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  • Books  (2,457)
  • thema EDItEUR::C Language and Linguistics::CF Linguistics  (1,243)
  • bic Book Industry Communication::M Medicine  (1,213)
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  • 1
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    Electrospun and Electrosprayed Formulations for Drug Delivery (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: This book is comprised of important reviews and cutting-edge original research papers concerning electrospun and electrosprayed formulations in drug delivery. Electrospinning and electrospraying have, in recent years, attracted increasing attention in the pharmaceutical sector, with research in the area advancing rapidly. It is now possible to prepare extremely complex systems using multi-fluid processes, and to increase production rates to an industrial scale. Electrospun formulations can be produced under GMP conditions and are in clinical trials. In this volume, we explore a range of topics around electrospinning and electrospraying in controlled drug delivery. Four reviews cover the exciting potential of cyclodextrin-containing fibers and the many potential biomedical applications of electrospun fibers. The use of electrospinning to prepare amorphous systems and improve the dissolution rate and solubility of poorly soluble active ingredients is addressed, and the possibilities of such materials in tissue engineering are comprehensively covered. The six original research papers cover the effect of molecular properties on API release from Eudragit-based electrospun fibers; ferulic acid solid dispersions; electrospun medicines to treat psoriasis; scale up of electrospinning and its use to produce low-dose tablets; transepithelial permeation of drugs released from electrospun fibers, and the possibilities for the synergistic chemophotothermal treatment of cancer.
    Keywords: R5-920 ; RM1-950 ; tissue engineering ; cyclodextrin ; permeability ; poly (vinylpyrrolidone-co-vinyl acetate) ; crystalline ; antibacterial ; drug delivery ; homogenization ; capsaicin ; combination therapy ; high-shear mixing ; cyclodextrin-inclusion complexes ; amorphous ; high-speed electrospinning ; PMVE/MA ; aqueous solubility enhancement ; sieve analysis ; Raman mapping ; Eudragit ; nanofibers ; psoriasis ; PCL ; essential oils ; parameters ; antibiotics ; xanthan gum ; carvedilol ; amorphous composite ; coaxial electrospinning ; insoluble drug ; NIR-triggered drug release ; fast dissolution ; electrospinning ; oral drug delivery ; electrospun nanofibers ; poly-cyclodextrin ; TRPV1 ; gallic acid ; solid dispersion ; photothermal therapy ; drug release ; applications ; bic Book Industry Communication::M Medicine
    Language: English
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  • 2
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    Beverage Consumption Habits around the World: Association with Total Water and Energy Intakes (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: Fluid intake has barely been assessed, and hydration status has only rarely been measured in epidemiological studies. This hampers attempts to assess the adequacy of water intake at a population level. However, although guidelines have been established to determine how much water humans require to avoid dehydration and to optimize physical and psychological function, limited data are available on the total water and beverages intake. Therefore, the percentage of population with inadequate water intake is unknown. There is a clear need for studies in different settings around the world that quantify total water and beverage intake and explore associations between types of beverages consumed and energy intake.
    Keywords: R5-920 ; Adequate hydration ; Beverages consumption ; Water and energy intake ; bic Book Industry Communication::M Medicine
    Language: English
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  • 3
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    Neuroimmune Interface in Health and Diseases (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: It is now well appreciated that the immune system, in addition to its traditional role in defending the organism against pathogens, communicate in a well-organized fashion with the brain to maintain homeostasis and regulate a set of neural functions. Perturbation in this brain-immune interactions due to inflammatory responses may lead to psychiatric and neurological disorders. Microglia are one of the essential cells involved in the brain-immune interactions. Microglial cells are now not simply regarded as resident tissue macrophages in the brain. These cells are derived from myeloid progenitor cells in the yolk sac in early gestation, travel to the brain parenchyma and interact actively with neurons during the critical period of neurogenesis. Microglia provide a trophic support to developing neurons and take part in the neural wiring through the activity-dependent synapse elimination via direct neuron-microglia interactions. Altered microglial functions including changes in the gene expression due to early life inflammatory events or psychological and environmental stressors can be causally related to neurodevelopmental diseases and mental health disorders. This type of alterations in the neural functions can occur in the absence of infiltration of inflammatory cells in the brain parenchyma or leptomeninges. In this sense, the pathogenetic state underlying a significant part of psychiatric and neurological diseases may be similar to “para-inflammation”, an intermediate state between homeostatic and classical inflammatory states as defined by Ruslan Medzhitov (Nature 454:428-35, 2008). Therefore, it is important to study how systemic inflammation affects brain health and how local peripheral inflammation induces changes in the brain microenvironment. Chronic pain is also induced by disturbance in otherwise well-organized multisystem interplay comprising of reciprocal neural, endocrine and immune interactions. Especially, early-life insults including exposure to immune challenges can alter the neuroanatomical components of nociception, which induces altered pain response later in life. Recently the discrete roles of microglia and blood monocyte-derived macrophages are being defined. The distinction may be further highlighted by disorders in which the brain parenchymal tissue is damaged. Therefore, studies investigating the dynamics of immune cells in traumatic brain injury and neurotropic viral infections including human immunodeficiency virus, etc. as well as neurodegenerative diseases such as amyotrophic lateral sclerosis are promising to clarify the interplay between the central nervous and immune systems. The understanding of the histological architecture providing the infrastructure of such neuro-immune interplay is also essential. This Frontiers research topic brings together fourteen articles and aims to create a platform for researchers in the field of psychoneuroimmunology to share the recent theories, hypotheses and future perspectives regarding open questions on the mechanisms of cell-cell interactions with chemical mediators among the nervous, immune and endocrine systems. We hope that this platform would reveal the relevance of the studies on multisystem interactions to enhance the understanding of the mechanisms underlying a wide variety of neurological and psychiatric disorders.
    Keywords: R5-920 ; RC346-429 ; RC581-607 ; brain-immune interaction ; fatigue ; pain ; HIV ; neuroinflammation ; traumatic brain injury ; depression ; microglia ; amyotrophic lateral sclerosis ; autism ; bic Book Industry Communication::M Medicine
    Language: English
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  • 4
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    Die Sprache des Artakserksovo dejstvo (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-03-24
    Description: Die Arbeit besteht somit aus zwei Hauptteilen. Zunächst werden in den "Vorbemerkungen" die wichtigsten Begriffe gegeneinander abgegrenzt und ein Forschungsüberblick gegeben. Da die Entwicklung der russischen Sprache eng mit den jeweiligen geschichtlichen Ereignissen verknüpft ist, werden im ersten, mehr referierenden Teil die geschichtlichen Voraussetzungen für den Sprachwandel in einem kurzen Überblick dargelegt. Anschließend wird die sprachliche Umbruchsituation charakterisiert. Einen eigenen Abschnitt wird dabei die Einordnung des "Artakserksovo dejstvo" in den literarischen Kontext seiner Zeit bilden. Im zweiten Teil wird der Text des "Artakserksovo dejstvo" sprachlich untersucht.
    Keywords: Artakserksovo ; ausgehenden ; dejstvo ; Jahrhunderts ; Rußland ; Schellenberger ; Situation ; Sprache ; sprachlichen ; Studien ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: German
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  • 5
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    Der Imperativsatz im Slowakischen mit Blick auf andere westslawische Sprachen (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-03-24
    Description: The aim of this work is to integrate the West Slavic languages ​​into grammar and language comparisons using modern grammatical approaches. This is done using the example of the imperative sentence in Slovak with a view to other West Slavic languages. This type of sentence is examined for its formal and content-related characteristics. At the same time, its communicative-pragmatic potential is derived and explained from the structural meaning of this mode verbi. The demarcation between the grammar and the pragmatics of the imperative theorem will play an important role here.
    Description: Das Ziel dieser Arbeit ist es, die westslawischen Sprachen unter Anwendung moderner grammatiktheoretischer Ansätze in den Grammatik- und Sprachvergleich zu integrieren. Dies erfolgt am Beispiel des Imperativsatzes im Slowakischen mit Blick auf andere westslawische Sprachen. Dieser Satztyp wird hinsichtlich seiner formalen und inhaltlichen Eigenschaften untersucht. Zugleich wird sein kommunikativ-pragmatisches Potential aus der Strukturbedeutung dieses Modus verbi abgeleitet und erklärt. Dabei wird die Grenzziehung zwischen der Grammatik und der Pragmatik des Imperativsatzes eine wichtige Rolle spielen.
    Keywords: Blick ; Grammatik ; grammatiktheoretisch ; Imperativsatz ; Linguistik ; Pragmatik ; Satztyps ; Semantik ; Slavische Sprachwissenschaft ; Slowakischen ; Späth ; Sprachen ; Strukturbedeutung ; Syntax ; westslawische ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: German
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  • 6
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    Narrazioni ibride post-sovietiche (2022)
    Firenze University Press
    Details
    Publication Date: 2024-03-24
    Description: In light of the dramatic events which have been shocking Ukraine since November 2013, this work’s itinerary aims at functioning as a basis for the formulation of new contact points, for a dialogue between traditions and cultures which nowadays are again being shaken by the events of history. The author examines the self-identification paths of the literary phenomenon of Russian language in Ukraine. With the help of interviews with important representatives of the Ukrainian Russian-speaking literary scene, made on the eve of the so-called 'Ukrainian crisis', the author shall closely observe the origins of the marginal nature of these 'post-Soviet hybrid narratives'.
    Keywords: thema EDItEUR::C Language and Linguistics::CF Linguistics ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DS Literature: history and criticism
    Language: Italian
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  • 7
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    Recursos Críticos: história da cooperação técnica Opas-Brasil em recursos humanos para a saúde (1975-1988) (2021)
    SciELO Books - Editora FIOCRUZ
    Details
    Publication Date: 2023-12-21
    Description: Um livro valioso, que analisa com clareza o papel fundamental dos recursos humanos para a saúde e o desenvolvimento, bem como o contexto e o impacto da reforma sanitária e a relação entre as iniciativas internacionais, nacionais e locais em prol da mudança dos serviços de saúde. Além de examinar os antecedentes e os principais atores da área de recursos humanos e explicar com detalhes as negociações que visavam transformar em prioridade nacional a formação de recursos humanos e a distribuição dos trabalhadores de saúde no território, Recursos Críticos está apoiado em uma sólida pesquisa bibliográfica, testemunhos fascinantes e análise original, que fazem da obra uma contribuição significativa no campo da memória da saúde pública e uma ferramenta indicativa de perspectivas de futuro para trabalhadores na área da saúde. É uma pesquisa histórica de grande qualidade, voltada para a análise da cooperação Opas-Brasil, e um incentivo à realização de novos estudos sobre as interfaces entre a atuação de agências internacionais e os interesses nacionais, partindo do conceito de arenas ou espaços de negociação.
    Keywords: R5-920 ; Brasil ; Recursos humanos em saúde ; Planos e programas de saúde ; Cooperação técnica ; Organização Pan-Americana da Saúde ; bic Book Industry Communication::M Medicine
    Language: Portuguese
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  • 8
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    A Reader in Slovak Linguistics (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-03-24
    Description: 〈P〉The authors of the articles are Slovak linguists who work within various spheres of linguistics. Represented in the volume are authors who started their scientific activity in the pre-war period, directly or indirectly building on the work of the Prague Linguistic Circle, but soon differentiating themselves and contributing to linguistic theory with original works, as well as a newer generation of linguists who entered linguistics within the last two decades. 〈/P〉
    Keywords: Kacala ; Linguistics ; Linguistik ; Prague Linguistic Circle ; pre-war period ; Reader ; Semantics ; Slavische Sprachwissenschaft ; Slovak ; Slovak linguists ; Studies ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: German
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  • 9
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    České stupňování (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-03-24
    Description: 〈P〉Die 1972 von den Frankfurter Slavisten Olexa Horbatsch und Gerd Freidhof begründete Reihe Specimina philologiae Slavicae wird heute von Holger Kuße (Dresden), Peter Kosta (Potsdam), Beatrix Kreß (Hildesheim), Franz Schindler (Gießen), Barbara Sonnenhauser (Zürich) und Nadine Thielemann (Wien) herausgeben. In der Reihe erscheinen Monographien, Sammelbände und Lehrbücher zu allen Gebieten der Slavistik, der Sprach-, der Literatur- und der Kulturwissenschaft. In der Sprachwissenschaft erscheinen sowohl sprachhistorische als auch innovative Arbeiten zur Pragmatik und Semantik, zu slavischen Kleinsprachen und zur Diskurslinguistik. In der Literatur- und Kulturwissenschaft gehört zu den besonderen Interessensgebieten die Russische Philosophie.〈/P〉
    Keywords: České ; comparison ; Czech ; Degrees ; Linguistik ; Literatur ; Marvan ; Philologie ; Slawistik ; Sprachwissenschaft ; stupňování ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: German
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  • 10
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    Inhibiting PARP as a Strategic Target in Cancer (2021)
    Frontiers Media SA
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    Publication Date: 2023-12-21
    Description: Poly-ADP ribose polymerase (PARP) proteins are critical mediators of DNA repair. Many traditional anti-cancer chemotherapy agents overwhelm a cell’s ability to repair DNA damage in order to kill proliferating malignant cells. Recent evidence suggests that cancers within and across tissue types have specific defects in DNA repair pathways, and that these defects may predispose for sensitivity and resistance to various classes of cytotoxic agents. Breast, ovarian and other cancers develop in the setting of inherited DNA repair deficiency, and these cancers may be more sensitive to cytotoxic agents that induce DNA strand breaks, as well as to inhibitors of PARP activity. A series of recent clinical trials has tested whether PARP inhibitors can achieve synthetic lethality in hereditary DNA repair-deficient tumors. At the current time, mutation of BRCA serves as a potential, but not comprehensive, biomarker to predict response to PARP inhibitor therapy. Mechanisms of resistance to PARP inhibitors are only recently being uncovered. Future studies seek to identify sporadic cancers that harbor genomic instability rendering susceptibility to PARP inhibitors that compound lethal DNA damage.
    Keywords: R5-920 ; RC254-282 ; DNA reapir ; PARP inhibitor ; Homologous Recombination ; combination therapy ; DNA Damage ; Cancer ; bic Book Industry Communication::M Medicine
    Language: English
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  • 11
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    International Perspectives on Health and Safety Among Dairy Workers Challenges, Solutions and the Future (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: This e-book provides the insight into occupational health and safety problems, challenges and solutions of the dairy sector. Thirty-two authors have been sharing their results and knowledge reflecting the challenges from small scale farming up to industrial style. The worldwide trend of growing farm sizes and a reduction in numbers is one of the major drivers for the changes in the working environment. Musculoskeletal disorders are among the most prevalent health problems of people working on farms. Nevertheless mechanisation has not reduced the number of complaints, and new problems arise due to the changing working environment.
    Keywords: R5-920 ; RA1-1270 ; immigrant workers ; Dairy farming ; OHS ; MSS ; MSD ; bic Book Industry Communication::M Medicine
    Language: English
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  • 12
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    From Ptolemaus to Copernicus: The Evolving System of Gluten-Related Disorder (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: Gluten is the major protein of wheat and other cereals (rye and barley); it is responsible for triggering celiac disease (CD) in genetically predisposed individuals. Until a few years ago, CD was the major (if not the only) well-known gluten-related disorder. However, in recent years, it has become clear that gluten proteins may activate different pathological mechanisms, leading to a wide spectrum of human diseases, including non-celiac gluten sensitivity (NCGS), gluten ataxia, neuro-psychiatric disorders, and many others. Conceptually, we have therefore moved from a Ptolemaic to a Copernican system, i.e., CD is no longer the “center of the universe”, but is just one of the possible worlds of gluten intolerance. Many other gluten planets do indeed exist and deserve the attention of researchers and clinicians alike. Although different gluten-related disorders show specific epidemiological, pathophysiological, and clinical aspects, these conditions share a trigger and treatment: the gluten-free diet. For a very long time, awareness of these disorders has been limited and, therefore, the epidemiology of gluten-related disorders is still a “work in progress”. Current research strives to clarify the boundaries between these entities, their disease mechanisms, and how a proper diagnosis can be implemented.
    Keywords: R5-920 ; gluten-related disorders；celiac disease；gluten intolerance ; bic Book Industry Communication::M Medicine
    Language: English
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  • 13
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    On reconstructing Proto-Bantu grammar (2023)
    Language Science Press | Language Science Press
    Details
    Publication Date: 2024-03-24
    Description: This book is about reconstructing the grammar of Proto-Bantu, the ancestral language at the origin of current-day Bantu languages. While Bantu is a low-level branch of Niger-Congo, the world’s biggest phylum, it is still Africa’s biggest language family. This edited volume attempts to retrieve the phonology, morphology and syntax used by the earliest Bantu speakers to communicate with each other, discusses methods to do so, and looks at issues raised by these academic endeavours. It is a collective effort involving a fine mix of junior and senior scholars representing several generations of expert historical-comparative Bantu research. It is the first systematic approach to Proto-Bantu grammar since Meeussen’s Bantu Grammatical Reconstructions (1967). Based on new bodies of evidence from the last five decades, most notably from northwestern Bantu languages, this book considerably transforms our understanding of Proto-Bantu grammar and offers new methodological approaches to Bantu grammatical reconstruction.
    Keywords: Language Arts & Disciplines ; Linguistics ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: English
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  • 14
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    The Languages of COVID-19 (2023)
    Routledge
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    Publication Date: 2024-04-06
    Description: This collection advocates languages-based, translational research to be part of the partnerships and collaborations required to make sense of, and respond to, COVID-19 as one of the major global challenges of our time.　Bringing together scholars and practitioners from a wide range of disciplines, this volume is bound by a common thread stressing the importance of linguistic sensitivity, (inter)cultural knowledge and translational mediation in the frontline response to COVID-19. Featuring contributors from around the world and reflecting on the language used to frame COVID-19 in diverse cultural contexts of the Global North and Global South, the book proposes that paying attention to the transmission of ideas, ideologies, narratives and history through processes of translation results in a broadening of social, cultural and medical understandings of COVID-19. Spanning nearly 20 signed and spoken languages, the volume argues that only in going beyond an Anglophone perspective can we better understand the cultural, social and political facets of the pandemic and, in turn, produce a comprehensive, efficient global response to disease management.　This book will be of interest to scholars in translation and interpreting studies, modern languages, applied linguistics, cultural studies, Deaf Studies, intercultural communication and medical humanities.
    Keywords: Language Arts & Disciplines ; Linguistics ; Language Arts & Disciplines ; thema EDItEUR::C Language and Linguistics::CF Linguistics ; thema EDItEUR::C Language and Linguistics::CB Language: reference and general
    Language: English
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  • 15
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    Microglia in Health and Disease: A Unique Immune Cell Population (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Microglia are essential for the development and function of the adult brain. Their ontogeny, together with the absence of turnover from the periphery and the singular environment of the central nervous system (CNS), make microglia a unique cell population compared to other tissue-macrophages. The unique properties and functions of microglial cells, such as their role in synaptic pruning or the exceptional capacity to scan the brain parenchyma and rapidly react to its perturbations, have emerged in recent years. In the coming years, understanding how microglia acquire and maintain their unique profiles in order to fulfil distinct tasks in the healthy CNS and how these are altered in disease, will be essential to develop strategies to diagnose or treat CNS disorders with an immunological component. This Research Topic covers several aspects of microglial biology, ranging from their origin and the functional role of microglia during development and lifespan, their molecular properties compared with other brain and peripheral immune cells to microglial phenotypes and functional states in neurodegenerative diseases and brain tumours. In conclusion, the present Research Topic provides a comprehensive overview of our current understanding of several cellular and molecular mechanisms that make microglia a unique immune cell population within the healthy CNS as well as under inflammatory, neurodegenerative and tumorigenic processes.
