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  • Articles  (1,929)
  • Nature America Inc.  (1,929)
  • Process Engineering, Biotechnology, Nutrition Technology  (1,929)
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  • Articles  (1,929)
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  • 1
    Electronic Resource
    Electronic Resource
    Japan bans human cloning (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 366-366 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Japan's Science and Technology Agency (Tokyo) has released draft legislation that prohibits the use of cloning techniques for human reproductive purposes. It also bars implantation of chimeric embryos—consisting of human and animal cells—into human or animal uteri for reproductive ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/74352
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  • 2
    Electronic Resource
    Electronic Resource
    Edible vaccine success (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 367-367 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] ProdiGene (College Station, TX) announced in February that its patented edible vaccine confers protection against the common transmissible gastrointestinal virus in pigs. The vaccine, produced from maize genetically modified to express antigens of the virus, is the first of its kind to demonstrate ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/74356
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  • 3
    Electronic Resource
    Electronic Resource
    Call for food safety body (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 367-367 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] John Krebs, chair designate of the new UK Food Standards Agency (Nat. Biotechnol. 17, 945), has called for the creation of an international advisory panel to address all sides of the GM food debate, including the safety and regulation of exports, economic development, and environmental and ethical ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/74360
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  • 4
    Electronic Resource
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    Reversible immortality (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 368-368 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] A multinational team of researchers has shown that acute liver failure in a rat model can be prevented using a reversibly immortalized line of human hepatocytes. Though transplantation of primary hepatocytes has been suggested as a treatment for liver failure, the new work (Science 287, ...
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    URL: http://dx.doi.org/10.1038/74369
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  • 5
    Electronic Resource
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    In and out (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 370-370 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Nuclear import and export signals can be hard to detect in protein sequences because of their small size and lack of coherent motifs. In this issue, Rhee et al present a genetic method for detecting these signals based on a functional assay in yeast cells. First they modified the bacterial LexA ...
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    URL: http://dx.doi.org/10.1038/74377
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  • 6
    Electronic Resource
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    Artificial antigen presenting cells (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 370-370 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The infusion of large numbers of antigen-specific cytotoxic T lymphocytes (CTLs) is a promising therapeutic strategy in the fight against certain cancers and infectious diseases. This process currently involves the time-consuming differentiation or stimulation of natural antigen-presenting ...
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    URL: http://dx.doi.org/10.1038/74385
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  • 7
    Electronic Resource
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    Accessorizing biomaterials (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 371-371 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Fibrin is a natural biomaterial that has found uses in surgery and tissue engineering as a tissue sealant and matrix for cellular ingrowth. An important feature is its ability to be remodeled and replaced by the protease activities associated with cells during their migration and invasion. In ...
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    URL: http://dx.doi.org/10.1038/74397
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  • 8
    Electronic Resource
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    Cellular magnetism (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 371-371 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] By tracking cells' movements in whole organisms, scientists hope to learn how cellular migration contributes to processes such as immune response, angiogenesis, and embryogenesis. Magnetic resonance imaging (MRI) provides a way of doing this non-invasively and with cellular resolution. However, ...
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    URL: http://dx.doi.org/10.1038/74399
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  • 9
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    Identifying DNA targets of chromatin proteins (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 371-371 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] DNA-binding proteins control many essential cellular processes such as transcription, DNA repair, and DNA replication, to name a few. Identifying the DNA sequences that bind such proteins can provide considerable insight to these processes, however, methods for doing so are cumbersome and prone ...
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    URL: http://dx.doi.org/10.1038/74403
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  • 10
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    Creating molecular clues to uncover gene function (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 379-380 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Given a crime scene with scattered bodies and several suspects—but no smoking gun—the keen detective establishes a time line detailing who was where when. The indelible imprint each of the suspects makes on the environment through fingerprints, footprints, and the loss of hair, skin ...
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    URL: http://dx.doi.org/10.1038/74426
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  • 11
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    New paths to pain relief (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 387-391 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] For a great many people, debilitating pain is a constant backdrop to daily life. In the United States alone, 40 million currently suffer from chronic recurrent headaches, 35 million from persistent back pain, and 5 million from cancer-related pain, which is often unresponsive to the most potent ...
