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  • Books  (3,837)
  • Frontiers Media SA  (2,449)
  • Presses universitaires de Rennes  (1,388)
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  • 1
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: social-decision making ; animal behavior ; behavioral ecology ; animal collective behavior ; animal SDM ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 2
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    Presses universitaires de Rennes
    Publication Date: 2022-01-31
    Description: Décriée la stylistique, mais pourquoi au juste ? Les uns, comme Jean-Michel Adam, considèrent que la linguistique suffit, les autres, plus littéraires, renoncent trop tôt à se doter d’outils d’analyse pour comprendre les formes de ce que Molinié a décidé d’appeler « stylicité ». Le malaise stylistique tient en fait à ses ambitions : être une linguistique du discours en général, d’une part, être une linguistique du discours littéraire en particulier, d’autre part. On lui reproche son esprit po...
    Keywords: analyse du discours littéraire ; stylistique ; Français (langue)
    Language: French
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  • 3
    Publication Date: 2024-04-05
    Description: After a quarter of century of rapid technological advances, research has revealed the complexity of cancer, a disease intimately related to the dynamic transformation of the genome. However, the full understanding of the molecular onset of this disease is still far from achieved and the search for mechanisms of treatment will follow closely. It is here that Nanotechnology enters the fray offering a wealth of tools to diagnose and treat cancer. In fact, the National Cancer Institute predicts that over the next years, nanotechnology will result in important advances in early detection, molecular imaging, targeted and multifunctional therapeutics, prevention and control of cancer. Nanotechnology offers numerous tools to diagnose and treat cancer, such as new imaging agents, multifunctional devices capable of overcome biological barriers to deliver therapeutic agents directly to cells and tissues involved in cancer growth and metastasis, and devices capable of predicting molecular changes to prevent action against precancerous cells. Nanomaterials-based delivery systems in Theranostics (Diagnostics & Therapy) provide better penetration of therapeutic and diagnostic substances within the body at a reduced risk in comparison to conventional therapies. At the present time, there is a growing need to enhance the capability of theranostics procedures where nanomaterials-based sensors may provide for the simultaneous detection of several gene-associated conditions and nanodevices with the ability to monitor real-time drug action. These innovative multifunctional nanocarriers for cancer theranostics may allow the development of diagnostics systems such as colorimetric and immunoassays, and in therapy approaches through gene therapy, drug delivery and tumor targeting systems in cancer. Some of the thousands and thousands of published nanosystems so far will most likely revolutionize our understanding of biological mechanisms and push forward the clinical practice through their integration in future diagnostics platforms. Nevertheless, despite the significant efforts towards the use of nanomaterials in biologically relevant research, more in vivo studies are needed to assess the applicability of these materials as delivery agents. In fact, only a few went through feasible clinical trials. Nanomaterials have to serve as the norm rather than an exception in the future conventional cancer treatments. Future in vivo work will need to carefully consider the correct choice of chemical modifications to incorporate into the multifunctional nanocarriers to avoid activation off-target, side effects and toxicity. Moreover the majority of studies on nanomaterials do not consider the final application to guide the design of nanomaterial. Instead, the focus is predominantly on engineering materials with specific physical or chemical properties. It is imperative to learn how advances in nanosystem’s capabilities are being used to identify new diagnostic and therapy tools driving the development of personalized medicine in oncology; discover how integrating cancer research and nanotechnology modeling can help patient diagnosis and treatment; recognize how to translate nanotheranostics data into an actionable clinical strategy; discuss with industry leaders how nanotheranostics is evolving and what the impact is on current research efforts; and last but not least, learn what approaches are proving fruitful in turning promising clinical data into treatment realities.
    Keywords: QD1-999 ; Q1-390 ; Nanoparticles ; Gene Therapy ; Immunotherapy ; bioimaging ; theranostics ; nanomaterials ; Drug delivery ; Nanomedicine ; Cancer ; Phototherapy ; thema EDItEUR::P Mathematics and Science::PN Chemistry
    Language: English
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  • 4
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: omics ; epigenetics ; pharmacogenetics ; CYP ; risk prediction ; microbiota ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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  • 5
    Publication Date: 2024-04-11
    Description: It has become more evident that many microalgae respond very differently than land plants to diverse stimuli. Therefore, we cannot reduce microalgae biology to what we have learned from land plants biology. However, we are still at the beginning of a comprehensive understanding of microalgae biology. Microalgae have been posited several times as prime candidates for the development of sustainable energy platforms, making thus the in-depth understanding of their biological features an important objective. Thus, the knowledge related to the basics of microalgae biology must be acquired and shared rapidly, fostering the development of potential applications. Microalgae biology has been studied for more than forty years now and more intensely since the 1970’s, when genetics and molecular biology approaches were integrated into the research programs. Recently, studies on the molecular physiology of microalgae have provided evidences on the particularities of these organisms, mainly in model species, such as Chlamydomonas reinhardtii. Of note, cellular responses in microalgae produce very interesting phenotypes, such as high lipid content in nitrogen deprived cells, increased protein content in cells under high CO2 concentrations, the modification of flagella structure and motility in basal body mutant strains, the different ancient proteins that microalgae uses to dissipate the harmful excess of light energy, the hydrogen production in cells under sulfur deprivation, to mention just a few. Moreover, several research groups are using high-throughput and data-driven technologies, including “omics” approaches to investigate microalgae cellular responses at a system-wide level, revealing new features of microalgae biology, highlighting differences between microalgae and land plants. It has been amazing to observe the efforts towards the development and optimization of new technologies required for the proper study of microalgae, including methods that opened new paths to the investigation of important processes such as regulatory mechanisms, signaling crosstalk, chemotactic mechanisms, light responses, chloroplast controlled mechanisms, among others. This is an exciting moment in microalgae research when novel data are been produced and applied by research groups from different areas, such as bioprocesses and biotechnology. Moreover, there has been an increased amount of research groups focused in the study of microalgae as a sustainable source for bioremediation, synthesis of bioproducts and development of bioenergy. Innovative strategies are combining the knowledge of basic sciences on microalgae into their applied processes, resulting in the progression of many applications that hopefully, will achieve the necessary degree of optimization for economically feasible large-scale applications. Advances on the areas of basic microalgae biology and novelties on the essential cellular processes were revealed. Progress in the applied science showed the use of the basic science knowledge into fostering translational research, proposing novel strategies for a sustainable world scenario. In this present e-book, articles presented by research groups from different scientific areas showed, successfully, the increased development of the microalgae research. Herewith, you will find articles ranging from bioprospecting regional microalgae species, through advances in microalgae molecular physiology to the development of techniques for characterization of biomass and the use of biomass into agriculture and bioenergy production. This e-book is an excellent source of knowledge for those working with microalgae basic and applied sciences, and a great opportunity for researchers from both areas to have an overview of the amazing possibilities we have for building an environmentally sustainable future once the knowledge is translated into novel applications.
    Keywords: TA1-2040 ; TP248.13-248.65 ; QK1-989 ; Q1-390 ; Biotechnology ; biomass ; Hydrogen ; bioenergy ; Nutrients ; Lipids ; Microalgae ; Biofuels ; sustainability ; Carbon Dioxide ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: English
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  • 6
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    Presses universitaires de Rennes
    Publication Date: 2024-03-26
    Description: Écrire la crise ce n'est pas la raconter. C'est montrer comment elle modifie nos manières de raconter. Encore faut-il s'entendre sur le mot lui-même car peut-on appeler crise (du grec « krisis » : changement brutal) cette lente dissolution des valeurs de la modernité qui nous fait entrer dans un « après » informulable, sinon par le terme souvent controversé de postmodernité ? Au-delà des polémiques que suscite cette notion, il s'agit ici de considérer le postmoderne non pas comme une régression anti-moderne mais comme la prise de conscience d'un certain nombre de dévoiements du projet moderne qui nous projettent dans une ère de turbulence dont les arts, et en particulier la littérature, portent la marque. Ainsi considéré, le postmodernisme n'est ni une école, ni une avant-garde. Il témoigne avant tout d'une crise de culture à la transition des deux siècles, qui s'est transformée en culture de la crise, de sorte que, non seulement la pensée, la science et les arts, s'en trouvent affectés, mais de manière plus profonde encore, la société et l'individu. C'est pourquoi cet essai se propose à la fois, d'examiner l'hypothèse postmoderne comme mise en turbulence des valeurs de la modernité, et de définir le postmodernisme en littérature comme une esthétique qui met en relation les configurations sociales et certaines formes d'écriture contemporaine.
    Keywords: postmodernité ; crise ; roman ; littérature contemporaine ; poésie contemporaine ; thema EDItEUR::D Biography, Literature and Literary studies::DS Literature: history and criticism::DSB Literary studies: general
    Language: French
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  • 7
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: oligodendrocyte ; Schwann cell ; oligodendrocyte precursor cell ; myelin ; myelin repair ; axon physiology ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 8
    Publication Date: 2023-12-21
    Description: It is now well appreciated that the immune system, in addition to its traditional role in defending the organism against pathogens, communicate in a well-organized fashion with the brain to maintain homeostasis and regulate a set of neural functions. Perturbation in this brain-immune interactions due to inflammatory responses may lead to psychiatric and neurological disorders. Microglia are one of the essential cells involved in the brain-immune interactions. Microglial cells are now not simply regarded as resident tissue macrophages in the brain. These cells are derived from myeloid progenitor cells in the yolk sac in early gestation, travel to the brain parenchyma and interact actively with neurons during the critical period of neurogenesis. Microglia provide a trophic support to developing neurons and take part in the neural wiring through the activity-dependent synapse elimination via direct neuron-microglia interactions. Altered microglial functions including changes in the gene expression due to early life inflammatory events or psychological and environmental stressors can be causally related to neurodevelopmental diseases and mental health disorders. This type of alterations in the neural functions can occur in the absence of infiltration of inflammatory cells in the brain parenchyma or leptomeninges. In this sense, the pathogenetic state underlying a significant part of psychiatric and neurological diseases may be similar to “para-inflammation”, an intermediate state between homeostatic and classical inflammatory states as defined by Ruslan Medzhitov (Nature 454:428-35, 2008). Therefore, it is important to study how systemic inflammation affects brain health and how local peripheral inflammation induces changes in the brain microenvironment. Chronic pain is also induced by disturbance in otherwise well-organized multisystem interplay comprising of reciprocal neural, endocrine and immune interactions. Especially, early-life insults including exposure to immune challenges can alter the neuroanatomical components of nociception, which induces altered pain response later in life. Recently the discrete roles of microglia and blood monocyte-derived macrophages are being defined. The distinction may be further highlighted by disorders in which the brain parenchymal tissue is damaged. Therefore, studies investigating the dynamics of immune cells in traumatic brain injury and neurotropic viral infections including human immunodeficiency virus, etc. as well as neurodegenerative diseases such as amyotrophic lateral sclerosis are promising to clarify the interplay between the central nervous and immune systems. The understanding of the histological architecture providing the infrastructure of such neuro-immune interplay is also essential. This Frontiers research topic brings together fourteen articles and aims to create a platform for researchers in the field of psychoneuroimmunology to share the recent theories, hypotheses and future perspectives regarding open questions on the mechanisms of cell-cell interactions with chemical mediators among the nervous, immune and endocrine systems. We hope that this platform would reveal the relevance of the studies on multisystem interactions to enhance the understanding of the mechanisms underlying a wide variety of neurological and psychiatric disorders.
    Keywords: R5-920 ; RC346-429 ; RC581-607 ; brain-immune interaction ; fatigue ; pain ; HIV ; neuroinflammation ; traumatic brain injury ; depression ; microglia ; amyotrophic lateral sclerosis ; autism ; bic Book Industry Communication::M Medicine
    Language: English
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  • 9
    Publication Date: 2024-04-05
    Description: In the past two decades there have been significant advances made in understanding the cellular and molecular alterations that occur with brain ageing, as well as with our understanding of age-related brain diseases. Ageing is associated with a mid-life decline in many cognitive domains (eg. Attention, working memory, episodic memory) that progresses with advancing age and which may be potentiated by a variety of diseases. However, despite the breadth of attempts to explain it, the underlying basis for age-related memory impairment remains poorly understood. Both normal and “pathological” ageing (as in age-related neurodegenerative disorders such as Alzheimer’s disease) may be associated with overlapping and increased levels of “abnormal” pathology, and this may be a potential mediator of cognitive decline in both populations. An emerging hypothesis in this field is that metal ion dys/homeostasis may represent a primary unifying mechanism to explain age- and disease-associated memory impairment – either indirectly via an effect on disease pathogenesis, or by a direct effect on signaling pathways relevant to learning and memory. There remains a concerted worldwide effort to deliver an effective therapeutic treatment for cognitive decline associated with ageing and/or disease, which is currently an unmet need. There have been numerous clinical trials conducted specifically testing drugs to prevent cognitive decline and progression to dementia, but to date the results have been less than impressive, highlighting the urgent need for a greater understanding of the neurobiological basis of memory impairment in ageing and disease which can then drive the search for effective therapeutics.
    Keywords: RC321-571 ; Q1-390 ; Down Syndrome ; Amyotrophic Lateral Sclerosis ; Parkinson's disease ; aluminium ; Iron ; TBI ; Cognition ; Copper ; Alzheimer's disease ; Zinc ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 10
    Publication Date: 2024-04-04
    Description: Evolution of the horse has been an often-cited primary example of evolution, as well as one of the classic and important stories in paleontology for over a century and a half, due to their rich fossil record across 5 continents: North America, South America, Europe, Asia and Africa. The recent horse has served a profound role in human ancestry, including agriculture, commerce, sport, transport, warfare, and in prehistory, for the subsistence of humans. Many studies have examined the evolution of the Equidae and chronicled the striking changes in skulls, dentition, limbs, and body size which have long been perceived to be a response to environmental shifts through time. Most comprehensive studies heretofore have: (1) focused on the “Great Transformation”- changes that occurred in the early Miocene, (2) involved tracking long-term diversity or paleoecological trends on a single continent or within a geographical locality, or (3) concentrated on the 3-toed hipparions. The Plio–Pleistocene evolutionary stage of horse evolution is punctuated by the great climatic fluctuations of the Quaternary beginning 2.6 Ma which influenced Equus evolution, biogeographic dispersion and adaptation on a nearly global scale. The evolutionary biology of Equus evolution across its entire range remains relatively poorly understood and often highly controversial. Some of this lack of understanding is due to assumptions that have arisen because of the relatively derived craniodental and postcranial anatomy of Equus and its close relatives which has seemed to imply that that these forms occupied relatively homogenous and narrow dietary and locomotor niches - notions that have not been adequately addressed and rigorously tested. Other challenges have revolved around teasing apart environmentally-driven adaptation versus phylogenetically defined morphological change. Geochronologic age control of localities, geographic provinces and continents has improved, but in no way is absolute and can be reexamined in our proposed volume. Temporal resolution for paleodietary, paleohabitat and paleoecological interpretations are also challenging for understanding the evolution of Equus. Our proposed volume attempts to assemble a group of experts who will address multiple dimensions of Equus’ evolution in time and space.