    Keywords: R5-920 ; RC346-429 ; RC581-607 ; inflammation ; brain tumour ; neurodegeneration ; microglia ; ontogeny ; bic Book Industry Communication::M Medicine
    Language: English
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  • 16
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    HLA-G-mediated Immune Tolerance: Past and New Outlooks (2021)
    Frontiers Media SA
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    Publication Date: 2023-12-21
    Description: The non-classical HLA class I molecule HLA-G is different from classical HLA class I molecules because of the low polymorphism in the coding region, the fact that HLA-G primary transcript is alternatively spliced in seven isoforms, and the inhibitory action on immune cells. Although HLA-G is low polymorphic, variants in both promoter and 3’ un-translated region (UTR) of HLA-G locus regulate its expression. In healthy conditions, a basal level of HLA-G gene transcription is observed in most cells and tissues; however, translation into HLA-G protein is restricted to trophoblasts in the placenta, where it participates in promoting tolerance at the fetal-maternal interface. HLA-G is also expressed by thymic epitelial, cornea, mesenchymal stem cells, nail matrix, pancreatic beta cells, erythroid, and endothelial precursors. HLA-G can be neo-expressed in adult tissues in pathological conditions, and its expression has been documented autoimmune disorders, viral infections, and cancer. In the latter setting de novo HLA-G expression is associated with the capability of tumor cells to evade the immune control. In the last decade it has become evident that HLA-G expression on T cells and antigenpresenting cells confers to these cells tolerogenic properties. This Research Topic focused on i) summarizing updated clinical and immunological evidences that HLA-G expression is associate with beneficial or detrimental tolerance, ii) gathering new insights into the mechanisms governing the expression of HLA-G in healthy and pathological conditions, such as pre-eclampsia, and iii) examining the mechanisms underlying HLA-G mediated tolerance.
    Keywords: R5-920 ; RC581-607 ; Pregnancy ; Autoimmunity ; Immuno-modulation ; Pre-Eclampsia ; Infections ; Exosomes ; HLA-G ; polymorphisms ; tolerance ; Cancer ; bic Book Industry Communication::M Medicine
    Language: English
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  • 17
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    Jeux de mots et créativité (2022)
    De Gruyter | De Gruyter
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    Publication Date: 2024-03-24
    Description: This volume seeks to shed light on the interdependencies between wordplay and language creativity. Contributions explore the most diverse genres and discourses throughout History —anagrams, medieval fatrasies, the works of Rabelais, children books, slam, riddles, and contemporary constrained writing—, trying to understand their theoretical, didactic and historical impact.
    Keywords: Semiotics ; Literature ; Linguistics ; Language creativity ; Constrained writing ; thema EDItEUR::C Language and Linguistics ; thema EDItEUR::C Language and Linguistics::CF Linguistics ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DS Literature: history and criticism ; thema EDItEUR::D Biography, Literature and Literary studies::DS Literature: history and criticism::DSB Literary studies: general
    Language: French
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  • 18
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    Current Trends and Future Directions in Prosthetic and Implant Dentistry in the Digital Era (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
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    Publication Date: 2023-01-05
    Description: Advancements in digital technologies are reshaping the world of dentistry, from prosthodontics to implant dentistry. Intraoral scanners, facial scanners, 3D printers, and milling machines have revolutionized the clinical approach and operative workflow in daily practice. However, digital dentistry brings several challenges to clinicians due to the rapid evolution of new technologies and the lack of evidence-based guidelines for their correct use. The aim of this Special Issue is to cover the latest advances in the development and application of digital technologies in prosthetic and implant dentistry. We wish to provide both clinicians and researchers with a comprehensive and up-to-date source of information on current trends, limitations, and potential future applications of digital technologies in daily clinical practice.
    Keywords: dental implants ; digital impression ; intraoral scanner ; CAD/CAM materials ; toothbrushing wear ; surface ; roughness ; surface integrity ; alveolar remodeling ; tooth extraction ; intraoral digital scanning ; imaging superimposition ; less traumatic surgery ; socket healing ; implantology ; computer-aided surgery ; image-guided surgery ; zygomatic implants ; navigation system ; dental implant ; bone level ; prospective study ; sub-crestal placement ; emergence profile ; guided surgery ; digital workflow ; stereolithographic surgical guide ; accuracy ; CAD–CAM ; DICOM–STL ; static guided surgery ; clinical study ; intraoral scanners ; digital dentistry ; impression techniques ; full-arch impression ; elderly population ; dimensional measurement accuracy ; implant scan ; operator ; precision ; scan area ; trueness ; occlusion ; overloading ; complications ; implant-supported restorations ; marginal bone loss ; oral implantology ; intraoral scan ; cone-beam computed tomography ; oral surgery ; emergence angle ; retrospective study ; bic Book Industry Communication::M Medicine
    Language: English
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  • 19
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    COVID-19: Current Status and Future Prospects (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
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    Publication Date: 2023-04-05
    Description: On 11 March 2020, the World Health Organization declared COVID-19 a global pandemic, and the disease now affects nearly every country and region. Nearly 18 months later, COVID-19, caused by SARS-CoV-2, continues to present significant challenges to health systems, public health, and the economy of countries across both hemispheres. The morbidity and mortality of the infection caused by SARS-CoV-2 has been significant, and various waves of disease outbreaks initially overwhelmed hospitals and clinics in many countries and continue to do so. This influences everyone, and public health countermeasures have been dramatic in terms of their impact on employment, social systems, and mental health. This Special Issue collection follows on from the Special Issue “COVID-19: Current Challenges and Future Perspectives” and provides an avenue for authors from various disciplines to provide feedback on the response to and our future global preparedness for COVID-19, as well as to disseminate critical information about SARS-CoV-2 and the associated COVID-19 pandemic.
    Keywords: COVID-19 ; new-onset DM ; severe infection ; mortality ; outbreak ; P.1 variant ; Gamma variant ; SARS-CoV-2 infection ; whole-genome sequencing ; pandemic ; overweight ; obesity ; Peru ; psychological impacts ; public health ; preparedness ; mRNA-1273 ; BNT162b2 ; TAK-919 ; SARS-CoV-2 ; post-vaccination ; healthcare personnel ; vaccination ; asymptomatic infection ; HIV ; infectious disease ; excess mortality ; regdanvimab ; remdesivir ; severe ; community transmission ; population density gradient ; Dhaka ; Bangladesh ; dengue ; undifferentiated febrile illness ; antigen testing ; variants ; reinfections ; breakthrough infections ; vaccine hesitancy ; sub-Saharan Africa ; pulmonary fibrosis ; postacute COVID-19 syndrome ; tuberculosis ; helminth coinfection ; coronavirus ; coordination ; health operations and technical expertise ; AFRO ; diarrhea ; liver ; pancreas ; inflammatory bowel diseases ; liver transplantation ; reproduction rate ; phylogenetic analysis ; clade GK ; D614G ; P681R ; cross-reactivity ; haemorrhage ; thrombocytopenia ; thrombosis ; severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) ; molecular diagnostics ; real-time polymerase chain reaction (RT-qPCR) ; economy ; income levels ; waves ; policy ; turning points ; occupational exposure ; risk factors ; personal protective equipment ; SIR model ; socio-behavioral aspects ; interaction distance ; school reopening strategy ; self-medication ; over-the-counter ; medicine use ; Pakistan ; clinical features ; Luanda ; Angola ; socioeconomic status ; risk perception ; risk prevention practices ; qualitative ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
    Language: English
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    Linguistics for legal interpretation (2023)
    UJ Press
    Details
    Publication Date: 2024-03-24
    Description: Linguistics for Legal Interpretation is a language resource for scholars and practitioners of law who engage and work with statutory interpretation. It draws on lexical semantics, pragmatics and sociolinguistics to both understand and solve language challenges central to the interpretation effort. In addition, this book offers best practice guidelines for dictionary use as well as an introduction to corpus linguistic methods to assist legal interpreters in determining either ordinary or technical meaning. The book illustrates the various language tools and devices by applying them to case law and legislation, and it does so in an accessible style of writing. Terrence R Carney is Associate Professor of Afrikaans Linguistics at the University of South Africa. He specialises in the language of law.
    Keywords: legal language, linguistics, legal interpretation ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: English
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    Rutas de la lingüística en la Argentina (2023)
    Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación | Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación
    Details
    Publication Date: 2024-03-24
    Description: Este libro recoge las conferencias dictadas en el marco de la I Jornada Académica de la Maestría en Lingüística.
    Description: Published
    Description: Este libro recoge las conferencias dictadas en el marco de la I Jornada Académica de la Maestría en Lingüística. La propuesta de este volumen es la de comenzar a trazar un recorrido por las diferentes orientaciones teóricas de la disciplina que han tenido lugar en el territorio nacional y plantear un estado de la cuestión, apuntando así a la reflexión sobre las bases teóricas, metodológicas y experiencias concretas que han conformado el panorama de la lingüística en la Argentina. Para ello, contamos con la colaboración de diferentes especialistas que, en los trabajos recopilados, trazan los primeros puntos en el mapa propuesto.
    Keywords: P1-1091 ; Argentina ; filología ; Jornada Académica de la Maestría en Lingüística ; lingüística ; thema EDItEUR::C Language and Linguistics::CF Linguistics ; thema EDItEUR::1 Place qualifiers::1K The Americas::1KL Latin America – Mexico, Central America, South America::1KLS South America::1KLSA Argentina
    Language: Spanish
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    Nach der Einsprachigkeit (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-03-24
    Description: Postkoloniale Konstellationen lassen sich nicht (mehr) in das Eigene und das Andere, in das Originäre und das Nachgeahmte, in ein Hier und Dort auseinanderdividierenden. Sie sind geprägt von Verflechtungen, Hybri-disierungen und wechselseitigen Aneignungsprozessen. In diesem Band analysiert die Autorin Texte von Jurij Brězan, Irena Brežná, Mascha Dabić, Róža Domašcyna, Olga Grjasnowa, Barbi Marković, Olga Martynova und Aleksandar Tišma. Sie zeigt auf, dass alle Werke sich mit multiplen Zuge-hörigkeiten, Mehrsprachigkeit und Übersetzung auseinandersetzen. Die Texte dekonstruieren Grenzen sprachlicher und kultureller Zugehörigkeit, thematisieren aber auch Diskriminierung, Rassismus und Antisemitismus. Damit beschreiben sie mehrsprachige Welten jenseits von hegemonialer Einsprachigkeit.
    Keywords: Aleksandar Tišma ; Barbi Marković ; deutsche ; Einsprachigkeit ; Hitzke ; Jurij Brězan ; Mehrsprachigkeit ; Olga Grjasnowa ; Olga Martynova ; Postkoloniale Literatur ; Slavisch ; Sorbische Literatur ; Texte ; transkulturell ; Übersetzung ; Verflechtung ; thema EDItEUR::C Language and Linguistics::CF Linguistics ; thema EDItEUR::D Biography, Literature and Literary studies::DS Literature: history and criticism::DSB Literary studies: general
    Language: German
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    Pathogenesis and Targeted Therapy of Epilepsy (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-04-05
    Description: Epilepsy is one of the most prevalent neurological disorders and is characterized by recurrent seizures resulting from abnormal neuronal excitability in the central nervous system. Despite the availability of thirty-six antiseizure medications, about one-third of patients with epilepsy do not respond to the pharmacological treatment and develop a so-called “pharmaco-resistant epilepsy” or “refractory epilepsy.” Thus, there is an urgent need to develop novel, effective therapies based on novel mechanisms underlying neuronal excitability that leads to seizures. This reprint’s original research papers and review articles highlight unknown mechanisms underlying pharmaco-resistant resistant epilepsy, epileptogenesis, and seizure suppression.
    Keywords: 3CAI ; GRIA1 ; GRIA2 ; intractable epilepsy ; PICK1 ; protein kinase C ; pericytes ; mural cells ; cytokine ; blood-brain barrier ; neuroinflammation ; 3-phosphoinositide-dependent protein kinase-1 ; AKT ; cyclosporin A ; GluA1 ; GluR1 ; PDK1 ; refractory seizure ; temporal lobe epilepsy ; hippocampus ; 4-aminopyridine ; epilepsy model ; long-term potentiation ; AMPA receptor ; audiogenic epilepsy ; rodents ; fear reaction ; behavior genetics ; c-Fos ; early gene activation ; epileptogenesis ; lipopolysaccharide ; pentylenetetrazole ; post-traumatic epilepsy ; seizure susceptibility ; traumatic brain injury ; epilepsy ; ghrelin ; ghrelin receptor ; anxiety ; TRPV1 channels ; neuronal activity ; neuropsychiatric comorbidity ; immunofluorescence ; audiogenic kindling ; acoustically evoked seizures ; EACT ; generalized tonic-clonic seizures ; inherited epilepsy ; TMEM1A channels ; wild running seizures ; astrocyte ; ML365 ; pharmacoresistant epilepsy ; cortical atrophy ; hippocampal atrophy ; intracerebral electrode ; magnetic resonance imaging ; posttraumatic epilepsy ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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    Proceedings of the VIIth GSCP International Conference (2022)
    Firenze University Press
    Details
    Publication Date: 2024-03-24
    Description: The 7th International Conference of the Gruppo di Studi sulla Comunicazione Parlata, dedicated to the memory of Claire Blanche-Benveniste, chose as its main theme Speech and Corpora. The wide international origin of the 235 authors from 21 countries and 95 institutions led to papers on many different languages. The 89 papers of this volume reflect the themes of the conference: spoken corpora compilation and annotation, with the technological connected fields; the relation between prosody and pragmatics; speech pathologies; and different papers on phonetics, speech and linguistic analysis, pragmatics and sociolinguistics. Many papers are also dedicated to speech and second language studies. The online publication with FUP allows direct access to sound and video linked to papers (when downloaded).
    Keywords: thema EDItEUR::C Language and Linguistics::CF Linguistics ; thema EDItEUR::C Language and Linguistics::CF Linguistics::CFF Historical and comparative linguistics ; thema EDItEUR::D Biography, Literature and Literary studies
    Language: English
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    Cross Talk between Lymph Node Lymphatic Endothelial Cells and T Cells in Inflammation and Cancer (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Lymphocytes constantly survey the lymph nodes in search for potential infection by a pathogen. They enter the afferent lymphatic vessel that serves as a conduit to transport the motile lymphocytes to the draining lymph node. Lymphatic vessels (LVs) are present in most vascularized tissues. They are traditionally regarded as passive conduits for soluble antigens and leukocytes. Afferent LVs begin as blind ended capillaries, which give rise to collecting vessels that merge and connect with draining lymph nodes (dLNs). Initial lymphatic capillaries are composed of Lymphatic Endothelial Cells (LECs) connected by discontinuous cell junctions, which join to form larger collecting lymphatic vessels, and ultimately feed into the LN subcapsular sinus. Within the LN, LECs are localized to the subcapsular, cortical, and medullary sinuses, where they interact with incoming and exiting leukocytes. LECs, and in general LN stromal cells, have emerged in the recent years as active players in the immune response. In support to this,studies have shown that the immune response generated during inflammation and under pathologic conditions is accompanied by modeling of the LVs and generation of new lymphatics, a process known as lymphangiogenesis. These facts strongly suggest that LECs and stromal LN cells in general, are not inert players but rather are part of the immune response by organizing immune cells movement, exchanging information and supplying survival factors. The purpose of this research topic is to review the role of the LECs during immune homeostasis and cancer. Considering the critical role of lymphangiogenesis in many pathologies like chronic and acute inflammation, autoimmunity, wound healing, graft rejection, and tumor metastasis, it is important to understand the molecular mechanisms that govern the cross talks between the LECs and immune cells during homeostasis and inflammation.
    Keywords: R5-920 ; RC581-607 ; Liver Injury ; Lymphatic Vessels ; Lymphatic Vasculature ; Tumor Microenvironment ; PD-L1 ; Antigen Presenting Cells ; Lymphatic Endothelial Cells ; T cell trafficking ; T cells ; bic Book Industry Communication::M Medicine
    Language: English
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    L’emprise de la grammaire (2022)
    ENS Éditions
    Details
    Publication Date: 2024-03-24
    Description: How can we understand the philosophy of linguistics by taking the discipline’s actual theoretical pluralism as our starting point? By what criteria can grammatical research be assessed if we abandon a competitive model of theorising? Through an investigation of different areas of linguistics, this book brings to light certain hermeneutic properties of linguistic theorisation which are currently poorly understood and sometimes not even yet noticed. As a complement to these investigations, the book analyses a number of questions that arise in the “ideological” criticism of contemporary linguistics, examining the discipline’s theoretical activity in light of the socio-ideological realities on which it depends, sometimes unwittingly. Uniting two approaches to linguistics that are rarely brought into dialogue, the book opens up the possibility of an alternative understanding of the complexity of the particular textual objects that are grammatical theories.
    Keywords: philosophy of linguistics ; history of linguistics ; linguistics ; ideological critique of linguistics ; hermeneutics ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: French
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    Transmucosal Absorption Enhancers in the Drug Delivery Field (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: Development of strategies to assist the movement of poorly permeable molecules across biological barriers has long been the goal of drug delivery science. In the last three decades, there has been an exponential increase in advanced drug delivery systems that aim to address this issue. However, most proprietary delivery technologies that have progressed to clinical development are based on permeation enhancers (PEs) that have a history of safe use in man. This Special Issue entitled “Transmucosal Absorption Enhancers in the Drug Delivery Field” aims to present the current state-of-the-art in the application of PEs to improve drug absorption. Emphasis is placed on identification of novel permeation enhancers, mechanisms of barrier alteration, physicochemical properties of PEs that contribute to optimal enhancement action, new delivery models to assess PEs, studies assessing safety of PEs, approaches to assist translation of PEs into effective oral, nasal, ocular and vaginal dosage forms and combining PEs with other delivery strategies.
