ISSN:
1573-4986
Schlagwort(e):
sialyltransferase
;
galactosyltransferase
;
inhibitor
;
nucleoside monosaccharide conjugates
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Chemie und Pharmazie
Notizen:
Abstract The inhibition of the α-2,6-sialyltransferase from rat liver, the α-2,3-sialyltransferase from porcine submandibular gland and of the galactosyltransferase from human milk were studied using monosaccharide-, nucleoside- and nucleotide-derivatives of their naturally occurring donor substrates cytidine 5′-monophosphate-N-acetylneuraminic acid and uridine 5′-diphosphate-galactose, respectively. Only the corresponding nucleosides/nucleotides showed inhibitory activity. Periodate oxidation of CMP or CMP-Neu5Ac and of UMP or UDP-Gal led to reduced inhibitory efficiency with the respective transferase. The type and reversibility of the inhibition of some of these compounds, as well as the corresponding Ki values were determined.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1023/A:1018560931389