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    URL: http://dx.doi.org/10.1038/74438
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  • 12
    Electronic Resource
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    Target watching with a beady eye (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 383-383 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] When it comes to monitoring the location and migration of cells within the body, reporter groups with magnetic properties can be irresistible. In this issue, Lewin and colleagues label stem and progenitor cells ex vivo with superparamagnetic iron oxide nanoparticles that have been coated with ...
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    URL: http://dx.doi.org/10.1038/74432
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  • 13
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    Large-scale functional analysis using peptide or protein arrays (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 393-397 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The array format for analyzing peptide and protein function offers an attractive experimental alternative to traditional library screens. Powerful new approaches have recently been described, ranging from synthetic peptide arrays to whole proteins expressed in living cells. Comprehensive sets of ...
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    URL: http://dx.doi.org/10.1038/74442
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  • 14
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    Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 399-404 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We describe the derivation of pluripotent embryonic stem (ES) cells from human blastocysts. Two diploid ES cell lines have been cultivated in vitro for extended periods while maintaining expression of markers characteristic of pluripotent primate cells. Human ES cells express the transcription ...
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    URL: http://dx.doi.org/10.1038/74447
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  • 15
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    People (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 464-464 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] FeRx (San Diego, CA) has named Vicente Anido Jr. to its board of directors. Most recently, he was president and CEO of CombiChem, which was sold to DuPont Pharmaceuticals last year. Wolfgang Berthold has been appointed senior vice president of biopharmaceutical sciences at IDEC Pharmaceuticals ...
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    URL: http://dx.doi.org/10.1038/74556
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  • 16
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    Progress against AIDS (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 466-467 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] There is significant progress in the development of drugs against AIDS and AIDS-related conditions, with more than 100 new medicines currently being tested in various clinical trials. These medicines promise to enhance the pipeline of more than 60 drugs already in use against the disease. Despite ...
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    URL: http://dx.doi.org/10.1038/74566
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  • 17
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    Synchronizing expectations (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 239-239 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Lateness is the principle cause of time-keeping grouches, but not in biotechnology. In our every day lives, we are incensed by trains delays, offended by correspondence impromptly returned, inconvenienced by deadlines missed, deflated by unmet company projections, and chided for anniversaries ...
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    URL: http://dx.doi.org/10.1038/73582
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  • 18
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    Sampling kinases in single cells (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 250-250 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Kinases and phosphatases play key roles in the diverse networks transmitting signals within and between cells. Most assays of physiological kinase activation involve measurements representing the average of the response of large populations of cells, which may or may not be heterogeneous in ...
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    URL: http://dx.doi.org/10.1038/73650
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  • 19
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    Hemophilia bypassed (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 251-251 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Hemophilia is caused by deficiencies or defects in blood coagulation Factor IX or Factor VIII. However, therapies based on simply replacing these defective or deficient plasma proteins with recombinant versions can lead to the development of inhibitory antibodies. In this case, alternate ...
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    URL: http://dx.doi.org/10.1038/73667
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  • 20
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    Biosafety rules get thumbs up (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 253-253 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The Biosafety Protocol, the international agreement that stemmed from the 1992 UN Convention on Biodiversity (CBD) and that threatened the future of trade in genetically engineered crops, has—perhaps surprisingly—been largely welcomed by all parties. Industrial representatives, ...
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    URL: http://dx.doi.org/10.1038/73669
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  • 21
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    Biotechnology venture capital booms in Japan (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 256-256 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Japan is in the throes of a biotech venture boom, as institutional investors and venture capitalists—previously unknown in the industry—have begun to focus on biotechnology. However, some analysts and investors in Japan doubt whether the country has the infrastructure to sustain ...
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    URL: http://dx.doi.org/10.1038/73675
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  • 22
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    Combinatorial chemistry gives cell biology some muscle (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 261-262 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Combinatorial chemistry is revolutionizing the drug discovery process by facilitating the synthesis and analysis of an almost unlimited number of organic compounds. Now we may wonder if the pharmaceutical field was merely a training ground for the invasion of combinatorial chemistry into all ...
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    URL: http://dx.doi.org/10.1038/73684
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  • 23
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    Spinal cord rejuvenation (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 249-249 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] In an approach that might someday be used to treat traumatic nerve damage, researchers have used neurotrophic factors to regenerate sensory axons into the spinal cords of adult rats (Nature 403, 312–316, 2000). “These experiments relate to a specific type of spinal cord injury ...