    Keywords: R5-920 ; RM1-950 ; chitosan ; intestinal epithelial cells ; ocular delivery ; amphiphilic polymers ; cornea ; tight junction modulator ; cyclodextrin ; permeability ; gemini surfactant ; transferrin ; compound 48/80 ; epithelial permeability ; cervicovaginal tumors ; nanoparticles ; confocal laser scanning microscopy ; safety ; formulation ; salcaprozate sodium ; intestinal absorption ; FITC-dextran ; curcumin ; block copolymers ; nasal vaccination ; whole leaf ; brush border ; ocular drug delivery ; vaccine adjuvant ; nanoparticle ; nasal delivery ; efflux ; permeation enhancers ; absorption enhancers ; nose to brain delivery ; small intestine ; epithelium ; CNS disorders ; absorption modifying excipients ; insulin ; absorption enhancer ; gel ; intestinal delivery ; thermogel system ; Caco-2 ; biocompatibility studies ; absorption enhancement ; man ; PN159 ; poorly absorbed drug ; tryptophan ; tight junction ; oral macromolecule delivery ; penetration enhancer ; intestinal permeation enhancers ; nanocrystals ; simvastatin ; nanomedicine ; enterocyte ; N-dodecyl-?-D-maltoside (DDM) ; cell-penetrating peptide ; quaternization ; KLAL ; nasal ; nasal permeability ; transmucosal drug delivery ; Caco-2 cells ; mast cell activator ; penetration enhancers ; drug delivery ; nose-to-brain ; bioenhancer ; polymeric micelles ; mucoadhesion ; cell-penetrating peptide (CPP) ; simulated intestinal fluid ; vaginal delivery ; nasal formulation ; pharmacokinetic interaction ; sodium caprate ; clinical trial ; transmucosal permeation ; drug absorption enhancer ; sugar-based surfactants ; nanocapsules ; imatinib ; teriparatide ; osteoporosis ; hydrophobization ; F-actin ; combined microsphere ; transepithelial electrical resistance ; oral delivery ; ocular conditions ; metabolism ; antimicrobial peptide ; permeation enhancer ; drug administration ; antiepileptic drug ; amino acid ; in vivo studies ; sodium cholate (NaC) ; epithelial transport ; preclinical ; nose to brain transport ; pharmacokinetics ; chitosan derivatives ; ophthalmology ; tight junctions ; sheep ; cationic functionalization ; GLP-1 ; pulmonary ; and liposome ; cytochrome P450 ; claudin ; P-glycoprotein ; in situ hydrogel ; mucoadhesiveness ; PTH 1-34 ; Aloe vera ; oral peptides ; bic Book Industry Communication::M Medicine
    Language: English
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    Очерки по истории и культуре староверов Эстонии III [Studies on the history and culture of Old Believers in Estonia III] (2021)
    University of Tartu Press
    Details
    Publication Date: 2024-03-23
    Description: Acta Slavica Estonica is an international series of publications on current issues of Russian and other Slavic languages, literatures and cultures. This volume continues the tradition of publishing studies on the history and culture of the Old Believers in Estonia. It includes research papers on the topic, as well as transcripts of recorded texts from the Old Believers. The special focus of the volume is on the island Piirissaar, its history, architecture, people and their language, customs and traditions.
    Keywords: cultural studies ; Slavic studies ; Russian linguistics ; Russian dialects ; Russian onomastics ; folklore ; Russian lexicology ; old believers ; idiolects ; thema EDItEUR::1 Place qualifiers::1D Europe::1DT Eastern Europe::1DTE Estonia ; thema EDItEUR::2 Language qualifiers::2A Indo-European languages::2AG Slavic (Slavonic) languages::2AGR Russian ; thema EDItEUR::C Language and Linguistics::CF Linguistics ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRM Christianity::QRMB Christian Churches, denominations, groups::QRMB2 Orthodox and Oriental Orthodox Churches ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBG Popular beliefs and controversial knowledge::JBGB Folklore studies / Study of myth (mythology) ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSC Rural communities ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSL Ethnic studies::JBSL1 Ethnic groups and multicultural studies
    Language: Russian , Estonian
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    Eine semantische Analyse der Perfektivierungspraefigierung im Russischen. Fallstudie pere- (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-03-24
    Description: The work consists of two parts. The first part deals exclusively with the aspect properties of Russian prefigured verbs. A perfective analysis for Russian is proposed, which allows to grasp the semantic differences between imperfective Simplizia and its derivative derivatives in semantic terms. The second part of the thesis is an application of the proposed perfective analysis to Russian pere-prefixed verbs. It is shown that the meaning variants of pere-prefixed verbs in Russian can be derived from a general prefix scheme and the semantics of the stem verb.
    Description: Die Arbeit besteht aus zwei Teilen. Der erste Teil befaßt sich ausschließlich mit den aspektuellen Eigenschaften russischer präfigierter Verben. Es wird eine Perfektivanalyse für das Russische vorgeschlagen, die es ermöglicht, die semantischen Unterschiede zwischen imperfektiven Simplizia und ihren perfektiven Derivata in semantischen Termen zu erfassen. Der zweite Teil der Arbeit stellt eine Anwendung der vorgeschlagenen Perfektivanalyse auf russische pere-präfigierte Verben dar. Es wird gezeigt, daß die Bedeutungsvarianten pere-präfigierter Verben im Russischen aus einem allgemeinen Präfixschema und der Semantik des Stammverbs abgeleitet werden können.
    Keywords: Analyse ; Demjjanow ; Eine ; Fallstudie ; imperfektives Simplizia ; pere ; Perfektivaxiome ; Perfektivierung im Lexikon ; Perfektivierungspräfigierung ; Perfektiv-Imperfektivtest ; Russischen ; semantische ; Verbpräfigierung ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: German
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    Firenze e la lingua italiana fra nazione ed Europa (2022)
    Firenze University Press
    Details
    Publication Date: 2024-03-24
    Description: The volume collects the proceedings of the conference “Firenze e la lingua italiana tra nazione ed Europa” (Florence and the Italian language between nation and Europe), which was held from on May 27 and 28 2004 in the Aula Magna of the University of Florence and the Accademia della Crusca. As known, Florence played a central role in the process of national linguistic unification and thanks to its international vocation the city has promoted the spread and knowledge of the Italian language and culture all over Europe and in the world. Beyond any celebratory enthusiasm, the conference has been an occasion of open discussion on the cultural identity of the city in the contemporary context, through a critical reflection on its history (in particular on some significant moments of the Florentine culture between the nineteenth and twentieth centuries) and on its linguistic primacy.
    Keywords: Lingua italiana ; Linguistica ; Storia ; Atti di convegno ; Firenze ; Europa ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: Italian
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    Die Entstehung des slavischen phonologischen Systems und seine Entwicklung bis zum Ende der Periode der slavischen Spracheinheit (2021)
    Peter Lang International Academic Publishers
    Details
    Publication Date: 2024-03-24
    Description: In der Reihe Slavistische Beiträge werden vor allem slavistische Dissertationen des deutschsprachigen Raums sowie vereinzelt auch amerikanische, englische und russische publiziert. Darüber hinaus stellt die Reihe ein Forum für Sammelbände und Monographien etablierter Wissenschafter/innen dar.
    Keywords: Ende ; Entstehung ; Entwicklung ; Linguistik ; Mareš ; Periode ; Philologie ; phonologischen ; Russland ; seine ; Slavische Sprachwissenschaft ; slavischen ; Spracheinheit ; Systems ; thema EDItEUR::C Language and Linguistics::CF Linguistics ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: German
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    Social and structural aspects of language contact and change (2023)
    Language Science Press | Language Science Press
    Details
    Publication Date: 2024-03-24
    Description: This book brings together papers that discuss social and structural aspects of language contact and language change. Several papers look at the relevance of historical documents to determine the linguistic nature of early contact varieties, while others investigate the specific processes of contact-induced change that were involved in the emergence and development of these languages. A third set of papers look at how new datasets and greater sensitivity to social issues can help to (re)assess persistent theoretical and empirical questions as well as help to open up new avenues of research. In particular they highlight the heterogeneity of contemporary language practices and attitudes often obscured in sociolinguistic research. The contributions all focus on language variation and change but investigate it from a variety of disciplinary and empirical perspectives and cover a range of linguistic contexts.
    Keywords: Language Arts & Disciplines ; Linguistics ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: English
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    Hramatika slovenska (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-03-24
    Description: Die Beschäftigung mit den sprachlichen Merkmalen der Gennadius-Bibel (1499) und Ostroger Bibel (1580/81) hat die Herausgabe der Zizanij-Grammatik (1596), der ersten umfangreicheren Abhandlung über die kirchenslavische Sprache bei den Ostslaven, sinnvoll und wünschenswert erscheinen lassen. Sie stellt sowohl durch den normativen Charakter im grammatikalische Teil als auch durch die staken Einflüsse der Volkssprache in den vorausgehenden und nachfolgenden Teilen ein interessantes Denkmal der letzten Dekade des 16.Jh. dar.
    Keywords: Hramatika ; kirchenslavische Grammatik ; kirchenslavische Sprache ; Linguistik ; Ostroger Bibel ; slavische Sprachwissenschaft ; slovenska ; Zizanij-Grammatik ; Zyzanij ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: Slovenian
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    Chapter 13 The social organization of (in-)attention (2023)
    Taylor & Francis | New Perspectives on Goffman in Language and Interaction | Routledge
    Details
    Publication Date: 2024-03-24
    Description: “Attention” is a primordial topic throughout Goffman’s work. Already his dissertation thesis (1953) includes a separate chapter on “the organization of attention”. In his later studies he developed various concepts related to attention, such as focused/unfocused interaction or “civil inattention”. Although attention is evidently a crucial dimension of the interactional order, Goffman did not elaborate this topic systematically. The study of attention was later refined and enriched by conversation analysts who underlined the role of visual displays of attentiveness in social interaction. Against the backdrop of the notion of “focused interaction”, this paper examines how the psychological approach to “joint attention” differs from or amplifies Goffman’s studies. Based on some of Cartier-Bresson’s photos, it is shown that the contrasting set of focused/unfocused interaction needs to be supplemented by a third type of attention order, in which members are collectively oriented to an outward event. After a discussion of some of the practices of sustaining and re-establishing a focus of attention, empirical evidence is provided that certain interactional purposes can be achieved by displaying inattention. In the final discussion of Goffman’s concept of “civil inattention”, some historical and sociological dimensions are pointed out along which this concept can be further studied.
    Keywords: co-presence; co-present bodies within space; social interaction; interactional sociolinguistics; interactional foundations of the self; participation; Erving Goffman; Lorenza Mondada; conversation analysis; sociolinguistics; interactional linguistics; language sciences; ethnomethodology; Anssi Peräkylä; self and identity; interaction studies; language and interaction; language and social interaction ; thema EDItEUR::C Language and Linguistics::CB Language: reference and general ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: English
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    Die Funktion des Verbalaspekts im Praesens historicum des Russischen (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-03-24
    Description: 〈P〉In der Reihe 〈I〉Slavistische Beiträge〈/I〉 werden vor allem slavistische Dissertationen des deutschsprachigen Raums sowie vereinzelt auch amerikanische, englische und russische publiziert. Darüber hinaus stellt die Reihe ein Forum für Sammelbände und Monographien etablierter Wissenschafter/innen dar.〈/P〉
    Keywords: Funktion ; historicum ; Linguistik ; Panzer ; Philologie ; Praesens ; Russischen ; Russland ; Slavische Sprachwissenschaft ; Sprachwissenschaft ; Verbalaspekts ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: German
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    Recent Progress of Nanomedicine and Targeted Drug Delivery for Cancer Treatment (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-04-05
    Description: Currently, cancer is the second leading cause of death worldwide and is the most complex and challenging disease known to humankind. Due to the complex underlying mechanisms of tumorigenesis and tumor metastasis, as well as the intrinsic limitations of conventional cancer therapies, the effective treatment of cancer remains a great challenge. Novel therapeutic strategies with superior anticancer ability urgently need to be discovered. In recent years, nano-drug delivery systems have been extensively investigated and applied as alternatives to conventional cancer treatments. Cancer nanomedicines aim to achieve the targeted delivery of chemotherapeutic drugs to the tumor site, utilizing strategies such as passive targeting, active targeting and stimuli-triggered drug release, while simultaneously decreasing drug accumulation in normal tissues, which together lead to improved therapeutic efficacy and reduced side effects. Currently, several cancer nanomedicines are in regular use, and several others are in various stages of development.This Special Issue will highlight recent progress in the development of novel nanomedicines and targeted drug delivery systems for cancer therapy.
    Keywords: graphene quantum dot ; targeted drug delivery ; photothermal therapy ; chemo-therapy ; polymeric prodrug ; theranostic nanocomplex ; pH-triggering releasing ; magnetic targeting ; magnetic hyperthermia ; magnetic resonance imaging ; docetaxel ; adenosine receptors ; PLGA ; nanoparticles ; lung cancer ; Notch signaling ; RBPJ protein ; drug repurposing ; fidaxomicin ; acarbose ; schaftoside ; breast cancer ; experimental skin cancer ; entrapment efficacy ; ethosomes ; metformin ; in vitro permeation ; zeta potential ; sesamol ; albumin nanoparticles ; doxorubicin ; oxidative stress ; antioxidants ; tumor-derived membrane vesicles ; cancer therapy ; tumor vaccine ; personalized immunotherapy ; low-density lipoprotein ; nanoparticle ; tumor microenvironment-responsive ; magnetic nanofluid ; improved magnetic resonance imaging ; neutral-responsive Fenton reaction ; enhanced chemodynamic therapy ; brain targeting ; folate receptor ; glioma cancer ; erlotinib ; blood–brain barrier ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
    Language: English
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    L. N. Tolstoj i T. M. Bondarev. Perepiska. 1885-1898 (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-03-24
    Description: The series Lectures and Treatises on Slavic Studies, which has been published since 1980, offers opportunities for publication, especially for smaller monographs, which, in terms of their scope, are located between the journal article and the large book. It will cover topics from the whole area of ​​Slavic languages, literatures and cultures as well as their interrelations. In addition to investigations, bibliographies, research reports and editions are published. The authors of the previous volumes come from America, Canada, Germany, Finland, Poland, Russia, Switzerland, Slovenia, the Czech Republic and Hungary.
    Description: Die seit 1980 erscheinende Reihe Vorträge und Abhandlungen zur Slavistik bietet Publikationsmöglichkeiten vor allem für kleinere Monographien, die ihrem Umfang nach zwischen Zeitschriftenbeitrag und großem Buch anzusiedeln sind. Aufgenommen werden Themen aus dem Gesamtbereich der slavischen Sprachen, Literaturen und Kulturen sowie ihrer Wechselbeziehungen. Neben Untersuchungen werden auch Bibliographien, Forschungsberichte und Editionen veröffentlicht. Die Autoren und Autorinnen der bisherigen Bände kommen aus Amerika, Kanada, Deutschland, Finnland, Polen, Rußland, Schweiz, Slowenien, Tschechische Republik und Ungarn.
    Keywords: 1885 ; 1898 ; Bondarev ; Briefe ; Donskov ; Erinnerungen ; Literaturwissenschaft ; Perepiska ; Russland ; Tagebücher ; Tolstoj ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: German
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    A aquisição de língua materna e não materna (2021)
    Language Science Press
    Details
    Publication Date: 2024-03-24
    Description: The present volume is an introduction to the study of Language Acquisition, especially centered on Portuguese. Even though the different chapters always take Portuguese as a point of departure, a comparative perspective is assumed and Portuguese data is compared to data from other languages, when relevant. This book aims at filling a gap in the literature: an introductory textbook to be used by students of Language Acquisition in Portuguese-speaking countries. The book is composed by chapters authored by several Portuguese and Brazilian researchers and it presents in textbook format a relevant part of the research results obtained during the last decades. The book starts with a general historical presentation of the field. The following chapters explore the acquisition of phonology and syntax and consider the problem of typical and atypical development, as well as linguistic assessment. Bilingualism and L2 acquisition are the topics of two independent chapters. Two final chapters discuss the development of linguistic awareness, in relation to the acquisition of writing.
    Keywords: language acquisition ; bilingualism ; acquisition of syntax ; textbook ; linguistic assessment ; l2 acquisition ; acquisition of phonology ; portugese ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: Miscellaneous languages
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    Extracellular Vesicle-Mediated Processes in Cardiovascular Diseases (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: It is long known that many cells can shed extracellular vesicles, small membrane-enclosed cell fragments. Although the existence of extracellular vesicles has been recognized for many years, researchers are only beginning to understand their physiologic significance. Several recent studies have demonstrated that extracellular vesicles released from cells serve as a mode of cellular communication. They can carry diverse molecular payload (e.g. nucleic acids, bioactive lipids and proteins) to distal organs and recipient cells. Extracellular vesicles can be classified into three major groups: exosomes, microvesicles, and apoptotic bodies. All these types of extracellular vesicles can be found in a variety of biologic specimen and their numbers, distribution and composition may serve as biomarkers for various disorders, including cardiovascular disease. Although extracellular vesicle-mediated processes are currently best characterized in the fields of cancer biology and neurobiology, evidence is accumulating that extracellular vesicles play a key role in the pathophysiology of diabetes, thrombosis, inflammation and cardiovascular calcification. In this Research Topic, we invited review and methodological articles that advance our understanding of extracellular vesicle-related processes in vascular biology.
    Keywords: R5-920 ; Angiogenesis ; Atherosclerosis ; Extracellular vesicles ; Calcification ; Biomarkers ; Cardiovascular disease ; Inflammation ; Exosomes ; Platelets ; Heart valve ; bic Book Industry Communication::M Medicine
    Language: English
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    Prognostic Factors for Pediatric Tumors (2024)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2024-01-08
    Description: In this Special Issue, recent advancements in the field of pediatric tumors are discussed, and novel prognostic markers are critically appraised. Greater understanding of the heterogeneity of pediatric cancers will ultimately lead to new therapeutic strategies with the potential to provide new prospects for precision medicine in pediatric oncology.
    Keywords: undernutrition ; obesity ; nutritional status ; childhood cancer ; overall survival ; event-free survival ; relapse ; treatment-related toxicity ; review ; sarcoma botryoides ; fertility-sparing surgery ; embryonal rhabdomyosarcoma ; genital tract ; prognosis ; treatment ; local debulking ; neoadjuvant chemotherapy ; radiation ; ovarian cancer ; adolescents ; diagnosis ; therapy ; guidelines ; children ; papillary thyroid cancer ; proto-oncogene B-raf gene (BRAF) ; craniopharyngioma ; recurrence ; risk factors ; youth ; acute lymphoblastic leukemia (ALL) ; child ; genetics ; CDKN2A/2B deletions ; fluorescent in situ hybridization (FISH) ; multiple-ligation probe amplification (MLPA) ; copy-number alterations (CNAs) ; risk stratification ; minimal residual disease (MRD) ; cardiotoxicity ; chemotherapeutics agents ; biomarkers ; omics technology ; medulloblastoma ; tumor ; histologic ; pediatrics ; micro-RNAs ; non-coding RNAs ; molecular subgroup ; stratification ; acute lymphoblastic leukemia ; proteomics ; oncology ; chemotherapy ; cardiac function tests ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
    Language: English
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    Kalle Päätalo tutkijoiden silmin (2022)
    Finnish Literature Society / SKS | Finnish Literature Society
    Details
    Publication Date: 2024-04-01
    Description: The Finnish novelist Kaarlo (Kalle) Alvar Päätalo’s (1919–2000) main work, the Iijoki series, consists of 26 novels (comprising ca. 17 000 pages) and was written in 1971–1998. In this book the text corpus in Kielipankki concerning Päätalo’s works is introduced to the readers, as well as the possibilities of digital text mining. This book includes scientific articles concerning the works of Kalle Päätalo. It also gives ideas for the research that can be carried out in the future. The authors of this book are researchers in the fields of history, linguistics and literature, respectively. The research results presented in this book speak for the fact that the Iijoki series is a significant source material for future research, for example from the point of view of oral history, language variation, metalanguage, swearing and the reader’s reception. The possibilities for future research seem to be quite plentiful.
