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  • Molecular Diversity Preservation International  (495,622)
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  • 1
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    A differential pressure instrument with wireless telemetry for in-situ measurement of fluid flow across sediment-water boundaries (2009)
    Molecular Diversity Preservation International
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    Publication Date: 2022-05-25
    Description: © 2009 The Authors. This article is distributed under the terms of the Creative Commons Attribution (3.0) License. The definitive version was published in Sensors 9 (2009): 404-429, doi:10.3390/s90100404.
    Description: An instrument has been built to carry out continuous in-situ measurement of small differences in water pressure, conductivity and temperature, in natural surface water and groundwater systems. A low-cost data telemetry system provides data on shore in real time if desired. The immediate purpose of measurements by this device is to continuously infer fluxes of water across the sediment-water interface in a complex estuarine system; however, direct application to assessment of sediment-water fluxes in rivers, lakes, and other systems is also possible. Key objectives of the design include both low cost, and accuracy of the order of ±0.5 mm H2O in measured head difference between the instrument’s two pressure ports. These objectives have been met, although a revision to the design of one component was found to be necessary. Deployments of up to nine months, and wireless range in excess of 300 m have been demonstrated.
    Keywords: Pressure sensor ; Wireless ; Hydrology ; Data logger ; Oceanographic instrumentation
    Repository Name: Woods Hole Open Access Server
    Type: Article
    Format: application/pdf
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  • 2
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    Effect of Drilling Fluid Invasion on Natural Gas Hydrate Near-Well Reservoirs Drilling in a Horizontal Well (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-29
    Description: Horizontal wells can significantly improve the gas production and are expected to be an efficient exploitation method for the industrialization of natural gas hydrates (NGHs) in the future. However, the near-wellbore hydrate is highly prone to decomposition during the drilling process, owing to the disturbance aroused by the factors such as the drilling fluid temperature, pressure, and salinity. These issues can result in the engineering accidents such as bit sticking and wellbore instability, which are required for further investigations. This paper studies the characteristics of drilling fluid invasion into the marine NGH reservoir with varied drilling fluid parameters via numerical simulation. The effects of the drilling fluid parameters on the decomposition behavior of near-wellbore hydrates are presented. The simulating results show that the adjustments of drilling fluid density within the mud safety window have limited effects on the NGH decomposition, meanwhile the hydrates reservoir is most sensitive to the drilling fluid temperature variation. If the drilling fluid temperature grows considerably due to improper control, the range of the hydrates decomposition around the horizontal well tends to expand, which then aggravates wellbore instability. When the drilling fluid salinity varies in the range of 3.5–7.5%, the increase in the ion concentration speeds up the hydrate decomposition, which is adverse to maintaining wellbore stability.
    Electronic ISSN: 1996-1073
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by Molecular Diversity Preservation International
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  • 3
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    Understanding the High Creep Resistance of MRI 230D Magnesium Alloy through Nanoindentation and Atom Probe Tomography (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-29
    Description: Due to their low density, magnesium alloys are very appealing for light-weight constructions. However, the use of the most common magnesium alloy, AZ91 (Mg 9 wt.% Al, 1 wt.% Zn), is limited to temperatures below 150 °C due to creep failure. Several alloys with an improved creep resistance have been developed in the past, for example the alloy MRI 230D or Ca-alloyed AZ91 variants. However, there is an ongoing discussion in the literature regarding the mechanisms of the improved creep resistance. One factor claimed to be responsible for the improved creep resistance is the intermetallic phases which form during casting. Another possible explanation is an increased creep resistance due to the formation of precipitates. To gain more insight into the improved creep resistance of MRI 230D, nanoindentation measurements have been performed on the different phases of as-cast, creep-deformed and heat-treated samples of MRI 230D and Ca-alloyed AZ91 variants. These nanoindentation measurements clearly show that the intermetallic phase (IP) of the alloy MRI 230D does not lose strength during creep deformation in contrast to the Ca-alloyed AZ91 variants. High-temperature nanoindentation measurements performed at 200 °C clearly show that the intermetallic phases of the MRI 230D alloy maintain their strength. This is in clear contrast to the Ca-alloyed AZ91 variants, where the IP is significantly softer at 200 °C than at room temperature. Atom probe measurements have been used to gain insight into the differences in terms of chemical composition between the IPs of MRI 230D and the Ca-alloyed AZ91 variants in order to understand the dissimilar behaviour in terms of strength loss with increasing temperature.
