ISSN:
1612-1112
Keywords:
Column liquid chromatography
;
Nitrofuran derivatives
;
Structure-activity relationships
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary Quantitative structure-activity relationships were performed on a set of 5-nitrofuran derivatives. The correlation parameters used were hydrophobicity and connectivity. The former was measured by means of the capacity factor (log k o ′ ) obtained by HPLC and the latter through the molecular valence connectivity index1 χ v obtained by computational methods. The biological activity data considered were growth inhibition percentages ofT. cruzi (GI % (48 h)) and half-maximal inhibitory concentration of Glutathione Reductase (I0.5 (max)). Good adjustment, r=0.98, was obtained if a logarithmic model is used for I0.5 (max) correlations. When GI% is considered, correlations were poorer and the consideration of both structural parameters was necessary for their improvement, r=0.94.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02274545