    Keywords: authors; Kalle Päätalo; dialects; language of literature; Finnish language literature; Finnish language ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::C Language and Linguistics::CF Linguistics ; thema EDItEUR::D Biography, Literature and Literary studies
    Language: Finnish
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    Interprétations du discours métalinguistique (2022)
    Firenze University Press
    Details
    Publication Date: 2024-03-24
    Description: Ancient linguistic reflection in India was able to combine the analysis of Sanskrit with the awareness that the language through which this analysis is conducted (Sanskrit) is different from the object it examines. Although this language-tool finds its dimension in the artificial Sanskrit of the sütras - the aphorisms of Påñini's grammar - metalinguistic discourse is not restricted to specialized discourse: common speech abounds in metalinguistic notations. The present work focuses on the testimonies of the grammatical school of Pâininian origin, by trying to retrace the course by which metalanguage left the field of naive linguistics to become an object of the school.
    Keywords: Lingua sanscrita ; Linguistica ; Cultura indiana ; India ; thema EDItEUR::C Language and Linguistics::CF Linguistics ; thema EDItEUR::N History and Archaeology::NH History::NHB General and world history ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDH Philosophical traditions and schools of thought ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs
    Language: Italian
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    Polymer Materials in Biomedical Application (2022)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2022-03-21
    Description: Recently, the development of polymeric materials for biomedical applications has advanced significantly. Polymeric materials are favored in the development of therapeutic devices, including temporary implants and three-dimensional scaffolds for tissue engineering and in vitro disease modelling.Further advancements have also occurred in the utilization of polymeric materials for pharmacological applications, such as delivery vehicles for drug release.We would like to invite you to contribute to this Special Issue. Research topics of interest include, but are not limited to, recent advances related to 3D cell culture, biomaterials, tissue engineering, disease modelling, hydrogel, organoids, drug discovery, bioimaging, cardio-renal, metabolic disease, and stem cell biology.
    Keywords: hydrogels ; crosslinking ; degradable ; gamma (γ)-irradiation ; sterilization ; sterility assurance ; antibacterial ability ; jojoba ; Simmondsia ; chemistry ; liquid wax ; biology ; toxicity ; pharmaceutical/industrial uses ; articular cartilage ; mechanical properties ; tribological properties ; antibacterial ; pathogens ; infectious diseases ; silver nanoparticles ; wound care ; wound dressings ; polymers ; gelatin ; nanofibers ; sponges ; Ag/RGO nanocomposites ; green preparation ; anticancer performance ; potential mechanism ; oxidative stress ; hydrogel ; poloxamer 407 polymer ; poloxamer 407 gel ; transungual drug delivery ; onychomycosis ; ungual penetration enhancer ; Terbinafine ; diafiltration ; SAXS ; aromatic interactions ; poly(sodium 4-styrenesulfonate) ; chlorpheniramine ; polyelectrolyte ; aggregation ; coaxial electrospinning ; extracellular matrix ; myelination ; oligodendrocyte ; water-soluble materials ; orthokeratology lens ; protein deposition ; optical characteristics ; rubbing ; chitosan ; kenaf ; nanocrystalline cellulose ; platelet lysate ; wound healing ; carbohydrate polymers blends ; functional food ; antioxidant activity ; co-microencapsulation ; spray drying ; bacteria viability (Bacillus clausii) ; probiotics ; itraconazole ; self-emulsifying nanovesicles ; transungual ; anti-fungal ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
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    How to improve immune reconstitution in allogeneic hematopoietic stem cell transplantation? (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is widely used in the treatment of haematological malignancies as a form of immunotherapy acting through a graft-versus-leukemia (GvL) reaction. This curative allogeneic response can be associated with severe drawbacks, such as frequent and severe graft-versus-host disease (GvHD) and a long-lasting immunodeficiency, especially now with the development of innovative strategies such as umbilical cord blood transplantation or transplants from haplo-identical family donors (Haplo-HSCT). In the long-term follow-up of these patients, severe post-transplant infections, relapse or secondary malignancies may be directly related to persistent immune defects.Reconstitution of the different lymphocyte populations (B, T, NK, NKT) and antigen presenting cells of myeloid origin (monocytes, macrophages and dendritic cells) should be considered not only quantitatively but especially qualitatively, in terms of functional subsets. Immune deficiency leading to an increased susceptibility to infections lasts for more than a year. Although infections that occur in the first month mostly result from a deficiency in both granulocytes and mononuclear cells (MNC), later post-engraftment infections are due to a deficiency in MNC subsets, primarily CD4 T-cells and B-cells. T-cell reconstitution has been extensively studied because of the central role of T-cells in mediating both GvHD, evidenced by the reduced incidence of this complication following T-Cell depletion, and a GvL effect as shown by DLI. In the recent years there has been renewed interest in the role of NK-cells, especially in the context of Haplo-HSCT, and in B-cell reconstitution.This Frontiers Research Topic will provide state of the art knowledge of the mechanisms of immune reconstitution in an allogeneic environment, in order to improve monitoring and therapeutic intervention in allo-HSCT patients.
    Keywords: R5-920 ; RC581-607 ; cell therapy ; Immune reconstitution ; Haplo-SCT ; HSCT ; Thymic function ; bic Book Industry Communication::M Medicine
    Language: English
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    Lenguaje y cultura: Homenaje a Angelita Martínez (2023)
    Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación | Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación ; IdIHCS
    Details
    Publication Date: 2024-03-24
    Description: This volume in homage to the academic and teaching work of Angelita Martínez aims to recognize the career trajectory of a tireless researcher. Her work is well-known in the most recognized spaces of dissemination of linguistics. In this school, Facultad de Humanidades y Ciencias de la Educación (FaHCE), she developed her teaching and research work, first from the Chair of Hispanic Philology, and then from the Chair of Linguistics. She currently leads the Center for Linguistic Studies and Research and the Master's Degree Program in Linguistics. Her work has allowed her to consolidate academic and personal connections both nationally and internationally, reflected in this compilation through a series of works by linguists belonging to different theoretical perspectives and geographic locations who share her interest in the workings of language. This volume also includes the contributions of disciples who have completed their postgraduate studies and who account for their journey and achievements attained under the guidance of their generous mentor.
    Description: Published
    Description: Este volumen en homenaje a la labor académica y docente de Angelita Martínez pretende reconocer la trayectoria de una investigadora incansable. Su obra se conoce en los espacios de mayor difusión de la ciencia lingüística. En esta Facultad desarrolló su tarea docente y de investigación, en primer término, desde la cátedra de Filología Hispánica, y luego desde la cátedra de Lingüística. Actualmente conduce el Centro de Estudios e Investigaciones Lingüísticas y la Maestría en Lingüística. Su labor le ha permitido consolidar vínculos académicos y personales tanto nacionales como internacionales, que se plasman en esta compilación a través de una serie de trabajos de lingüistas pertenecientes a distintas perspectivas teóricas y espacios geográficos que comparten su interés por el funcionamiento del lenguaje. Se incluyen además los trabajos de discípulas que han finalizado sus posgrados y que dan cuenta del camino transitado y los logros alcanzados de la mano de su generosa formadora.
    Keywords: Angelita Martínez ; Lenguaje ; Lingüística ; Memorias ; thema EDItEUR::C Language and Linguistics::CF Linguistics ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DN Biography and non-fiction prose
    Language: Spanish
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    Zur Vitalitaet slavischer Idiome in Deutschland (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-03-24
    Description: Germany has gradually become Europe's largest immigration country and is increasingly shaped by the image of a multicultural and multilingual society. However, the issue of multilingualism receives little attention, especially with regard to Slavic migration idioms. The aim of the present study is the empirical investigation of the current language behavior of Slavophone immigrants and the determination of the vitality of their native languages. On the basis of a nationwide survey of 500 immigrants detailed microsociological data on the use of Slavic languages ​​depending on persons, topics and situations will be collected and the influence of linguistic ecological factors such as attitudes, motivations, identity and social network of speakers on language use and language content will be investigated. In addition, on the basis of interdisciplinary approaches to the description of linguistic minorities, the vitality of slavins is analyzed comparatively, showing the current situation and the future development of Slavia in Germany in general and specific tendencies of ethnolects in particular.
    Description: Deutschland hat sich sukzessive zum größten Einwanderungsland Europas entwickelt und wird immer stärker vom Bild einer multikulturellen und multilingualen Gesellschaft geprägt. Dem Thema Mehrsprachigkeit aber wird insbesondere in Bezug auf slavische Migrationsidiome nur wenig Beachtung geschenkt. Ziel der vorliegenden Studie ist die empirische Erforschung des aktuellen Sprachverhaltens slavophoner Immigranten und die Bestimmung der Vitalität ihrer Muttersprachen. Anhand einer deutschlandweiten Enquete unter 500 Zuwanderern werden detaillierte mikrosoziologische Daten zum Gebrauch der slavischen Sprachen in Abhängigkeit von Personen, Themen und Situationen erhoben und der Einfluss sprachökologischer Faktoren wie Attitüden, Motivationen, Identität und soziales Netzwerk der Sprecher auf die Sprachverwendung und den Spracherhalt untersucht. Zudem wird auf der Grundlage interdisziplinärer Ansätze zur Beschreibung von Sprachminderheiten die Vitalität der Slavinen komparativ analysiert, womit die gegenwärtige Situation und die zukünftige Entwicklung der Slavia in Deutschland im Allgemeinen und spezifische Tendenzen der Ethnolekte im Besonderen aufgezeigt werden.
    Keywords: Germany ; migration idioms ; immigration ; Achterberg ; Deutschland ; Ethnolinguistischen Vitalität ; Idiome ; Immigrantensprachen ; Immigration nach Deutschland ; Mehrsprachigkeit ; slavischer ; Sprachkontakt ; Vitalität ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: German
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    Legitime Sprachen, legitime Identitäten (2021)
    transcript Verlag | transcript Verlag
    Details
    Publication Date: 2024-03-24
    Description: Das Einüben der Fähigkeit, mit sprachlicher und kultureller Vielfalt produktiv umzugehen, ist ein Kernanliegen des zeitgemäßen Fremdsprachenunterrichts. Doch wie ist der Umgang mit dieser im Klassenzimmer organisiert? Daniel H. Rellstab analysiert auf der Basis eines von Erving Goffman geprägten Interaktionsverständnisses Interaktionen in »Deutsch als Fremdsprache«-Klassenzimmern. Dabei zeigt er, welche Ressourcen Lehrkräfte sowie Schülerinnen und Schüler in der Interaktion einsetzen, wie sie aushandeln, welche Sprachen legitim, welche illegitim sind, und wie sie dabei Identitäten und Normen re- und dekonstruieren.
    Keywords: Deutsch Als Fremdsprache ; Interaktion ; Interaktionsanalyse ; Multimodalität ; Mehrsprachigkeit ; Legitimität ; Sprachkompetenz ; Spracherwerb ; Didaktik ; Lernen ; Identität ; Normensystem ; Sprache ; Bildung ; Gesellschaft ; Sprachwissenschaft ; Interkulturalität ; Germanistik ; Bildungsforschung ; Pädagogik ; German As a Foreign Language ; Interaction ; Interaction Analysis ; Multimodality ; Multilinguism ; Legitimacy ; Language Competence ; Language Acquisition ; Didactics ; Learning ; Identity ; Standard System ; Language ; Education ; Society ; Linguistics ; Interculturalism ; German Literature ; Educational Research ; Pedagogy ; thema EDItEUR::C Language and Linguistics::CF Linguistics ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBC Cultural and media studies::JBCC Cultural studies ; thema EDItEUR::D Biography, Literature and Literary studies::DS Literature: history and criticism::DSB Literary studies: general
    Language: German
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    Chapter C10 Same Law, Different Texts (2021)
    Taylor & Francis | A Global History of Ideas in the Language of Law | Language and Law | Routledge
    Details
    Publication Date: 2024-03-24
    Description: Language plays an essential role both in creating law and in governing its implementation. Providing an accessible and comprehensive introduction to this subject, Language and Law:describes the different registers and genres that make up spoken and written legal language and how they develop over time; analyses real-life examples drawn from court cases from different parts of the world, illustrating the varieties of English used in the courtroom by speakers occupying different roles; addresses the challenges presented to our notions of law and regulation by online communication; discusses the complex role of translation in bilingual and multilingual jurisdictions, including Hong Kong and Canada; and provides readings from key scholars in the discipline, including Lawrence Solan, Peter Goodrich, Marianne Constable, David Mellinkoff, and Chris Heffer. With a wide range of activities throughout, this accessible textbook is essential reading for anyone studying language and law or forensic linguistics.
    Keywords: English for law ; English for specific purposes law ; forensic linguistics ; language and the law ; legal English ; legal genres ; thema EDItEUR::C Language and Linguistics::CB Language: reference and general ; thema EDItEUR::C Language and Linguistics::CF Linguistics ; thema EDItEUR::C Language and Linguistics::CF Linguistics::CFB Sociolinguistics ; thema EDItEUR::L Law::LA Jurisprudence and general issues ; thema EDItEUR::L Law::LA Jurisprudence and general issues::LAR Legal aspects of criminology ; thema EDItEUR::L Law::LA Jurisprudence and general issues::LAS Legal skills and practice
    Language: English
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    Rheumatic Diseases: Pathophysiology, Targeted Therapy, Focus on Vascular and Pulmonary Manifestations (2022)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2022-05-06
    Description: This e-book summarises the latest advances in the rheumatic diseases with a focus on the recent efforts of vascular and pulmonary manifestations and anticipate the new and future directions of these research topic. Rheumatic diseases represent a heterogeneous group of severe autoimmune disorders. The present Special Issue aims to provide an overview of the complexity of vascular and pulmonary manifestations of rheumatologic diseases and helps in knowledge to manage them. The eleven published articles here collected underline the complexity of rheumatic diseases and the difficult to treated them. The manuscripts provide an overview of the pathophysiology and current treatment regimes of these disorders, highlighting tools which assist with diagnosis, risk stratification and therapy. Finally, we underline the importance of a multidisciplinary team working using the skills of clinicians, radiologists, and pathologists.
    Keywords: systemic sclerosis ; scleroderma ; interstitial lung disease ; pulmonary function tests ; high-resolution computed tomography ; rheumatic ; pulmonary arterial hypertension ; targeted therapy ; systemic lupus erythematosus ; airway disease ; shrinking lung syndrome ; diffuse alveolar hemorrhage ; pleurisy ; infection ; cardiopulmonary exercise testing ; osteopontin ; connective tissue diseases ; pulmonary involvement ; microvascular involvement ; nailfold capillaroscopy ; rheumatoid arthritis ; interstitial lung diseases ; CX3CL1/fractalkine ; CX3CR1 ; M1 macrophage ; M2 macrophage ; SKG mice ; heart failure ; 3D-echocardiography ; ventricular function ; outcome ; ventricular-arterial coupling ; antifibrotic agents ; COVID-19 ; IPF ; progressive fibrosing ILD ; UIP ; pharmacological interactions ; fibromyalgia ; gastrointestinal symptoms ; probiotic ; VSL#3® ; efficacy ; tolerability ; polymyalgia rheumatica ; vagus nerve stimulation ; inflammatory response ; PMR ; t-vns ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
    Language: English
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    Recent advances in γδ T cell biology: New ligands, new functions, and new translational perspectives (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Gamma/delta (γδ) T-cells are a small subset of T-lymphocytes in the peripheral circulation but constitute a major T-cell population at other anatomical localizations such as the epithelial tissues. In contrast to conventional a/ß T-cells, the available number of germline genes coding for T-cell receptor (TCR) variable elements of γδ T-cells is very small. Moreover, there is a prefential localization of γδ T-cells expressing given Vgamma and Vdelta genes in certain tissues. In humans, γδ T-cells expressing the Vg9Vd2-encoded TCR account for anywhere between 50 and 〉95% of peripheral blood γδ T-cells, whereas cells expressing non-Vd2 genes dominate in mucosal tissues. In mice, there is an ordered appearance of γδ T-cell „waves“ during embryonic development, resulting in preferential localization of γδ T-cells expressing distinct VgammaVdelta genes in the skin, the reproductive organs, or gut epithelia. The major function of γδ T-cells resides in local immunosurveillance and immune defense against infection and malignancy. This is supported by the identification of ligands that are selectively recognized by the γδ TCR. As an example, human Vgamma9Vdelta2 T-cells recognize phosphorylated metabolites („phosphoantigens“) that are secreted by many pathogens but can also be overproduced by tumor cells, providing a basis for a role of these γδ T-cells in both anti-infective and anti-tumor immunity. Similarly, the recognition of endothelial protein C receptor by human non-Vdelta2 γδ T-cells has recently been identified to provide a link for the role for such γδ T-cells in immunity against epithelial tumor cells and cytomegalovirus-infected endothelial cells. In addition to „classical“ functions such as cytokine production and cytotoxicity, recent studies suggest that subsets of γδ T-cells can exert additional functions such as regulatory activity and – quite surpisingly – „professional“ antigen-presenting capacity. It is currently not well known how this tremendous extent of functional plasticity is regulated and what is the extent of γδ TCR ligand diversity. Due to their non-MHC-restricted recognition of unusual stress-associated ligands, γδ T-cells have raised great interest as to their potential translational application in cell-based immunotherapy. Topics of this Research Focus include: Molecular insights into the activation and differentiation requirements of γδ T-cells, role of pyrophosphates and butyrophilin molecules for the activation of human γδ T-cells, role of γδ T-cells in tumor immunity and in other infectious and non-infectious diseases, and many others. We are most grateful to all colleagues who agreed to write a manuscript. Thanks to their contributions, this E-book presents an up-to-date overview on many facets of the still exciting γδ T-cells.
    Keywords: R5-920 ; RC581-607 ; Infection ; Butyrophilin 3A1 ; Tumor-infiltrating lymphocytes ; cancer immunotherapy ; IL-17 ; Pyrophosphates ; bic Book Industry Communication::M Medicine
    Language: English
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    Traditional Medicines and Globalisation (2021)
    Maven Publishers
    Details
    Publication Date: 2022-04-28
    Description: The development of natural products requires the confluence of the modern techniques and integrated approaches in various fields of science and technology. Intention of this book is to highlight different aspects of globalization of traditional medicine with the focus on some crucial and contemporary issues on validation of natural products. Eminent scientists around the globe have contributed for this book on different issues of ethnopharmacology, traditional medicine and globalization. Given the importance on promotion and development of natural products, this book covers various aspects on revitalization of traditional medicines. The contributors have provided an insight into the modem aspects and future of traditional medicine inspired drug development, validation, safety related quality issues, sustainability and globalization. Bringing together expertise from academia and industry, this edited volume provides an overview of traditional medicine with wisdom and know-how in both innovation and commercialization, placing natural product research in a broader sense for readers. This edited volume contains 68 chapters emphasizing several thrust areas of ethnopharmacology and natural products. A wide diversity of chapters has been contributed by eminent personalities throughout the world including Dr. A. P. J. Abdul Kalam, Sri. Shekhar Dutt, Dr. Marco Leonti, Dr. G. A. Cordell, Dr. R. Verpoorte, Dr. P. J. Houghton, Dr. P. Pushpangadan, Dr. Y. K. Gupta, Dr. A.K.S. Rawat, Dr. S.K. Kulkarni, Dr. Colin W. Wright, Dr. S. C. Mandal, Dr. C. K. Katiyar, Dr. T. K. Mukherjee, Dr. S. Rajan, Dr. G. Schemda, Dr. P. K. Debnath, Dr. Bob Alkin, Dr. Elfin Y. Sukandar, Dr. N. Maity, Dr. A. K. Mitra, Dr. E. Hossain, Dr. H. Fukui, Dr. S.Bhadra, Dr. N. Neema, Dr. H. Mizuguchi, Dr. D. Chattopadhyay, Dr. T. Sen, Dr. Erdem Yesilada, Dr. S.K.Mitra, Dr. S.C. Bachar, Dr. S. Karmakar, Dr. G. B. J. Bailly, Dr. P. Haldar, Dr. Y. Oztruk, Dr. S. Pandit, and others. All representing the-state-of-the-art of the field, and thus would be interesting sources for information. This book will be of enormous help to the undergraduate and postgraduate students, researchers and academia and all others working in the area of Ethnopharmacology and natural product research. It will be an imperative addition to the libraries of technical and administrative personnel in the industries and Universities as a potential resource to update their knowledge.