    Electronic ISSN: 2075-4701
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
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  • 4
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    Does Physical Inactivity Induce Significant Changes in Human Gut Microbiota? New Answers Using the Dry Immersion Hypoactivity Model (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-29
    Description: Gut microbiota, a major contributor to human health, is influenced by physical activity and diet, and displays a functional cross-talk with skeletal muscle. Conversely, few data are available on the impact of hypoactivity, although sedentary lifestyles are widespread and associated with negative health and socio-economic impacts. The study aim was to determine the effect of Dry Immersion (DI), a severe hypoactivity model, on the human gut microbiota composition. Stool samples were collected from 14 healthy men before and after 5 days of DI to determine the gut microbiota taxonomic profiles by 16S metagenomic sequencing in strictly controlled dietary conditions. The α and β diversities indices were unchanged. However, the operational taxonomic units associated with the Clostridiales order and the Lachnospiraceae family, belonging to the Firmicutes phylum, were significantly increased after DI. Propionate, a short-chain fatty acid metabolized by skeletal muscle, was significantly reduced in post-DI stool samples. The finding that intestine bacteria are sensitive to hypoactivity raises questions about their impact and role in chronic sedentary lifestyles.
    Electronic ISSN: 2072-6643
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Published by Molecular Diversity Preservation International
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  • 5
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    Effects of Stand Structure and Topography on Forest Vegetation Carbon Density in Jiangxi Province (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-29
    Description: Stand structure and topography are important factors affecting forest vegetation carbon density (FVCD). Revealing the interaction mechanisms between stand structure and topography on FVCD is of great significance for enhancing forest vegetation carbon storage and achieving regional carbon neutrality. Based on stratified sampling, systematic distribution and forest continuous inventory sample plots in Jiangxi province, the variation characteristics of FVCD and its correlations with stand structure and topographic factors were studied. The results are as follows: (1) The average FVCD in Jiangxi province was 44.23 Mg/ha, which was dominated by the carbon density of the arbor layer, accounting for about 81.39% of the total forest—far lower than the average level of global FVCD, which proved that the forest in Jiangxi province was dominated by middle-age and young forests with low carbon density, and also showed that the potential for forest vegetation carbon storage in Jiangxi province was huge. (2) Except for vegetation carbon densities of shrub and herb layers, the vegetation carbon densities of other forest layers in Jiangxi province were significantly different among different forest types. Volume per unit area was the most important factor affecting the vegetation carbon densities of arbor and total forest, and vegetation carbon density–volume models of the main forests were built for vegetation carbon density calculation in Jiangxi province. (3) The vegetation carbon densities of arbor layer, snag and log layer, and total forest increased significantly with increases in elevation and slope. Except for the shrub layer and herb layer, the vegetation carbon densities of the other layers and the total forest had extremely significant or significant differences between slope position gradients—indicating that the effect of topography on FVCD in Jiangxi province was significant, mainly through influencing of forest distribution and human disturbance intensity.
    Electronic ISSN: 1999-4907
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Published by Molecular Diversity Preservation International
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  • 6
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    On Sustainable Consumption: The Implications of Trade in Virtual Water for the EU’s Food Security (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-29
    Description: The paper addresses the sustainability of the European Union’s food consumption through a water footprint assessment of selected vulnerable agricultural imports from a two-pronged perspective: (1) the degree of the EU’s dependence on global green water resources embedded in the apparent consumption of selected water-intensive agricultural products and (2) the degree of commitment of countries of origin to sustainability policies. The study argues that the vulnerability of the EU’s agricultural imports to water risks can be estimated based on the amount of green water consumed in producing crops in the countries of origin. The results show that the EU’s consumption of agricultural goods is highly dependent on virtual water imports for all six selected vulnerable agricultural products, from the lowest footprint for bananas (5 mil. km3) to the largest for coffee (69 mil. km3). The analysis also points to a greater concern for quality issues in the countries of origin (56.53%) relative to management (26.52%) and availability issues (16.85%), but the latter are to arise in importance for sustainable production in the years to come. Our conclusions contribute to building up a responsible commitment towards (1) development of environmental policies and the design of practical measures by providing quantitative information that makes problems more clearly defined and tangible, and (2) assessing the outcome of policies and practical measures by understanding their effects on the sustainability of food consumption.