    Keywords: Ecomorphology ; Equus ; Paleoecology ; Taxonomy ; Biogeography ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAF Ecological science, the Biosphere
    Language: English
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  • 11
    Publication Date: 2023-12-21
    Description: Poly-ADP ribose polymerase (PARP) proteins are critical mediators of DNA repair. Many traditional anti-cancer chemotherapy agents overwhelm a cell’s ability to repair DNA damage in order to kill proliferating malignant cells. Recent evidence suggests that cancers within and across tissue types have specific defects in DNA repair pathways, and that these defects may predispose for sensitivity and resistance to various classes of cytotoxic agents. Breast, ovarian and other cancers develop in the setting of inherited DNA repair deficiency, and these cancers may be more sensitive to cytotoxic agents that induce DNA strand breaks, as well as to inhibitors of PARP activity. A series of recent clinical trials has tested whether PARP inhibitors can achieve synthetic lethality in hereditary DNA repair-deficient tumors. At the current time, mutation of BRCA serves as a potential, but not comprehensive, biomarker to predict response to PARP inhibitor therapy. Mechanisms of resistance to PARP inhibitors are only recently being uncovered. Future studies seek to identify sporadic cancers that harbor genomic instability rendering susceptibility to PARP inhibitors that compound lethal DNA damage.
    Keywords: R5-920 ; RC254-282 ; DNA reapir ; PARP inhibitor ; Homologous Recombination ; combination therapy ; DNA Damage ; Cancer ; bic Book Industry Communication::M Medicine
    Language: English
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  • 12
    Publication Date: 2024-04-05
    Description: Neuromorphic engineering has just reached its 25th year as a discipline. In the first two decades neuromorphic engineers focused on building models of sensors, such as silicon cochleas and retinas, and building blocks such as silicon neurons and synapses. These designs have honed our skills in implementing sensors and neural networks in VLSI using analog and mixed mode circuits. Over the last decade the address event representation has been used to interface devices and computers from different designers and even different groups. This facility has been essential for our ability to combine sensors, neural networks, and actuators into neuromorphic systems. More recently, several big projects have emerged to build very large scale neuromorphic systems. The Telluride Neuromorphic Engineering Workshop (since 1994) and the CapoCaccia Cognitive Neuromorphic Engineering Workshop (since 2009) have been instrumental not only in creating a strongly connected research community, but also in introducing different groups to each other’s hardware. Many neuromorphic systems are first created at one of these workshops. With this special research topic, we showcase the state-of-the-art in neuromorphic systems.
    Keywords: RC321-571 ; Q1-390 ; neuromorphic engineering ; Learning ; Floating gate ; Neural Network ; spike-based ; event-based ; simulation ; dynamic vision sensor ; network ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 13
    Publication Date: 2023-12-21
    Description: This e-book provides the insight into occupational health and safety problems, challenges and solutions of the dairy sector. Thirty-two authors have been sharing their results and knowledge reflecting the challenges from small scale farming up to industrial style. The worldwide trend of growing farm sizes and a reduction in numbers is one of the major drivers for the changes in the working environment. Musculoskeletal disorders are among the most prevalent health problems of people working on farms. Nevertheless mechanisation has not reduced the number of complaints, and new problems arise due to the changing working environment.
    Keywords: R5-920 ; RA1-1270 ; immigrant workers ; Dairy farming ; OHS ; MSS ; MSD ; bic Book Industry Communication::M Medicine
    Language: English
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  • 14
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    Frontiers Media SA
    Publication Date: 2024-04-05
    Description: Despite the importance of mathematics in our educational systems little is known about how abstract mathematical thinking emerges. Under the uniting thread of mathematical development, we hope to connect researchers from various backgrounds to provide an integrated view of abstract mathematical cognition. Much progress has been made in the last 20 years on how numeracy is acquired. Experimental psychology has brought to light the fact that numerical cognition stems from spatial cognition. The findings from neuroimaging and single cell recording experiments converge to show that numerical representations take place in the intraparietal sulcus. Further research has demonstrated that supplementary neural networks might be recruited to carry out subtasks; for example, the retrieval of arithmetic facts is done by the angular gyrus. Now that the neural networks in charge of basic mathematical cognition are identified, we can move onto the stage where we seek to understand how these basics skills are used to support the acquisition and use of abstract mathematical concepts.
    Keywords: RC321-571 ; Q1-390 ; Neuroimaging ; development ; numerosity ; gifted ; Mathematical Cognition ; algebra ; abstract ; Expertise ; Arithmetic ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 15
    Publication Date: 2024-03-25
    Description: À l’aube des temps modernes, l’Europe est secouée par une série d’affrontements religieux. Par routine ou par paresse, on pense en premier lieu à l’irruption de Martin Luther et des autres protagonistes de la Réforme protestante et à la scission de la chrétienté latine. Mais toute l’Europe n’est pas chrétienne : les temps modernes s’ouvrent avec l’expulsion, les conversions forcées et la persécution des juifs et des musulmans dans la péninsule Ibérique de la Reconquista. Et il y a une Europe ottomane, elle aussi pluri-religieuse. L’expérience européenne des conflits religieux se fait en outre dans un horizon global de la rencontre avec d’autres religions et civilisations où les Européens découvrent leur propre barbarie. Celle-ci s’exprime dans les atrocités des guerres civiles, des guerres de religion en France à l’action des troupes de Cromwell en Irlande. Partant de la pluralité religieuse de l’espace européen, les affrontements de la première modernité se lisent comme un douloureux processus d’apprentissage d’accepter et de gérer cette pluralité irréductible. Ainsi naît une notion et forme historique, politique et culturelle de l’Europe qui intègre dans sa constitution la conflictualité religieuse. Les contributions ici réunies analysent ce processus couvrant tout l’espace européen. Cet ouvrage est né de la collaboration d’un groupe d’historien(ne)s européen(ne)s spécialistes de ces questions et montre la richesse du paysage historiographique européen.
    Keywords: D1-2009 ; Réforme ; islam ; conflits religieux ; judaïsme ; tolérance religieuse ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DN Biography and non-fiction prose
    Language: French
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  • 16
    Publication Date: 2023-12-21
    Description: Microglia are essential for the development and function of the adult brain. Their ontogeny, together with the absence of turnover from the periphery and the singular environment of the central nervous system (CNS), make microglia a unique cell population compared to other tissue-macrophages. The unique properties and functions of microglial cells, such as their role in synaptic pruning or the exceptional capacity to scan the brain parenchyma and rapidly react to its perturbations, have emerged in recent years. In the coming years, understanding how microglia acquire and maintain their unique profiles in order to fulfil distinct tasks in the healthy CNS and how these are altered in disease, will be essential to develop strategies to diagnose or treat CNS disorders with an immunological component. This Research Topic covers several aspects of microglial biology, ranging from their origin and the functional role of microglia during development and lifespan, their molecular properties compared with other brain and peripheral immune cells to microglial phenotypes and functional states in neurodegenerative diseases and brain tumours. In conclusion, the present Research Topic provides a comprehensive overview of our current understanding of several cellular and molecular mechanisms that make microglia a unique immune cell population within the healthy CNS as well as under inflammatory, neurodegenerative and tumorigenic processes.
    Keywords: R5-920 ; RC346-429 ; RC581-607 ; inflammation ; brain tumour ; neurodegeneration ; microglia ; ontogeny ; bic Book Industry Communication::M Medicine
    Language: English
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  • 17
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Exercise Science ; Performance ; Physiology ; Japan ; Olympics ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology
    Language: English
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  • 18
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: organohalide respiration ; Microbial reductive dehalogenation ; Dehalococcoides ; electron transport chain ; reductive dehalogenase ; Community composition and function ; bioremediation ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKF Pathology::MKFM Medical microbiology and virology ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical)
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  • 19
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: artificial reefs ; offshore oil and gas platforms ; coastal infrastructure ; aquaculture facilities ; anthropogenic influences ; ecological restoration ; marine conservation ; rigs-to-reef ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RB Earth sciences::RBK Hydrology and the hydrosphere::RBKC Oceanography (seas and oceans)
    Language: English
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  • 20
    Publication Date: 2023-12-21
    Description: The non-classical HLA class I molecule HLA-G is different from classical HLA class I molecules because of the low polymorphism in the coding region, the fact that HLA-G primary transcript is alternatively spliced in seven isoforms, and the inhibitory action on immune cells. Although HLA-G is low polymorphic, variants in both promoter and 3’ un-translated region (UTR) of HLA-G locus regulate its expression. In healthy conditions, a basal level of HLA-G gene transcription is observed in most cells and tissues; however, translation into HLA-G protein is restricted to trophoblasts in the placenta, where it participates in promoting tolerance at the fetal-maternal interface. HLA-G is also expressed by thymic epitelial, cornea, mesenchymal stem cells, nail matrix, pancreatic beta cells, erythroid, and endothelial precursors. HLA-G can be neo-expressed in adult tissues in pathological conditions, and its expression has been documented autoimmune disorders, viral infections, and cancer. In the latter setting de novo HLA-G expression is associated with the capability of tumor cells to evade the immune control. In the last decade it has become evident that HLA-G expression on T cells and antigenpresenting cells confers to these cells tolerogenic properties. This Research Topic focused on i) summarizing updated clinical and immunological evidences that HLA-G expression is associate with beneficial or detrimental tolerance, ii) gathering new insights into the mechanisms governing the expression of HLA-G in healthy and pathological conditions, such as pre-eclampsia, and iii) examining the mechanisms underlying HLA-G mediated tolerance.
    Keywords: R5-920 ; RC581-607 ; Pregnancy ; Autoimmunity ; Immuno-modulation ; Pre-Eclampsia ; Infections ; Exosomes ; HLA-G ; polymorphisms ; tolerance ; Cancer ; bic Book Industry Communication::M Medicine
    Language: English
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  • 21
    Publication Date: 2024-03-29
    Description: In the year 2013, ‘selfie’ was named word of the year by Oxford Dictionaries in recognition of dramatic changes in frequency, prominence, and register of the term. This drastic increase in selfie-taking was spurred by two factors. The first was the advent of smartphones equipped with front cameras and preview screens that made it easy to compose a photographic self-portrait by a process of deliberately exploring one’s image, choosing a pose, and finally taking the picture. The second key change contributing to the rise of the selfie age was the increasing availability of internet connections. It is estimated that about 50% of the world population has access to the internet today (2018; https://www.internetworldstats.com). At the end of the past century, this percentage was a mere 1%. The growth of the internet infrastructure simultaneously spurred the development of social network applications such as Facebook, Twitter, Snapchat, and Instagram, providing accessible media for sharing photographs including photographic self-portraits. However, despite their tremendous reach and popularity, selfies have so far received relatively little attention by the scientific community, especially within psychology. Thus, we proposed a Frontiers in Psychology Research Topic to expand empirical and theoretical work on the massively popular, yet scientifically unexplored, phenomenon of the selfie. The articles published in this eBook offer a multifaceted insight into current scholarly work on this topic.
    Keywords: BF1-990 ; Q1-390 ; group selfies ; self-esteem ; Human Computer Interaction (HCI) ; self-presentation ; selfie ; viewing perspective ; perception bias ; smartphones ; social media ; internet ; bic Book Industry Communication::J Society & social sciences::JM Psychology ; thema EDItEUR::J Society and Social Sciences::JM Psychology
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  • 22
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    Presses universitaires de Rennes
    Publication Date: 2024-03-26
    Description: Si le récit reste aujourd’hui fragile dans son retour en grâce, si le réel reste difficile à appréhender par la narration, la fiction peut-elle se glisser dans cet entre-deux ? La fiction peut-elle offrir des formes narratives et discursives inédites ? Peut-elle trouver dans la narration, dont l’attirance cependant doublée de dérision distanciée chez les écrivains d’aujourd’hui se fait nettement sentir, un support générique acceptable ou bien se cherche-t-elle, par l’entremise, et la mise en œuvre d’autres sémiotiques, une échappée belle à la croisée d’autres genres, d’autres supports ? Quelles sont les conditions de possibilité́, en somme, de son renouveau ou de sa survie ? Le présent recueil, issu d’une réflexion collective sur les grandes déterminations linguistiques et formelles des fictions narratives française du xxie siècle, tente donc de dégager les spécificités des écritures contemporaines de fiction par rapport aux écritures narratives du xxe siècle.
    Keywords: littérature ; littérature contemporaine ; narration ; thema EDItEUR::D Biography, Literature and Literary studies::DS Literature: history and criticism::DSA Literary theory
    Language: French
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  • 23
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    Frontiers Media SA
    Publication Date: 2024-03-31
    Description: The main physiological actions of the biologically most active metabolite of vitamin D, 1a,25-dihydroxyvitamin D3(1a,25(OH)2D3), are calcium and phosphorus uptake and transport and thereby controlling bone formation. Other emergent areas of 1a,25(OH)2D3 action are in the control of immune functions, cellular growth and differentiation. This fits both with the widespread expression of the VDR and the above described consequences of vitamin D deficiency. Transcriptome-wide analysis indicated that per cell type between 200 and 600 genes are primary targets of vitamin D. Since most of these genes respond to vitamin D in a cell-specific fashion, the total number of vitamin D targets in the human genome is far higher than 1,000. This is supported by the genome-wide view on VDR binding sites in human lymphocytes, monocytes, colon and hepatic cells. All genomic actions of 1a,25(OH)2D3 are mediated by the transcription factor vitamin D receptor (VDR) that has been the subject of intense study since the 1980’s. Thus, vitamin D signaling primarily implies the molecular actions of the VDR. In this research topic, we present in 15 chapters different perspectives on the action of vitamin D and its receptor, such as the impact of the genomewide distribution of VDR binding loci, ii) the transcriptome- and proteome-wide effects of vitamin D, iii) the role of vitamin D in health, iv) tissue-specific functions of vitamin D and v) the involvement of vitamin D in different diseases, such as infections, autoimmune diseases, diabetes and different types of cancer.
