ISSN:
0935-6304
Keywords:
Chromatography, LC and GC
;
Capillary
;
Theory
;
Ultimate resolution
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The expression for the resolution function, R, in terms of operating parameters for open tubular columns has been extended to include inlet contributions to the peak variance. Subsequent optimization has revealed the existence of optima in the column radius, the stationary phase thickness and the diffusion coefficient ratio in the stationary and mobile phases-in addition to the well-known optimum in the flow velocity. This implies that R at optimum becomes R=f(K)L0.6Vi-0.2, i.e. a function only of the column length, L, the inlet volume, Vi, and the concentration distribution coefficient, K. For given K, L and Vi all other parameters such as retention time and pressure drop can thus be directly computed. The information is finally consolidated in the form of contour diagrams. The text itself is cast in the form of a science fantasy.
Additional Material:
8 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jhrc.1240020403