    Keywords: Globalization ; traditional medicine ; bic Book Industry Communication::M Medicine
    Language: English
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    Onomastics of the “Chanson de Roland” (2023)
    De Gruyter | De Gruyter
    Details
    Publication Date: 2024-03-24
    Description: This ambitious study of the proper names of the Chanson de Roland proves that it is more tightly and profoundly structured and considerably richer in depicting reality than generally assumed, and that its prehistory can be traced back (almost) to the Frankish defeat. Paris and Bédier were right on the main point close to their hearts: the song has both the thoroughly sophisticated structure (Bédier) and the imposingly long prehistory (Paris).
    Keywords: Chanson de Roland ; Onomastics ; Epic Poem ; Medieval French Literature ; thema EDItEUR::C Language and Linguistics::CF Linguistics ; thema EDItEUR::C Language and Linguistics::CF Linguistics::CFF Historical and comparative linguistics ; thema EDItEUR::D Biography, Literature and Literary studies::DS Literature: history and criticism::DSB Literary studies: general::DSBB Literary studies: ancient, classical and medieval
    Language: English
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    VIOT 2018 (2021)
    Amsterdam University Press
    Details
    Publication Date: 2024-03-24
    Description: This book bundles 22 carefully selected contributions on recent research in language proficiency.
    Description: Dit boek bundelt 22 zorgvuldig geselecteerde bijdragen over recent onderzoek in de taalbeheersing.
    Keywords: Taalbeheersing ; communicatie ; onderzoek ; language proficiency ; communication ; research ; thema EDItEUR::C Language and Linguistics ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: Dutch
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    Research Topics in Medicines and How Our Board Members Are Engaged in Them (2022)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2022-06-21
    Description: With the development of analytical instruments, the academic system has become more complicated, producing new journals one after another. Therefore, it became much important to clarify what is original of “Medicines”. As the name Medicines indicates, it includes science and practice of caring for a patient and managing the diagnosis, prognosis, prevention, treatment or palliation of their injury or disease. Therefore, Medicines differs from other journals with similar title in that it covers a wide range of fields, from traditional medicine to rapidly developing molecular-targeted drugs, focusing on their pharmacological effects, structure–activity relationships, metabolic pathways, gene expression, using cultured cells, animals, and clinical trials. Most parts of this Special Issue were written by our editorial board members, who described the research topics and how they are engaged in their field of research. All of these articles are their life-long story. We collected a total number of 22 original works by basic researchers and clinical doctors. We hope that readers can get a chance to know the current status of diverse fields of medicines, and what your most important research themes are after reading these articles.
    Keywords: Hedychium ; traditional medicine ; coronarin D ; villosin ; anti-acetylcholinesterase ; antidiabetic ; anti-inflammatory ; antimicrobial ; antioxidant ; antitumor ; Genista tridentata ; Pterospartum tridentatum ; isoflavones ; flavonols ; genistein ; biochanin A ; rutin ; daidzein ; inflammatory bowel disease ; Crohn’s disease ; ulcerative colitis ; extra-intestinal manifestations ; orofacial granulomatosis ; tag-like lesions ; cobblestoning ; mucogingivitis ; lip swelling ; aphthous stomatitis ; Angelicae Sinensis Radix ; Danggui ; granules ; herb ; multivariate analysis ; ultra-performance liquid chromatography ; Tai Chi ; qigong ; immune system ; immunity ; inflammation ; telemedicine ; remote monitoring ; GER-e-TEC ; elderly patient ; artificial intelligence ; geriatric syndromes ; detection of the precursory signs of decompensation of geriatric syndromes ; renal cell cancer ; genomic landscape ; targeted therapy ; tumor evolution ; tumor heterogeneity ; allergic rhinitis ; quercetin ; human CD4+ T cells ; Th1/Th2 cytokine balance ; modulation ; in vitro ; intravascular catheter ; CRBSI ; biofilm ; CVC ; antifouling ; chromone ; tumor specificity ; QSAR analysis ; apoptosis ; cell cycle analysis ; contrast-enhanced ultrasound ; hepatocellular carcinoma ; LI-RADS ; chronic liver disease ; granuloma annulare ; granulomatous disorders of the skin ; inflammatory skin conditions ; medical dermatology ; biliary tract cancer ; cholangiocarcinoma ; PARP ; BRCA ; olaparib ; rucaparib ; liver cancer ; pancreatic adenocarcinoma ; pancreatic cancer ; sarcoidosis ; superior vena cava syndrome ; venous thrombosis ; RUCAM ; Roussel Uclaf Causality Assessment Method ; diagnostic algorithm ; iDILI ; iDrug induced liver injury ; DILI ; HILI ; herb induced liver injury ; Stachys L. ; traditional uses ; pharmacological activities ; phytochemicals ; bioactive compounds ; Kampo formulae ; alkaline extract of Sasa sp. ; pine cone extract ; povidone-iodine ; HSV ; HIV ; loss of infectivity ; solubilization method ; diaphragmatic breathing ; abdominal breathing ; breathing exercise ; systematic review ; randomized controlled trial ; respiratory function ; auricular acupuncture ; preoperative anxiety ; protocol ; randomized controlled trials ; meta-analysis ; boiogito ; knee osteoarthritis ; rat ; Yokukansan ; fentanyl ; transient receptor potential ankyrin 1 (TRPA1) channel ; phosphorylated extracellular signal-regulated kinase (pERK) ; whole-cell patch-clamp recording ; herbal medicine ; calcium metabolism ; bone metabolism ; protease ; osteoclast ; macrophage ; RANKL ; LPS ; TLR4 ; TREM2 ; bic Book Industry Communication::M Medicine
    Language: English
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    A grammar of Gyeli (Volume 2) (2021)
    Language Science Press | Language Science Press
    Details
    Publication Date: 2024-03-24
    Description: This grammar offers a grammatical description of the Ngòló variety of Gyeli, an endangered Bantu (A80) language spoken by 4,000-5,000 "Pygmy" hunter-gatherers in southern Cameroon. It represents one of the most comprehensive descriptions of a northwestern Bantu language. The grammatical description, which is couched in a form-to-function approach, covers all levels of language, ranging from Gyeli phonology to its information structure and complex clauses. It draws on nineteen months of fieldwork carried out as part of the "Bagyeli/Bakola" DoBeS (Documentation of Endangered Languages) project between 2010 and 2014. The resulting multimodal corpus from that project, which includes texts of diverse genres such as traditional stories, narratives, multi-party conversations and dialogues, procedural texts, and songs, provides the empirical basis for the grammatical description. The documentary text collection, supplemented by data from elicitation work, questionnaires, and experiments, are accessible in the Bagyeli/Bakola collection of The Language Archive. With additional ethnographic, sociolinguistic, diachronic, and comparative remarks, the grammar may appeal to a wider audience in general linguistics, typology, Bantu studies, and anthropology. In 2019, the grammar received the Pāṇini Award by the Association for Linguistic Typology.
    Keywords: Language Arts & Disciplines ; Linguistics ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: English
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    Roots of language (2021)
    Language Science Press
    Details
    Publication Date: 2024-03-24
    Description: Roots of language was originally published in 1981 by Karoma Press (Ann Arbor). It was the first work to systematically develop a theory first suggested by Coelho in the late nineteenth century: that the creation of creole languages somehow reflected universal properties of language. The book also proposed that the same set of properties would be found to emerge in normal first-language acquisition and must have emerged in the original evolution of language. These proposals, some of which were elaborated in an article in Behavioral and Brain Sciences (1984), were immediately controversial and gave rise to a great deal of subsequent research in creoles, much of it aimed at rebutting the theory. The book also served to legitimize and stimulate research in language evolution, a topic regarded as off-limits by linguists for over a century. The present edition contains a foreword by the author bringing the theory up to date; a fuller exposition of many of its aspects can be found in the author’s most recent work, More than nature needs (Harvard University Press, 2014).
    Keywords: pidgin ; creole ; language origins ; language evolution ; Semantics ; Stratum (linguistics) ; Verb ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: English
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    La relación médico-paciente (2021)
    Publicacions i Edicions de la Universitat de Barcelona
    Details
    Publication Date: 2023-12-21
    Description: La relación médico-paciente está sometida a varias presiones. La financiación de la asistencia sanitaria puede determinar tanto la percepción colectiva del acceso a los recursos sociales (prestaciones económicas, centros de atención especializada, ayudas a domicilio, entre otros) como la prescripción de medicamentos y de pruebas complementarias. Además de las prioridades del financiador o de los beneficiarios de los resultados económicos, las campañas publicitarias influyen también en el criterio del paciente, al que la industria farmacéutica halaga convenciéndolo de que posee conocimientos de medicina y de que es un consumidor con el poder de escoger, cuando en realidad decide porque tiene los medios económicos para pagar su elección. En este libro se analizan las razones que empujan a los profesionales de la sanidad hacia una parcialidad interesada, así como las consecuencias éticas que ello tiene sobre el individuo y sobre la eficiencia del sistema sanitario.
    Keywords: R5-920 ; RA1-1270 ; BJ1-1725 ; Relacions metge-pacient ; Medicina ; Dret ; bic Book Industry Communication::M Medicine
    Language: Spanish
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    Global health issues of aflatoxins in food and agriculture: Challenges and opportunities (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Aflatoxins are a group of polyketide mycotoxins that are produced mainly by members of the genus Aspergillus. Production of these toxic secondary metabolites is closely related to fungal development (Keller et al., 2005; Jamali et al., 2012). Contamination of food, feed and agricultural commodities by aflatoxins poses enormous economic and serious health concerns because these chemicals are highly carcinogenic and can directly influence the structure of DNA. The resulting genetic defects can lead to fetal misdevelopment and miscarriages; aflatoxins are also known to suppress immune systems (Razzaghi-Abyaneh et al., 2013). In a global context, aflatoxin contamination is a constant concern between the 35N and 35S latitude where developing countries are mainly situated. With expanding boundaries of developing countries, aflatoxin contamination has become a persistent problem to those emerging areas (Shams-Ghahfarokhi et al., 2013). The continuing threat by aflatoxin contamination of food, feed and agricultural commodities to the world population has made aflatoxin research one of the most exciting and rapidly developing study areas of microbial toxins. The present research topic includes six review articles, three mini reviews and four original research articles. Contributors highlight current global health issues arising from aflatoxins and aflatoxigenic fungi and cover important aspects of aflatoxin research including contamination of crops, epidemiology, molecular biology and management strategies. Special attention is given to fungus-plant host interactions, biodiversity and biocontrol, sexual recombination in aflatoxigenic aspergilli, potential biomarkers for aflatoxin exposure in humans and safe storage programs.
    Keywords: R5-920 ; QR1-502 ; Q1-390 ; TX341-641 ; genetic diversity ; Public Health ; Aspergillus flavus ; Genomics ; MicroRNAs ; Fungus host interactions ; biological control ; aflatoxin ; agricultural crops ; bic Book Industry Communication::M Medicine
    Language: English
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    Emerging Materials for Additive Manufacturing (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-03-07
    Description: In this reprint, state-of-the-art research and review articles on emerging material systems for additive manufacturing (AM) are collected, with a focus on the process–structure–properties relationships. Additive manufacturing (AM) has grown and evolved rapidly in recent years. There are many exciting research and translational works in many areas of application, such as biomedical, aerospace and electronics. These advancements are typically coupled with materials development, which has resulted in more functionalities added to 3D-printed parts, such as multi-material fabrications and integration with machine learning or digital twins. Such enhancements in functionalities have enabled the evolution of AM from a rapid prototyping tool to an actual manufacturing solution. In this reprint, two reviews and thirteen original research articles are included to highlight the latest development in the field of materials science for AM.
    Keywords: titanium scaffolds ; 3D printing ; pore design ; selective laser melting ; lattice structures ; torsion ; design ; additive manufacturing ; functionally gradient lattice ; torsional stiffness ; energy absorption ; failure behavior ; ferritic steel ; heat treatment ; SLM ; nuclear application ; laser powder bed fusion ; solidification crack ; hot crack ; aluminum alloy powder ; EN AW-5083 ; AA5083 ; AlSi10Mg ; powder bed fusion ; metal matrix composites ; laser powder-bed fusion ; aluminum alloys ; reinforcement ; ceramic particulates ; grain refinement ; crystallographic texture ; mechanical properties ; laser-directed energy deposition ; melt pool ; process maps ; multi-fidelity Gaussian process ; Bayesian Optimization ; uncertainty quantification ; K418 alloy ; orientation ; phase ; microhardness ; color 3D printing ; penetration depth ; chromaticity ; image-based metric ; color reproduction ; Ti-24Nb-4Zr-8Sn ; titanium alloy ; biomedical engineering ; microstructure ; X-ray diffraction ; directed energy deposition ; shape-memory alloys ; joining of metals ; elemental powders ; 3D concrete printing (3DCP) ; hybrids ; geopolymer ; frost resistance ; UV radiation ; thermal conductivity ; surface finishing ; physical vapor deposition ; composites ; recycling ; polymer-matrix composites (PMCs) ; direct ink writing ; liquid deposition modeling ; glass fibers ; stainless steel ; AISI 316L ; AISI 630 (17-4PH) ; AISI 420 ; AISI 440C ; carbon content ; online monitoring ; electron beam melting ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
    Language: English
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    A Short Media History of English Literature (2022)
    De Gruyter | De Gruyter
    Details
    Publication Date: 2024-03-26
    Description: This book explores the history of literature as a history of changing media and modes of communication, from manuscript to print, from the codex to the computer, and from paper to digital platforms. It argues that literature has evolved, and continues to evolve, in sync with material forms and formats that engage our senses in multiple ways. Because literary experiences are embedded in, and enabled by, media, the book focuses on literature as a changing combination of material and immaterial features. The principal agents of this history are no longer genres, authors, and texts but configurations of media and technologies. In telling the story of these combinations from prehistory to the present, Ingo Berensmeyer distinguishes between three successive dominants of media usage that have shaped literary history: performance, representation, and connection. Using English literature as a test case for a long view of media history, this book combines an unusual bird’s eye view across periods with illuminating readings of key texts. It will prove an invaluable resource for teaching and for independent study in English or comparative literature and media studies.
    Keywords: Media ; literature ; history ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DS Literature: history and criticism ; thema EDItEUR::C Language and Linguistics::CF Linguistics ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBC Cultural and media studies::JBCT Media studies
    Language: English
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    Marine Compounds and Cancer (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: In Western countries, cancer is among the most frequent causes of death. Despite striking advances in cancer therapy, especially by the so called “targeted agents”, there is still an urgent need for new drugs in oncology. Hope comes from the marine environment, which is a rich source of natural compounds showing anti-cancer activity. To date, four marine cytotoxic substances, namely cytarabine, trabectidine, eribulin, and monomethyl auristatin E (as a drug-antibody conjugate named vedotin) have made it into clinical routine. Many more are in all phases of clinical testing, and a plethora of substances has already been examined for in vitro and in vivo activity. Interestingly, more and more precise research tools allow the dissection of the molecular mode of action of these cytotoxic substances, thereby uncovering the specific drug targets in cancer cells. This development will blur the edges between “targeted” and “untargeted” therapy, and will hopefully lead to a more directed use of cancer medicine (based on a molecular rationale of activity) in the future. This Topical Collection will cover the whole scope from agents with cancer-preventive activity, to novel and previously characterized compounds with anti-cancer activity, both in vitro and in vivo, and the latest status of clinical development from drug trials. Of note, compounds possessing pro-carcinogenic activity or mediating cancer cell survival are also within the scope of this Topical Collection. In addition, a special focus will be placed on current shortfalls and possible strategies to overcome obstacles in the area of marine anti-cancer drug development.
    Keywords: R5-920 ; toxicology ; marine toxins ; drug discovery ; marine natural compounds and their derivatives ; xenograft models ; drug combination ; cancer ; drug resistance ; cancer-preventive activity ; molecular effects ; molecular targets ; bic Book Industry Communication::M Medicine
    Language: English
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    Personalized Medicine for Parkinson's Disease (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-02-02
    Description: Personalized medicine for Parkinson’s disease is a growing and emerging concept in light of recent recognition that Parkinson’s is a syndromic condition affecting multiple neurotransmitter systems, as well as brain and extracranial structures. The clinical expression is, thus, heterogeneous, and presentation age can range from the 30s to the 90s, with PD in older patients being associated with significant neuropathological comorbidity as well, involving not just misfolded alpha synuclein deposition but also amyloid and tau. Traditional and largely guideline-driven “one size fits all” management strategies adopted in clinical practice are, therefore, often inadequate in holistic management of a patient, particularly when aspects of motor and nonmotor symptoms are taken into consideration. In this supplement of JPM, we present a selection of papers which address several possible strands of personalized medicine in PD, ranging from genomic precision medicine to digital “checklists” to ensure delivery of holistic personalized medicine involving nonpharmacological strategies, as well. We are soliciting any papers addressing biomarkers, genetics and pharmacogenetics, treatment or complementary therapies for personalized or individualized treatment for PD.