    Keywords: QP1-981 ; Q1-390 ; Vitamin D ; Immune System ; Genomics ; vitamin D receptor ; Physiology ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology
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  • 24
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: resting-state fMRI ; fMRI denoising ; vascular modulation ; head motion ; arousal ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 25
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    Presses universitaires de Rennes
    Publication Date: 2022-07-01
    Description: Ce livre est un hommage à Jean Baudouin, professeur émérite de science politique qui achève sa carrière après quatre décennies d’enseignement et de recherche à l’université Rennes 1. Après une introduction qui présente son itinéraire et son apport à la science politique française, ses collègues, amis et élèves abordent les grands domaines et les principales thématiques qui ont occupé sa pensée. Les contributions de ce volume s’organisent autour de trois parties. La première, qui porte sur les radicalités politiques, explore principalement le phénomène communiste, envisagé dans ses dimensions nationale et mondiale, tout en offrant également de nouvelles perspectives sur les évolutions récentes de l’extrême gauche et l’engagement frontiste. La deuxième partie, centrée sur la question de la démocratie libérale, associe l’étude d’auteurs classiques à un questionnement conceptuel qui vient éclairer l’actualité la plus brûlante concernant la démocratie, la place du religieux ou encore la situation de l’Union européenne. La troisième partie vient enfin contribuer à l’étude de l’engagement des intellectuels en politique, en attirant l’attention sur des figures aussi différentes que Charles Fourier, Louis Aragon, Francis Delaisi, Emmanuel Mounier, Michel Foucault ou les intellectuels maoïstes. L’ensemble se clôt sur la reprise d’un article important de Jean Baudouin, datant de 1997 et devenu aujourd’hui introuvable, précisant la conception du politique défendue par ce professeur au positionnement singulier. Cet ouvrage entend ainsi offrir au lecteur une vue panoramique sur un courant dynamique de la science politique française – la théorie politique – dont il a été l’un des principaux animateurs et dont il reste l’un des plus éminents représentants. Cet ouvrage rassemble les contributions de Jean Baudouin, Philippe Bénéton, David Bisson, Goulven Boudic, Daniel Bourmaud, Philippe Braud, Bernard Bruneteau, Sébastien Caré, Gwendal Châton, Stéphane Courtois, Jean-Marie Donégani, Michel Hastings, François Hourmant, Marc Lazar, Arnauld Leclerc, Jacques Le Goff, Pascal Perrineau, Philippe Portier, Philippe Raynaud et Thuriane Séveno. Sa publication a bénéficié du soutien de l’Institut du droit public et de la science politique (IDPSP) de l’université Rennes 1, ainsi que de la faculté de droit et de science politique.
    Keywords: communisme ; politique ; démocratie ; bic Book Industry Communication::J Society & social sciences::JP Politics & government
    Language: French
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    Frontiers Media SA
    Publication Date: 2022-01-31
    Description: This research topic is focused on recent advances in our understanding of effects of mechanical loading on the skeleton, and research methods used in addressing these. Though it is well established that mechanical loading provides an essential stimulus for skeletal growth and maintenance, there have been major advances recently in terms of our understanding of the molecular pathways involved, which are thought to provide novel drug targets for treating osteoporosis. The articles included in this topic encompass the full spectrum of laboratory and clinical research, and range from review articles, editorials, hypothesis papers and original research articles. Together, they demonstrate how mechanical loading underpins many aspects of bone biology, including the pathogenesis and treatment of osteoporosis and other clinical disorders associated with skeletal fragility.
    Keywords: RC648-665 ; R5-920 ; mechanical loading ; bone architecture ; accelerometers ; osteoblast ; osteoporosis ; osteoclast ; fractures ; distraction osteogenesis
    Language: English
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  • 27
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    Frontiers Media SA
    Publication Date: 2024-04-05
    Description: Glial cells are no longer considered passive bystanders in neuronal brain circuits. Not only are they required for housekeeping and brain metabolism, they are active participants in regulating the physiological function and plasticity of brain circuits and the online control of behavior both in invertebrate and vertebrate model systems. In invertebrates, glial cells are essential for normal function of sensory organs (C. elegans) and necessary for the circadian regulation of locomotor activity (D. melanogaster). In the mamallian brain, astrocytes are implicated in the regulation of cortical brain rhythms and sleep homeostasis. Disruption of AMPA receptor function in a subset of glial cell types in mice shows behavioral deficits. Furthermore, genetic disruption of glial cell function can directly control behavioral output. Regulation of ionic gradients by glia can underlie bistability of neurons and can modulate the fidelity of synaptic transmission. Grafting of human glial progenitor cells in mouse forebrain results in human glial chimeric mice with enhanced plasticity and improved behavioral performance, suggesting that astrocytes have evolved to cope with information processing in more complex brains. Taken together, current evidence is strongly suggestive that glial cells are essential contributors to information processing in the brain. This Research Topic compiles recent research that shows how the molecular mechanisms underlying glial cell function can be dissected, reviews their impact on plasticity and behavior across species and presents novel approaches to further probe their function.
    Keywords: RC321-571 ; Q1-390 ; Cerebellum ; C. elegans ; Astrocytes ; DREADD ; Cortex ; plasticity ; Gq ; Behavior ; glia ; Hippocampus ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Thy-1 ; CD90 ; Signal Transduction ; cell-cell interaction ; Cell-matrix interaction ; Scaffold ; Nanodomains ; integrin ; Mechanotransduction ; Cancer ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
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  • 29
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: export ; secretion ; pathogens ; toxins ; macromolecular machineries ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCJ Infectious and contagious diseases
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  • 30
    Publication Date: 2023-12-21
    Description: Lymphocytes constantly survey the lymph nodes in search for potential infection by a pathogen. They enter the afferent lymphatic vessel that serves as a conduit to transport the motile lymphocytes to the draining lymph node. Lymphatic vessels (LVs) are present in most vascularized tissues. They are traditionally regarded as passive conduits for soluble antigens and leukocytes. Afferent LVs begin as blind ended capillaries, which give rise to collecting vessels that merge and connect with draining lymph nodes (dLNs). Initial lymphatic capillaries are composed of Lymphatic Endothelial Cells (LECs) connected by discontinuous cell junctions, which join to form larger collecting lymphatic vessels, and ultimately feed into the LN subcapsular sinus. Within the LN, LECs are localized to the subcapsular, cortical, and medullary sinuses, where they interact with incoming and exiting leukocytes. LECs, and in general LN stromal cells, have emerged in the recent years as active players in the immune response. In support to this,studies have shown that the immune response generated during inflammation and under pathologic conditions is accompanied by modeling of the LVs and generation of new lymphatics, a process known as lymphangiogenesis. These facts strongly suggest that LECs and stromal LN cells in general, are not inert players but rather are part of the immune response by organizing immune cells movement, exchanging information and supplying survival factors. The purpose of this research topic is to review the role of the LECs during immune homeostasis and cancer. Considering the critical role of lymphangiogenesis in many pathologies like chronic and acute inflammation, autoimmunity, wound healing, graft rejection, and tumor metastasis, it is important to understand the molecular mechanisms that govern the cross talks between the LECs and immune cells during homeostasis and inflammation.
    Keywords: R5-920 ; RC581-607 ; Liver Injury ; Lymphatic Vessels ; Lymphatic Vasculature ; Tumor Microenvironment ; PD-L1 ; Antigen Presenting Cells ; Lymphatic Endothelial Cells ; T cell trafficking ; T cells ; bic Book Industry Communication::M Medicine
    Language: English
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  • 31
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    Presses universitaires de Rennes
    Publication Date: 2024-03-25
    Description: Il y a deux cents ans, le décret impérial du 17 mars 1808, en 144 articles, organisait l’Université impériale fondée en 1806. Restaurant les facultés, précisant les grades mais aussi la hiérarchie interne du personnel administratif et enseignant, cet imposant décret jetait les bases de notre système contemporain d’Instruction publique. C’est aussi par ce décret qu’apparaît le recteur d’académie, défini comme le représentant direct du Grand-Maître parisien, chef d’un espace territorial nouveau, l’académie, composée d’un regroupement de plusieurs départements pour la gestion des affaires éducatives. Parfois menacée de suppression, souvent modifiée dans ses attributions règlementaires, la fonction rectorale a surmonté les multiples changements de régime qu’a connus la France depuis 1808, s’affirmant comme une spécificité française. Cet ouvrage revient sur les deux cents ans d’engagements polymorphes des recteurs d’académie au service du développement de l’Instruction publique. Il associe de larges synthèses sur la naissance de la fonction et les principales phases de son évolution, les analyses plus spécifiques sur certains de leurs engagements, tout en proposant des études de cas académiques ou biographiques. Ces contributions permettent ainsi de mieux connaître les recteurs et leur fonction mais aussi de réaliser, par leur intermédiaire, une véritable plongée dans l’histoire de nos structures éducatives contemporaines.
    Keywords: D1-2009 ; Troisième République ; monarchie de Juillet ; Éducation nationale ; instruction publique ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DN Biography and non-fiction prose
    Language: French
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Heart Rate ; Heart rate variability ; Autonomic Nervous System ; infants ; Children ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology
    Language: English
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  • 33
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    Presses universitaires de Rennes
    Publication Date: 2024-03-25
    Description: De la Hollande aux Fens anglais, du Schleswig-Holstein à la plaine padane, l’Europe moderne a été marquée par la conquête des marais littoraux et intérieurs. Bien qu’elle n’ait pas souffert de faim de terres, la France a également participé à cette modernisation agricole modifiant les rapports entre l’homme et la nature. Par le prisme de l’histoire de neuf marais asséchés en France au cours du XVIIe, cet ouvrage, fondé sur l’exploitation d’archives nombreuses, françaises et néerlandaises, met en lumière le rôle de la monarchie et de son aristocratie ministérielle dans la conduite de ce processus. Grâce à des dispositifs juridiques et des méthodes de gestion novateurs, mais aussi par un soutien politique constant, la monarchie a permis la mise en culture d’espaces traditionnellement consacrés à la pêche, à la chasse ou à la cueillette. Richelieu et ses créatures, puis Mazarin et ses associés ont ainsi procédé à l’importation d’un modèle hydraulique et agricole d’inspiration néerlandaise, ancré dans l’économie européenne et aux conséquences sociales et environnementales encore marquantes de nos jours. Les bonifications françaises du XVIIe siècle montrent l’importance des liens entre les élites politiques françaises et les élites commerçantes néerlandaises. Ainsi, l’histoire des assèchements offre un regard original sur l’histoire politique du XVIIe siècle français, révélant les enjeux territoriaux de la centralisation monarchique et du développement de l’État.
    Keywords: D1-2009 ; marais ; XVIIe siècle ; histoire agricole ; histoire de France ; aménagement du territoire ; histoire politique ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DN Biography and non-fiction prose
    Language: French
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    Publication Date: 2022-01-31
    Description: J.-J.-L. Graslin (1727-1790) est connu à Nantes pour être le créateur du quartier devenu le cœur de la Cité, autour de la place et du théâtre qui portent son nom. Mais la vie et l’œuvre de ce receveur général des Fermes du roi, négociant, manufacturier et aménageur, restent très méconnues, alors qu’il fut aussi un lettré et un économiste d’envergure opposé aux physiocrates. Il est ainsi représentatif de ces hommes des Lumières qui, en province comme à Paris, vont transformer la France au cour...
    Keywords: biographie ; aménagement ; économiste ; histoire de France ; aménageur ; Siècle des Lumières ; Ancien Régime (XIX-XVIIIe)
    Language: French
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  • 35
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: NMDAR = N-methyl-d-aspartate receptor ; Enzymes - metabolism ; enzyme drug target ; d-serine ; L-serine ; thema EDItEUR::P Mathematics and Science::PD Science: general issues
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    Frontiers Media SA
    Publication Date: 2024-03-30
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: biobank ; samples ; data ; biobank network ; BBMRI
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    Publication Date: 2022-01-31
    Description: L'historien médiéviste ne vit pas qu'au milieu des parchemins ou sur les monticules de fouille. Il entend aussi reprendre une interrogation centrale de nos civilisations contemporaines : les rapports entre les hommes et leurs espaces de vie. Il s'agit de partir en quête de ce que la période médiévale a pu élaborer dans ce domaine, avec la disparition des cadres politiques des empires antiques et de leurs héritiers carolingiens. La démarche adoptée ici se caractérise par une prise en compte dé...
    Keywords: profession ; histoire médiévale ; étude des territoires ; médiéviste ; historien ; étude transdisciplinaire
    Language: French
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  • 38
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Microbial ; activity ; extracellular enzyme ; marine ; freshwater ; Metabolic potential ; function ; metabolic ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKF Pathology::MKFM Medical microbiology and virology ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical)
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    Presses universitaires de Rennes
    Publication Date: 2024-04-02
    Description: Aux États-Unis, la notion de race est utilisée de manière routinière par les médecins en tant que variable biologique, culturelle ou sociale, selon les situations de soins. Croisant les notions de citoyenneté, de responsabilité et de droits civiques, ainsi que les questionnements autour de la politisation de la science, cet ouvrage retrace l’histoire de la médicalisation du corps noir par la profession psychiatrique aux États-Unis, du xxe siècle jusqu’à l’époque contemporaine. Conjuguant l’histoire et la sociologie, il est ainsi question de retracer les différents régimes par lesquels la notion de race a été jugée pertinente par les psychiatres pour naturaliser les différences corporelles des années 1920 jusqu’à l’époque contemporaine. En s’appuyant sur un corpus d’archives personnelles de médecins, d’institutions de soins et de centres de recherche en psychiatrie, ainsi que sur une enquête qualitative réalisée auprès de psychiatres en Californie, ce livre démontre que la catégorie de race irrigue encore et toujours les pratiques et les discours institutionnels, aussi bien dans les représentations que les médecins véhiculent des corps soignés, que dans les stratégies de naturalisation du social employées pour prendre en charge leurs patients.
