ISSN:
1432-1041
Keywords:
calcium entry blockers
;
PY 108-068
;
PN 200-110
;
alpha1-/alpha2-adrenoceptors
;
essential hypertension
;
forearm
;
vascular resistance
;
B-HT 933
;
methoxamine
;
vasoconstriction
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The influence of treatment with the calcium entry blockers PY 108-068 (PY) and PN 200-110 (PN) on α1- and α2-adrenoceptor mediated vasoconstriction has been investigated in the forearms of hypertensive patients. Changes in forearm vascular resistance (FVR) in response to the intra-arterial infusion of drugs were determined at the end of a placebo period and after 2–4 weeks of treatment with PY or PN. The drugs used were the selective agonists methoxamine (α1) and B-HT 933 (α2). During placebo, basal FVR was dose-dependently increased by methoxamine and B-HT 933. Basal blood pressure was lowered during PN but not during PY. Treatment with the calcium entry blockers did not influence the effect of methoxamine, but the vasoconstriction induced by B-HT933 was attenuated by both of the calcium entry blockers. These results confirm the findings in animal studies that calcium entry blockers preferentially inhibit the α2-adrenoceptor mediated vasoconstriction induced by selective agonists.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00542182
