be used in the synthesis of chiral pharmaceuticals. Mononuclear non-heme Fe(II)/α-ketoglutarate-dependent dioxyge...
Print ISSN:
1755-1307
Electronic ISSN:
1755-1315
Topics:
Geography
,
Geosciences
,
Physics
