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  • Books  (3,177)
  • thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DN Biography and non-fiction prose  (1,964)
  • bic Book Industry Communication::M Medicine  (1,213)
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  • Books  (3,177)
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  • 1
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    Centro de estudios mexicanos y centroamericanos
    Publication Date: 2024-03-25
    Keywords: D1-2009 ; Nayarit ; tierra ; situación agraria ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DN Biography and non-fiction prose
    Language: Spanish
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  • 2
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    Publications des Archives nationales
    Publication Date: 2024-03-25
    Description: La journée d’étude « Le consulat de France à Cadix (1666-1740) : institution, intérêts et enjeux », organisée par les Archives nationales, fut l’occasion de faire le point sur les enjeux politico-diplomatiques, les intérêts commerciaux et les rivalités entre Européens autour du consulat français de Cadix entre 1660 et 1750. Elle s’articule autour de quatre thèmes principaux : les archives du consulat de Cadix sous l’Ancien Régime, la représentation et la présence françaises en Espagne sous le roi Philippe V, le grand commerce à Cadix et enfin l'importance de Cadix pour les places maritimes et financières françaises.
    Keywords: D1-2009 ; réseau consulaire français ; nation française de Cadix ; correspondance consulaire ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DN Biography and non-fiction prose
    Language: French
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  • 3
    Publication Date: 2024-03-25
    Description: Le but de l’Union européenne est aujourd’hui de bâtir une société politique commune, à même de prolonger une intégration qui, de fait, ne s’est basée jusqu’ici que sur des éléments matériels. Ainsi, la thématique identitaire prend-elle de l’importance, donnant la priorité aux sciences humaines dans la réflexion sur notre avenir communautaire, mais aussi sur notre passé commun. Forts de ce constat, différents chercheurs en sciences humaines ont décidé de croiser leurs regards sur l’histoire de la construction européenne. Le but en était également de confronter différentes méthodes d’investigation, et de faite le bilan d’études parallèles qui ne demandaient qu’à s’entrecroiser au profit de toutes C’est cette première journée programmatique que nous publions ici : elle contient les principaux questionnements qui touchent les chercheurs sur l’Europe dans les spécialités du droit, de la géographie et de l’histoire. Bien entendu, les pistes lancées ne peuvent qu’être enrichies par les futures rencontres, mais elles donnent d'ores et déjà une direction à une collaboration inédite, et des réponses, bien entendu à approfondir, aux premières questions que pose cette analyse pluridimensionnelle de l’Europe.
    Keywords: D1-2009 ; géographie ; Union européenne ; histoire ; droit ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DN Biography and non-fiction prose
    Language: French
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  • 4
    Publication Date: 2024-03-25
    Keywords: D1-2009 ; écrits ; XXème siècle ; musique ; littérature ; entretiens ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DN Biography and non-fiction prose
    Language: French
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  • 5
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: This book is comprised of important reviews and cutting-edge original research papers concerning electrospun and electrosprayed formulations in drug delivery. Electrospinning and electrospraying have, in recent years, attracted increasing attention in the pharmaceutical sector, with research in the area advancing rapidly. It is now possible to prepare extremely complex systems using multi-fluid processes, and to increase production rates to an industrial scale. Electrospun formulations can be produced under GMP conditions and are in clinical trials. In this volume, we explore a range of topics around electrospinning and electrospraying in controlled drug delivery. Four reviews cover the exciting potential of cyclodextrin-containing fibers and the many potential biomedical applications of electrospun fibers. The use of electrospinning to prepare amorphous systems and improve the dissolution rate and solubility of poorly soluble active ingredients is addressed, and the possibilities of such materials in tissue engineering are comprehensively covered. The six original research papers cover the effect of molecular properties on API release from Eudragit-based electrospun fibers; ferulic acid solid dispersions; electrospun medicines to treat psoriasis; scale up of electrospinning and its use to produce low-dose tablets; transepithelial permeation of drugs released from electrospun fibers, and the possibilities for the synergistic chemophotothermal treatment of cancer.