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    URL: http://dx.doi.org/10.1038/73634
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  • 24
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    Technical Reports (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 251-251 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Actinomycete bacteria produce the majority of the microbial metabolites that have found use in medicine and agriculture. Until now, these bacteria have not been sufficiently characterized to allow efficient genetic manipulation. The genes necessary to produce a given metabolite tend to be ...
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    URL: http://dx.doi.org/10.1038/73659
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  • 25
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    Inquiry into gene therapy widens (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 254-255 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Scrutiny of gene therapy continued in February when a US Senate subcommittee held a hearing to discuss current oversight procedures, in light of revelations that only 6% of serious side effects in certain gene therapy clinical trials had been reported to the US National Institutes of Health (NIH; ...
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    URL: http://dx.doi.org/10.1038/73673
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  • 26
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    Geron issued UK Dolly patents (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 256-257 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Geron Corp (Menlo Park, CA) announced the issuance of two patents by the UK Patent Office covering the nuclear transfer technology used to produce Dolly the sheep, the first animal cloned from an adult cell. Although the announcement on January 19 prompted a 30% hike in Geron share price to ...
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    URL: http://dx.doi.org/10.1038/73677
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  • 27
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    Novel fluorescent approaches for studying cell signaling in single cells (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 262-263 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] It has been nearly 50 years since the role of 3′,5′-cAMP as a second messenger was discovered, opening the field of signal transduction. Since then, the combined efforts of geneticists and biochemists have provided a consistent picture about the plethora of signaling pathways ...
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    URL: http://dx.doi.org/10.1038/73687
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  • 28
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    Biotechnology development a stroll in the park? (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 270-272 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Toward the end of the real estate boom of the 1980s, a new type of business facility began to dot the landscape of industrialized countries. With an emphasis on catering to the special needs of the emerging biotechnology industry, these “bioparks” and “biotechnology ...
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  • 29
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    Blood products part of FDA xenotransplant plan (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 258-258 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] In January, US Food and Drug Administration (FDA; Rockville, MD) officials announced a broad action plan for regulating xenotransplant products and procedures—and also sought expert advice on framing principles for easing those restrictions when xenotransplantation moves from being mainly ...
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  • 30
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    Effects in live cells of a c- myc anti-gene PNA linked to a nuclear localization signal (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 300-303 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Peptide nucleic acids (PNA) are synthetic homologs of nucleic acids in which the phosphate-sugar polynucleotide backbone is replaced by a flexible polyamide. In this study, a PNA construct was employed as an anti-gene agent in intact cells in culture. The cell lines studied were derived from ...
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  • 31
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    Inverting enantioselectivity by directed evolution of hydantoinase for improved production of l -methionine (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 317-320 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Using directed evolution, we have improved the hydantoinase process for production of L-methionine (L-met) in Escherichia coli. This was accomplished by inverting the enantioselectivity and increasing the total activity of a key enzyme in a whole-cell catalyst. The selectivity of all known ...
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  • 32
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    Rapigene bargain buy for Qiagen (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 132-132 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] In January, Qiagen (Venlo Park, The Netherlands) acquired the genomic analysis company Rapigene from Celltech Chiroscience (Slough, UK). The buyout comes as the fallout from the merger of Celltech (Slough, UK), Chiroscience (Cambridge, UK), and Medeva (London) (Nat. Biotechnol. 18, 7, 2000). ...
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  • 33
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    Recent patents in cloning (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 351-351 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
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    URL: http://dx.doi.org/10.1038/73822
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  • 34
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    Sugary synthetic genes (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 135-135 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] By constructing synthetic genes to express predicted glycosylation consensus sequences, researchers at Ohio University (Athens, OH) and Michigan State University (East Lansing, MI) have identified a simple glycosylation code in plants. Despite the central importance of glycosylation in the ...
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  • 35
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    Europe ratifies plant patents (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 129-129 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: Cheryl H. Agris' article (Nat. Biotechnol. 17, 197–198, 1999) on “Intellectual property protection for plants,” subsection “IP protection in Europe” requires clarification and updating.... Plant or animal varieties are excepted from patentability under ...
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  • 36
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    Field tests on managing resistance to Bt -engineered plants (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 339-342 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Several important crops have been engineered to express toxins of Bacillus thuringiensis (Bt) for insect control. In 1999, US farmers planted nearly 8 million hectares (nearly 20 million acres) of transgenic Bt crops approved by the EPA. Bt-transgenic plants can greatly reduce the use of ...