    Keywords: psychology ; racialization ; United States of America ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSL Ethnic studies
    Language: French
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: precise genome editing ; CRISPR ; HDR efficiency ; biallelic HDR targeting ; off-target effect ; animal model ; base editing ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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    Presses universitaires de Rennes
    Publication Date: 2024-03-25
    Description: D'une guerre à l'autre se dessine une période d'âge d'or pour les activités caritatives, caractérisée par l'émergence de nombreuses institutions humanitaires, telles que le Joint, l'American Friends Service Committee (AFSC), OXFAM, CARE, mais aussi par l'influence décisive d'organisations telles que l'American Relief Administration (ARA), les différentes Croix-Rouge nationales, le Comité international de la Croix-Rouge ou la Commission for Relief in Belgium (CRB). Cet ouvrage propose un regard neuf sur l'histoire des organisations humanitaires. D'une guerre à l'autre, le livre propose une étude des actions d'entraide pour les populations souffrant de la faim à travers l'un des objets les plus emblématiques des actions de secours durant cette période, le colis alimentaire. En ouvrant le colis, en interrogeant son parcours depuis son lieu de fabrication et sa distribution aux bénéficiaires, nous pouvons reconstruire une histoire de l'humanitaire à travers une histoire sociale et culturelle des actions philanthropiques. Compagnies du secours, les organisations philanthropiques mobilisent flottes de bateaux, trains, camions, alors que leurs colis sont entassés dans des palettes facilement transportables. Objet de l'économie de marché, le colis s'adapte aux attentes des donateurs, aux conditions logistiques et aux besoins des destinataires. Bref, le colis facilite la cristallisation d'une communauté de donateurs et d'un espace d'intervention humanitaire construit par l'engagement des organisations non gouvernementales, des organisations internationales et des États en guerre.
    Keywords: D1-2009 ; aide humanitaire ; entraide ; guerre ; histoire sociale ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DN Biography and non-fiction prose
    Language: French
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  • 42
    Publication Date: 2024-04-05
    Description: In this EBook, we highlight how newly emerging techniques for non-invasive manipulation of the human brain, combined with simultaneous recordings of neural activity, contribute to the understanding of brain functions and neural dynamics in humans. A growing body of evidence indicates that the neural dynamics (e.g., oscillations, synchrony) are important in mediating information processing and networking for various functions in the human brain. Most of previous studies on human brain dynamics, however, show correlative relationships between brain functions and patterns of neural dynamics measured by imaging methods such as electroencephalography (EEG), magnetoencephalography (MEG), near-infrared spectroscopy (NIRS), positron emission tomography (PET) and functional magnetic resonance imaging (fMRI). In contrast, manipulative approaches by non-invasive brain stimulation (NIBS) have been developed and extensively used. These approaches include transcranial magnetic stimulation (TMS) and transcranial electric stimulation (tES) such as transcranial direct current stimulation (tDCS), alternating current stimulation (tACS), and random noise stimulation (tRNS), which can directly manipulate neural dynamics in the intact human brain. Although the neural-correlate approach is a strong tool, we think that manipulative approaches have far greater potential to show causal roles of neural dynamics in human brain functions. There have been technical challenges with using manipulative methods together with imaging methods. However, thanks to recent technical developments, it has become possible to use combined methods such as TMS–EEG coregistration. We can now directly measure and manipulate neural dynamics and analyze functional consequences to show causal roles of neural dynamics in various brain functions. Moreover, these combined methods can probe brain excitability, plasticity and cortical networking associated with information processing in the intact human brain. The contributors to this EBook have succeeded in showcasing cutting-edge studies and demonstrate the huge impact of their approaches on many areas in human neuroscience and clinical applications.
    Keywords: RC321-571 ; Q1-390 ; non-invasive brain stimulation NIBS ; TMS-EEG ; Transcranial magnetic stimulation TMS ; transcranial electric stimulation tES ; Coregistration ; Near-infrared spectroscopy NIRS ; Functional magnetic resonance imaging fMRI ; transcranial direct current stimulation tDCS ; transcranial alternating current stimulation tACS ; transcranial random noise stimulation tRNS ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 43
    Publication Date: 2024-04-05
    Description: Bálint’s syndrome is named after the Hungarian physician who first reported a remarkable case of a man with complex visuospatial deficits following bilateral lesions within parietal and occipital cortex (Bálint, 1909). The syndrome has three primary symptoms: simultanagnosia (impaired spatial awareness of more than one object at time), optic ataxia (misreaching to visual targets) and ocular apraxia (described by Bálint as “psychic paralysis of gaze”). Balint’s patients not only cannot perceive more than one object at time and therefore show poor comprehension of multi-object visual scenes i.e. poor detection of all the objects present and difficulty in grasping the relationship between them; in addition they typically fail to reach towards location of the single object, which they can perceive. The deficit of the allocation of spatial attention in Balint’s syndrome has been linked to a problem in feature binding which results in illusory conjunctions. Patients with Balint’s syndrome also show deficits in global processing i.e. when integration of multiple local elements into global compound shapes is required. Consequently, Balint’s syndrome provides a unique opportunity to study the nature and neuroanatomy of human visuospatial processing, in particular multi-level object representation, spatial awareness and the distribution of visual attention. The studies collected here cover both the anatomical and the cognitive mechanisms of the different symptoms associated with the syndrome. Furthermore, the dissociations between the components of Bálints’ syndrome, in particular simultanagnosia and optic ataxia, can also co-occur with visual neglect and extinction and the different combinations of reported lesions raises a question about the status of the syndrome and whether it should be merely treated as a historical compilation of symptoms which may or may not coexist cohesively. This interesting argument is raised here.
    Keywords: RC321-571 ; Q1-390 ; posterior cortical atrophy ; Balints syndrome ; optic ataxia ; Posterior parietal cortex ; simultanagnosia ; ocular apraxia ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 44
    Publication Date: 2022-01-31
    Description: L’acteur fut longtemps un mal-aimé des discours savants sur le cinéma : sa présence semblait un matériau précaire, fuyant, offrant peu de prise à l’analyse et à la théorie. Cependant les temps changent et, grâce aux efforts de nombreux critiques et universitaires, l’acteur s’est imposé au cours des dernières décennies comme objet légitime d’étude et de recherche. C’est de cette évolution qu’a voulu témoigner le colloque « L’acteur de cinéma, approches pluridisciplinaires », organisé à l’autom...
    Keywords: Hollywood ; kammerspiel ; star ; cinéma ; acteur
    Language: French
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  • 45
    Publication Date: 2024-03-25
    Description: Les missions d’évangélisation catholiques auprès des populations autochtones nord-amérindiennes de l’Ouest canadien, au XIXe siècle et au XXe siècle, s’offrent à la recherche en sciences sociales comme un laboratoire d’expériences de la rencontre interculturelle propice à l’étude des processus d’adaptation à l’altérité. Missionnaires et missionnés s’observent, interagissent et construisent une histoire commune. Sur une toile de fond teintée de post-colonialisme, les protagonistes s’expriment au sujet de cette période de cohabitation forcée. Entre individualités et collectivités, entre mémoire et renouveau, la rencontre entre religieuses et autochtones se donne à voir. La fabrique de cet espace commun est ici abordée sous l’angle du féminin, par l’intermédiaire des mémoires féminines des missions. Cet ouvrage propose une mise en confrontation de deux cultures en contexte de missions d’évangélisation et ce, à travers les mécanismes de rencontre dans lesquels les constructions culturelles du masculin, du féminin et de la relation entre les sexes ne sont pas étrangères.
    Keywords: D1-2009 ; 20th century ; 19th Century ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DN Biography and non-fiction prose
    Language: French
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  • 46
    Publication Date: 2024-04-05
    Description: The tale of cyclic GMP has been astonishing. Having overcome an initial disbelief, cyclic GMP has risen to its present eminence as a premium cellular signal transduction messenger of not only hormonal extracellular but also of the intracellular signals. This research topic focuses on the pathways and functions of membrane guanylate cyclases in different tissues of the body and their interplay with intracellular sensory signals where in many cases, cyclic GMP along with Ca2+ have taken on roles as synarchic co-messengers.
    Keywords: RC321-571 ; Q1-390 ; Glaucoma ; Visceral Pain ; Calcium ; membrane guanylate cyclase ; ANF-RGC ; Gene Therapy ; Cyclic GMP ; synaptic plasticity ; trafficking ; ROS-GC ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 47
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Microbial communities ; Pollutants ; Environmental risk assessment ; Bioindication ; Biodegradation ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKF Pathology::MKFM Medical microbiology and virology ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical)
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  • 48
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    Presses universitaires de Rennes
    Publication Date: 2022-01-31
    Description: Les compromissions de l'épiscopat avec le régime du maréchal Pétain constituent l'un des faits majeurs du catholicisme français au vingtième siècle. Elles ne sauraient être analysées dans la seule chronologie de l'Occupation, ni sans tenir compte de l'identité longue d'une génération au pouvoir durant trente ans dans l'Église. Celle-ci s'est en effet construite autour d'un évènement-matrice – la Grande Guerre – et d'un acte de naissance – la condamnation de l'Action française voulue par Pie X...
    Keywords: évêque ; Etat ; XXème siècle ; patriotisme ; Église catholique ; France ; Eglise
    Language: French
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  • 49
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    Presses universitaires de Rennes
    Publication Date: 2024-03-25
    Description: Peut-on imaginer une manifestation sans chansons ? Qu'il s'agisse d'entonner à pleins poumons des hymnes au fort pouvoir identifiant, ou de détourner des airs connus… tout rassemblement politique connait son intermède chantant. Cette habitude a son histoire. Depuis les mazarinades et la Révolution française, elle accompagne l'irruption de la foule dans la vie de la cité. Au 19e siècle elle prend cependant une nouvelle ampleur. Sous l'influence de Béranger et de ses nombreux imitateurs, les chansons commentant l'actualité deviennent de plus en plus nombreuses et circulent de plus en plus facilement. Les développements de l'imprimé, des sociabilités, des populations migrantes expliquent ces évolutions. La parole chansonnière, perçue comme une « voix du peuple », devient alors un enjeu politique de première importance. Comment se forme cette culture qui ne tarde pas à revendiquer une certaine autonomie ? Que dit-elle ? Comment se diffuse-t-elle ? Comment les autorités et les élites peuvent-elles essayer de la domestiquer ? Ce livre propose une réflexion sur toutes ces questions. Il permet ainsi de participer au débat sur la politisation des populations dans la France pré-démocratique.
    Keywords: D1-2009 ; musique ; histoire culturelle ; chanson ; musique et politique ; histoire sociale ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DN Biography and non-fiction prose
    Language: French
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  • 50
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Alzheimer's disease ; Neurodegeneration ; Peptides ; cognitive ; model ; Parkinson's disease ; database ; transgenic ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 51
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Sport ; performance ; physiology ; kinesiology ; biomechanics ; health ; exercise ; physical activity ; athletes ; training ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::S Sports and Active outdoor recreation ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKW Sports injuries and medicine
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  • 52
    Publication Date: 2024-04-05
    Description: In the search for simple explanations of the natural world, its complicated textures are often filed down to a smoothened surface of our liking. The impetus for this Research Topic was borne out of a need to re-ignite interest in the complex – in this case in the context of ion channels in the nervous system. Ion channels are the large proteins that form regulated pores in the membranes of cells and, in the brain, are essential for the transfer, processing and storage of information. These pores full of twists and turns themselves are not just barren bridges into cells. More and more we are beginning to understand that ion channels are like bustling medieval bridges (packed with apartments and shops) rather than the more sleek modern variety – they are dynamic hubs connected with many structures facilitating associated activities. Our understanding of these networks continues to expand as our investigative tools advance. Together these articles highlight how the complexity of ion channel signaling nexuses is critical to the proper functioning of the nervous system.
    Keywords: RC321-571 ; Q1-390 ; Nervous System ; Ion Channels ; Interactome ; cellular signaling ; Protein complexes ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 53
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Brainstem monoamine neurons ; locus coeruleus ; emotion ; pain ; morphometry ; amphetamine derivatives ; sleep ; gaze ; trigeminal nerve ; microglia. ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 54
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    Presses universitaires de Rennes
    Publication Date: 2024-04-02
    Description: Cet ouvrage interroge les formes que revêtent les mémoires, le rapport du politique au passé, le rapport de la société avec les experts et les chercheurs. Évoquer la question de la reconstruction d’une société après un épisode traumatique permet de retracer les filiations qui se font ou se défont au prisme de la mémoire et de l’histoire d’un pays. Le sujet principal est ici la guerre de Vendée, mais il aborde aussi d’autres conflits intraétatiques : Saint-Domingue devenue Haïti, l’Algérie, la Nouvelle-Calédonie du xvie siècle à nos jours. Ces contributions comparatives passent par l’archéologie, l’ethnologie, la littérature et l’histoire. Ce volume permet une meilleure compréhension de l’histoire et de la mémoire des guerres civiles telles qu’elles ont été pensées, écrites, reconstruites et transmises par les acteurs, les témoins, les contemporains, les historiens. Les douze textes, ponctués par les conclusions de Jean-Clément Martin, permettent de mieux entrer dans la fabrique des mémoires des guerres civiles d’hier et d’aujourd’hui.
    Keywords: guerre civile ; amnistie ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: French
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  • 55
    Publication Date: 2024-04-05
    Description: Genome-wide association studies (GWAS) for complex disorders with large case-control populations have been performed on hundreds of traits in more than 1200 published studies (http://www.genome.gov/gwastudies/) but the variants detected by GWAS account for little of the heritability of these traits, leading to an increasing interest in using family based designs. While GWAS studies are designed to find common variants with low to moderate attributable risks, family based studies are expected to find rare variants with high attributable risk. Because family-based designs can better control both genetic and environmental background, this study design is robust to heterogeneity and population stratification. Moreover, in family-based analysis, the background genetic variation can be modeled to control the residual variance which could increase the power to identify disease associated rare variants. Analysis of families can also help us gain knowledge about disease transmission and inheritance patterns. Although a family-based design has the advantage of being robust to false positives, novel and powerful methods to analyze families in genetic epidemiology continue to be needed, especially for the interaction between genetic and environmental factors associated with disease. Moreover, with the rapid development of sequencing technology, advances in approaches to the design and analysis of sequencing data in families are also greatly needed. The 11 articles in this book all introduce new methodology and, using family data, substantial new findings are presented in the areas of infectious diseases, diabetes, eye traits, autism spectrum disorder and prostate cancer.
