Publication Date:
2021-05-19
Description:
Daily topical application of the aqueous ethanolic extract of the marine sea grass, Thalassia
testudinum, on mice skin exposed to UVB radiation resulted in a dose dependent recovery of the
skin macroscopic alterations over a 6-day period. Maximal effect (90%) occurred at a dose of 240
μg/cm2, with no additional effects at higher doses. Bioassay-guided fractionation of the plant extract
resulted in the isolation of thalassiolin B (1). Topical application of 1 (240 μg/cm2) markedly reduces
skin UVB-induced damage. In addition, thalassiolin B scavenged 2,2-diphenyl-2-picrylhydrazyl
radical with an EC50=100 μg/ml. These results suggest that thalassiolin B is responsible for the skin
regenerating effects of the crude extract of T. testudinum
Description:
Published
Description:
Flavonoids, Thalassiolin B, DPPH scavenged, antioxidant activity, Skin regenerating activity, Thalassia testudinum
Keywords:
Chemistry
;
Pharmacology
;
Chemistry
;
Pharmacology
Repository Name:
AquaDocs
Type:
Journal Contribution