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    Analyzing the USPTO's revised utility guidelines (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 349-350 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] On December 21, 1999, the United States Patent and Trademark Office issued two new directives: “Revised Utility Examination Guidelines” and “Revised Interim Guidelines for Examination of Patent Applications under 35 USC § 112, paragraph 1 “Written Description’ ...
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    Stem cell nuclear transfer (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 135-135 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The successful generation of live mice from cloned mouse embryonic stem (ES) cells opens up new possibilities for the creation of transgenic mice (Proc. Nat. Acad. Sci. USA 96, 14984–14989, 1999). Previously, viable clones had only been obtained from freshly isolated, ill-defined donor cells. ...
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    Designer science and the “omic” revolution (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 127-127 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Following the success of the human genome project effort, several other “omic” disciplines have emerged, with the goal of analyzing the components of a living organism in its entirety. Proteomics (the complete set of proteins produced in a cell), phenomics (the complete set of ...
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    The pharmacological basis of anti-IgE therapy (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 157-162 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The treatment of asthma and allergic rhinitis using unique, humanized anti-IgE monoclonal antibodies with very particular binding specificities is now supported by the results of multiple phase II and III human clinical studies. The therapeutic efficacy of this approach is attributable to ...
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    Genomic integration and gene expression by a modified adenoviral vector (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 176-180 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] A replication-deficient recombinant adenovirus encoding luciferase was constructed using 5′ and 3′ long terminal repeat (LTR) sequences of the Moloney murine leukemia virus. Gene expression was observed in cultured cells in vitro and in submandibular gland, cortex, and caudate ...
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    Investigation of gene therapy begins (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 143-144 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The US Food and Drug Administration (FDA; Rockville, MD) and the National Institutes of Health (NIH; Bethesda, MD) have responded to widespread concerns about the risks of gene therapy with public meetings, reviews and investigations, and a series of administrative changes to deal with gene therapy ...
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    Golden rice (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 135-135 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] In a major technical accomplishment, a team of researchers has inserted three genes into rice to allow the plant to produce beta carotene, the precursor required for animals to make vitamin A. The work, reported in Science (287, 303–305, 2000) is a significant step beyond the single-gene ...
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    A new way to integrate (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 136-136 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Adenovirus is a widely studied vector for gene therapy. Although the virus can be produced at high titers and directs efficient transduction and gene expression in vivo, the latter is only transient in nature. This is due in part to the episomal nature of the vector and has led to attempts to ...
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    Avoiding Frankendrugs (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 1225-1225 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The future looks bright for health biotechnology. However, a decade ago, the future also looked bright for agricultural biotechnology. Since then, billions of dollars in profits and share value have been lost, and the food security of billions of people may have been set back. Deutsche Bank's ...
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    GMO roundup (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 1229-1229 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] &cirf; According to Greenpeace, its candidate in the US presidential election, the mutant tiger, FrankenTony, received the support of 1,275 voters. Greenpeace does not say how many of these were Floridians. &cirf; Research published in Nature Neuroscience this month (Nat. Neurosci. 3, 1301, ...
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    Mouse genome in 2001 (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 1229-1229 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The Mouse Sequencing Consortium (MSC) was formed in October to accelerate and expand the sequencing begun by the US National Human Genome Research Institute (NHGRI; Bethesda, MD) in September 1999. The aim of the public–private enterprise is to sequence 93–95% of the widely-used ...
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    Rationally designed anti-HER2/neu peptide mimetic disables P185 HER2/neu tyrosine kinases in vitro and in vivo (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 194-198 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Monoclonal antibodies specific for the p185HER2/neu growth factor receptor represent a significant advance in receptor-based therapy for p185HER2/neu-expressing human cancers. We have used a structure-based approach to develop a small (1.5 kDa) exocyclic anti-HER2/neu peptide mimic (AHNP) ...
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    Epidermal growth factor receptor dimerization monitored in live cells (2000)
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    Nature biotechnology 18 (2000), S. 218-222 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We present a method for monitoring receptor dimerization at the membrane of live cells. Chimeric proteins containing the epidermal growth factor (EGF) receptor extracellular and transmembrane domains fused to weakly complementing β-galactosidase (β-gal) deletion mutants were expressed in ...