    Keywords: QH426-470 ; Q1-390 ; Regional heritability ; prostate cancer ; infectious diseases ; MCMC ; combining studies screening ; conditional-logistic linkage ; Informatics ; autism ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical)
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  • 56
    Publication Date: 2023-12-21
    Description: It is long known that many cells can shed extracellular vesicles, small membrane-enclosed cell fragments. Although the existence of extracellular vesicles has been recognized for many years, researchers are only beginning to understand their physiologic significance. Several recent studies have demonstrated that extracellular vesicles released from cells serve as a mode of cellular communication. They can carry diverse molecular payload (e.g. nucleic acids, bioactive lipids and proteins) to distal organs and recipient cells. Extracellular vesicles can be classified into three major groups: exosomes, microvesicles, and apoptotic bodies. All these types of extracellular vesicles can be found in a variety of biologic specimen and their numbers, distribution and composition may serve as biomarkers for various disorders, including cardiovascular disease. Although extracellular vesicle-mediated processes are currently best characterized in the fields of cancer biology and neurobiology, evidence is accumulating that extracellular vesicles play a key role in the pathophysiology of diabetes, thrombosis, inflammation and cardiovascular calcification. In this Research Topic, we invited review and methodological articles that advance our understanding of extracellular vesicle-related processes in vascular biology.
    Keywords: R5-920 ; Angiogenesis ; Atherosclerosis ; Extracellular vesicles ; Calcification ; Biomarkers ; Cardiovascular disease ; Inflammation ; Exosomes ; Platelets ; Heart valve ; bic Book Industry Communication::M Medicine
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  • 57
    Publication Date: 2022-01-31
    Description: This eBook presents illustrative examples of genetic chaperonopathies affecting primarily nerves and muscles and discusses molecular mechanisms and treatment targeting chaperones, i.e., chaperonotherapy.
    Keywords: Q1-390 ; small-Hsp ; Hsp60/CCT/BBS ; Indirect/Secondary Chaperonopathies ; Genetic Chaperonopathies ; Hsp40/DnaJ ; chaperonotherapy
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  • 58
    Publication Date: 2024-04-05
    Description: Virus-caused asthma, we now call a phenotype of asthma. Regardless of the significance and popularity of this disease, the etiology of the virus-induced asthma have not well understood. In addition, a few effective vaccines have been applied to prevent respiratory virus infection. To solve the issues, it is essential to clarify and delineate both aspects of the virus and host defense systems including acute/chronic inflammation and airway tissue remodeling. To deeply review and discuss pathophysiology and epidemiology of virus-induced asthma, this topics includes new findings of the host immunity, pathology, epidemiology, and virology of asthma/chronic obstructive pulmonary disease (COPD). We believe that these works are well summarized and informative to glimpse the field of virus- associated asthma and COPD, and may help understanding the basic and clinical aspects of the diseases.
    Keywords: QR1-502 ; QK1-989 ; Q1-390 ; virus-induced asthma ; Pathology ; respiratory virus ; human immunity ; Epidemiology ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical)
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  • 59
    Publication Date: 2023-12-21
    Description: Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is widely used in the treatment of haematological malignancies as a form of immunotherapy acting through a graft-versus-leukemia (GvL) reaction. This curative allogeneic response can be associated with severe drawbacks, such as frequent and severe graft-versus-host disease (GvHD) and a long-lasting immunodeficiency, especially now with the development of innovative strategies such as umbilical cord blood transplantation or transplants from haplo-identical family donors (Haplo-HSCT). In the long-term follow-up of these patients, severe post-transplant infections, relapse or secondary malignancies may be directly related to persistent immune defects.Reconstitution of the different lymphocyte populations (B, T, NK, NKT) and antigen presenting cells of myeloid origin (monocytes, macrophages and dendritic cells) should be considered not only quantitatively but especially qualitatively, in terms of functional subsets. Immune deficiency leading to an increased susceptibility to infections lasts for more than a year. Although infections that occur in the first month mostly result from a deficiency in both granulocytes and mononuclear cells (MNC), later post-engraftment infections are due to a deficiency in MNC subsets, primarily CD4 T-cells and B-cells. T-cell reconstitution has been extensively studied because of the central role of T-cells in mediating both GvHD, evidenced by the reduced incidence of this complication following T-Cell depletion, and a GvL effect as shown by DLI. In the recent years there has been renewed interest in the role of NK-cells, especially in the context of Haplo-HSCT, and in B-cell reconstitution.This Frontiers Research Topic will provide state of the art knowledge of the mechanisms of immune reconstitution in an allogeneic environment, in order to improve monitoring and therapeutic intervention in allo-HSCT patients.
    Keywords: R5-920 ; RC581-607 ; cell therapy ; Immune reconstitution ; Haplo-SCT ; HSCT ; Thymic function ; bic Book Industry Communication::M Medicine
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  • 60
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    Presses universitaires de Rennes
    Publication Date: 2022-01-31
    Description: Fallait-il, à l'occasion du 7e centenaire de sa mort, revenir sur l'existence même d'Yves Hélori ? Les universités de Brest et de Rennes 2 ont préféré s'interroger sur la destinée posthume du saint : qu'est-il devenu pour les générations qui se sont succédé depuis ce 19 mai 1303 où il rendit l'âme dans son manoir de Kermartin ? D'emblée surgissent à l'esprit quantité d'images, issues de l'hagiographie officielle ou de la tradition orale, nées de l'émotion suscitée par telle ou telle œuvre, no...
    Keywords: missions catholiques ; religion chrétienne
    Language: French
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    Publication Date: 2024-04-02
    Description: Au début du siècle dernier, le sultan du Maroc vient de signer un traité qui place désormais son pays sous le protectorat de la France (30 mars 1912). À l’ombre du maréchal Lyautey, un sultan de substitution, totalement soumis aux nouveaux maîtres français, a été proclamé. Cependant, nombreux sont ceux qui, au Maroc, refusent le fait accompli et se révoltent face à la mainmise étrangère sur le pays. Ainsi, dans le Sud marocain, Moulay Ahmed el Hiba, fils d’un marabout ouest-saharien (Ma el Aïnin), se fait proclamer sultan du Jihad en 1912 ; une première fois à Tiznit, la seconde à Marrakech. Ces événements ont donné naissance à un mouvement qui pendant plus de vingt ans (1912-1934) symbolisera pour ces populations berbères et ouest-sahariennes la résistance à l’avancée inéluctable des troupes coloniales françaises et espagnoles. Fondée sur une analyse croisée d’archives inédites, aussi bien françaises que marocaines, l’auteur fait la lumière sur un événement fondateur de la conquête coloniale du Maroc. Mythifiée, récupérée ou occultée, la figure fondatrice du mouvement hibiste est encore aujourd’hui le sujet d’un conflit mémoriel ayant pour objet l’Ouest saharien.
    Keywords: Berbères ; colonialisme ; protectorat ; thema EDItEUR::N History and Archaeology::NH History::NHH African history ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999
    Language: French
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    Frontiers Media SA
    Publication Date: 2024-04-05
    Description: Transfer cells are anatomically specialized cells optimized to support high levels of nutrient transport in plants. These cells trans-differentiate from existing cell types by developing extensive and localized wall ingrowth labyrinths to amplify plasma membrane surface area which in turn supports high densities of membrane transporters. Unsurprisingly, therefore, transfer cells are found at key anatomical sites for nutrient acquisition, distribution and exchange. Transfer cells are involved in delivery of nutrients between generations and in the development of reproductive organs and also facilitate the exchange of nutrients that characterize symbiotic associations. Transfer cells occur across all taxonomic groups in higher plants and also in algae and fungi. Deposition of wall ingrowth-like structures are also seen in “syncytia” and “giant cells” which function as feeding sites for cyst and root-knot nematodes, respectively, following their infection of roots. Consequently, the formation of highly localized wall ingrowth structures in diverse cell types appears to be an ancient anatomical adaption to facilitate enhanced rates of apoplasmic transport of nutrients in plants. In some systems a role for transfer cells in the formation of an anti-pathogen protective barrier at these symplastic discontinuities has been inferred. Remarkably, the extent of cell wall ingrowth development at a particular site can show high plasticity, suggesting that transfer cell differentiation might be a dynamic process adapted to the transport requirements of each physiological condition. Recent studies exploiting different experimental systems to investigate transfer cell biology have identified signaling pathways inducing transfer cell development and genes/gene networks that define transfer cell identity and/or are involved in building the wall ingrowth labyrinths themselves. Further studies have defined the structure and composition of wall ingrowths in different systems, leading in many instances to the conclusion that this process may involve previously uncharacterized mechanisms for localized wall deposition in plants. Since transfer cells play important roles in plant development and productivity, the latter being relevant to crop yield, especially so in major agricultural species such as wheat, barley, soybean and maize, understanding the molecular and cellular events leading to wall ingrowth deposition holds exciting promise to develop new strategies to improve plant performance, a key imperative in addressing global food security. This Research Topic presents a timely and comprehensive treatise on transfer cell biology to help define critical questions for future research and thereby generating a deeper understanding of these fascinating and important cells in plant biology.
    Keywords: QK1-989 ; Q1-390 ; Wall ingrowth ; Arabidopsis thaliana ; synctial cells ; Zea mays ; transfer cells ; endosperm transfer cells ; Giant Cells ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PST Botany and plant sciences
    Language: English
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  • 63
    Publication Date: 2024-04-05
    Description: Research during the past decade highlights the strong link between appetitive feeding behavior, reward and motivation. Interestingly, stress levels can affect feeding behavior by manipulating hypothalamic circuits and brain dopaminergic reward pathways. Indeed, animals and people will increase or decrease their feeding responses when stressed. In many cases acute stress leads to a decrease in food intake, yet chronic social stressors are associated to increases in caloric intake and adiposity. Interestingly, mood disorders and the treatments used to manage these disorders are also associated with changes in appetite and body weight. These data suggest a strong interaction between the systems that regulate feeding and metabolism and those that regulate mood. This Research Topic aims to illustrate how hormonal mechanisms regulate the nexus between feeding behavior and stress. It focuses on the hormonal regulation of hypothalamic circuits and/or brain dopaminergic systems, as the potential sites controlling the converging pathways between feeding behavior and stress.
    Keywords: RC321-571 ; Q1-390 ; stress ; Obesity ; Dopamine ; Ghrelin ; Leptin ; Seasonal regulation ; feeding ; HPA axis ; Hypothalamus ; circadian rhythms ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 64
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    Unknown
    Presses universitaires de Rennes
    Publication Date: 2024-04-05
    Description: Ce livre s’efforce de réparer une injustice : proposer une réflexion d’ensemble sur l’œuvre du philosophe français Mikel Dufrenne (1910-1995) qui semble un peu délaissée voire méconnue aujourd’hui. Si sa démarche phénoménologique héritée de Husserl le conduit immanquablement à s’interroger sur la place singulière que l’objet esthétique occupe dans notre monde, son projet est plus ambitieux. L’attention que Mikel Dufrenne porte aux différents arts (les arts plastiques, la musique, la poésie) ainsi qu’à la richesse des expériences esthétiques vécues, décrites et commentées, lui permet en effet de viser un but supérieur : non seulement redéfinir et réorganiser la phénoménologie autour de la question de l’art, mais faire de l’œuvre ce qui permet de remonter vers un principe originaire, la Nature, qui fonde toute création. Cette tâche singulière et méconnue méritait bien un effort philosophique collectif dont le présent ouvrage est le fruit.
    Keywords: esthétique ; histoire de l'art ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy
    Language: French
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  • 65
    Publication Date: 2024-04-05
    Description: euromodulation is among the fastest-growing areas of medicine, involving many diverse specialties and affecting hundreds of thousands of patients with numerous disorders worldwide. It can briefly be described as the science of how electrical, chemical, and mechanical interventions can modulate the nervous system function. A prominent example of neuromodulation is deep brain stimulation (DBS), an intervention that reflects a fundamental shift in the understanding of neurological and psychiatric diseases: namely as resulting from a dysfunctional activity pattern in a defined neuronal network that can be normalized by targeted stimulation. The application of DBS has grown remarkably and more than 130,000 patients worldwide have obtained a DBS intervention in the past 30 years—most of them for treating movement disorders. This Frontiers Research Topics provides an overview on the current discussion beyond basic research in DBS and other brain stimulation technologies. Researchers from various disciplines, who are working on broader clinical, ethical and social issues related to DBS and related neuromodulation technologies, have contributed to this research topic.
    Keywords: RC321-571 ; Q1-390 ; Informed Consent ; Deep Brain Stimulation ; Depression ; Neurosurgery ; Movement Disorders ; Neuromodulation ; Enhancement ; Neuroethics ; Philosophy ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 66
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    Unknown
    Presses universitaires de Rennes
    Publication Date: 2022-01-31
    Description: Durant les dernières décennies du XXe siècle, la guerre des sexes a continue d’agiter les étendards, l’affirmation de l’identité a agiter les esprits, pour le plus grand profit d’un théâtre hante par le mythe et le social. La question du genre a été très présente dans le théâtre anglophone. Question fondamentale, comme le montre cet ouvrage, qu’il s’agisse d’auteurs déjà considères comme des classiques du théâtre américain (O’Neill, Miller) ou du théâtre britannique (Bond), de régionalistes (...
    Keywords: identité ; genre ; théâtre ; littérature de langue anglaise
    Language: French
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  • 67
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    Unknown
    Presses universitaires de Rennes
    Publication Date: 2024-04-02
    Description: Terre de mélanges culturels et de politiques coloniales, la Tunisie a attiré de l’Europe des courants d’immigrations aussi bien que des visées impérialistes. La trajectoire des Juifs italiens, dits Livournais, s’inscrit au carrefour de ces axes. Une communauté enracinée en Tunisie depuis le xviie siècle, mais toujours assimilée au monde européen. Une population cosmopolite, mais jalousement attachée à Livourne et à l’Italie. Une double minorité, à l’égard tant de la nombreuse population juive locale que des cent mille émigrés italiens vivant en Tunisie au début du xxe siècle, mais toujours caractérisée par une forte identité collective. Pendant l’entre-deux-guerres, la place sociale de cette communauté fut remise en cause par une série de phénomènes convergents : l’essor du nationalisme tunisien, les tensions diplomatiques italo-françaises, et surtout par la montée au pouvoir du régime fasciste, résolu à encadrer les communautés d’émigration dans sa politique impériale. Sur la base de fonds d’archives et de témoignages inédits, ce travail reconstruit le parcours des Juifs italiens de Tunisie face aux stratégies de fascisation de Rome, en interrogeant les croisements identitaires dans les contextes d’émigration, la question de l’adhésion de masse au totalitarisme et le poids des médiateurs au sein des sociétés coloniales.
