ISSN:
1095-8649
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Biology
Notes:
Peripheral blood neutrophils were studied in eels injected with phosphate buffered saline, bacterial lipopolysaccharide (LPS), carrageenan (CAR), LPS and CAR together (CAR/LPS(T)), CAR and LPS 4 days later (CAR/LPS(S)), zymosan and latex beads. All stimuli caused a left shift toward neutrophil immaturity but LPS-elicited neutrophils, particularly in CAR/LPS stimulated eels, were often extremely basophilic, enlarged, vacuolated and had a large nucleus with poorly differentiated nuclear chromatin. These intensely basophilic neutrophils (IBN) had few granules and lower acid phosphatase and non-specific esterase, but higher PAS levels, compared to normal neutrophils. Ultrastructurally, IBN showed loss of cytoplasmic content that gave a ragged appearance, the nucleus was often immature and many rough endoplasmic reticulum profiles restricted the distribution of reduced numbers of cytoplasmic granules. These features are attributed to asynchronous development, and IBN are compared with mammalian toxic neutrophils.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1095-8649.1988.tb05397.x