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    Intracellular trehalose improves the survival of cryopreserved mammalian cells (2000)
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    Nature biotechnology 18 (2000), S. 163-167 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We report that the introduction of low concentrations of intracellular trehalose can greatly improve the survival of mammalian cells during cryopreservation. Using a genetically engineered mutant of Staphylococcus aureus α-hemolysin to create pores in the cellular membrane, we were able to ...
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    Analysis of vertebrate SCL loci identifies conserved enhancers (2000)
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    Nature biotechnology 18 (2000), S. 181-186 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The SCL gene encodes a highly conserved bHLH transcription factor with a pivotal role in hemopoiesis and vasculogenesis. We have sequenced and analyzed 320 kb of genomic DNA composing the SCL loci from human, mouse, and chicken. Long-range sequence comparisons demonstrated multiple peaks of ...
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    A reliable, noninvasive technique for spindle imaging and enucleation of mammalian oocytes (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 223-225 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Factors affecting the efficiency of animal cloning remain to be elucidated. Enucleation of recipient oocytes is a critical step in cloning procedures and typically is performed by aspirating a portion of the cytoplasm underlying the first polar body. Enucleation is evaluated using epifluorescence ...
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    Knee-jerk response (2000)
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    Nature biotechnology 18 (2000), S. 1223-1223 
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    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] What are we to make of the dispute between Immune Response (Carlsbad, CA) and academic researchers over the publication of unfavorable clinical trial data on the company's anti-HIV vaccine Remune? On the face of it—at least, on the face presented in the press—corporate bad boys have ...
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    Direct action (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 1227-1227 
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    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor For the benefit of your readers, I hope that the technical analysis in your publication is superior to your editorial on the impact of Greenpeace's activities on biotechnology companies (Nat. Biotechnol. 18, 1015, 2000). The idea that the poor employment prospects of Ecogen's ...
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    Breaching principles (2000)
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    Nature biotechnology 18 (2000), S. 1227-1227 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor I read with interest the articles by Anna Meldolesi published in the September issue (Nat. Biotechnol. 18, 919, 2000) that discuss the “rejection” on 16 December 1999 of three oils derived from GM oilseed rape and four products derived from GM corn by the Italian ...
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    Chinese gov't chips in to industry (2001)
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    Nature biotechnology 19 (2001), S. 12-13 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The Chinese National State Planning Commission announced in November that it will invest RMB 200 million (US$ 24 million) over two years in the Beijing National Center for Biochip Design and Engineering (NCBDE). Observers think the effort, with its experienced director and focus on ...
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    Cantab failure shows need for wide portfolio (2000)
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    Nature biotechnology 18 (2000), S. 1238-1238 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The failure in mid-October of Cantab's (Cambridge, UK) lead vaccine TH-GW for the treatment of genital warts knocked more than two-thirds off the company's share price, forcing the resignation of CEO Jurek Sikorski and leaving Cantab up for sale. During the past three months, this and other ...
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    Efficient nonviral transfection of dendritic cells and their use for in vivo immunization (2000)
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    Nature biotechnology 18 (2000), S. 1273-1278 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Immunization with dendritic cells (DCs) transfected with genes encoding tumor-associated antigens (TAAs) is a highly promising approach to cancer immunotherapy. We have developed a system, using complexes of plasmid DNA expression constructs with the cationic peptide CL22, that transfects human ...
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    Increasing galactose consumption by Saccharomyces cerevisiae through metabolic engineering of the GAL gene regulatory network (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 1283-1286 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Increasing the flux through central carbon metabolism is difficult because of rigidity in regulatory structures, at both the genetic and the enzymatic levels. Here we describe metabolic engineering of a regulatory network to obtain a balanced increase in the activity of all the enzymes in the ...
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    A ubiquitin-based tagging system for controlled modulation of protein stability (2000)
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    Nature biotechnology 18 (2000), S. 1298-1302 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Many biotechnology applications depend on the expression of exogenous proteins in a predictable and controllable manner. A key determinant of the intracellular concentration of a given protein is its stability or “half-life.” We have developed a versatile and reliable system for ...
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    Stable correction of a genetic deficiency in human cells by an episome carrying a 115 kb genomic transgene (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 1311-1314 
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    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Persistent expression of a transgene at therapeutic levels is required for successful gene therapy, but many small vectors with heterologous promoters are prone to vector loss and transcriptional silencing. The delivery of genomic DNA would enable genes to be transferred as complete loci, ...