    Keywords: Parkinson’s disease ; movement disorders ; periodontitis ; periodontal disease ; hematologic tests ; Vitamin D ; oral health ; Parkinson’s Disease ; cognition ; GABAergic signaling ; cerebellum ; MRS ; response inhibition ; non-motor symptoms ; carer stress ; older persons with Parkinson’s disease ; education ; lifestyle behaviours ; diet ; cross-sectional ; population study ; neurological disorders ; precision medicine ; genetics ; clinical trials ; Parkinson’s disease (PD) ; cognitive rehabilitation ; intervention ; deep brain stimulation ; levodopa-carbidopa intestinal gel ; apomorphine ; radiofrequency ; focused ultrasound ; induced pluripotent stem cells ; cell therapy ; gene therapy ; personalized medicine ; advanced Parkinson’s disease (APD) ; apomorphine subcutaneous infusion therapy ; pain ; intrajejunal ; levodopa ; motor and non-motor symptoms ; PKG (KinetiGrap) ; rehabilitation ; device-aided therapies ; personalised medicine ; Alzheimer’s disease ; clinical trial ; impulsive-compulsive disorders (ICD) ; dopaminergic therapy ; genetic markers ; pharmacogenetic ; polymorphisms ; insomnia ; sleep quality ; assessment ; young onset Parkinson’s (YOPD) ; Emiratis ; expatriate ; genetic ; epigenetics ; societal impact ; device aided therapies ; quality of life ; non motor symptoms ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJN Neurology & clinical neurophysiology
    Language: English
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    Entre as fronteiras do ensino, da pesquisa e da extensão (2022)
    SciELO Books - Editora UFFS | SciELO Books - Editora UFFS
    Details
    Publication Date: 2024-03-24
    Description: Entre as Fronteiras do Ensino, da Pesquisa e da Extensão: estudos na área de Letras abrange vários estudos no campo da Linguística, da Literatura e do Ensino, os quais resultam de projetos de ensino, pesquisa e/ou extensão desenvolvidos na graduação e na pós-graduação. Trata-se de textos que revelam sobreposições e/ou aproximações entre duas ou mais fronteiras, demonstrando um pouco da diversa rede de trabalhos que constitui o campo dos estudos linguísticos e literários atualmente. A obra demonstra a qualidade e a diversidade de pesquisas e projetos desenvolvidos na região sul do Brasil, reunindo estudos que ampliam as fronteiras do ensino, da pesquisa e da extensão nas diferentes áreas de Letras tanto da graduação quanto da pós-graduação. Seus textos revelam possibilidades de afastamentos, de toques e de aproximações, demonstrando um pouco da diversa rede de estudos que compõe o campo dos estudos linguísticos e literários atualmente. O livro destina-se a profissionais da área de Letras, bem como a pessoas que se interessem por estudos da área.
    Keywords: Linguistics ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: Portuguese
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    Urological Cancer 2022 (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-04-05
    Description: In the urological sphere, the number of tumor malignancies caused by cancer is continuously growing in Western countries. Although this is mainly due to the contemporary increase in the life expectancy of people in these geographic areas, many other factors are also contributing to this growth. Urological cancer is a complex and varied disease which affects different organs and mainly affects the male population. In fact, in most statistics, kidney, prostate, and bladder cancer are regularly included in the top-ten list of the most frequent neoplasms in males. The female population, however, has also been increasingly affected by renal and bladder cancer in the last decade. From these facts, it is clear that urological cancer is a problem of major concern in developed societies. This Topic Issue of Cancers intends to shed some light on the complexity of this field and will consider all useful and appropriate contributions from scientists and clinicians in order to improve urological cancer knowledge for patients’ benefit.
    Keywords: high-risk prostate cancer ; androgen receptor axis ; castration resistance ; neuroendocrine carcinoma ; PARP inhibition ; immunotherapy ; cancer genome ; precision targeting ; robot-assisted partial nephrectomy ; renal cell carcinoma ; indocyanine green ; nephron sparing ; prostate cancer survivors ; follow-up care ; primary health care ; general practice ; process evaluation ; Consolidated Framework for Implementation Research ; prostate-specific membrane antigen positron-emission tomography ; multiparametric magnetic-resonance imaging ; primary diagnosis ; prostate cancer ; systematic review ; diagnosis ; PSMA ; PSA ; tumor ; PET scan ; bladder cancer ; bisphenol A ; bisphenol S ; energy metabolism ; migration ; proliferation ; carbon-ion radiotherapy ; elderly patients ; radiotherapy ; particle beam therapy ; life expectancy ; systemic immune-inflammation index ; Charlson comorbidity index ; CAPRA-S ; early survival ; male incontinence ; robotic prostatectomy ; clear cell renal cell carcinoma ; ferroptosis ; prognostic model ; TCGA ; E-MTAB-1980 ; GLS2 ; pazopanib ; real-world data ; non-interventional study ; time on drug ; nivolumab ; everolimus ; trial-eligibility ; ureteral neoplasms ; urinary bladder neoplasms ; ureteroscopy ; CNTF ; CNTFRα ; LNCaP ; 22Rv1 ; castration resistant ; castration sensitive ; STAT3 ; ERK ; MMP ; biomarker ; Gleason grade ; transforming growth factor-β family ; activin ; INHBA ; INHBB ; INHBC ; prostate-specific antigen ; false-positive results ; real world-data ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
    Language: English
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    Illokutive Strukturen und Dialoganalyse (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-03-24
    Description: The aim of this work is to describe dialog structures: dialogue structures that express different attitudes of interlocutors to the conversation and the partner. In addition, however, my hope is to be able to point out a possible way through the description of a dialogical attitude and the corresponding discussion structures, using specific "techniques" so structured and structured conversations that they lead to real understanding and thus to an improvement of the culture of dialogue.
    Description: Das Ziel dieser Arbeit ist es, Dialogstrukturen zu beschreiben: Dialogstrukturen, die Ausdruck unterschiedlicher Haltungen von Gesprächspartnern zum Gespräch und zum Partner sind. Darüber hinaus jedoch ist meine Hoffnung, durch die Beschreibung einer dialogischen Gesprächshaltung und der entsprechenden Gesprächsstrukturen einen möglichen Weg zu weisen, mittels bestimmter "Techniken" Gespräche so strukturieren und gestalten zu können, daß sie zu wirklichem Verständnis und damit zu einer Verbesserung der Dialogkultur fuhren.
    Keywords: dialog structures ; basierend ; begründete ; Dialoganalyse ; dialogisch ; Dialogstrukturen ; Eine ; erweiterte ; Gesprächshaltung ; Illokutive ; Linguistik ; narrativen ; neueren ; Prosa ; Scharpenack ; Slavische Sprachwissenschaft ; Sprechakttheorie ; Strukturen ; Tschechische Republik ; tschechischen ; Unrath ; Untersuchungen ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: German
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    Epigenetics of B Cells and Antibody Responses (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Epigenetics is the study of changes in gene activity that are heritable but not caused by changes in the DNA sequence. By modulating gene activities, epigenetic changes regulate cell functions. They include DNA methylation, histone posttranslational modifications and gene silencing by the action of non-coding RNAs, particularly microRNAs. It is now clear that epigenetic changes regulate B cell development. By acting in concert with networks of transcription factors, they modulate the activation of B cell lineage specific gene programs and repress inappropriate gene transcription in particular B cell differentiation states. A hallmark of B cell development in the bone marrow is the assembly of the B cell receptor (BCR) for antigen through rearrangement of immunoglobulin heavy (IgH) and light (IgL) chain V(D)J genes, as mediated by RAG1/RAG2 recombinases. Ig V(D)J rearrangement critically times the progression from pro-B cell to pre-B cell and, finally, mature B cell. Such progression is modulated by epigenetic marks, such as DNA methylation and histone posttranslational modifications, that increase chromatin accessibility and target RAG/RAG2 to V, D and J DNA. It is also dependent on the expression of multiple microRNAs. Mice deficient in Ago2, which is essential for microRNA biogenesis and function, have B cell development blocked at the pro-B cell stage. In agreement with this, B cell specific ablation of microRNA by B cell-specific knockout of Dicer virtually blocks B cell differentiation at the pro-B to pre-B cell transition. After mature B cells encounter antigen, changes of the epigenetic landscape are induced by the same stimuli that drive the antibody response; such epigenetic changes underpin the maturation of the antibody response itself. They instruct those B cell differentiation processes, somatic hypermutation (SHM), class switch DNA recombination (CSR) and plasma cell differentiation, that are central to the maturation of the antibody response as well as differentiation of memory B cells. Inducible histone modifications, together with DNA methylation and microRNAs modulate the transcriptome, particularly the expression of activation-induced cytidine deaminase (AID), central to SHM and CSR, and B lymphocyte-induced maturation protein-1 (Blimp-1), which is central to plasma cell differentiation. Combinatorial histone modifications also function as histone codes in the targeting of the CSR and, possibly, the SHM machinery to the Ig locus by recruiting specific adaptors (histone code readers) that can in turn target and/or stabilize CSR/SHM factors. Epigenetic alterations in memory B cells contribute to their functionally distinction from their naive counterparts. Memory B cells inherit epigenetic information from their precursors and acquire new epigenetic marks, which make these resting B cells poised to promptly respond to antigen. The cross/feedback regulation of different epigenetic modifications/elements further increases the complexity of the B cell epigenome, which interacts with the genetic information for precise modulation of gene expression. It is increasingly evident that epigenetic dysregulation in B cells, including aberrant expression of microRNAs, can result in aberrant antibody responses to microbial pathogens, emergence of pathogenic autoantibodies or B cell neoplastic transformation. Epigenetic marks are potential targets for new therapeutics in autoimmunity and B cell malignancy.
    Keywords: R5-920 ; RC581-607 ; BLIMP-1 ; CSR ; immunoglobulin ; memory B cell ; Plasma cell ; V(D)J Recombination ; microRNA ; SHM ; AID ; epigenetics ; bic Book Industry Communication::M Medicine
    Language: English
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    Chapter 3 Human– computer interaction in pun translation (2022)
    Taylor & Francis | Routledge
    Details
    Publication Date: 2024-03-24
    Description: creative texts; translation technologies; machine translation; computer-aided translation; translation practice
    Keywords: creative texts; translation technologies; machine translation; computer-aided translation; translation practice ; thema EDItEUR::C Language and Linguistics::CB Language: reference and general ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: English
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    Der polnische Aphorismus (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-03-24
    Description: Die vorliegende Arbeit behandelt die "Unfrisierten Gedanken" von Stanisław Jerzy Lec. Der Untersuchung der Aphorismen Lec' im dritten Kapitel geht eine theoretische Begründung unseres Aphorismusverständnisses im zweiten Kapitel voraus sowie im ersten Kapitel ein Überblick über die Geschichte des Aphorismus in Polen.
    Keywords: Aphorismus ; Aphoristik ; Gedanken ; Jerzy ; Krupka ; Linguistik ; Literaturwissenschaft ; Philologie ; Platz ; Polen ; polnische ; polnischen ; Sprachwissenschaft ; Stanisław ; Unfrisierten ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: German
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    The evolution of grounded spatial language (2021)
    Language Science Press
    Details
    Publication Date: 2024-03-24
    Description: This book presents groundbreaking robotic experiments on how and why spatial language evolves. It provides detailed explanations of the origins of spatial conceptualization strategies, spatial categories, landmark systems and spatial grammar by tracing the interplay of environmental conditions, communicative and cognitive pressures. The experiments discussed in this book go far beyond previous approaches in grounded language evolution. For the first time, agents can evolve not only particular lexical systems but also evolve complex conceptualization strategies underlying the emergence of category systems and compositional semantics. Moreover, many issues in cognitive science, ranging from perception and conceptualization to language processing, had to be dealt with to instantiate these experiments, so that this book contributes not only to the study of language evolution but to the investigation of the cognitive bases of spatial language as well.
    Keywords: robotic experiments ; spatial language ; spatial grammar ; Adjective ; Adverb ; Anatomical terms of location ; Chinese grammar ; Evolution ; Frame of reference ; Parsing ; Preposition and postposition ; Semantics ; Syntax ; thema EDItEUR::C Language and Linguistics::CF Linguistics ; thema EDItEUR::U Computing and Information Technology
    Language: English
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    Experimental models of early exposure to alcohol: a way to unravel the neurobiology of mental retardation (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Excessive alcohol drinking represents a major social and public health problem for several countries. Alcohol abuse during pregnancy leads to a complex syndrome referred to as fetal alcohol spectrum disorders (FASD), chiefly characterized by mental retardation. The effects of early exposure to ethanol can be reproduced in laboratory animals and this helped to answer several key questions concerning the human pathology. The interest of experimental models of FASD is twofold. First, they increase our knowledge about the dose and modality of alcohol consumption able to induce damaging effects on the developing brain. Second, experimental models of FASD can provide useful hints to elucidate the basic mechanisms leading to the intellectual disability. In fact, experimental exposure to alcohol can be carried out during discrete, often very restricted, time windows. As a consequence, FASD models, though depending on the multifaceted interference of alcohol with several molecular pathways, can provide valuable information about which specific developmental periods and brain areas are critically involved in the genesis of mental retardation. Putting together data obtained through several experimental paradigms of alcohol exposure and those deriving from other genetic and non-genetic models, one can figure out to what extent different types of mental retardation share common pathogenetic mechanisms. The present Research Topic is aimed at establishing the state of the art of the current research on experimental FASD, focusing on differences and homologies with other types of intellectual disability. The ultimate goal is to find out a common roadmap in view of future therapeutical approaches.
    Keywords: R5-920 ; RC435-571 ; RJ1-570 ; glial cells ; development ; Amygdala ; Fetal Alcohol Spectrum Disorders ; Cerebral Cortex ; Intellectual Disability ; epigenetics ; Apoptosis ; bic Book Industry Communication::M Medicine
    Language: English
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    Morpho-Syntactic Expansions in Translation from English into Slovenian as a Prototypical Response to the Complexity of the Original (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-03-24
    Description: 〈P〉This work deals with the morpho-syntactic expansions which occur in translation from English into Slovenian, proceeding from the assumption that such expansions are the most common, "prototypical" response of the translator when faced by an original containing grammatically complex structures.〈/P〉
    Keywords: Complexity ; Control group ; English ; Expansions ; from ; into ; Milena ; Milojević ; Morpho ; Morpho-syntactic expansions ; non-systemic expansion ; Original ; Prototypical ; Response ; Sheppard ; Slovenian ; Syntactic ; Translation ; translation studiesw ; unit of translation ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: English
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    A grammar of Sanzhi Dargwa (Volume 2) (2021)
    Language Science Press | Language Science Press
    Details
    Publication Date: 2024-03-24
    Description: Sanzhi Dargwa belongs to the Dargwa (Dargi) languages (ISO dar; Glottocode sanz1248) which form a subgroup of the East Caucasian (Nakh-Dagestanian) language family. Sanzhi Dargwa is spoken by approximately 250 speakers and is severely endangered. This book is the first comprehensive descriptive grammar of Sanzhi, written from a typological perspective. It treats all major levels of grammar (phonology, morphology, syntax) and also information structure. Sanzhi Dargwa is structurally similar to other East Caucasian languages, in particular Dargwa languages. It has a relatively large consonant inventory including pharyngeal and ejective consonants. Sanzhi morphology is concatenative and mainly suffixing. The language exhibits a mixture of dependent-marking in the form of a rich case inventory and head-marking in the form of verbal agreement. Nouns are divided into three genders. Verbal inflection conflates tense/aspect/mood/evidentiality in a rich array of synthetic and analytic verb forms as well as participles, converbs, a masdar (verbal noun), and infinitive and some other forms used in analytic tenses and subordinate clauses. Salient traits of the grammar are two independently operating agreement systems: gender/number agreement and person agreement. Within the nominal domain, modifiers agree with the head nominal in gender/number. Agreement within the clausal domain is mainly controlled by the argument in the absolutive case. Person agreement operates only at the clausal level and according to the person hierarchy 1, 2 〉 3. Sanzhi has ergative alignment in the form of gender/number agreement and ergative case marking. The most frequent word order at the clause level is SOV, though all other logically possible word orders are also attested. In subordinate clauses, word order is almost exclusively head-final.
    Keywords: Language Arts & Disciplines ; Linguistics ; General ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: English
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    Studien zum Dual (2021)
    Peter Lang International Academic Publishing Group
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    Publication Date: 2024-03-24
    Description: The aim of this study is to describe and analyze the dual system of the New Testament of Miklavuš Jakubica (1548), because of the Du. a variety of individual studies exist, such. For example, to discuss the numerus category in Slavic in general, general representations of Sorbian with descriptions of dual paradigms, descriptions of individual inflectional paradigms of Ns, their peculiarities and genesis (...). The author sets himself the goal, after some introductory remarks on the translation of the NT by Miklawuš Jakubica in the second chapter, to discuss theoretical foundations of the morphological category, essentially referring to the number in general, the origin of the Du. and its different forms, like natural or free, you. with two and both and anaphoric you. will be received. The investigation is done both from a synchronous and a diachronic point of view, since paradigmatic comparisons with older ns. Grammars as well as with the contemporary language to be drawn.
    Description: Die vorliegende Untersuchung verfolgt das Ziel, das Dualsystem des Neuen Testaments des Miklawuš Jakubica ( 1548) zu beschreiben und zu analysieren, da über den Du. eine Vielzahl von Einzeluntersuchungen existieren, wie z. B. zur Erörterung der Numeruskategorie im Slavischen im allgemeinen, allgemeine Darstellungen zum Sorbischen mit Beschreibungen der Dualparadigmen, Beschreibungen einzelner Flexionsparadigmen des Ns., deren Besonderheiten und Genese (...). Der Verfasser stellt sich das Ziel, nach einigen einleitenden Bemerkungen zur Übersetzung des NT von Miklawuš Jakubica im 2. Kapitel theoretische Grundlagen zur morphologischen Kategorie zu erörtern, wobei im wesentlichen auf den Numerus im allgemeinen, den Ursprung des Du. und dessen verschiedene Formen, wie natürlicher oder freier, Du. mit zwei und beide und anaphorischer Du. eingegangen wird. Die Untersuchung erfolgt sowohl aus synchroner als auch aus diachroner Sicht, da paradigmatische Vergleiche mit älteren ns. Grammatiken als auch mit der Gegenwartssprache gezogen werden sollen.
    Keywords: 1548 ; Analyse ; Darstellung ; Dual ; Genese ; Jakubica ; Miklawuš ; Neuen ; niedersorbischen ; Numeruskategorie ; paradigmatische Vergleiche ; Slavische Sprachwissenschaft ; sprachwissenschaftliche ; Studien ; Testament ; Theologie ; Unger ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: German
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    Saúde, trabalho e formação profissional (2021)
    SciELO Books - Editora FIOCRUZ
    Details
    Publication Date: 2023-12-21
    Description: Reúne textos de especialistas das áreas de Saúde e de Educação com longa, competente e comprometida atuação na luta por mudanças sociais, preocupados com um (con)viver humano mais solidário. A obra mostra ser possível a constituição de serviços de saúde com profissionais sensíveis e preparados para atuar em tempos de novas exigências técnicas e de capacitação profissional. Por instigar a (re)pensar o aperfeiçoamento técnico e ético do trabalho, com idéias e propostas originais e atuais, trata-se, certamente, de contribuição de relevância para aqueles que, direta ou indiretamente, encontram-se engajados na causa do Sistema Único de Saúde.
    Keywords: R5-920 ; Pessoal técnico de saúde-educação ; Ocupação em saúde ; educação profissional ; bic Book Industry Communication::M Medicine
    Language: Portuguese
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    Regards sur le signifiant (2023)
    Presses Sorbonne Nouvelle
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    Publication Date: 2024-03-24
    Description: Le présent ouvrage reflète les préoccupations d’un universitaire chargé de longue date d’un cours d’histoire de la langue pour candidats à l’agrégation d’espagnol. On peut y voir, à ce titre, un recueil qui s’adresse tout particulièrement à des étudiants et notamment à ceux qui cherchent des réponses – ou des éléments de réponse – à quelques-unes des questions que posent la morphologie et la syntaxe de l’espagnol ancien (l’un des textes que doit commenter devant son jury un futur agrégé d’espagnol est en effet un classique de la langue ancienne). Cet ouvrage, cependant, ne se substitue pas à une grammaire historique. Il ne traite qu’un nombre limité de questions de morphosyntaxe espagnole – choisies parmi celles qu’un hispaniste a le plus de chances de devoir aborder dans le commentaire linguistique d’un texte ancien – et il vise avant tout à illustrer une certaine façon de décrire une langue. Par delà l’étude de quelques cas de motivation du signe linguistique, il vise à montrer ce que peut être une grammaire de l’espagnol lorsqu’on choisit d’accorder aux signifiants de cette langue une attention prioritaire.