    Keywords: juifs ; judaïsme ; italien ; fascisme ; émigration et immigration ; colonialisme ; diaspora ; totalitarisme ; antisémitisme ; mémoire ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHH African history
    Language: French
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  • 68
    Publication Date: 2024-03-29
    Description: The integration of multisensory information is an essential mechanism in perception and in controlling actions. Research in multisensory integration is concerned with how the information from the different sensory modalities, such as the senses of vision, hearing, smell, taste, touch, and proprioception, are integrated to a coherent representation of objects. Multisensory integration is central for action control. For instance, when you grasp for a rubber duck, you can see its size and hear the sound it produces. Moreover, identical physical properties of an object can be provided by different senses. You can both see and feel the size of the rubber duck. Even when you grasp for the rubber duck with a tool (e.g. with tongs), the information from the hand, from the effect points of the tool and from the eyes are integrated in a manner to act successfully. Over the recent decade a surge of interest in multisensory integration and action control has been witnessed, especially in connection with the idea that multiple sensory sources are integrated in an optimized way. For this perspective to mature, it will be helpful to delve deeper into the information processing mechanisms and their neural correlates, asking about the range and constraints of this mechanisms, about its localization and involved networks.
    Keywords: BF1-990 ; Q1-390 ; recalibration ; haptic ; Human Information Processing ; Vision ; Perception ; reference frame ; Acoustics ; Tool Use ; bic Book Industry Communication::J Society & social sciences::JM Psychology ; thema EDItEUR::J Society and Social Sciences::JM Psychology
    Language: English
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  • 69
    Publication Date: 2024-03-25
    Description: Faut-il reprendre à son compte des catégories d’État sans en interroger la genèse et la construction, sans dépasser le langage impersonnel et neutralisant du droit, sans en analyser l’efficience et les effets ? Faut-il admettre que les « récidivistes » désignent historiquement un même groupe homogène et véhiculent les mêmes impensés, les mêmes peurs, les mêmes fantasmes depuis plus de deux siècles ? Ou faut-il poser comme point de départ à toute tentative de compréhension des objets « récidive » et « récidivistes » que ce sont des catégories juridiques historiquement situées, des construits politiques qui se sont imposés par la force du droit et qui ont perduré au prix de changements de sens masqués par l’apparente neutralité de la qualification juridique. Tentant d’ouvrir cette seconde voie, cet ouvrage se propose de redonner aux « récidivistes » une dimension historique, d’analyser la consolidation de cette catégorie au XIXe siècle et les raisons et les effets de sa permanence, dont on mesure aujourd’hui encore toute l’actualité. Fruit d’une rencontre de chercheurs issus de différentes disciplines (histoire, socio-histoire, droit, histoire du droit, sociologie), ce livre essaie d’éclairer la question en multipliant et confrontant les points de regard dans la perspective d’embrasser le plus largement un objet tout à la fois juridique, historique, politique et sociologique. C’est au prix (de la poursuite) d’une telle discussion interdisciplinaire que les enjeux liés à la récidive peuvent être mis à jour et par la suite analysés et éclairés.
    Keywords: D1-2009 ; récidiviste ; histoire de la justice ; récidive ; histoire des représentations ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DN Biography and non-fiction prose
    Language: French
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  • 70
    Publication Date: 2024-03-25
    Description: On sait que la Troisième République a assuré renseignement primaire élémentaire pour tous et créé l’enseignement secondaire des jeunes filles. On sait moins qu’à partir de 1880 la France s’est progressivement couverte d’écoles primaires supérieures et de cours complémentaires offrant aux filles et aux garçons des études prolongées au-delà du certificat d’études. Ces « collèges du peuple », pour reprendre une expression d’époque, allaient permettre à des enfants issus de milieux modestes d’accéder à des emplois d’encadrement moyen. Le présent ouvrage étudie cette zone obscure dans le passé de l’institution scolaire. Rompant avec l’explication habituelle de la croissance de la scolarisation en termes de « demande sociale », il montre la contribution de l’institution scolaire à son propre développement : ainsi le succès de renseignement primaire supérieur tient à la fois à ses relations organiques avec renseignement primaire élémentaire et à sa souplesse d’adaptation à des populations aux intérêts variés. Autre découverte : à certaines périodes, les collectivités locales ont été des acteurs décisifs du développement de la scolarisation. Une dernière partie examine les relations entre les débats sur « l’école unique », apparus dès 1900, et les évolutions institutionnelles qui ont abouti à l’unification partielle des filières d’enseignement prolongé. La conclusion propose un schéma d’ensemble pour analyser l’école, qui renouvelle les interrogations sur l’école développées par les sciences sociales depuis trente ans.
    Keywords: D1-2009 ; enseignement ; politiques publiques ; éducation ; histoire de France ; mixité sociale ; histoire de l'éducation ; école ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DN Biography and non-fiction prose
    Language: French
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  • 71
    Publication Date: 2024-04-05
    Description: Volume I, entitled “Augmentation of Brain Functions: Brain-Machine Interfaces”, is a collection of articles on neuroprosthetic technologies that utilize brain-machine interfaces (BMIs). BMIs strive to augment the brain by linking neural activity, recorded invasively or noninvasively, to external devices, such as arm prostheses, exoskeletons that enable bipedal walking, means of communication and technologies that augment attention. In addition to many practical applications, BMIs provide useful research tools for basic science. Several articles cover challenges and controversies in this rapidly developing field, such as ways to improve information transfer rate. BMIs can be applied to the awake state of the brain and to the sleep state, as well. BMIs can augment action planning and decision making. Importantly, BMI operations evoke brain plasticity, which can have long-lasting effects. Advanced neural decoding algorithms that utilize optimal feedback controllers are key to the BMI performance. BMI approach can be combined with the other augmentation methods; such systems are called hybrid BMIs. Overall, it appears that BMI will lead to many powerful and practical brain-augmenting technologies in the future.
    Keywords: RC321-571 ; Q1-390 ; microcircuits ; Brain machine interface (BMI) ; nootropics ; tDCStranscranial direct current stimulation ; neural networks ; neuroprosthesis ; TMS ; implants ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 72
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    Unknown
    Presses universitaires de Rennes
    Publication Date: 2022-01-31
    Description: De 1459 à 1461, la ville d'Arras en Artois fut le théâtre d'une violente persécution dirigée contre des hommes et des femmes que l'inquisiteur du diocèse accusait de se rendre à la « vauderie », c'est-à-dire au sabbat des sorciers. Trente ans plus tard, la mémoire des victimes fut réhabilitée par le Parlement de Paris. Plus connu sous le nom de Vauderie d'Arras, ce célèbre procès en sorcellerie du XVe siècle a longtemps fait figure d'anomalie dans le cadre historique de la grande chasse aux s...
    Keywords: persécutions ; pouvoir ; sorcellerie ; répression ; procès ; histoire de France ; Vaudois (mouvement)
    Language: French
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  • 73
    Publication Date: 2023-12-21
    Description: Gamma/delta (γδ) T-cells are a small subset of T-lymphocytes in the peripheral circulation but constitute a major T-cell population at other anatomical localizations such as the epithelial tissues. In contrast to conventional a/ß T-cells, the available number of germline genes coding for T-cell receptor (TCR) variable elements of γδ T-cells is very small. Moreover, there is a prefential localization of γδ T-cells expressing given Vgamma and Vdelta genes in certain tissues. In humans, γδ T-cells expressing the Vg9Vd2-encoded TCR account for anywhere between 50 and 〉95% of peripheral blood γδ T-cells, whereas cells expressing non-Vd2 genes dominate in mucosal tissues. In mice, there is an ordered appearance of γδ T-cell „waves“ during embryonic development, resulting in preferential localization of γδ T-cells expressing distinct VgammaVdelta genes in the skin, the reproductive organs, or gut epithelia. The major function of γδ T-cells resides in local immunosurveillance and immune defense against infection and malignancy. This is supported by the identification of ligands that are selectively recognized by the γδ TCR. As an example, human Vgamma9Vdelta2 T-cells recognize phosphorylated metabolites („phosphoantigens“) that are secreted by many pathogens but can also be overproduced by tumor cells, providing a basis for a role of these γδ T-cells in both anti-infective and anti-tumor immunity. Similarly, the recognition of endothelial protein C receptor by human non-Vdelta2 γδ T-cells has recently been identified to provide a link for the role for such γδ T-cells in immunity against epithelial tumor cells and cytomegalovirus-infected endothelial cells. In addition to „classical“ functions such as cytokine production and cytotoxicity, recent studies suggest that subsets of γδ T-cells can exert additional functions such as regulatory activity and – quite surpisingly – „professional“ antigen-presenting capacity. It is currently not well known how this tremendous extent of functional plasticity is regulated and what is the extent of γδ TCR ligand diversity. Due to their non-MHC-restricted recognition of unusual stress-associated ligands, γδ T-cells have raised great interest as to their potential translational application in cell-based immunotherapy. Topics of this Research Focus include: Molecular insights into the activation and differentiation requirements of γδ T-cells, role of pyrophosphates and butyrophilin molecules for the activation of human γδ T-cells, role of γδ T-cells in tumor immunity and in other infectious and non-infectious diseases, and many others. We are most grateful to all colleagues who agreed to write a manuscript. Thanks to their contributions, this E-book presents an up-to-date overview on many facets of the still exciting γδ T-cells.
    Keywords: R5-920 ; RC581-607 ; Infection ; Butyrophilin 3A1 ; Tumor-infiltrating lymphocytes ; cancer immunotherapy ; IL-17 ; Pyrophosphates ; bic Book Industry Communication::M Medicine
    Language: English
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  • 74
    Publication Date: 2024-04-05
    Description: Photosystem II is a 700-kDa membrane-protein super-complex responsible for the light-driven splitting of water in oxygenic photosynthesis. The photosystem is comprised of two 350-kDa complexes each made of 20 different polypeptides and over 80 co-factors. While there have been major advances in understanding the mature structure of this photosystem many key protein factors involved in the assembly of the complex do not appear in the holoenzyme. The mechanism for assembling this super-complex is a very active area of research with newly discovered assembly factors and subcomplexes requiring characterization. Additionally the ability to split water is inseparable from light-induced photodamage that arises from radicals and reactive O2 species generated by Photosystem II chemistry. Consequently, to sustain water splitting, a “self repair” cycle has evolved whereby damaged protein is removed and replaced so as to extend the working life of the complex. Understanding how the biogenesis and repair processes are coordinated is among several important questions that remain to be answered. Other questions include: how and when are the inorganic cofactors inserted during the assembly and repair processes and how are the subcomplexes protected from photodamage during assembly? Evidence has also been obtained for Photosystem II biogenesis centers in cyanobacteria but do these also exist in plants? Do the molecular mechanisms associated with Photosystem II assembly shed fresh light on the assembly of other major energy-transducing complexes such as Photosystem I or the cytochrome b6/f complex or indeed other respiratory complexes? The contributions to this Frontiers in Plant Science Research Topic are likely to reveal new details applicable to the assembly of a range of membrane-protein complexes, including aspects of self-assembly and solar energy conversion that may be applied to artificial photosynthetic systems. In addition, a deeper understanding of Photosystem II assembly — particularly in response to changing environmental conditions — will provide new knowledge underpinning photosynthetic yields which may contribute to improved food production and long-term food security.
    Keywords: QK1-989 ; Q1-390 ; Arabidopsis thaliana ; photoactivation ; photosynthesis ; Chlamydomonas reinhardtii ; cyanobacteria ; biogenesis ; Photosystem II ; photodamage ; Nicotiana tabacum ; Synechocystis sp. PCC 6803 ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PST Botany and plant sciences
    Language: English
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  • 75
    Publication Date: 2024-04-05
    Description: Big data is revolutionizing our ability to measure and study the human brain. New technology increases the resolution of images that are being study as well as enables researchers to study the brain as it functions. These technological advances are combined with efforts to collect neuroimaging data on large numbers of subjects, in some cases longitudinally. This combination of advances in measurement and scope of studies requires novel development in the statistical analysis. Fast, scalable, robust and accurate models and approaches need to be developed to make headway on these problems. This volume represents a unique collection of researchers providing deep insights on the statistical analysis of big neuroimaging data.
    Keywords: RC321-571 ; Q1-390 ; fMRI ; Neuroscience ; functional connectivity ; EEG ; Classification ; prediction ; big data ; MEG ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 76
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    Presses universitaires de Rennes
    Publication Date: 2024-03-25
    Description: En 1954, Djibo Bakary, un activiste nationaliste de gauche nigérien fonda l’Union Démocratique Nigérienne (UDN), un parti politique qui visait non seulement à combattre la domination coloniale, mais aussi à réaliser une transformation large de la société nigérienne. Le parti fut salué par le cri de ralliement « Sawaba », un terme haoussa qui indique le soulagement par rapport à l’adversité et un retour au calme et à la sérénité soulignant l’aspiration des Nigériens à être délivrés de la pauvreté et de l’oppression coloniale sous toutes ses formes. Le Sawaba, dont le noyau était constitué d’un « petit peuple » de ruraux ayant migré en ville, remporta les premières élections générales au suffrage universel du Niger en 1957 et forma le tout premier gouvernement autonome du pays, sous suzeraineté française. En 1958, le mouvement eut maille à partir avec le pouvoir gaulliste de France préférant l’indépendance immédiate à une nouvelle forme d’autonomie et appelant à rejeter la constitution de la Ve République. Les Français, compte tenu la situation stratégique du Niger, réagirent de manière implacable. En violation flagrante de la constitution, un nouveau gouverneur émascula le gouvernement Bakary. La campagne du Sawaba fut contrecarrée. Le parti, interdit, devint une organisation militaire menant la guérilla. Cependant, la guérilla du Sawaba (1960-1966), soutenue par des régimes gauchistes étrangers, aboutit à un échec entraînant la destruction définitive du mouvement. Le récit des luttes du Sawaba n’est pas dénué d’ambigüité, ce qui renvoie au caractère hybride du mouvement et aux métamorphoses vécues au long de son existence. Les sawabistes se montrèrent un mélange singulier d’activistes politiques et de combattants qui, au lieu de faire violence à la population, s’engagèrent dans la bataille comme les agitateurs de rue qu’ils furent jadis – certes armés, mais avec l’espoir de plaire à l’électeur et d’entraîner une fin instantanée aux souffrances du peuple. Millénariste plutôt que militariste, cette mentalité donne la clef de la tragédie de leur défaite.
