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m-Chlorobenzhydroxamic Acid–an Inhibitor of Cyanide-Insensitive Respiration in Trypanosoma brucei (1973)

EVANS, D. A. ; BROWN, R. C.

Oxford, UK : Blackwell Publishing Ltd

The @journal of eukaryotic microbiology 20 (1973), S. 0

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ISSN: 1550-7408

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Biology

Notes: Cyanide-insensitive respiration of bloodstream and culture forms of T. brucei was inhibited by m-chlorobenz-hydroxamic acid (m-CLAM). The cyanide-sensitive respiration of culture forms of this organism was not affected by m-CLAM. This compound is the 1st really effective inhibitor to be described that acts specifically on the cyanide-insensitive respiration of the T. brucei group of trypanosomes; as such it may be of some importance as a trypanocidal drug.Evidence is adduced which suggests that a branched electron transport chain is present in culture forms of T. brucei and that the cyanide-insensitive terminal oxidase found in these stages is the same as that found in bloodstream forms.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1550-7408.1973.tb06024.x

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