Keywords:
Pharmacology.
;
Medicinal chemistry.
;
Cancer.
;
Microtechnology.
;
Microelectromechanical systems.
;
Pharmacovigilance.
;
Pharmacology.
;
Medicinal Chemistry.
;
Cancer Biology.
;
Microsystems and MEMS.
;
Drug Safety and Pharmacovigilance.
Description / Table of Contents:
Chapter 1. Cancer -- Chapter 2. Types of cancer -- Chapter 3. Classification -- Chapter 4. Cancer or tumor nomenclature -- Chapter 5. Heterogeneity -- Chapter 6. Invasion and metastasis -- Chapter 7. How cancer arises? -- Chapter 8. Epidemiology -- Chapter 9. Economic burden -- Chapter 10. Treatment modalities -- Chapter 11. Chemotherapy -- Chapter 12. Properties of metals and metal complexes -- Chapter 13. Platinum based anticancer agents -- Chapter 14. Chemistry of cisplatin -- Chapter 15. Mechanism of action of platinum drugs -- Chapter 16. Non-platinum anticancer agents -- Chapter 17. Chemistry of gold -- Chapter 18. Gold and its complexes in medicine -- Chapter 19. Auranofin and its analogues -- Chapter 20. Classes of gold complexes -- Chapter 21. Mechanisms of action of anticancer gold complexes -- Chapter 22. Perspectives.
Abstract:
This book presents an overview of cancer and the genesis, and development of different treatment strategies and modalities against cancer. The emergence of gold and its complexes as promising anticancer chemotherapeutic agents have the potential to substitute or replace the platinum based chemotherapeutic agents. Gold complexes have demonstrated considerable anti-proliferative properties, chiefly attributed to their anti-mitochondrial effects, they make gold complexes excellent candidates as anti-cancer agents compared to their platinum-based counterparts. This book provides a critical review of recent advances made in the development of gold complexes as anti-cancer agents. In this context, it examines a number of different ligand architectures, provides comprehensive information on gold complexes’ mechanism of action and toxicity issues and, in closing, outlines future research directions.
Type of Medium:
Online Resource
Pages:
IX, 173 p. 124 illus., 29 illus. in color.
,
online resource.
Edition:
1st ed. 2021.
ISBN:
9789813363144
URL:
https://doi.org/10.1007/978-981-33-6314-4
DOI:
10.1007/978-981-33-6314-4
DDC:
615
Language:
English
