ISSN:
0887-6134
Keywords:
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Positive ion fast atom bombardment mass spectra of the opioid pentapeptides leucine enkephalin (1) (H-Tyr-Gly-Gly-Phe-Leu-OH or YGGFL), methionine enkephalin (2) (H-Tyr-Gly-Gly-Phe-Met-OH or YGGFM) and leucine enkephalin-2H2 (3) (H-Tyr-2Gly-2H2-Gly-Phe-Leu-OH or YGGFL-2H2) have been recorded in glycerol. The following experiments have been carried out: (i) dimer studies [2M + 1]+; (ii) decompositions of dimers: daughter ions from (YGGFL)2, (YGGFL-YGGFL-2H2) and (YGGFL-2H2)2 as well as (YGGFM-YGGFL) and (YGGFM)2 dimers; (iii) solvation site and pyridine collision-activated dissociation studies for dimer ions; (iv) mechanism of formation of [(2M + 1) - Gly4]+ ions.
Additional Material:
7 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/bms.1200180502