    Keywords: hispanique ; morphosyntaxe espagnole ; grammaire du signifiant ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: French
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    Raccontare la guerra (2022)
    Firenze University Press
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    Publication Date: 2024-03-24
    Description: War is an event, theme, topos that induces fiction more than any other – stimulating, one might say, superego-like instances of historical fidelity – to press on its own boundaries, inhibit the space of the invention and merge with non-fictional forms of writing (memorial, diary, reportage ...). But in what way and to what extent its literary (as well as theatrical, cinematographical, comic book...) representation has changed – in terms of tone and strategies, in the degree of deformation of the known and shared reality – in the space of a Century that has seen the transformation of war strategies, media coverage and consequently the collective imagination linked to conflicts? The volume, conceived and edited by Nicola Turi, while tracing the individual path of known and lesser-known authors, in relation to the main theme of the book, both Italian and not (from Leopardi to Zanzotto, from Gadda to Calvino, from Salsa to Dessí, from Luzi and Fenoglio to Leavitt, Eisner and Celestini), also stimulates and elaborates a profound reflection on the bewilderment and natural attraction of the artistic gesture (from time to time in the name of fierce irony, desperate incredulity, the elegiac testimony) for evil, pain, the martial distortion of the human, social and political context.
    Keywords: thema EDItEUR::C Language and Linguistics::CF Linguistics ; thema EDItEUR::C Language and Linguistics::CF Linguistics::CFF Historical and comparative linguistics ; thema EDItEUR::D Biography, Literature and Literary studies ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DS Literature: history and criticism
    Language: Italian
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    Immune responses to AAV vectors, from bench to bedside (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: The recent wave of clinical studies demonstrating long-term therapeutic efficacy highlights the enormous potential of gene therapy as an approach to the treatment of inherited disorders and cancer. While in recent years lentiviral vectors have dominated the field of ex vivo gene therapy in man, adeno-associated virus (AAV) vectors have become the platform of choice for the in vivo gene delivery, both local and systemic.Despite the achievements in the clinic however, a number of hurdles remain to be overcome in gene therapy, these include availability of scalable vector production systems, potential issues associated with insertional mutagenesis, and concerns related to immunogenicity of gene therapeutics. For AAV vectors, clinical trials showed that immunity directed against the vector could either prevent transduction of a target tissue or limit the duration of therapeutic efficacy. Initial observations in the context of a gene therapy trial for hemophilia spurred over a decade efforts by gene therapists and immunologists to understand the mechanism and identify factors that contribute to AAV’s immunogenicity, including the prevalence of B cell and T cell immunity to wild type AAV in humans and the interaction of AAV vectors with the innate and adaptive immune system. Despite a number of important contributions in particular in the more recent past, our knowledge on the immunology of gene transfer is still rudimental; this is partly due to the fact that the basic understanding of the complex balance between tolerance and immunity to an antigen, key aspect of gene transfer with AAV, keeps evolving rapidly. However, continuing work towards a better definition of the interaction of viral vectors with the immune system has led to significant advances in the knowledge of the factors influencing the outcome of gene transfer, such as the vector dose, the immune privilege of certain tissues, and the induction of tolerance to an antigen. A better understanding of the structure-function relationship of the viral capsid has boosted the development of novel immune-escape vector variants. In addition, novel immunomodulatory strategies were established to prevent or reduce anti-capsid immunity have been developed and are being tested in preclinical models and in clinical trials. Together, these advances are bringing us closer to the goal of achieving safe and sustained therapeutic gene transfer in humans. In this research topic, a collection of Original Research and Review Articles highlights critical aspects of the interaction between gene AAV vectors and the immune system, discussing how these interactions can be either detrimental or constitute an advantage, depending on the context of gene transfer, and providing tools and resources to better understand the issue of immunogenicity of AAV vectors in gene transfer.
    Keywords: R5-920 ; RC581-607 ; antibody response ; Clinical Trial ; Gene Therapy ; Regulatory T Cell ; Immunomodulation ; Tolerance induction ; adaptive and innate immunity ; adeno-associated virus ; Vaccine ; Epitopes ; bic Book Industry Communication::M Medicine
    Language: English
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    Travaux de linguistique hispanique (2023)
    Presses Sorbonne Nouvelle
    Details
    Publication Date: 2024-03-24
    Description: Rouen, Brest, Limoges, Aix-en-Provence, Toulouse..., c’est à une fuite vers le sud, une fuite en zigzag, que faisait penser récemment la carte des universités françaises dans lesquelles la recherche en linguistique hispanique avait donné lieu à des rencontres entre spécialistes. Contourné – évité ? – par l’ouest, Paris ne semblait pas avoir de place sur cette carte, il n’en va plus de même depuis les 8, 7 et 10 février 1996, c’est-à-dire depuis que s’est tenu à la Sorbonne le VIIe Colloque de Linguistique Hispanique. Venus pour l’occasion de presque toutes les universités françaises mais aussi de Belgique, d’Espagne et de Pologne, de nombreux chercheurs ont confronté leurs points de vue durant trois jours et ont apporté leur contribution à la connaissance des langues de la Péninsule ibérique. Ce sont ces points de vue que rassemble le présent volume. Ils éclairent certaines particularités – diachroniques ou synchroniques – du castillan, du portugais, du catalan et du galicien. Ils permettent de mieux comprendre ce que sont les structures phonétique, phonologique, morphologique, syntaxique, lexicologique et sémantique de ces langues. Ils illustrent les principales méthodes d’analyse que l’on emploie aujourd’hui dans les sciences du langage. Ils permettent en somme de prendre la mesure des progrès réalisés dans un domaine où le savoir est exploité non seulement à des fins pédagogiques – l’enseignement des langues – mais aussi – et de plus en plus – à des fins industrielles (il nourrit de nos jours les « industries » de ta langue).
    Keywords: sémantique ; phonétique ; syntaxe ; lexicologie ; phonologie ; morphologie ; industries de la langue ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: French
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    Malyj dialektologičeskij atlas balkanskich jazykov. Serija grammatičeskaja (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-03-24
    Description: Der hier vorliegende Kartenband behandelt die grammatischen Kategorien des Substantivs in den Sprachen Südosteuropas, wobei die Sprachdaten aus 12 südosteuropäischen Ortspunkten auf 127 Karten präsentiert werden. Als Grundlage dient das Sprachmaterial, das in internationaler Zusammenarbeit im Rahmen des Forschungsprojektes "Malyj dialektologičeskij atlas balkanskich jazykov/Kleiner Balkansprachatlas" erhoben und bearbeitet wurde
    Keywords: atlas ; balkanskich ; dialektologičeskij ; grammatičeskaja ; imeni ; jazykov ; Kategorii ; Kleiner Balkansprackatlas ; Linguistik ; Malyj ; nogo ; Serija ; slavische Sprachwissenschaft ; Sobolev ; Sprachkarten ; Südosteuropäische Sprachen ; suščestvitel ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: Russian
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    Chapter 4 Preschool education (2021)
    Taylor & Francis | Routledge
    Details
    Publication Date: 2024-03-24
    Description: "The Routledge Handbook of Translation and Education will present the state of the art of the place and role of translation in educational contexts worldwide. It lays a sound foundation for the future interdisciplinary cooperation between Translation Studies and Educational Linguistics. By adopting a transdisciplinary perspective, the handbook will bring together the various fields of scholarly enquiry and practice that make a valuable contribution to enlarging the notion of translation and diversifying its uses in education. Each contribution provides an overview of the historical background to a given educational setting. Focusing on current research approaches and empirical findings, this volume outlines the development of pedagogical approaches, methods, assessment and curriculum design. The handbook also examines examples of pedagogies that integrate translation in the curriculum, the teaching method’s approach, design and procedure as well as assessment. Based on a multilingual and applied-oriented approach, the handbook is essential reading for postgraduate students, researchers and advanced undergraduate students of Translation Studies, and educationalists and educators in the 21st century post-global era."
    Keywords: Sara Laviosa ; Maria González-Davies ; Translation Studies ; Translation ; Applied Linguistics ; Communication Studies ; Multilingualism ; Educational Theory ; Educational Linguistics ; Education ; Bilingualism ; Intercultural ; Interpreting Studies ; Language Learning ; Language Education ; Deaf Education ; Sign Language ; Teacher Training ; thema EDItEUR::C Language and Linguistics::CF Linguistics ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: English
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    Marine Natural Products as Anticancer Agents 2.0 (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-07-14
    Description: Global cancer incidence and death are expected to increase in the next decades. Inappropriate therapeutic regimens and tumor recurrence due to the development of drug resistance are two major clinical challenges impacting poor patient outcomes, which is critical to the discovery and development of new anticancer drugs. Over the last few decades, the marine environment has proved to be a key source of molecules with potent anticancer properties. The Special Issue, “Marine Natural Products as Anticancer Agents 2.0”, gathered eleven publications, including two reviews and nine research articles, about the anticancer activities of marine natural and/or derived products on in vitro 2D and 3D cellular models, and/or in vivo models of colorectal, breast, lung, myeloma, liver, leukemia, and melanoma cancers. Altogether, the eleven scientific papers published in this Special Issue provide an exciting overview of marine natural products as potential anticancer agents.
    Keywords: Clavatadine C ; spirocyclic bromotyrosines ; cytotoxicity ; cancer selectivity ; marine compounds ; melanoma A-375 cell line ; Sarcophyton convolutum ; sarcoconvolutum A–E ; cembrenoids ; anti-angiogenesis ; bromophenols ; tube formation ; vasculogenic mimicry ; brefeldin A ; ester derivative ; chronic myelogenous leukemia ; BCR-ABL ; proliferation inhibition ; molecular modeling ; 5-O-(N-Boc-l-alanine)-renieramycin T ; Xestospongia sp. ; marine sponge ; lung cancer ; anti-cancer ; cancer stem cells ; apoptosis ; Akt ; c-Myc ; migrastatics ; cell migration ; cell invasion ; metastasis ; terpenes ; algae ; marine natural products ; mitochondrial dysfunction ; oxidative stress ; anticancer ; Sphaerococcus coronopifolius ; seaweed ; Laminaria japonica ; Laminaria japonica peptides ; cancer ; liver ; cell cycle ; porphyrin ; Isabela ; hemin ; X-ray diffraction ; NOESY NMR ; cytotoxic ; colorectal cancer ; 5-fluorouracil ; 7S,15R-dihydroxy-16S,17S-epoxy-docosapentaenoic acid ; tumor-associated macrophages ; chemoresistance ; fucoidan ; immunopotentiation ; immunomodulatory ; immunotherapy ; cancer treatment ; cytokines ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
    Language: English
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    How mobile robots can self-organise a vocabulary (2021)
    Language Science Press
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    Publication Date: 2024-03-24
    Description: One of the hardest problems in science is the symbol grounding problem, a question that has intrigued philosophers and linguists for more than a century. With the rise of artificial intelligence, the question has become very actual, especially within the field of robotics. The problem is that an agent, be it a robot or a human, perceives the world in analogue signals. Yet humans have the ability to categorise the world in symbols that they, for instance, may use for language. This book presents a series of experiments in which two robots try to solve the symbol grounding problem. The experiments are based on the language game paradigm, and involve real mobile robots that are able to develop a grounded lexicon about the objects that they can detect in their world. Crucially, neither the lexicon nor the ontology of the robots has been preprogrammed, so the experiments demonstrate how a population of embodied language users can develop their own vocabularies from scratch.
    Keywords: language in robots ; artificial intelligence ; Feature extraction ; Feature vector ; Joint attention ; Lexicon ; Reference ; Symbol grounding problem ; Talking Heads ; thema EDItEUR::C Language and Linguistics::CF Linguistics ; thema EDItEUR::U Computing and Information Technology
    Language: English
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    Chapter B1 Linguistic Features of Legal Language (2021)
    Taylor & Francis | A Global History of Ideas in the Language of Law | Language and Law | Routledge
    Details
    Publication Date: 2024-03-24
    Description: Language plays an essential role both in creating law and in governing its implementation. Providing an accessible and comprehensive introduction to this subject, Language and Law:describes the different registers and genres that make up spoken and written legal language and how they develop over time; analyses real-life examples drawn from court cases from different parts of the world, illustrating the varieties of English used in the courtroom by speakers occupying different roles; addresses the challenges presented to our notions of law and regulation by online communication; discusses the complex role of translation in bilingual and multilingual jurisdictions, including Hong Kong and Canada; and provides readings from key scholars in the discipline, including Lawrence Solan, Peter Goodrich, Marianne Constable, David Mellinkoff, and Chris Heffer. With a wide range of activities throughout, this accessible textbook is essential reading for anyone studying language and law or forensic linguistics.
    Keywords: English for law ; English for specific purposes law ; forensic linguistics ; language and the law ; legal English ; legal genres ; thema EDItEUR::C Language and Linguistics::CB Language: reference and general ; thema EDItEUR::C Language and Linguistics::CF Linguistics ; thema EDItEUR::C Language and Linguistics::CF Linguistics::CFB Sociolinguistics ; thema EDItEUR::L Law::LA Jurisprudence and general issues ; thema EDItEUR::L Law::LA Jurisprudence and general issues::LAR Legal aspects of criminology ; thema EDItEUR::L Law::LA Jurisprudence and general issues::LAS Legal skills and practice
    Language: English
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    CD4+ T cell differentiation in infection: amendments to the Th1/Th2 axiom (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: CD4+ T lymphocytes play an essential role in host defense against bacterial, parasitic and viral infections. During infection, under the influence of intrinsic signals received through peptide-MHC/TCR interactions and extrinsic signals provided by pathogen-conditioned dendritic and other accessory cells, CD4+ T cells proliferate and differentiate into specialized T helper (Th) effectors, which produce distinct sets of cytokines tailored to combat a specific class of microbes. The concept of CD4+ T cell multi-functionality was developed after the seminal discovery of Th1 and Th2 cells nearly 30 years ago. Although the Th1/Th2 paradigm has successfully withstood the test of time, in the past decade additional Th subsets (Th17, Tfh, Th22, Th9) have been identified. Similarly, single cell analyses of cytokines and master transcriptional factors have revealed that, at the population level, CD4+ T cell responses are far more heterogeneous than initially anticipated. While some of the checkpoints in Th cell specification have been identified, recent studies of transcriptional and epigenetic regulation have uncovered a significant flexibility during the course CD4+ T lymphocyte polarization. In addition, Th cells expressing cytokines with counteracting functions, as a measure of self-regulation, display yet another level of diversity. Understanding the mechanisms that control the balance between stability vs. plasticity of Th effectors both at the time of initiation of immune response and during development of CD4 T cell memory is critical for the rational design of better vaccines and new immunotherapeutic strategies. This research topic will cover current views on Th cell development, with a focus on the mechanisms that govern differentiation, function and regulation of effector Th cells in the context of microbial infections.
    Keywords: R5-920 ; RC581-607 ; Infection ; Dendritic Cells ; Cytokines ; Immunoregulation ; CD4 lymphocytes ; Memory ; long noncoding RNA ; Macrophages ; Metabolism ; Th1 Th2 ; bic Book Industry Communication::M Medicine
    Language: English
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    La mise à jour (2022)
    Presses Universitaires de Bordeaux
    Details
    Publication Date: 2024-03-24
    Description: L’anthropologie est toujours allée chercher dans la linguistique les instruments de son renouvellement. La philologie allemande est à l’origine de l’œuvre de Boas (1858-1942) et de son école ; Jacobson a participé au structuralisme. Ces deux types de linguistiques ont fourni des instruments d’analyse mais ont aussi puissamment contribué à définir des objets d’études, la culture comme un tout, chez le premier (contre l’évolutionnisme), les relations structurales pour les seconds. Actuellement, l’élaboration depuis une vingtaine d’années d’un nouveau type de linguistique - la pragmatique - entraîne nécessairement le développement d’une nouvelle anthropologie. Elle a tendance à examiner "leur façon, non leur sujet” selon l’expression de Montaigne, en ce sens que les modalités d’expression révèlent entre autres la qualité des informations ou le contexte dans lequel elles s’expriment. Ainsi quand vous rencontrez les mots, de catégorie préconstruite, d’acte de langage, de discours naturel, de locuteur, de contexte, d’attitude textuelle, de stratégie rhétorique, d’ethnologie indigène... vous vous trouvez devant des préoccupations qui peuvent se situer sous l’étiquette d’ethnopragmatique. Chacune de ces expressions s’opposent à d’autres (locuteur : informateur, catégorie préconstruite : catégorie indigène, ...) mais surtout indiquent l’inscription dans une anthropologie d’un certain type et la présence de certaines préoccupations : le détail de la parole Indigène joue un rôle central et ne se déploie et ne s’analyse qu’en interaction avec l’enquêteur. Ce livre cherche à préciser les démarches utilisées par l’ethnopragmatique, les courants et les auteurs dont elle se réclame et propose quelques tentatives d’applications.
    Keywords: méthodologie ; épistémologie ; déconstruction ; enquête ; Landes ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: French
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    Communicating Medicine (2021)
    Ledizioni
    Details
    Publication Date: 2023-12-21
    Description: This study investigates eighteenth-century medical writing, particularly concerning the elaboration and the communication of medicine in such reference works as universal dictionaries of arts and sciences, medical dictionaries, and handbooks. Most of the vernacular texts under scrutiny here were issued in the second half of the century, a period in which the advancements in medical research, medical education and medical practice favoured the circulation of an expanding medical vocabulary and stimulated medical writing as a whole. A vast amount of reference works was produced for experts and non-experts alike: medical topics were common in social settings, in personal and communal letters, in specialised journals, in pamphlets and in magazines. All this unprecedented activity certainly contributed to the vernacularisation, and the dissemination of medicine in different kinds of works and different text types. The texts examined in the study are representative of their authors’ effort to expand medical knowledge and to define medicine as an independent science based on strict observation, as well as to establish intelligibility within and outside the disciplinary discourse community.
    Keywords: R5-920 ; english ; medicine ; language ; communication ; bic Book Industry Communication::M Medicine
    Language: English
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    Языковые категории в сознании и творчестве русского поэта (2022)
    Peter Lang International Academic Publishing Group | Peter Lang AG
    Details
    Publication Date: 2024-03-23
    Description: Поэзия – сфера свободного словесного творчества. Тем не менее, поэт должен придерживаться каких-то языковых норм. Механизмы внутренней речи, преобразования смысла и эмоций в текст получают в книге лингвистическую интерпретацию. Материалом для наблюдений и выводов служит русская поэзия, в основном ХХ века (Б. Пастернак, О. Мандельштам, М. Цветаева, Б. Окуджава, Ю. Левитанский, А. Кушнер и др.).
