Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

9354342 hits in 0.931 seconds
Refine your search
Collection
Keywords
Years
Select All   Deselect All   Toggle Selection   Add To Mindlist   Mail Export   File Export
1.
PAPER CURRENT
Erratum to: Regioselective Glucuronidation of Andrographolide and Its Major Derivatives: Metabolite Identification, Isozyme Contribution, and Species Differences (2014)
Publication Date: 2014-10-22
Electronic ISSN: 1550-7416
Topics: Chemistry and Pharmacology
2.
PAPER CURRENT
Biodegradable Microparticles Loaded with Doxorubicin and CpG ODN for In Situ Immunization Against Cancer (2014)
Publication Date: 2014-10-22
Description: ABSTRACT In situ immunization is based on the concept that it is possible to break immune tolerance by inducing tumor cell death in situ in a manner that provides antigen-presenting cells such as dendritic cells (DCs) with a wide selection of tumor antigens that can then be presented to the immune system and result in a therapeutic anticancer immune response. We designed a comprehensive approach to in situ immunization using poly(lactic-co-glycolic acid) (PLGA)-biodegradable microparticles (MPs) loaded with doxorubicin (Dox) and CpG oligodeoxynucleotides (CpG) that deliver Dox (chemotherapy) and CpG (immunotherapy) in a sustained-release fashion when injected intratumorally. Dox induces immunogenic tumor cell death while CpG enhances tumor antigen presentation by DCs. PLGA MPs allow their safe co-delivery while evading the vesicant action of Dox. In vitro, we show that Dox/CpG MPs can kill B and T lymphoma cells and are less toxic to DCs. In vivo, Dox/CpG MPs combined with antibody therapy to enhance and maintain the T cell response generated systemic immune responses that suppressed injected and distant tumors in a murine B lymphoma model, leading to tumor-free mice. The combination regimen was also effective at reducing T cell lymphoma and melanoma tumor burdens. In conclusion, Dox/CpG MPs represent an efficient and safe tool for in situ immunization that could provide a promising component of immunotherapy for patients with a variety of types of cancer.
Electronic ISSN: 1550-7416
Topics: Chemistry and Pharmacology
3.
PAPER CURRENT
Emerging Technologies to Increase Ligand Binding Assay Sensitivity (2014)
Publication Date: 2014-10-22
Description: Abstract Ligand binding assays (LBAs) have been the method of choice for protein analyte measurements for more than four decades. Over the years, LBA methods have improved in sensitivity and achieved larger dynamic ranges by using alternative detection systems and new technologies. As a consequence, the landscape and application of immunoassay platforms has changed dramatically. The introduction of bead-based methods, coupled with single molecule detection standardization and the ability to amplify assay signals, has improved the sensitivity of many immunoassays, in some cases by several logs of magnitude. Three promising immunoassay platforms are described in this article: Single Molecule Counting (SMC™) from Singulex Inc, Single Molecule Arrays (Simoa™) from Quanterix Corporation, and Immuno-PCR (Imperacer®) from Chimera Biotec GmbH. These platforms have the potential to significantly improve immunoassay sensitivity and thereby address the bioanalytical needs and challenges faced during biopharmaceutical drug development.
Electronic ISSN: 1550-7416
Topics: Chemistry and Pharmacology
4.
PAPER CURRENT
Comparative Pharmacology and Toxicology of Pharmaceuticals in the Environment: Diphenhydramine Protection of Diazinon Toxicity in Danio rerio but Not Daphnia magna (2014)
Publication Date: 2014-10-22
Description: Abstract Pharmaceuticals and other contaminants of emerging concern present unique challenges to environmental risk assessment and management. Fortunately, mammalian pharmacology and toxicology safety data are more readily available for pharmaceuticals than other environmental contaminants. Identifying approaches to read-across such pharmaceutical safety information to non-target species represents a major research need to assess environmental hazards. Here, we tested a biological read-across hypothesis from emergency medicine with common aquatic invertebrate and vertebrate models. In mammals, the antihistamine diphenhydramine (DPH) confers protection from poisoning by acetylcholinesterase inhibition because DPH blocks the acetylcholine receptor. We employed standardized toxicity methods to examine individual and mixture toxicity of DPH and the acetylcholinesterase inhibitor diazinon (DZN) in Daphnia magna (an invertebrate) and Danio rerio (zebrafish, a vertebrate). Though the standardized Fish Embryo Toxicity method evaluates early life stage toxicity of zebrafish (0–3 days post fertilization, dpf), we further evaluated DPH, DZN, and their equipotent mixture during three development stages (0–3, 3–6, 7–10 dpf) in zebrafish embryos. Independent action and concentration addition mixture models and fish plasma modeling were used to assist interpretation of mixture toxicity experiments. Though our primary hypothesis was not confirmed in acute studies with Daphnia magna, DPH conferred a protective effect for acute DZN toxicity to zebrafish when DPH plasma levels were expected to be greater than mammalian therapeutic, but lower than acutely lethal, internal doses. We further observed that timing of developmental exposure influenced the magnitude of DZN and DPH toxicity to zebrafish, which suggests that future zebrafish toxicity studies with pharmaceuticals and pesticides should examine exposure during developmental stages.