    Electronic ISSN: 2071-1050
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by Molecular Diversity Preservation International
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  • 7
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    Solvent and pH Stability of Poly(styrene-alt-maleic acid) (PSaMA) Membranes Prepared by Aqueous Phase Separation (APS) (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-29
    Description: In the single-polyelectrolyte aqueous phase separation (APS) approach, membranes are prepared by precipitating a weak polyelectrolyte from a concentrated aqueous solution using a pH switch. This has proven to be a versatile and more sustainable method compared to conventional approaches as it significantly reduces the use of organic solvents. Poly(styrene-alt-maleic acid) (PSaMA) is a polymer that has been extensively investigated for APS and has been the basis for both open and dense membranes with good performances. These membranes are chemically crosslinked and, in this work, we further investigated ultrafiltration (UF) and nanofiltration (NF) membranes prepared with PSaMA for their stability in various organic solvents and under different pH conditions. It was shown that these membranes had stable performances in both isopropanol (IPA) and toluene, and a slightly reduced performance in N-methyl-2-pyrollidone (NMP). However, PSaMA did not perform well as a selective layer in these solvents, indicating that the real opportunity would be to use the UF-type PSaMA membranes as solvent-stable support membranes. Additionally, the membranes proved to be stable in an acidic-to-neutral pH regime (pH 2–7); and, due to the pH-responsive nature of PSaMA, for the NF membranes, a pH-dependent retention of Mg2+ and SO42− ions was observed and, for the UF membranes, a strong responsive behavior was observed, where the pH can be used to control the membrane permeability. However, long-term exposure to elevated pH conditions (pH 8–10) resulted in severe swelling of the NF membranes, resulting in defect formation, and compaction of the UF membranes. For the UF membranes, this compaction did prove to be reversible for some but not all of the membrane samples measured. These results showed that in aqueous systems, membranes prepared with PSaMA had interesting responsive behaviors but performed best at neutral and acidic pH values. Moreover, the membranes exhibited excellent stability in the organic solvents IPA and toluene
    Electronic ISSN: 2077-0375
    Topics: Biology , Chemistry and Pharmacology
    Published by Molecular Diversity Preservation International
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  • 8
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    A Vision-Based Approach for the Analysis of Core Characteristics of Volcanic Ash (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-29
    Description: Volcanic ash fall-out represents a serious hazard for air and road traffic. The forecasting models used to predict its time–space evolution require information about the core characteristics of volcanic particles, such as their granulometry. Typically, such information is gained by the spot direct observation of the ash collected at the ground or by using expensive instrumentation. In this paper, a vision-based methodology aimed at the estimation of ash granulometry is presented. A dedicated image processing paradigm was developed and implemented in LabVIEW™. The methodology was validated experimentally using digital reference images resembling different operating conditions. The outcome of the assessment procedure was very encouraging, showing an accuracy of the image processing algorithm of 1.76%.
    Electronic ISSN: 1424-8220
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Published by Molecular Diversity Preservation International
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  • 9
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    Parental Book-Reading to Preterm Born Infants in NICU: The Effects on Language Development in the First Two Years (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-29
    Description: Background: After preterm birth, infants are at high risk for delays in language development. A promising intervention to reduce this risk is represented by the exposure to parental voices through book-reading in Neonatal Intensive Care Units (NICU). This study investigated the possible advantages of book-reading to preterm neonates during their NICU stay on their subsequent language development. Methods: 100 families of preterm infants were recruited. The parents of 55 preterm infants (Reading Group) received a colored picture-book on NICU admission and were supported to read to their neonate as often as possible and to continue after hospital discharge. Forty-five infants (Control Group) were recruited before the beginning of the intervention. Infant language development was assessed with the Hearing and Language quotients of the Griffith Mental Development Scale at the corrected ages of 3, 6, 9, 12, 18 and 24 months. Results: Regardless of group membership, Hearing and Language mean quotients decreased between 9 and 18 months; nevertheless, this decrease was considerably reduced in the Reading group, compared to the Control Group. Conclusions: Reading in NICUs represents a suitable intervention that could positively influence language development and parent-infant relationships in preterm children. The study findings support its implementation as a preventive measure.