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    Biotech weighs up the options in obesity (2001)
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    Nature biotechnology 19 (2001), S. 25-28 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] In the past few decades, technological innovations have created a society where most forms of work are lighter, travel less strenuous, and lifestyles more sedentary. Add to this the overconsumption of food, in particular high-fat convenience foods, and you have the perfect recipe for a ...
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    GM crop data—agronomy and ecology in tandem (2001)
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    Nature biotechnology 19 (2001), S. 3-3 
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    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] At a recent international gathering of biosafety researchers, a European scientist overheard our American dialects and commented dryly, “I didn't think you Yanks cared about this sort of thing [biosafety].” There is, unfortunately, a grain of truth in that statement. However, we do ...
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    Local endostatin treatment of gliomas administered by microencapsulated producer cells (2001)
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    Nature biotechnology 19 (2001), S. 29-34 
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    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We describe a technique for the treatment of malignant brain tumors based on local delivery of the anti-angiogenic protein endostatin from genetically engineered cells encapsulated in ultrapure sodium alginate. Alginate consists of L-guluronic and D-mannuronic acid, which in the presence of ...
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    Continuous release of endostatin from microencapsulated engineered cells for tumor therapy (2001)
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    Nature biotechnology 19 (2001), S. 35-39 
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    Notes: [Auszug] Research studies suggest that tumor-related angiogenesis contributes to the phenotype of malignant gliomas. We assessed the effect of local delivery of the angiogenesis inhibitor endostatin on human glioma cell line (U-87MG) xenografts. Baby hamster kidney (BHK) cells were stably transfected ...
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    Phosphoramidate oligonucleotides as potent antisense molecules in cells and in vivo (2001)
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    Nature biotechnology 19 (2001), S. 40-44 
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    Notes: [Auszug] Antisense oligonucleotides are designed to specifically hybridize to a target messenger RNA (mRNA) and interfere with the synthesis of the encoded protein. Uniformly modified oligonucleotides containing N3′–P5′ phosphoramidate linkages exhibit (NP) extremely high-affinity ...
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    Scanning of guanine–guanine mismatches in DNA by synthetic ligands using surface plasmon resonance (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 51-55 
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    Notes: [Auszug] Here we have designed and synthesized ligands that specifically bind with high affinity (Kd = 53 nM) to the guanine (G)–guanine mismatch, one of four types of single-nucleotide polymorphism (SNP). Detection of the G-G mismatch was performed by a surface plasmon resonance ...
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    A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 45-50 
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    Notes: [Auszug] A large proportion of the 6,000 genes present in the genome of Saccharomyces cerevisiae, and of those sequenced in other organisms, encode proteins of unknown function. Many of these genes are “silent,” that is, they show no overt phenotype, in terms of growth rate or other fluxes, ...
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    Rapid identification and characterization of hammerhead-ribozyme inhibitors using fluorescence-based technology (2001)
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    Nature biotechnology 19 (2001), S. 56-61 
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    Notes: [Auszug] The ability to rapidly identify small molecules that interact with RNA would have significant clinical and research applications. Low-molecular-weight molecules that bind to RNA have the potential to be used as drugs. Therefore, technologies facilitating the rapid and reliable identification of ...
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    GMO roundup (2001)
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    Nature biotechnology 19 (2001), S. 5-5 
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    Notes: [Auszug] &cirf; UK civil servants prove themselves as adept as ever at handling potentially sensitive genetic modification issues. In the run up to the trial of four people accused of vandalizing crops in Scotland, Mae-Wan Ho of the Institute of Science in Society (London) announced at a press conference ...
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    FDA gene rules impractical (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 5-5 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Current US Food and Drug Administration guidelines for long term followup are unfeasible for trial sponsors and patients, especially individual investigators on five-year NIH grants and less well-financed biotechnology companies. So concluded the Biological Response Modifiers Advisory Committee ...
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    Blech settles with SEC (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 5-5 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] US Federal officials have settled a civil lawsuit with David Blech, barring the former biotechnology financier from being associated with a broker or dealer. In the early 1990s, Blech bankrolled such startup firms as GeneMedicine (Woodlands, TX), Incyte Genomics (Palo Alto, CA), and Guilford ...