Electronic ISSN: 1550-7416
Topics: Chemistry and Pharmacology
5.
PAPER CURRENT
Publication Date: 2014-10-22
Description: Accounts of Chemical ResearchDOI: 10.1021/ar5001378
Print ISSN: 0001-4842
Electronic ISSN: 1520-4898
Topics: Chemistry and Pharmacology
6.
PAPER CURRENT
Acid-Catalyzed Conversion of Xylose in 20 Solvents: Insight into Interactions of the Solvents with Xylose, Furfural, and the Acid Catalyst (2014)
Publication Date: 2014-10-22
Description: ACS Sustainable Chemistry & EngineeringDOI: 10.1021/sc5004659
Electronic ISSN: 2168-0485
Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
7.
PAPER CURRENT
Identification of Parton Pairs in a Dijet Event and Investigation of Its Effects on Dijet Resonance Search (2014)
Publication Date: 2014-10-22
Description: Being able to distinguish parton pair type in a dijet event could significantly improve the search for new particles that are predicted by the theories beyond the Standard Model at the Large Hadron Collider. To explore whether parton pair types manifesting themselves as a dijet event could be distinguished on an event-by-event basis, I performed a simulation based study considering observable jet variables. I found that using a multivariate approach can filter out about 80% of the other parton pairs while keeping more than half of the quark-quark or gluon-gluon parton pairs in an inclusive QCD dijet distribution. The effects of event-by-event parton pair tagging for dijet resonance searches were also investigated and I found that improvement on signal significance after applying parton pair tagging can reach up to 4 times for gluon-gluon resonances.
Print ISSN: 1687-7357
Electronic ISSN: 1687-7365
Topics: Physics
Published by Hindawi
8.
PAPER CURRENT
The Influence of Topography on East African October to December Climate: Sensitivity Experiments with RegCM4 (2014)
Publication Date: 2014-10-22
Description: The influence of topography on east African climate is investigated using the International Centre for Theoretical Physics Regional Climate Model, with focus on October to December season. Results show that the mean rainfall (temperature) significantly reduces (increases) over the region when topography elevation is reduced. Based on the model, when topography over the selected region (KTU) is reduced to 25%, the mean rainfall (temperature) over east Africa is reduced (increased) by about 19% (1.4°C). The maximum rainfall (temperature) reduction (increase) is however observed around the region over which topography is reduced. The reduction in topography elevation resulted in an anomalous moisture divergence at low level and descending motion over the region. KTU topography enhances the surface heat flux over KTU region and tends to enhance convection over both KTU and the east African region. The topography also helps in the generation of the high frequency mesoscale and subsynoptic disturbances over the region. These disturbances produce precipitation over the region and may also enhance precipitation systems over remote areas due to propagation of the disturbances. The magnitude of the zonal wind speed at 850 hpa increases with the decrease in topography elevation.
Print ISSN: 1687-9309
Electronic ISSN: 1687-9317
Topics: Geosciences , Physics
Published by Hindawi
9.
PAPER CURRENT
Dynamics of deterministic and stochastic multi-group MSIRS epidemic models with varying total population size (2014)
Publication Date: 2014-10-22
Description: In this paper, we extend the deterministic single-group MSIRS epidemic model to a multi-group model, and we also extend the deterministic multi-group framework to a stochastic one and formulate it as a stochastic differential equation. In the deterministic multi-group model, the basic reproduction number R0 is a threshold that completely determines the persistence or extinction of the disease. By using Lyapunov function techniques, we show that if R0>1, then the disease will prevail, the infective condition persists and the endemic state is asymptotically stable in a feasible region. If R0⩽1, then the infective condition disappears and the disease dies out. For the stochastic version, we perform a detailed analysis on the asymptotic behavior of the stochastic model, which also depends on the value of R0, when R0>1, we determine the asymptotic stability of the endemic equilibrium by measuring the difference between the solution and the endemic equilibrium of the deterministic model in time-averaged data. Numerical methods are used to illustrate the dynamic behavior of the model and to solve the systems.
Print ISSN: 1687-1839
Electronic ISSN: 1687-1847
Topics: Mathematics
Published by SpringerOpen
10.
PAPER CURRENT
Towards improved precision in the Quantification of Surface-Enhanced Raman Scattering Enhancement Factor: A Renewed Approach (2014)
Publication Date: 2014-10-22
Description: Analyst, 2014, Accepted ManuscriptDOI: 10.1039/C4AN01778A, PaperArumugam Sivanesan, Witold Adamkiewicz, Govindasamy Kalaivani, Agnieszka Kaminska, Jacek Waluk, Robert Holyst, Emad KiriakousThis paper demonstrates a renewed procedure for the quantification of surface-enhanced Raman scattering (SERS) enhancement factor with improved precision. The principle of this method relies on deducting the resonance Raman...The content of this RSS Feed (c) The Royal Society of Chemistry
Print ISSN: 0003-2654
Electronic ISSN: 1364-5528
Topics: Chemistry and Pharmacology