    Print ISSN: 1661-7827
    Electronic ISSN: 1660-4601
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
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  • 10
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    An Integrated of Hydrogen Fuel Cell to Distribution Network System: Challenging and Opportunity for D-STATCOM (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-29
    Description: The electric power industry sector has become increasingly aware of how counterproductive voltage sag affects distribution network systems (DNS). The voltage sag backfires disastrously at the demand load side and affects equipment in DNS. To settle the voltage sag issue, this paper achieved its primary purpose to mitigate the voltage sag based on integrating a hydrogen fuel cell (HFC) with the DNS using a distribution static synchronous compensator (D-STATCOM) system. Besides, this paper discusses the challenges and opportunities of D-STATCOM in DNS. In this paper, using HFC is well-designed, modeled, and simulated to mitigate the voltage sag in DNS with a positive impact on the environment and an immediate response to the issue of the injection of voltage. Furthermore, this modeling and controller are particularly suitable in terms of cost-effectiveness as well as reliability based on the adaptive network fuzzy inference system (ANFIS), fuzzy logic system (FLC), and proportional–integral (P-I). The effectiveness of the MATLAB simulation is confirmed by implementing the system and carrying out a DNS connection, obtaining efficiencies over 94.5% at three-phase fault for values of injection voltage in HFC D-STATCOM using a P-I controller. Moreover, the HFC D-STATCOM using FLC proved capable of supporting the network by 97.00%. The HFC D-STATCOM based ANFIS proved capable of supporting the network by 98.00% in the DNS.
    Electronic ISSN: 1996-1073
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by Molecular Diversity Preservation International
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  • 11
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    Demand-Side Flexibility Impact on Prosumer Energy System Planning (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-29
    Description: Apart from numerous technical challenges, the transition towards a carbon-neutral energy supply is greatly hindered by limited economic feasibility of renewable energy sources. This results in their slow and bounded penetration in both commercial and residential sectors that are responsible for over 40% of final energy consumption. This paper aims to demonstrate that combined application of sophisticated planning methodologies at building-level and presents incentive mechanisms for renewables that can result in prosumers, featuring hybrid renewable energy systems (HRES), with economic performance comparable to that of conventional energy systems. The presented research enhances existing planning methodologies by integrating appliance-level demand side management into the decision process and investigates its effect on the planning problem. Moreover, the proposed methodology features an innovative and holistic approach that simultaneously assess electrical and thermal domain in both an isolated and grid-connected context. The analyzed hybrid system consists of solar photovoltaic, wind turbine and battery with thermal supply featuring solar thermal collector and a ground-source heat pump. Overall optimization problem is modeled as a mixed-integer linear program, while ranking of all feasible alternatives is made by the multicriteria decision-making algorithm against several technological, economic, and environmental criteria. A real-life scenario of energy system retrofit for a building in the United Kingdom was employed to demonstrate overall cost savings of 12% in the present market and regulation context.
    Electronic ISSN: 1996-1073
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by Molecular Diversity Preservation International
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  • 12
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    Real-Time 2-D Lidar Odometry Based on ICP (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-29
    Description: This study presents a 2-D lidar odometry based on an ICP (iterative closest point) variant used in a simple and straightforward platform that achieves real-time and low-drift performance. With a designated multi-scale feature extraction procedure, the lidar cloud information can be utilized at multiple levels and the speed of data association can be accelerated according to the multi-scale data structure, thereby achieving robust feature extraction and fast scan-matching algorithms. First, on a large scale, the lidar point cloud data are classified according to the curvature into two parts: smooth collection and rough collection. Then, on a small scale, noise and unstable points in the smooth or rough collection are filtered, and edge points and corner points are extracted. Then, the proposed tangent-vector-pairs based on edge and corner points are applied to evaluate the rotation term, which is significant for producing a stable solution in motion estimation. We compare our performance with two excellent open-source SLAM algorithms, Cartographer and Hector SLAM, using collected and open-access datasets in structured indoor environments. The results indicate that our method can achieve better accuracy.