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    OGS/Glaxo biomarker deal (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 5-5 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Proteomics company Oxford GlycoSciences (Oxford, UK) has signed a deal with Glaxo Wellcome (Greenford, UK) to identify biomarkers—proteins whose expression change during illness. Biomarkers can be used not only to detect and monitor a disease, but also to improve the design and assessment of ...
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    Aventis to shed ag (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 5-5 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The supervisory board of Aventis SA (Strasbourg, France) revealed plans in November to divest the agricultural business Aventis CropScience (Lyon, France) by the end of 2001 in order to focus on pharmaceuticals, which accounts for 75% of the parent business. The divestment may take the form of an ...
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    Interference-based detection of nucleic acid targets on optically coated silicon (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 62-65 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Sequence-specific detection of polynucleotides typically requires modified reporter probes that are labeled with radioactive, fluorescent, or luminescent moieties. Although these detection methods are capable of high sensitivity, they require instrumentation for signal detection. In certain ...
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    FDA withholds xeno data (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 6-6 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The Campaign for Responsible Transplantation (CRT; New York) filed a lawsuit late in November against the FDA claiming officials are withholding information on xenotransplantation research. Following Freedom of Information Act requests that began last March, CRT director Alix Fano has been leading ...
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    French ethics law revised (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 6-6 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The French government has proposed changes to its 1994 Bioethics law to allow research on human embryos and facilitate the development of new therapies from work on embryonic stem cells (ESCs). Under the amended law, researchers will be able to derive stem cells from “spare” embryos ...
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    Lysostaphin expression in mammary glands confers protection against staphylococcal infection in transgenic mice (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 66-70 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Infection of the mammary gland, in addition to causing animal distress, is a major economic burden of the dairy industry. Staphylococcus aureus is the major contagious mastitis pathogen, accounting for approximately 15–30% of infections, and has proved difficult to control using standard ...
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    Conflicts of interest reports (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 6-6 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Conflicts of interest between collaborating academics and private firms are both common and poorly regulated by university officials, according to two new studies (NEJM, 343, 1621, 2000). The first, conducted by researchers at the University of California at San Francisco (UCSF), looked at the top ...
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    German genomics effort (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 6-6 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The first deadline for proposals for a new bacterial genome research initiative in Germany is January 8. Over the next three years, Germany's federal ministry of education and science (BMBF) plans to distribute up to 40 million DM ($US 17.4 million) evenly between three networks comprising ...
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    Research collaborations (2001)
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    Nature biotechnology 19 (2001), S. 6-6 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] There is a box associated with this article, available ...
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    Overexpression of the Bt cry 2Aa2 operon in chloroplasts leads to formation of insecticidal crystals (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 71-74 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] In nuclear transgenic plants, expression of multiple genes requires introduction of individual genes and time-consuming subsequent backcrosses to reconstitute multi-subunit proteins or pathways, a problem that is compounded by variable expression levels. In order to accomplish expression of ...
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    A helper phage to improve single-chain antibody presentation in phage display (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 75-78 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We show here that the number of single-chain antibody fragments (scFv) presented on filamentous phage particles generated with antibody display phagemids can be increased by more than two orders of magnitude by using a newly developed helper phage (hyperphage). Hyperphage have a wild-type pIII ...
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    Blood into brains (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 7-7 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Cells generated from bone marrow transplants can migrate from the circulation into the brain and differentiate into neurons, according to a report in Science (290, 1779–1782, 2000). Spurred on by evidence that bone marrow cells can transform into glial cells, Éva Mezey and her ...
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    Counting alleles reveals a connection between chromosome 18q loss and vascular invasion (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 78-81 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The analysis of loss of heterozygosity (LOH) is perhaps the most widely used technique in cancer genetics. In primary tumors, however, the analysis of LOH is fraught with technical problems that have limited its reproducibility and interpretation. In particular, tumors are mixtures of neoplastic ...
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    Arabidopsis sequenced (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 7-7 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The first complete sequence of a plant genome was published last month, bringing to an end a four-year effort by the Arabidopsis sequencing consortium. Last month's Nature (408, 816–826, 2000) provides the genome sequences of chromosomes 1, 3, and 5 of thale cress (Arabidopsis thaliana), ...
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    Catalytic DNA lead probe (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 7-7 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Nanomolar concentrations of lead can be harmful to health, but current forms of detection are relatively insensitive and require sophisticated off-site analysis. Now, Jing Li and colleague Yi Lu have developed a DNA-based lead “probe” that can detect levels of the toxic metal ion ...