    Keywords: A. Kushner ; B. Okudzhava ; B. Pasternak ; Innere Sprache ; Linguistische Interpretation ; M. Tsvetaeva ; Norman ; O. Mandelstam ; Russische Poesie ; Yu. Levitan ; А. Кушнер ; категории ; поэта ; русского ; сознании ; творчестве ; Ю. Левитанский ; Языковые ; thema EDItEUR::2 Language qualifiers::2A Indo-European languages::2AG Slavic (Slavonic) languages ; thema EDItEUR::C Language and Linguistics::CF Linguistics ; thema EDItEUR::D Biography, Literature and Literary studies::DS Literature: history and criticism::DSB Literary studies: general
    Language: Russian
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    Três ensaios de bioética (2021)
    SciELO Books - Editora FIOCRUZ
    Details
    Publication Date: 2023-12-21
    Description: Leitores interessados no desenvolvimento teórico da bioética e, ao mesmo tempo, em sua aplicação na solução de conflitos morais certamente encontrarão neste livro materiais de grande valor. Cada capítulo coloca a bioética em um contexto diferente: na clínica, na genômica e na biossegurança. No primeiro ensaio, discutem-se as possibilidades dessa ‘caixa de ferramentas’ chamada bioética para compreender e tentar resolver conflitos de interesses e valores no âmbito das relações entre profissionais e usuários dos serviços de saúde. No segundo, o autor aplica as ferramentas da bioética ao caso dos conflitos morais que envolvem a genômica, contemplando argumentos favoráveis e contrários às práticas da engenharia genética e contribuindo para o raciocínio crítico e sem preconceitos sobre o tema. Por fim, o terceiro capítulo trata da interface entre a bioética e a biossegurança, que têm preocupações comuns, como a questão dos riscos, mas abordagens distintas – enquanto a bioética se ocupa dos valores morais, a biossegurança lança mão de medidas técnicas, administrativas e legais.
    Keywords: R5-920 ; bic Book Industry Communication::M Medicine
    Language: Portuguese
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    Extracellular Vesicles: Biology and Potentials in Cancer Therapeutics (2022)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2022-02-01
    Description: Extracellular vesicles (EVs) are particles wrapped in a lipid bilayer membrane and are naturally released from cells. This kind of cargo vessel is a nanostructure that mainly transfers lipids, proteins, various nucleic acid fragments, and metabolic components to neighboring cells or distant parts of the body through the circulatory system. EVs are of great significance to the communication mechanism between cells. This book collects feature articles to enhance our understanding of the biological characteristics of EVs and their potential applications.
    Keywords: extracellular vesicle ; precision oncology ; cancer biomarker ; prostate cancer ; drug delivery ; extracellular vesicles ; lysosome ; nanocarriers ; ultrasound ; size exclusion chromatography ; differential ultracentrifugation ; head and neck squamous cell carcinoma (HNSCC) ; exosomes ; cancer ; biomarker ; diagnostic ; therapy ; liquid biopsy ; small extracellular vesicles (sEV) ; tumor-derived exosomes (TEX) ; melanoma cell-derived exosomes (MTEX) ; proteomics ; tumor microenvironment ; biomarkers ; ectosomes ; neoplasia ; microvesicles ; small extracellular vesicles ; isolation ; purification ; size-exclusion chromatography ; ultracentrifugation ; sucrose density cushion ; lymph node ; spleen ; solid tissue ; microvesicle ; exosome ; cancer therapeutic ; drug carrier ; flow cytometry ; immunophenotyping ; swarm detection ; tumor-associated macrophages ; macrophage polarization ; mannose receptor ; HIV-1 Nef ; glioblastoma ; microRNA ; immunoprecipitation ; CD44 ; human milk ; nutrient ; microbiota ; microRNAs ; nanocommunicator ; diagnostic biomarker ; drug delivery vehicle ; personalized cancer immunotherapy ; therapeutic agents ; cell-to-cell communication ; ionising radiation ; non-targeted effects ; signalling ; imaging flow cytometry ; biomarker reservoirs ; cancer diagnostics ; disease monitoring ; large EVs ; ovarian cancer cells ; ES-2 ; OAW-42 ; adipose tissue origin mesenchymal stem cells ; n/a ; bic Book Industry Communication::M Medicine
    Language: English
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    Chomskyan (R)evolutions (2021)
    John Benjamins Publishing Company | John Benjamins Publishing Company
    Details
    Publication Date: 2024-03-24
    Description: It is not unusual for contemporary linguists to claim that “Modern Linguistics began in 1957” (with the publication of Noam Chomsky’s Syntactic Structures). Some of the essays in Chomskyan (R)evolutions examine the sources, the nature and the extent of the theoretical changes Chomsky introduced in the 1950s. Other contributions explore the key concepts and disciplinary alliances that have evolved considerably over the past sixty years, such as the meanings given for “Universal Grammar”, the relationship of Chomskyan linguistics to other disciplines (Cognitive Science, Psychology, Evolutionary Biology), and the interactions between mainstream Chomskyan linguistics and other linguistic theories active in the late 20th century: Functionalism, Generative Semantics and Relational Grammar. The broad understanding of the recent history of linguistics points the way towards new directions and methods that linguistics can pursue in the future.
    Keywords: Language Arts & Disciplines ; Linguistics ; General ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: English
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    Lipid Signaling in T Cell Development and Function (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Lipids are best known as energy storing molecules and core-components of cellular membranes, but can also act as mediators of cellular signaling. This is most prominently illustrated by the paramount importance of the phospholipase C (PLC) and phosphoinositide 3-kinase (PI3K) signaling pathways in many cells, including T cells and cancer cells. Both of these enzymes use the lipid phosphatidylinositol(4,5)bisphosphate (PIP2) as their substrate. PLCs produce the lipid product diacylglycerol (DAG) and soluble inositol(1,4,5)trisphosphate (IP3). DAG acts as a membrane tether for protein kinase C and RasGRP proteins. IP3 is released into the cytosol and controls calcium release from internal stores. The PI3K lipid product phosphatidylinositol(3,4,5)trisphosphate (PIP3) controls signaling by binding and recruiting effector proteins such as Akt and Itk to cellular membranes. Recent research has unveiled important signaling roles for many additional phosphoinositides and other lipids. The articles in this volume highlight how multiple different lipids govern T cell development and function through diverse mechanisms and effectors. In T cells, lipids can orchestrate signaling by organizing membrane topology in rafts or microdomains, direct protein function through covalent lipid-modification or non-covalent lipid binding, act as intracellular or extracellular messenger molecules, or govern T cell function at the level of metabolic regulation. The cellular activity of certain lipid messengers is moreover controlled by soluble counterparts, exemplified by symmetric PIP3/inositol(1,3,4,5)tetrakisphosphate (IP4) signaling in developing T cells. Not surprisingly, lipid producing and metabolizing enzymes have gained attention as potential therapeutic targets for immune disorders, leukemias and lymphomas.
    Keywords: R5-920 ; RC581-607 ; eicosanoid ; Inositol ; diacylglyerol ; PI3K ; Vitamin D ; T cell ; SHIP ; Pten ; Adipokine ; Lipid ; bic Book Industry Communication::M Medicine
    Language: English
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    Foundations of Paleoparasitology (2021)
    SciELO Books - Editora FIOCRUZ
    Details
    Publication Date: 2023-12-21
    Description: Unprecedented initiative in the world, the book compiles the available knowledge on the subject and presents the state-of-the-art in paleoparasitology – term coined about 30 years ago by Brazilian Fiocruz researcher Luiz Fernando Ferreira, pioneer in this science which is concerned with the study of parasites in the past. Multidisciplinary by essence, paleoparasitology gathers contributions from social scientists, biologists, historians, archaeologists, pharmacists, doctors and many other professionals, either in biomedical or humanities fields. With varied applications such as in evolutionary or migration studies, their results often depend on the association between laboratory findings and cultural remains. The book is divided into four parts - Parasites, Hosts, and Human Environment; Parasites Remains Preserved in Various Materials and Techniques in Microscopy and Molecular Diagnostics; Parasite Findings in Archeological Remains: a paleographic view; and Special Studies and Perspectives. Signed by authors from various countries such as Argentina, USA, Germany and France, the book has chapters devoted to the discoveries of paleoparasitology on all continents.
    Keywords: R5-920 ; MEDICAL ; bic Book Industry Communication::M Medicine
    Language: English
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    Advances in the Diagnosis and Treatment of Thyroid Carcinoma (2022)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2022-10-25
    Description: This reprint is related to the latest research in the field of thyroid surgery, including molecular and imaging diagnosis, surgical treatment, and the treatment of recurrent disease and advanced thyroid carcinoma.
    Keywords: thyroid carcinoma ; prophylactic central lymph node dissection ; lymph node metastases ; RET ; medullary thyroid carcinoma ; clinical management ; variants of uncertain significance ; differentiated thyroid cancer ; papillary thyroid cancer ; minimal extrathyroidal extension ; radioactive iodine therapy ; prognosis ; TNM ; histology ; multifocality ; lymph node metastasis ; vascular invasion ; autoimmune thyroid diseases ; radioiodine refractory ; Lenvatinib ; 18F-FDG-PET/CT ; cost-benefit analysis ; economics ; medical ; thyroid neoplasms ; radiomics ; ultrasound ; magnetic resonance imaging ; computer tomography ; prediction ; classification ; angiogenic microenvironment ; prognostic factors ; antiangiogenic therapy ; therapeutic target ; tumor microenvironment ; tumor behavior ; proliferation pathways ; cell cycle control pathways ; angiogenesis process ; thyroid cancer ; Gal-3 expression ; NIFTP ; EFVPTC ; lymphocytic thyroiditis (LT) ; immunohistochemical (IHC) analysis ; molecular imaging ; theranostics ; companion diagnostics ; immunoPET ; anaplastic thyroid cancer ; poorly thyroid cancer ; genetic landscape ; genetically guided therapy ; fluorodeoxyglucose F18 (18F-FDG) ; positron emission tomography (PET) ; magnetic resonance imaging (MRI) ; recurrence ; neoplasm metastasis ; thyroid surgery ; hypoparathyroidism ; fluorescence-guided surgery ; near-infrared autofluorescence ; PRKAR1A ; PKA ; Carney complex ; cAMP ; bone metastasis ; metastasectomy ; stereotactic radiosurgery ; ultrasound imaging ; thyroid nodule ; fine-needle aspiration ; papillary thyroid carcinoma ; lobectomy ; operative extent ; CONUT score ; tyrosine kinase inhibitors ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
    Language: English
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    Tonal placement in Tashlhiyt (2021)
    Language Science Press
    Details
    Publication Date: 2024-03-24
    Description: In most languages, words contain vowels, elements of high intensity with rich harmonic structure, enabling the perceptual retrieval of pitch. By contrast, in Tashlhiyt, a Berber language, words can be composed entirely of voiceless segments. When an utterance consists of such words, the phonetic opportunity for the execution of intonational pitch movements is exceptionally limited. This book explores in a series of production and perception experiments how these typologically rare phonotactic patterns interact with intonational aspects of linguistic structure. It turns out that Tashlhiyt allows for a tremendously flexible placement of tonal events. Observed intonational structures can be conceived of as different solutions to a functional dilemma: The requirement to realise meaningful pitch movements in certain positions and the extent to which segments lend themselves to a clear manifestation of these pitch movements.
    Keywords: berber languages ; pitch movements ; vowels ; voice ; tonal events ; Intonation (linguistics) ; Phonetics ; Phonology ; Prosody (linguistics) ; Schwa ; Sonorant ; Stress (linguistics) ; Syllable ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: English
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    Biomedical Insights that Inform the Diagnosis of ME/CFS (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severe chronic health condition that is often misunderstood or ignored by health establishments. The lack of definitive diagnostic markers to separate ME/CFS patients from the healthy population as well as from other chronic disorders is problematic for both health professionals and researchers. A consortium of Australian researchers gathered to systematically understand ME/CFS, ranging from a deep analysis of clinical and pathology data to metabolomic profiles and the investigation of mitochondrial function. From this broad collaboration, a number of compelling insights have arisen that may form the basis of specific serum, blood, and/or urinary biomarkers of ME/CFS. This Special Edition reports on a conference centred on these biomedical discoveries, with other contributions, with a translation focus for predictive markers for ME/CFS diagnosis. By supporting health professionals with developments in diagnostics for this condition, the patients and their families will hopefully benefit from an improved recognition of the biomedical underpinnings of the condition and will be better able to access the care that is urgently required. This Special Edition contains a mix of speaker submissions and other accepted manuscripts that contributed to our objective of advancing biomedical insights to enable the accurate diagnosis of ME/CFS.
    Keywords: R5-920 ; RM1-950 ; fatigue syndrome ; n/a ; work rehabilitation ; tryptophan metabolism ; substrate inhibition ; myalgic encephalomyelitis ; 3-dioxygenase ; ME (Myalgic Encephalomyelitis) ; assessment ; myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) ; muscles ; hypoacetylation ; circadian rhythm ; immune system ; chronic ; CFS (Chronic Fatigue Syndrome) ; energy metabolism ; ME/CFS ; immunological ; cytokine ; bistability ; diagnosis ; biomarker ; symptoms ; kynurenine pathway ; inflammation and immunity ; metabolism ; neuro-inflammation ; pathology ; signaling ; exercise ; Epstein Barr virus ; methylhistidine ; hypothalamic–pituitary–adrenal axis ; potential biomarkers ; critical point ; inflammation ; histone deacetylation ; participatory research ; neurology ; neuroimmune ; activin ; mitochondria ; patient-driven questionnaire ; medical retirement ; machine learning ; prognosis ; gut microbiota ; post-exertional malaise ; chronic fatigue syndrome ; mathematical model ; reference intervals ; diagnostic biomarker ; indoleamine-2 ; bic Book Industry Communication::M Medicine
    Language: English
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    Karel Teige fra Cecoslovacchia, URSS ed Europa (2022)
    Firenze University Press
    Details
    Publication Date: 2024-03-24
    Description: Karel Teige was one of the leading theorists of the Czech avant-garde, and his activity is bound up with the most enriching cultural contributions made to the Czech Republic in the first half of the twentieth century. Proclaiming himself a Marxist, he was frequently at odds with Czech liberal-pragmatic thought. The emergence of European totalitarianism coincided with a major turning-point in his life when, towards the end of the 1930s, he had to come to terms with the Nazi invasion of his country and with the local version of Stalinism. After the War he was marginalised from cultural life and he died of a heart attack while being persecuted in a ferocious campaign of defamation by the Communist Party. The book offers a portrait of this protagonist of European culture and of the process of rediscovery that in the 1960s reintegrated his work and his thought into the extraordinary cultural revival that blossomed in the Prague Spring of 1968.
    Keywords: thema EDItEUR::C Language and Linguistics::CF Linguistics ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DS Literature: history and criticism
    Language: Italian
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    Programming the HPA-axis by early life experience: Mechanisms of stress susceptibility and adaptation (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Experiences during early life program the central nervous- and endocrine-systems with consequences for susceptibility to physical and mental disorders. These programming effects depend on genetic and epigenetic factors, and their outcome leads to an adaptive or maladaptive phenotype to a given later environmental context. This Research Topic focused on the hypothalamus-pituitary-adrenal (HPA)-axis and stress-related phenotypes, and on how HPA-axis programming by the environment precisely occurs. We included original research, mini-review and review papers on a broad range of topics related to HPA-axis programming.
    Keywords: R5-920 ; RC648-665 ; RC321-571 ; Q1-390 ; HPA axis ; Vulnerability ; resilience ; early life stress ; materna ; bic Book Industry Communication::M Medicine
    Language: English
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    Makrokonstruktionen (2022)
    De Gruyter | De Gruyter
    Details
    Publication Date: 2024-03-24
    Description: The study investigates adverbial structures in spoken French that combine three or more discursive elements in a complex way. These structures are modeled in accordance with the terms of construction grammar as “macro constructions.” Drawing upon an extensive corpus, this study analyzes them with regard to their local emergence in interaction and their sedimentation.
    Keywords: Complex Syntax ; Interaction ; Construction ; Grammar ; Spoken French ; thema EDItEUR::C Language and Linguistics::CF Linguistics ; thema EDItEUR::C Language and Linguistics::CF Linguistics::CFK Grammar, syntax and morphology
    Language: German
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    The Challenges of COVID-19 with Obesity-Related Cancers (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-05-11
    Description: This reprint emphasizes the perspectives and challenges surrounding COVID-19 and obesity-related cancers, including but not limited to the risk factors of severe COVID-19 in cancer patients; the complications of COVID-19 in cancer patients; the challenges in cancer treatment and surgery; guidelines for cancer care during COVID-19; delayed diagnosis and suboptimal cancer management; the impact of COVID-19 on cancer screening, early diagnosis and cancer presentation; immune response after SARS-CoV-2 infection and vaccination in cancer patients; psychological distress among cancer survivors; telehealth in cancer care; the role of diet and nutraceuticals in the prevention of severe COVID-19 and cancer; and the effects of COVID-19 pandemic on cancer research.
    Keywords: COVID-19 ; neutropenia ; G-CSF treatment ; respiratory failure ; colorectal neoplasms ; gastrointestinal neoplasms ; immune checkpoint inhibitors ; neoplasms ; oncogenic viruses ; oncolytic virotherapy ; post-acute COVID-19 syndrome ; reactive oxygen species ; tumor escape ; SARS-CoV-2 ; thyroid cancer ; differentiated thyroid cancer ; COVID-19 severity ; inflammation ; immunity ; oxidative stress ; obesity ; SARS-Cov-2 ; oncology ; cancer screening ; clinical trials ; melanoma ; management ; pandemic ; teledermatology ; diagnostic delay ; immunotherapy ; vaccination ; lymph adenopathy ; cancer ; nutraceuticals ; supplements ; colorectal ; meta-analysis ; gynecologic oncology ; malignancy ; blood cancer ; hematologic malignancy ; leukemia ; lymphoma ; multiple myeloma ; myelodysplasia ; breast cancer ; cancer care ; screening ; surgery ; psychological distress ; cancer therapies ; immunogenicity ; safety ; vaccine hesitancy ; tumor subtype ; mortality ; intensive care unit ; medico-administrative data ; France ; n/a ; bic Book Industry Communication::M Medicine
    Language: English
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    Accessible Communication (2021)
    Frank & Timme
    Details
    Publication Date: 2024-03-29
    Description: Easy-to-Understand (E2U) text practices enable and facilitate accessible communication. E2U refers both to Plain and to Easy Language. These two powerful methods of language and content comprehension enhancement are illustrated through several examples in English, starting from the seminal role of the Anglophone world in promoting plain and lucid style. Originally implemented in written texts, today the employment of these simplified language varieties should infiltrate new communication services that are more complex and multifaceted. Thanks to the EASIT project, the integration of E2U strategies into a selection of audiovisual services is being successfully researched. After advancing simplification proposals in the area of subtitling and audio description, Elisa Perego reports on the results of a cross-country survey conducted during the initial stages of the EASIT project: She pinpoints the background, activity, and training experience of those who currently work in the sector of E2U in Europe, and identifies the skills and the competences of, as well as a training path and materials for, future hybrid professionals.
    Keywords: Audio description; audiovisual translation; blind; EASIT; easy language; inclusion; accessibility; plain language; plain english; visually impaired; voice-over ; bic Book Industry Communication::J Society & social sciences::JN Education::JNF Educational strategies & policy ; bic Book Industry Communication::C Language::CF linguistics ; thema EDItEUR::J Society and Social Sciences::JN Education::JNF Educational strategies and policy ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: English
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