Publication Date:
2023-04-05
Description:
Epilepsy is one of the most prevalent neurological disorders and is characterized by recurrent seizures resulting from abnormal neuronal excitability in the central nervous system. Despite the availability of thirty-six antiseizure medications, about one-third of patients with epilepsy do not respond to the pharmacological treatment and develop a so-called “pharmaco-resistant epilepsy” or “refractory epilepsy.” Thus, there is an urgent need to develop novel, effective therapies based on novel mechanisms underlying neuronal excitability that leads to seizures. This reprint’s original research papers and review articles highlight unknown mechanisms underlying pharmaco-resistant resistant epilepsy, epileptogenesis, and seizure suppression.
Keywords:
3CAI
;
GRIA1
;
GRIA2
;
intractable epilepsy
;
PICK1
;
protein kinase C
;
pericytes
;
mural cells
;
cytokine
;
blood-brain barrier
;
neuroinflammation
;
3-phosphoinositide-dependent protein kinase-1
;
AKT
;
cyclosporin A
;
GluA1
;
GluR1
;
PDK1
;
refractory seizure
;
temporal lobe epilepsy
;
hippocampus
;
4-aminopyridine
;
epilepsy model
;
long-term potentiation
;
AMPA receptor
;
audiogenic epilepsy
;
rodents
;
fear reaction
;
behavior genetics
;
c-Fos
;
early gene activation
;
epileptogenesis
;
lipopolysaccharide
;
pentylenetetrazole
;
post-traumatic epilepsy
;
seizure susceptibility
;
traumatic brain injury
;
epilepsy
;
ghrelin
;
ghrelin receptor
;
anxiety
;
TRPV1 channels
;
neuronal activity
;
neuropsychiatric comorbidity
;
immunofluorescence
;
audiogenic kindling
;
acoustically evoked seizures
;
EACT
;
generalized tonic-clonic seizures
;
inherited epilepsy
;
TMEM1A channels
;
wild running seizures
;
astrocyte
;
ML365
;
pharmacoresistant epilepsy
;
cortical atrophy
;
hippocampal atrophy
;
intracerebral electrode
;
magnetic resonance imaging
;
posttraumatic epilepsy
;
n/a
;
bic Book Industry Communication::M Medicine
;
bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
Language:
English
Format:
application/octet-stream
