Electronic Resource
Palo Alto, Calif.
:
Annual Reviews
Annual Review of Genetics
35 (2001), S. 149-191
ISSN:
0066-4197
Source:
Annual Reviews Electronic Back Volume Collection 1932-2001ff
Topics:
Biology
Notes:
Abstract The endoplasmic reticulum (ER) serves as a way-station during the biogenesis of nearly all secreted proteins, and associated with or housed within the ER are factors required to catalyze their import into the ER and facilitate their folding. To ensure that only properly folded proteins are secreted and to temper the effects of cellular stress, the ER can target aberrant proteins for degradation and/or adapt to the accumulation of misfolded proteins. Molecular chaperones play critical roles in each of these phenomena.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1146/annurev.genet.35.102401.090313
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