ISSN:
1352-8661
Keywords:
free radicals
;
imaging
;
double resonance
;
field cycling
;
DNP
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
,
Physics
Notes:
Abstract Proton—electron double-resonance imaging (PEDRI) has been developed recently for imaging free radicals in biological samples and small animals. This article summarizes the techniques of PEDRI and the related field-cycled method, FC-PEDRI, and discusses the difficulties in scaling the techniques up to whole-body size. Imaging free radicals with broad EPR lines in humans would require excessive radiofrequency (RF) power, but the use of magnetic field cycling alleviates this problem and improves the signal-to-noise ratio. The results of computer simulations of field-cycled PEDRI are presented, which show that optimum EPR irradiation frequencies exist, depending on the free radical's electron relaxation times and on the applied RF power.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01705251
