ISSN:
1352-8661
Keywords:
P-31 MRS
;
muscle bioenergetics
;
metabolic myopathies
;
diagnosis
;
therapeutic follow-up
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
,
Physics
Notes:
Abstract A standardized P-31 magnetic resonance spectroscopy (MRS) protocol for the exploration of muscle metabolism by P-31 MRS in trained and untrained subjects as well as in patients with intolerance to exercise has been developed to meet the specific requirements of a clinical environment. This protocol is based on a short-term intense exercise which is very informative and well accepted by volunteers and patients. Invariant metabolic parameters have been established to characterize the normal metabolic response to the protocol. As a matter of fact, the comparative analysis of normal and diseased muscle remains a major requirement to further define metabolic events surrounding muscle contraction and the metabolic anomalies underlying diseases. Deviations from normality can be directly interpreted in terms of specific pathologies in some favourable cases. In most cases, P-31 MRS provides valuable information which has to be processed in conjunction with traditional invasive biochemical, electrophysiological and histoenzymological tests. For malignant and exertional hyperthermias, P-31 MRS constitutes a diagnostic tool with 100% sensitivity, as compared to contracture tests. P-31 MRS has proved particularly useful in the therapeutic follow-up of palliative therapies (coenzyme Q treatment of mitochondriopathies) and in family investigations. It is now an accepted diagnostic tool in the array of tests which are used to characterize muscle disorders in clinical routine. This procedure is already approved for reimbursement in the public hospital system in Marseille, France.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01760406
