Publication Date:
1995-02-03
Description:
An RNA has been selected that rapidly aminoacylates its 2'(3') terminus when provided with phenylalanyl-adenosine monophosphate. That is, the RNA accelerates the same aminoacyl group transfer catalyzed by protein aminoacyl-transfer RNA synthetases. The best characterized RNA reaction requires both Mg2+ and Ca2+. These results confirm a necessary prediction of the RNA world hypothesis and represent efficient RNA reaction (〉 or = 10(5) times accelerated) at a carbonyl carbon, exemplifying a little explored type of RNA catalysis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Illangasekare, M -- Sanchez, G -- Nickles, T -- Yarus, M -- GM30881/GM/NIGMS NIH HHS/ -- GM48080/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1995 Feb 3;267(5198):643-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder 80309-0347.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7530860" target="_blank"〉PubMed〈/a〉
Keywords:
Acylation
;
Adenosine Monophosphate/*analogs & derivatives/metabolism
;
Aminoacylation
;
Base Sequence
;
Biological Evolution
;
Calcium/metabolism
;
Glycolates/metabolism
;
Magnesium/metabolism
;
Molecular Sequence Data
;
Nucleic Acid Conformation
;
Phenylalanine/*metabolism
;
RNA/chemistry/*metabolism
;
RNA, Catalytic/chemistry/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