    Keywords: D1-2009 ; 20th century ; Africa ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DN Biography and non-fiction prose
    Language: French
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  • 77
    Publication Date: 2024-04-11
    Description: The specialty section Earthquake Engineering is one branch of Frontiers in Built Environment and welcomes critical and in-depth submissions on earthquake ground motions and their effects on buildings and infrastructures. Manuscripts should yield new insights and ultimately contribute to a safer and more reliable design of building structures and infrastructures. The scope includes the characterization of earthquake ground motions (e.g. near-fault, far-fault, short-period, long-period), their underlying properties, their intrinsic relationship with structural responses, and the true behaviors of building structures and infrastructures under risky and uncertain ground motions. More specific topics include recorded ground motions, generated ground motions, response spectra, stochastic modeling of ground motion, critical excitation, geotechnical aspects, soil mechanics, soil liquefaction, soil-structure interactions, pile foundations, earthquake input energy, structural control, passive control, active control, base-isolation, steel structures, reinforced concrete structures, wood structures, building retrofit, structural optimization, uncertainty analysis, robustness analysis, and redundancy analysis. This eBook includes four original research papers, in addition to the Specialty Grand Challenge article, on the critical earthquake response of elastic-plastic structures under near-fault or long-duration ground motions which were published in the specialty section Earthquake Engineering. In the early stage of dynamic nonlinear response analysis of structures around 1960s, a simple hysteretic structural model and a simple sinusoidal earthquake ground motion input were dealt with together with random inputs. The steady-state response was tackled by an equivalent linearization method developed by Caughey, Iwan and others. In fact, the resonance plays a key role in the earthquake-resistant design and it has a strong effect even in case of near-fault ground motions. In order to draw the steady-state response curve and investigate the resonant property, two kinds of repetition have to be introduced. One is a cycle, for one forced input frequency, of the initial guess of the steady-state response amplitude, the construction of the equivalent linear model, the analysis of the steady-state response amplitude using the equivalent linear model and the update of the equivalent linear model based on the computed steady-state response amplitude. The other is the sweeping over a range of forced input frequencies. This process is quite tedious. Four original research papers included in this eBook propose a new approach to overcome this difficulty. Kojima and Takewaki demonstrated that the elastic-plastic response as continuation of free-vibrations under impulse input can be derived in a closed form by a sophisticated energy approach without solving directly the equations of motion as differential equations. While, as pointed out above, the approach based on the equivalent linearization method requires the repetition of application of the linearized equations, the method by Kojima and Takewaki does not need any repetition. The double impulse, triple impulse and multiple impulses enable us to describe directly the critical timing of impulses (resonant frequency) which is not easy for the sinusoidal and other inputs without a repetitive procedure. It is important to note that, while most of the previous methods employ the equivalent linearization of the structural model with the input unchanged, the method treated in this eBook transforms the input into a series of impulses with the structural model unchanged. This characteristic guarantees high accuracy and reliability even in the large plastic deformation range. The approach presented in this eBook is an epoch-making accomplishment to open the door for simpler and deeper understanding of structural reliability of built environments in the elastic-plastic range.
    Keywords: TA1-2040 ; fling-step input ; Critical response ; Long-duration ground motion ; double impulse ; forward-directivity input ; triple impulse ; robustness ; Near-fault ground motion ; Ground motion ; Ductility factor ; uncertainty ; resonance ; Structural parameter ; Earthquake Response ; Elastic-plastic response ; Interval analysis ; Multiple impulse ; Earthquake input energy ; redundancy ; Upper bound of input energy ; earthquake engineering ; critical excitation method ; Energy transfer function ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: English
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  • 78
    Publication Date: 2024-03-29
    Description: A conversation between two people can only take place if the words intended by each speaker are successfully recognized. Spoken word recognition is at the heart of language comprehension. This automatic and smooth process remains a challenge for models of spoken word recognition. Both the process of mapping the speech signal onto stored representations for words, and the format of the representation themselves are subject to debate. So far, existing research on the nature of spoken word representations has focused mainly on native speakers. The picture becomes even more complex when looking at spoken word recognition in a second language. Given that most of the world’s speakers know and use more than one language, it is crucial to reach a more precise understanding of how bilingual and multilingual individuals encode spoken words in the mental lexicon, and why spoken word recognition is more difficult in a second language than in the native language. Current models of native spoken word recognition operate under two assumptions: (i) that listeners’ perception of the incoming speech signal is optimal; and (ii) that listeners’ lexical representations are accurate. As a result, lexical representations are easily activated, and intended words are successfully recognized. However, these assumptions are compromised when applied to a later-learned second language. For a variety of reasons (e.g., phonetic/phonological, orthographic), second language users may not perceive the speech signal optimally, and they may still be refining the motor routines needed for articulation. Accordingly, their lexical representations may differ from those of native speakers, which may in turn inhibit their selection of the intended word forms. Second language users also have to solve a larger selection challenge—having words in more than one language to choose from. Thus, for second language users, the links between perception, lexical representations, orthography, and production are all but clear. Even for simultaneous bilinguals, important questions remain about the specificity and interdependence of their lexical representations and the factors influencing cross-language word activation. This Frontiers Research Topic seeks to further our understanding of the factors that determine how multilinguals recognize and encode spoken words in the mental lexicon, with a focus on the mapping between the input and lexical representations, and on the quality of lexical representations.
    Keywords: BF1-990 ; Q1-390 ; Phonological knowledge ; Second-language speech ; bilingual and bidialectal lexicon ; spoken word recognition ; lexical access ; orthographic knowledge ; bic Book Industry Communication::J Society & social sciences::JM Psychology ; thema EDItEUR::J Society and Social Sciences::JM Psychology
    Language: English
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  • 79
    Publication Date: 2024-03-31
    Description: This forum of comprehensive reviews and research studies on distinct aspects of the pathophysiology of BAV aortopathy provides both the state of the art in the knowledge on this complex disease and novel insights into its causes and consequences. The present collection of focused papers also envisions and proposes new therapeutic strategies, novel biomarkers and original risk stratification criteria, for the improvement of patient management.
    Keywords: QP1-981 ; Q1-390 ; smooth muscle cells ; microRNAs ; aortic root ; endothelial cells ; aortic surgery ; bicuspid aortic valve ; 4DFlow analysis ; aortopathy ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology
    Language: English
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  • 80
    Publication Date: 2024-03-29
    Description: This research topic stems from the "Interdisciplinary Approaches to Multilingualism" conference, which was hosted by the Language Research Centre at the University of Calgary. It was the first conference of its kind, which brought together the work of researchers, educators, and policy makers in the areas of first and second language acquisition from psycholinguistic and pedagogical perspectives. The goal was to provide an opportunity for participants to engage with the implications of multilingualism from a range of perspectives, including the effects of being bilingual from infancy to adulthood, the process and benefits of learning multiple languages, and the impact of multilingualism on society.
    Keywords: BF1-990 ; Q1-390 ; Developmental psycholinguistics ; second language literacy development ; Multilingualism ; psycholinguistic research methods ; Second language pedagogy ; bilingualism ; Second Language Acquisition ; bic Book Industry Communication::J Society & social sciences::JM Psychology ; thema EDItEUR::J Society and Social Sciences::JM Psychology
    Language: English
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  • 81
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    Presses universitaires de Rennes
    Publication Date: 2022-01-31
    Description: L'Europe est une affaire de construction politique et institutionnelle. C'est aussi affaire de médias et de médiatisation. Le présent ouvrage mène le lecteur dans les lieux où se fabrique l'Europe en tant qu'elle est (aussi) un enjeu de communication.
    Keywords: relations internationales ; Pays de l'Union européenne ; droit national ; politique culturelle ; communautés européennes ; droit européen ; communication
    Language: French
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  • 82
    Publication Date: 2024-04-05
    Description: In the last decade, sleep spindles have attracted steadily increasing attention. This interest is motivated by the many intriguing relationships between spindles and various diseases (e.g., schizophrenia, Parkinson, Alzheimer, autism, mental retardation), recovery processes (e.g., post brain stroke), and cognitive faculties (e.g., memory consolidation, intelligence, dream recall, sleep preservation). Nonetheless, a methodological wall has impeded the study of sleep spindles. Their investigation rests heavily on our ability to reliably and consistently identify spindle patterns from background EEG activity, a task involving many obstacles, including: a fuzzy definition of spindles, low inter-expert agreement on their scoring, lack of consensus on standard techniques for their automated detection, low reproducibility of observed characteristics and correlates, unavailability of large, standardized, high-quality databases, and inconsistencies in the methods used to evaluate the performance of automated detectors. The primary aims of this research topic were to bring together world-class researchers on a project designed to facilitate exchanges on methodological difficulties encountered in assessing sleep spindles and to promote standardized spindle-related resources. In preparing their contributions, authors were encouraged to use existing – or to propose new – publicly available resources for assessing sleep spindles. To allow fair and accurate comparison of reported results, the authors were also encouraged to validate their tools on a common benchmark. A database containing expert spindle scoring (i.e., the Montreal Archive of Sleep Studies) was made publicly available for that purpose.
    Keywords: RC321-571 ; Q1-390 ; Neural oscillations ; Electroencephalography (EEG) ; Sleep ; Sleep Spindles ; Memory ; IQ ; sigma waves ; automatic detection ; biomarker ; Open access ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 83
    Publication Date: 2024-03-25
    Description: Les pérégrinations des moines de Saint-Philibert depuis Noirmoutier jusqu’à Tournus sont souvent citées en exemple pour caractériser l’exode devant les incursions normandes au IXe siècle. La confrontation avec l’itinéraire d’autres groupes monastiques témoigne cependant de l’originalité de cette congrégation qui ne rejoint pas son établissement d’origine. En utilisant les données fournies par les sources diplomatiques, narratives et archéologiques, l’auteur définit les modalités de cet exode et ses implications sur la structure du monastère. Son rôle actif dans la réforme monastique carolingienne lui confère une place privilégiée sur la scène politique. Placé sous la protection royale, il est aussi soutenu par un groupe de la haute aristocratie, cerné grâce à une enquête prosopographique. Ce réseau de relations comme l’évolution de la politique territoriale de Charles le Chauve ont en partie déterminé l’itinéraire des moines et l’expansion du domaine monastique. Leur installation définitive à Tournus s’accompagne d’une réorganisation de l’ensemble de leur patrimoine. Il devient alors possible de s’interroger sur l’existence d’un réseau monastique précoce dont la structure reste ensuite liée aux particularismes de cette histoire mouvementée.
    Keywords: D1-2009 ; ordres monastiques ; monastère ; pèlerins ; vie monastique ; christianisme ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DN Biography and non-fiction prose
    Language: French
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  • 84
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    Presses universitaires de Rennes
    Publication Date: 2024-03-23
    Description: Excellant à représenter les passions nobles, Rembrandt est qualifié d’artiste du sublime par ses contemporains. Or, depuis que la Renaissance a redécouvert le traité de Longin, le sublime – ou l’art qui dépasse l’art – est l’objet de débats dans les cercles artistiques et religieux. Embrassant l’ensemble de l’œuvre gravé de l’artiste, ce livre fait dialoguer philosophie et histoire de l’art. Il soutient l’idée selon laquelle, même s’il n’est pas théoricien, Rembrandt contribue à renouveler la tradition d’interprétation du sublime. Le principe méthodologique consiste à dégager la pensée de l’artiste. Confronter la pratique du graveur à son iconographie religieuse, inédite dans un pays calviniste, aide à analyser la cohérence de cette pensée. Rembrandt renonce au modèle préalable du dessin pour s’immerger dans le sensible. Or son Christ est proche du Christ de la kénose tel qu’il est présenté par Paul dans ses épîtres : il s’incarne en se vidant de sa puissance. La contradiction entre l’humble et le sublime est au cœur de la pensée de Rembrandt, et on peut y voir un enjeu politique : figures de l’invisible social, ses mendiants évoquent la grandeur de l’homme.
    Keywords: esthétique ; histoire de l'art ; thema EDItEUR::A The Arts::AG The Arts: treatments and subjects::AGA History of art ; thema EDItEUR::A The Arts::AF The Arts: art forms::AFF Drawing and drawings ; thema EDItEUR::A The Arts::AG The Arts: treatments and subjects::AGB Individual artists, art monographs
    Language: French
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  • 85
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    Frontiers Media SA
    Publication Date: 2024-03-31
    Description: Energy metabolism is central to life and altered energy expenditure (EE) is often cited as a central mechanism responsible for development of the obese phenotype. Resting EE, EE of physical activity, cold induced thermogenesis and thermic effect of feeding add to produce total EE but can also affect each other. It is thus very important that each component be well measured. Measuring energy expenditure by indirect calorimetry is extremely simple in theory but the practice if far more difficult. Taking into account temperature in small sized animals, measuring accurately the effect of activity on EE, correcting EE for body size body composition, age sex etc… add difficulties in producing reliable data. The goal of this Research Topic was to call for the practical experience of main investigators trained to practice calorimetry in order to get their feedback and the way they deal with the various and specific problems of humans and animal calorimetry. The goal is to share the questions/solutions experienced by the contributors to inititate a “guide of the good practices” that can be periodically updated and used by all those who are and will be interested in measuring energy metabolism from the 20g mouse to the human and large farm animals.