    Keywords: R5-920 ; RM1-950 ; tissue engineering ; cyclodextrin ; permeability ; poly (vinylpyrrolidone-co-vinyl acetate) ; crystalline ; antibacterial ; drug delivery ; homogenization ; capsaicin ; combination therapy ; high-shear mixing ; cyclodextrin-inclusion complexes ; amorphous ; high-speed electrospinning ; PMVE/MA ; aqueous solubility enhancement ; sieve analysis ; Raman mapping ; Eudragit ; nanofibers ; psoriasis ; PCL ; essential oils ; parameters ; antibiotics ; xanthan gum ; carvedilol ; amorphous composite ; coaxial electrospinning ; insoluble drug ; NIR-triggered drug release ; fast dissolution ; electrospinning ; oral drug delivery ; electrospun nanofibers ; poly-cyclodextrin ; TRPV1 ; gallic acid ; solid dispersion ; photothermal therapy ; drug release ; applications ; bic Book Industry Communication::M Medicine
    Language: English
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  • 6
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    Presses universitaires François-Rabelais
    Publication Date: 2024-03-25
    Description: Malgré leurs apparences contraires, la guerre et le jeu ont des rapports multiples et intimes. En trois sections thématiques (historique et politique, littéraire, médiatique), cet ouvrage entreprend de décrire leurs connexions à l’ère moderne. La guerre classique, comme le jeu de Stratego ou les échecs, repose sur des champs réglés et symétriques. Avec la guerre moderne, cet espace agonal d’un combat « chevaleresque » comme jeu « noble » (Huizinga) cède sa place à un espace de la terreur et de la mort aléatoire et sans limites. Le terrorisme actuel s’apparente à un jeu de hasard mortel. La stratégie nucléaire, quand bien même fondée sur la théorie des jeux et un équilibre statistique, demeure aujourd’hui un pari macabre et fatal. Ce livre offre une réflexion dynamique et transversale sur les multiples facettes culturelles de cette relation paradoxale qui lie le jeu et la guerre moderne : de Naudé concevant le peuple comme un pion manipulé par un souverain démiurge, aux analogies médiatiques entre musique et guerre dans le documentaire filmique Heavy Metal in Baghdad, en passant par Schlieffen élaborant sa stratégie dans des Kriegsspiele militaires, ou encore par le Jeu de la Guerre de Debord et son adaptation « situationniste » en wargame informatique. Au final, Guerre et jeu offre une grille de lecture des grands équilibres et déséquilibres politico-stratégiques de notre monde et de l’histoire aux aléas d’une guerre hasardeuse.
    Keywords: D1-2009 ; terrorisme ; histoire politique ; jeu ; guerre ; histoire militaire ; stratégie ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DN Biography and non-fiction prose
    Language: French
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  • 7
    Publication Date: 2023-12-21
    Description: Fluid intake has barely been assessed, and hydration status has only rarely been measured in epidemiological studies. This hampers attempts to assess the adequacy of water intake at a population level. However, although guidelines have been established to determine how much water humans require to avoid dehydration and to optimize physical and psychological function, limited data are available on the total water and beverages intake. Therefore, the percentage of population with inadequate water intake is unknown. There is a clear need for studies in different settings around the world that quantify total water and beverage intake and explore associations between types of beverages consumed and energy intake.
    Keywords: R5-920 ; Adequate hydration ; Beverages consumption ; Water and energy intake ; bic Book Industry Communication::M Medicine
    Language: English
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  • 8
    Publication Date: 2024-03-25
    Description: „Was ist des Deutschen Vaterland?“ Diese berühmten, im Jahre 1813 von Ernst Moritz Arndt geschriebenen Worte werfen eine Frage auf, die im ganzen 19. Jahrhundert wie ein Leitmotiv wiederaufgenommen wird. Was ist Deutschland? Welche sind seine Grenzen? Wer kann es vereinen und leiten wollen? Mit welcher Verfassung? Dies sind einige der Hauptprobleme, mit denen sich die Deutschen beschäftigen, während sich die Idee eines deutschen Nationalstaates langsam aber sicher entwickelt.
