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Chromosomal assignment of a large tRNA gene cluster (tRNALeu, tRNAGln, tRNALys, tRNAArg, tRNAGly) to 17p13.1 (1991)

Morrison, N. ; Goddard, J. P. ; Ledbetter, D. H. ; [et al.]

Springer

Human genetics 〈Berlin〉 87 (1991), S. 226-230

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ISSN: 1432-1203

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary A cluster of tRNA genes (tRNA UAG Leu , tRNA CUG Gln , tRNA UUU Lys , tRNA UCU Arg ) and an adjacent tRNA GCC Gly have been assigned to human chromosome 17p12–p13.1 by in situ hybridization using a 4.2 kb human DNA fragment for tRNALeu, tRNAGln, tRNALys, tRNAArg, and, for tRNAGly, 1.3 kb and 0.58 kb human DNA fragments containing these genes as probes. This localization was confirmed and refined to 17p13.100–p13.105 using a somatic cell hybrid mapping panel. Preliminary experiments with the biotiny lated tRNA Leu, Gln, Lys, Arg probe and metaphase spreads from other great apes suggest the presence of a hybridization site on the long arm of gorilla (Gorilla gorilla) chromosome 19 and the short arm of orangutan (Pongo pygmaeus) chromosome 19 providing further support for homology between HSA17, GGO19 and PPY19.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00204190

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