    Keywords: QP1-981 ; Q1-390 ; Body Composition ; Thermogenesis ; brown adipose tissue ; Body Size ; Energy Expenditure ; indirect calorimetry ; physical activity ; metabolic Phenotyping ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology
    Language: English
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  • 86
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: biotechnology ; abiotic stress ; crop management ; oil quality ; table olive ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PST Botany and plant sciences
    Language: English
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  • 87
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    Presses universitaires de Rennes
    Publication Date: 2024-03-25
    Description: À l’issue de la brève guerre franco-italienne, treize communes savoyardes (Séez, Sainte-Foy-Tarentaise, Montvalezan, Bessans, Bramans, Lanslebourg, Lanslevillard, Sollières, Termignon), dauphinoises (Montgenèvre, Ristolas) et azuréennes (Fontan, Menton) furent occupées par les troupes du Regio Esercito à la fin juin 1940 et pratiquement annexées durant trois années, en vertu de l’application du « Bando Mussolini ». En réaction au débarquement allié en Afrique du Nord, la 4e armée occupa onze départements du Sud-Est (Alpes-Maritimes, Basses-Alpes, Hautes-Alpes, Isère, Savoie, Haute-Savoie, Var, Drôme en totalité, Bouches-du-Rhône, Vaucluse, Ain en partie) tandis que le VIIe corps d’armée débarquait en Corse, à partir du 11 novembre 1942. Quatre millions de Français furent donc occupés par deux cent mille soldats italiens, mais aussi par des Chemises noires et des policiers de l’OVRA. Cette présence étrangère suscita de multiples incidents, notamment dans les départements savoyards, la région niçoise et en Corse, où les prétentions irrédentistes étaient mal supportées. La répression ne fut pas si légère que l’on eut coutume de l’affirmer (une dizaine d’exécutés, une trentaine de morts sous la torture ou au combat, ouverture de camps de concentration à Sospel, Embrun et Modane, déportation de plusieurs centaines de résistants ou de personnalités jugées hostiles dans les pénitenciers de Ligurie, du Piémont, de l’île d’Elbe ou de Calabre). L’Occupant fut confronté à des questions incontournables en 1943 (la fortification du littoral, le STO, l’émergence des maquis, l’attitude à adopter vis-à-vis d’une importante communauté juive) tout en puisant largement dans les ressources économiques et les dépôts militaires. Au moment de la capitulation transalpine du 8 septembre 1943, quelques affrontements opposèrent les troupes italiennes à leurs anciens alliés à Chambéry, Grenoble, Gap et, surtout, en Corse où elles perdirent plusieurs centaines d’hommes.
    Keywords: D1-2009 ; Occupation ; Libération ; Deuxième Guerre mondiale ; fascisme ; relations franco-italiennes ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DN Biography and non-fiction prose
    Language: French
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  • 88
    Publication Date: 2023-12-21
    Description: Aflatoxins are a group of polyketide mycotoxins that are produced mainly by members of the genus Aspergillus. Production of these toxic secondary metabolites is closely related to fungal development (Keller et al., 2005; Jamali et al., 2012). Contamination of food, feed and agricultural commodities by aflatoxins poses enormous economic and serious health concerns because these chemicals are highly carcinogenic and can directly influence the structure of DNA. The resulting genetic defects can lead to fetal misdevelopment and miscarriages; aflatoxins are also known to suppress immune systems (Razzaghi-Abyaneh et al., 2013). In a global context, aflatoxin contamination is a constant concern between the 35N and 35S latitude where developing countries are mainly situated. With expanding boundaries of developing countries, aflatoxin contamination has become a persistent problem to those emerging areas (Shams-Ghahfarokhi et al., 2013). The continuing threat by aflatoxin contamination of food, feed and agricultural commodities to the world population has made aflatoxin research one of the most exciting and rapidly developing study areas of microbial toxins. The present research topic includes six review articles, three mini reviews and four original research articles. Contributors highlight current global health issues arising from aflatoxins and aflatoxigenic fungi and cover important aspects of aflatoxin research including contamination of crops, epidemiology, molecular biology and management strategies. Special attention is given to fungus-plant host interactions, biodiversity and biocontrol, sexual recombination in aflatoxigenic aspergilli, potential biomarkers for aflatoxin exposure in humans and safe storage programs.
    Keywords: R5-920 ; QR1-502 ; Q1-390 ; TX341-641 ; genetic diversity ; Public Health ; Aspergillus flavus ; Genomics ; MicroRNAs ; Fungus host interactions ; biological control ; aflatoxin ; agricultural crops ; bic Book Industry Communication::M Medicine
    Language: English
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  • 89
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: mass spectometry ; MALDI-TOF ; susceptibility testing ; carbapenamase ; resistance detection ; MRSA - Methicillin-resistant Staphylococcus aureus ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKF Pathology::MKFM Medical microbiology and virology ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical)
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  • 90
    Publication Date: 2024-04-05
    Description: Helicases are the proteins that bind to double- or single-stranded DNA and/or RNA chains to unwind higher order structures, usually consuming energy from the hydrolysis of ATP molecules. The biological roles of helicases are associated with a variety of DNA and/or RNA metabolisms, including DNA-replication, -repair, -recombination, RNA processing, and transcription. Dysfunctions of helicases cause various diseases, such as xeroderma pigmentosum (XP), premature aging syndrome, cancer and immunodeficiency, in humans. Moreover, recent genetic analyses revealed that mutations in helicase-encoding genes are frequently found in patients of specific diseases. Some helicases regulate cellular senescence by controlling integrity of genomes, and others play a role in neuromuscular functions presumably by modulating processing of mRNAs. However, the molecular mechanisms of how helicases are regulated in order to maintain our health are not yet fully understood. In this research topic, we will focus on the expression and functions of helicases and their encoding genes, reviewing recent research progresses that provide new insights into development of clinical and pharmaceutical treatments targeting helicases.
    Keywords: QH426-470 ; Q1-390 ; DNA Repair ; Aging ; helicases ; Telomere ; Cancer ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical)
    Language: English
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  • 91
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    Frontiers Media SA
    Publication Date: 2023-12-21
    Description: Epigenetics is the study of changes in gene activity that are heritable but not caused by changes in the DNA sequence. By modulating gene activities, epigenetic changes regulate cell functions. They include DNA methylation, histone posttranslational modifications and gene silencing by the action of non-coding RNAs, particularly microRNAs. It is now clear that epigenetic changes regulate B cell development. By acting in concert with networks of transcription factors, they modulate the activation of B cell lineage specific gene programs and repress inappropriate gene transcription in particular B cell differentiation states. A hallmark of B cell development in the bone marrow is the assembly of the B cell receptor (BCR) for antigen through rearrangement of immunoglobulin heavy (IgH) and light (IgL) chain V(D)J genes, as mediated by RAG1/RAG2 recombinases. Ig V(D)J rearrangement critically times the progression from pro-B cell to pre-B cell and, finally, mature B cell. Such progression is modulated by epigenetic marks, such as DNA methylation and histone posttranslational modifications, that increase chromatin accessibility and target RAG/RAG2 to V, D and J DNA. It is also dependent on the expression of multiple microRNAs. Mice deficient in Ago2, which is essential for microRNA biogenesis and function, have B cell development blocked at the pro-B cell stage. In agreement with this, B cell specific ablation of microRNA by B cell-specific knockout of Dicer virtually blocks B cell differentiation at the pro-B to pre-B cell transition. After mature B cells encounter antigen, changes of the epigenetic landscape are induced by the same stimuli that drive the antibody response; such epigenetic changes underpin the maturation of the antibody response itself. They instruct those B cell differentiation processes, somatic hypermutation (SHM), class switch DNA recombination (CSR) and plasma cell differentiation, that are central to the maturation of the antibody response as well as differentiation of memory B cells. Inducible histone modifications, together with DNA methylation and microRNAs modulate the transcriptome, particularly the expression of activation-induced cytidine deaminase (AID), central to SHM and CSR, and B lymphocyte-induced maturation protein-1 (Blimp-1), which is central to plasma cell differentiation. Combinatorial histone modifications also function as histone codes in the targeting of the CSR and, possibly, the SHM machinery to the Ig locus by recruiting specific adaptors (histone code readers) that can in turn target and/or stabilize CSR/SHM factors. Epigenetic alterations in memory B cells contribute to their functionally distinction from their naive counterparts. Memory B cells inherit epigenetic information from their precursors and acquire new epigenetic marks, which make these resting B cells poised to promptly respond to antigen. The cross/feedback regulation of different epigenetic modifications/elements further increases the complexity of the B cell epigenome, which interacts with the genetic information for precise modulation of gene expression. It is increasingly evident that epigenetic dysregulation in B cells, including aberrant expression of microRNAs, can result in aberrant antibody responses to microbial pathogens, emergence of pathogenic autoantibodies or B cell neoplastic transformation. Epigenetic marks are potential targets for new therapeutics in autoimmunity and B cell malignancy.
    Keywords: R5-920 ; RC581-607 ; BLIMP-1 ; CSR ; immunoglobulin ; memory B cell ; Plasma cell ; V(D)J Recombination ; microRNA ; SHM ; AID ; epigenetics ; bic Book Industry Communication::M Medicine
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  • 92
    Publication Date: 2024-03-29
    Description: The visual system consists of hierarchically organized distinct anatomical areas functionally specialized for processing different aspects of a visual object (Felleman & Van Essen, 1991). These visual areas are interconnected through ascending feedforward projections, descending feedback projections, and projections from neural structures at the same hierarchical level (Lamme et al., 1998). Accumulating evidence from anatomical, functional and theoretical studies suggests that these three projections play fundamentally different roles in perception. However, their distinct functional roles in visual processing are still subject to debate (Lamme & Roelfsema, 2000). The focus of this Research Topic is the roles of feedforward and feedback projections in vision. Even though the notions of feedforward, feedback, and reentrant processing are widely accepted, it has been found difficult to distinguish their individual roles on the basis of a single criterion. We welcome empirical contributions, theoretical contributions and reviews that fit into any one (or a combination) of the following domains: 1) their functional roles for perception of specific features of a visual object 2) their contributions to the distinct modes of visual processing (e.g., pre-attentive vs. attentive, conscious vs. unconscious) 3) recent techniques/methodologies to identify distinct functional roles of feedforward and feedback projections and corresponding neural signatures. We believe that the current Research Topic will not only provide recent information about feedforward/feedback processes in vision but also contribute to the understanding fundamental principles of cortical processing in general.
    Keywords: BF1-990 ; Q1-390 ; projections ; processes ; Feedback ; Vision ; feedforward ; Visual System ; mechanisms ; bic Book Industry Communication::J Society & social sciences::JM Psychology ; thema EDItEUR::J Society and Social Sciences::JM Psychology
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  • 93
    Publication Date: 2023-12-21
    Description: Excessive alcohol drinking represents a major social and public health problem for several countries. Alcohol abuse during pregnancy leads to a complex syndrome referred to as fetal alcohol spectrum disorders (FASD), chiefly characterized by mental retardation. The effects of early exposure to ethanol can be reproduced in laboratory animals and this helped to answer several key questions concerning the human pathology. The interest of experimental models of FASD is twofold. First, they increase our knowledge about the dose and modality of alcohol consumption able to induce damaging effects on the developing brain. Second, experimental models of FASD can provide useful hints to elucidate the basic mechanisms leading to the intellectual disability. In fact, experimental exposure to alcohol can be carried out during discrete, often very restricted, time windows. As a consequence, FASD models, though depending on the multifaceted interference of alcohol with several molecular pathways, can provide valuable information about which specific developmental periods and brain areas are critically involved in the genesis of mental retardation. Putting together data obtained through several experimental paradigms of alcohol exposure and those deriving from other genetic and non-genetic models, one can figure out to what extent different types of mental retardation share common pathogenetic mechanisms. The present Research Topic is aimed at establishing the state of the art of the current research on experimental FASD, focusing on differences and homologies with other types of intellectual disability. The ultimate goal is to find out a common roadmap in view of future therapeutical approaches.
    Keywords: R5-920 ; RC435-571 ; RJ1-570 ; glial cells ; development ; Amygdala ; Fetal Alcohol Spectrum Disorders ; Cerebral Cortex ; Intellectual Disability ; epigenetics ; Apoptosis ; bic Book Industry Communication::M Medicine
    Language: English
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  • 94
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Leishmaniasis ; immunobiology ; pathogenesis ; immunity ; virulence factors ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCJ Infectious and contagious diseases
    Language: English
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  • 95
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Particle-stabilised droplets ; foams ; fluid interfaces ; Pickering emulsions ; liquid marbles ; adsorption ; thema EDItEUR::P Mathematics and Science::PD Science: general issues
    Language: English
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  • 96
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: enhancement ; genetics ; therapeutics ; CRISPR ; editorial ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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  • 97
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    Presses universitaires de Rennes
    Publication Date: 2022-01-31
    Description: Comment entre-t-on en ville ? Cela paraissait simple au temps des bonnes murailles : sous l’oeil vigilant des gardes, on franchissait une porte monumentale, on passait un pont. La beauté de l’entrée était signe de puissance. Mais les villes n’ont pas toujours eu murs, fossés et clefs et aujourd’hui n’en n’ont plus… En 2001 une vingtaine de spécialistes, urbanistes, historiens et juristes ont confronté à Orléans leurs points de vue sur le sujet. À la lecture de la quinzaine de communications p...
    Keywords: étude urbaine ; histoire urbaine ; urbanisme ; passage ritualisé ; entrées (cérémonies) ; rituel d'accueil urbain
    Language: French
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  • 98
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    Presses universitaires de Rennes
    Publication Date: 2022-01-31
    Description: Pouvoir local et Révolution s'interroge sur les limites d'une centralisation dont Tocqueville avait fait la logique profonde et déterminante d'une Révolution surgie pour briser les privilèges des corps intermédiaires et des provinces et permettre ainsi l'édification d'une Nation homogène de citoyens libres et égaux en droits. Mais cette centralisation, même apparemment triomphante sous la Convention et, a fortiori, sous l'Empire, continue de se heurter à une sorte de frontière intérieure, cel...
    Keywords: centralisation ; administration centrale ; XVIIIe siècle ; Révolution française ; Etat ; Eglise ; XIXe siècle ; administration locale
    Language: French
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  • 99
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    Presses universitaires de Rennes
    Publication Date: 2022-01-31
    Description: Cinéma et peinture, cinéma et musique, cinéma et architecture… La peinture s’est longtemps définie par sa capacité sans égale à ressembler et, quand la photo a semblé lui ravir ce privilège, à regarder ou, plutôt, à montrer le travail du regard. C’est ainsi la rencontre entre peinture et photo qui a permis d’enrichir leurs territoires respectifs. De même, les théoriciens et les prescripteurs du cinéma ont tour à tour revendiqué des fonctions inspirées par (ou contre) d’autres arts. La musique...
    Keywords: cinéma ; histoire du cinéma
    Language: French
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  • 100
    Publication Date: 2024-04-05
    Description: The eBook "Building Strategies for Porcine Cancer Models" presents a series of articles demonstrating the state-of-the-art developments in pig models for cancer research. Renowned researchers dedicated to the reproduction, genomic and biological engineering of the pig model for biomedicine contribute to this special research area. Although advances in these areas are occurring at surprising speeds, they are still far from realizing all the potential benefits that this biological model could provide to science. The current biomedical models may limit the frontier of knowledge in the cancer research.
    Keywords: QH426-470 ; Q1-390 ; Pigs ; Cloning ; Genetic engineering ; Comparative Genomics ; Gene Editing ; Animal Models ; Cancer ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical)
    Language: English
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