    Keywords: D1-2009 ; Nation ; identität ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DN Biography and non-fiction prose
    Language: German
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  • 9
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    Presses universitaires du Midi
    Publication Date: 2024-03-25
    Description: La bataille de Zama (202 av. J.-C.) qui clôt la deuxième guerre punique voit s'affronter trois personnages : d'un côté Hannibal, champion de la domination carthaginoise en Afrique du Nord, et de l’autre Scipion, précurseur de la mainmise romaine sur la région, avec son allié de circonstance Massinissa, un souverain numide qui veut mettre à profit l’affrontement des deux premiers pour affirmer l’existence de son royaume berbère. La victoire de Rome fera progressivement basculer le Maghreb au sein de son Empire. L'étude des monnaies émises en Afrique du Nord de 400 av. J.-C. à 40 après J.-C. aide à comprendre comment Carthage, les cités et les souverains berbères du Maghreb antique ont été les acteurs de l’hellénisation de la région d'abord, puis ensuite de son intégration dans le grand ensemble méditerranéen de l'Empire romain.
    Keywords: D1-2009 ; histoire ; Antiquité ; monnaie ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DN Biography and non-fiction prose
    Language: French
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  • 10
    Publication Date: 2023-12-21
    Description: It is now well appreciated that the immune system, in addition to its traditional role in defending the organism against pathogens, communicate in a well-organized fashion with the brain to maintain homeostasis and regulate a set of neural functions. Perturbation in this brain-immune interactions due to inflammatory responses may lead to psychiatric and neurological disorders. Microglia are one of the essential cells involved in the brain-immune interactions. Microglial cells are now not simply regarded as resident tissue macrophages in the brain. These cells are derived from myeloid progenitor cells in the yolk sac in early gestation, travel to the brain parenchyma and interact actively with neurons during the critical period of neurogenesis. Microglia provide a trophic support to developing neurons and take part in the neural wiring through the activity-dependent synapse elimination via direct neuron-microglia interactions. Altered microglial functions including changes in the gene expression due to early life inflammatory events or psychological and environmental stressors can be causally related to neurodevelopmental diseases and mental health disorders. This type of alterations in the neural functions can occur in the absence of infiltration of inflammatory cells in the brain parenchyma or leptomeninges. In this sense, the pathogenetic state underlying a significant part of psychiatric and neurological diseases may be similar to “para-inflammation”, an intermediate state between homeostatic and classical inflammatory states as defined by Ruslan Medzhitov (Nature 454:428-35, 2008). Therefore, it is important to study how systemic inflammation affects brain health and how local peripheral inflammation induces changes in the brain microenvironment. Chronic pain is also induced by disturbance in otherwise well-organized multisystem interplay comprising of reciprocal neural, endocrine and immune interactions. Especially, early-life insults including exposure to immune challenges can alter the neuroanatomical components of nociception, which induces altered pain response later in life. Recently the discrete roles of microglia and blood monocyte-derived macrophages are being defined. The distinction may be further highlighted by disorders in which the brain parenchymal tissue is damaged. Therefore, studies investigating the dynamics of immune cells in traumatic brain injury and neurotropic viral infections including human immunodeficiency virus, etc. as well as neurodegenerative diseases such as amyotrophic lateral sclerosis are promising to clarify the interplay between the central nervous and immune systems. The understanding of the histological architecture providing the infrastructure of such neuro-immune interplay is also essential. This Frontiers research topic brings together fourteen articles and aims to create a platform for researchers in the field of psychoneuroimmunology to share the recent theories, hypotheses and future perspectives regarding open questions on the mechanisms of cell-cell interactions with chemical mediators among the nervous, immune and endocrine systems. We hope that this platform would reveal the relevance of the studies on multisystem interactions to enhance the understanding of the mechanisms underlying a wide variety of neurological and psychiatric disorders.
    Keywords: R5-920 ; RC346-429 ; RC581-607 ; brain-immune interaction ; fatigue ; pain ; HIV ; neuroinflammation ; traumatic brain injury ; depression ; microglia ; amyotrophic lateral sclerosis ; autism ; bic Book Industry Communication::M Medicine
    Language: English
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