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  • 1
    Publication Date: 2016-04-20
    Description: Objective Diffusion-weighted magnetic resonance imaging (DW-MRI) combined with intravoxel incoherent motion (IVIM) analysis may be applied for assessment of organ lesions, diffuse parenchymal pathologies, and therapy monitoring. The aim of this study was to determine IVIM reference parameters of abdominal organs for translational research in a large cohort of C57Bl/6 laboratory mice. Materials and methods Anesthetized mice ( n  = 29) were measured in a 4.7 T small-animal MR scanner with a diffusion-weighted echo-planar imaging sequence at the \(b\) -values 0, 13, 24, 55, 107, 260, 514, 767, 1020 s/mm 2 . IVIM analysis was conducted on the liver, spleen, renal medulla and cortex, pancreas, and small bowel with computation of the true tissue diffusion coefficient \(D_{\text{t}}\) , the perfusion fraction \(f_{\text{p}}\) , and the pseudodiffusion coefficient \(D_{\text{p}}\) . Microvessel density (MVD) was assessed by immunohistochemistry (IHC) against panendothelial cell antigen CD31. Results Mean values of the different organs [ \(D_{\text{t}}\) (10 −3  mm 2 /s); \(f_{\text{p}}\) (%); \(D_{\text{p}}\) (10 −3  mm 2 /s); MVD (MV/mm 2 )]: liver 1.15 ± 0.14; 14.77 ± 6.15; 50.28 ± 33.21, 2008.48 ± 419.43, spleen 0.55 ± 0.12; 9.89 ± 5.69; 24.46 ± 17.31; n.d., renal medulla 1.50 ± 0.20; 14.63 ± 4.07; 35.50 ± 18.01; 1231.88 ± 290.61, renal cortex 1.34 ± 0.18; 10.83 ± 3.70; 16.74 ± 6.74; 810.09 ± 193.50, pancreas 1.23 ± 0.22; 20.12 ± 7.46; 29.35 ± 17.82, 591.15 ± 86.25 and small bowel 1.06 ± 0.13; 16.48 ± 3.63; 15.31 ± 7.00; 420.50 ± 168.42. Unlike \(D_{\text{t}}\) and \(f_{\text{p}}\) , \(D_{\text{p}}\) correlates significantly with MVD ( r  = 0.90, p  = 0.037). Conclusion This systematic evaluation of murine abdominal organs with IVIM and MVD analysis allowed to establish reference parameters for future DW-MRI translational research studies on small-animal disease models.
    Print ISSN: 0968-5243
    Electronic ISSN: 1352-8661
    Topics: Medicine , Physics
    Published by Springer
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