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    Chlorobenzene degrader (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 7-7 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Scientists have traditionally relied on consortia of bacteria to degrade nasty mixtures of chlorinated hydrocarbons that often are recalcitrant environmental contaminants. Now, a team of German researchers has isolated a bacterium that is capable of degrading chlorobenzenes in isolation (Nature ...
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    Insulin mimics (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 7-7 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] A new gene therapy approach may overcome the problem of cleavage of proinsulin into active insulin for treatment of autoimmune type I diabetes. Researchers from Korea and Canada have engineered a liver-targeting recombinant adeno-associated virus (rAAV) that expresses a single-chain insulin analog ...
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    Patenting biotechnology inventions in China (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 83-84 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] China is the most populous country in the world, with over 1.2 billion people—a staggering consumer market for pharmaceutical and biotechnology products. With a fast-growing economy based on the government's drive for economic reform and modernization, China has in recent years twice revised ...
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    Recent patents in vaccines (2001)
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    Nature biotechnology 19 (2001), S. 85-85 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] There is a box assoicated with this article, available ...
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    The Nature Biotechnology 2001 New Year quiz (2001)
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    Nature biotechnology 19 (2001), S. 86-87 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] 1. Getting it together. Test your memory of events in mergers and acquisitions: (a) What business did Celltech (Leatherhead, UK) get from Medeva (Leatherhead, UK) and then pass on to PowderJect Pharmaceuticals (Oxford, UK) before it got people hopping mad in October? (b) Abgenix (Fremont, CA) ...
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    Promotions, advancements (2001)
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    Nature biotechnology 19 (2001), S. 88-88 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Dynavax Technologies (Berkeley, CA) has named three new vice presidents: Robert Lee Coffman as vice president and chief scientific officer (CSO); Stephen F. Tuck as vice president, biopharmaceutical development; and Gary Van Nest as vice president, preclinical research. Dr. Coffman was most ...
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    New Products (2001)
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    Nature biotechnology 19 (2001), S. 89-89 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Antibodies Cancer antigens Zymed offers eight monoclonal antibodies against cancer antigens CA 15-3 for breast cancer, CA 19-9 for colorectal and pancreatic cancer, CA 125 for non-mucinous ovarian cancer, and CA 72.4 for a variety of human adenocarcinomas. The Mabs are relatively tumor-specific ...
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    Tried and true antisense (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 8-8 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] On page 40, Faria et al. establish the mechanism of action of N3′-P5′ phosphoramidate (NP) oligonucleotides, which belong to a new generation of antisense reagents that have considerable promise as therapeutic reagents, as shown in a number of in vivo studies. Their extremely high ...
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    Got milk? (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 8-8 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Mastitis, a kind of infection of mammary tissue, costs the US dairy industry billions annually, and extracts an uncalculable cost in animal suffering. On page 66, Kerr et al. demonstrate a possible biotechnology solution: transgenic mice that secrete in their own milk a potent antibacterial ...
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    SNP detection made simpler? (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 8-8 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] High-throughput technologies for detecting SNPs require knowledge of sequence information, and alternatives for scanning without such information rely on cumbersome, gel-based methods. On page 51, Nakatani et al. provide an alternative. They have isolated small molecules called dimeric ...
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    Silent genes find a voice (2001)
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    Nature biotechnology 19 (2001), S. 8-8 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Of the many thousands of genes encoding proteins of unknown function, the most enigmatic are the “silent” ones—those that exhibit no detectable phenotype when deleted from the genome. On page 45, Raamsdonk et al. show that, at least in yeast, gene function can be accurately ...
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    Technical Reports (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 8-8 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Phage display of antibody libraries is an undeniably powerful technique for isolating highly specific antibodies. However, in the most widely used systems only a small percentage of the phage population carries an antibody, so the libraries are large and unwieldy to screen. On page 75, Rondot et ...
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    Technical Reports (2001)
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    Nature biotechnology 19 (2001), S. 8-8 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] On page 78, Zhou et al. describe a technique for scoring loss of heterozygosity in tumors. They used fluorescent molecular beacons and “digital PCR” to detect SNP loci for which the patient was heterozygous, and applied likelihood techniques to ask whether the markers were lost through ...
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