ISSN:
1612-1112
Keywords:
Column liquid chromatography
;
Mobile phase composition and column temperature
;
Retention prediction
;
Polycyclic aromatic hydrocarbons
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary The relationship between the logarithmic capacity factor measured in reversed-phase liquid chromatography and the operating conditions including the mobile phase composition and the column temperature is investigated. The strategy described herein can offer the possibility to predict the retention of polycyclic aromatic hydrocarbons without any experiments and standard materials, by utilizing equations describing the relationships between retention, temperature, mobile phase composition and physicochemical properties of the solutes previously stored in the program of the microcomputer-assisted retention prediction system. This concept is one of the most promising techniques for the optimization of the separation conditions in reversed-phase liquid chromatography.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02257289
