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A novel mutation that affects utilization of galactose in Saccharomyces cerevisiae (1980)

Nogi, Yasuhisa ; Fukasawa, Toshio

Springer

Current genetics 2 (1980), S. 115-120

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ISSN: 1432-0983

Keywords: Galactose fermentation ; Saccharomyces cerevisiae ; Regulatory mutant

Source: Springer Online Journal Archives 1860-2000

Topics: Biology

Notes: Summary A novel type of regulatory mutation for galactose metabolism in Saccharomyces cerevisiae is described. The mutation named gal11 was recessive, non-allelic to GAL4, GAL80, GAL2, or GAL3, and unlinked to the gene cluster of GAL1, GAL10, and GAL7. It caused a ‘coordinate’ reduction of galactokinase, galactose-1-P uridylyl transferase, and UDP-glucose 4-epimerase by a factor of more than 5, rendering the mutant cells galactose-nonfermenting. The effect of the mutation was manifested not only in cells grown on galactose but also in cells constitutively synthesizing the galactose-metabolizing enzymes.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00420623

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