    Electronic ISSN: 1424-8220
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
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  • 13
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    Multicomponent Approach to the Synthesis of 4-(1H-indol-3-yl)-5-(4-methoxyphenyl)furan-2(5H)-one (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-29
    Description: A simple one-pot approach was developed for the synthesis of furan-2(5H)-one derivative containing indole fragments. This method includes the telescoped multicomponent reaction of indole, 4-methoxyphenylglyoxal, and Meldrum’s acid. The synthetic utility of the prepared furan-2(5H)-one was demonstrated by condensation with 4-methoxybenzaldehyde. The advantages of this method include the employment of readily accessible starting materials, atom economy, process simplicity, and the easy isolation of the target products. The structure of the synthesized furanones was confirmed by 1H and 13C-NMR spectroscopy and high-resolution mass spectrometry with electrospray ionization (ESI-HRMS).
    Electronic ISSN: 1422-8599
    Topics: Chemistry and Pharmacology
    Published by Molecular Diversity Preservation International
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  • 14
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    FaTEMa: A Framework for Multi-Layer Fault Tolerance in IoT Systems (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-29
    Description: Fault tolerance in IoT systems is challenging to overcome due to its complexity, dynamicity, and heterogeneity. IoT systems are typically designed and constructed in layers. Every layer has its requirements and fault tolerance strategies. However, errors in one layer can propagate and cause effects on others. Thus, it is impractical to consider a centralized fault tolerance approach for an entire system. Consequently, it is vital to consider multiple layers in order to enable collaboration and information exchange when addressing fault tolerance. The purpose of this study is to propose a multi-layer fault tolerance approach, granting interconnection among IoT system layers, allowing information exchange and collaboration in order to attain the property of dependability. Therefore, we define an event-driven framework called FaTEMa (Fault Tolerance Event Manager) that creates a dedicated fault-related communication channel in order to propagate events across the levels of the system. The implemented framework assist with error detection and continued service. Additionally, it offers extension points to support heterogeneous communication protocols and evolve new capabilities. Our empirical results show that introducing FaTEMa provided improvements to the error detection and error resolution time, consequently improving system availability. In addition, the use of Fatema provided a reliability improvement and a reduction in the number of failures produced.
    Electronic ISSN: 1424-8220
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Published by Molecular Diversity Preservation International
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  • 15
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    ArcheoBot Experimental Tools for Archaeology and Cultural Heritage (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-29
    Description: ArcheoBot is a prototype of a Telegram Bot: it is an experimental prototype that builds on the common digital experiences of the authors of this article, aiming to offer a quick, powerful, easy to use tool. It aims to serve archaeological and topographical investigations quickly and to interface with other software for the management of collected data.
    Electronic ISSN: 2673-4931
    Topics: Energy, Environment Protection, Nuclear Power Engineering
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  • 16
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    Dynamics of Charged Particles Moving around Kerr Black Hole with Inductive Charge and External Magnetic Field (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-29
    Description: We mainly focus on the effects of small changes of parameters on the dynamics of charged particles around Kerr black holes surrounded by an external magnetic field, which can be considered as a tidal environment. The radial motions of charged particles on the equatorial plane are studied via an effective potential. It is found that the particle energies at the local maxima values of the effective potentials increase with an increase in the black hole spin and the particle angular momenta, but decrease with an increase of one of the inductive charge parameter and magnetic field parameter. The radii of stable circular orbits on the equatorial plane also increase, whereas those of the innermost stable circular orbits decrease. On the other hand, the effects of small variations of the parameters on the orbital regular and chaotic dynamics of charged particles on the non-equatorial plane are traced by means of a time-transformed explicit symplectic integrator, Poincaré sections and fast Lyapunov indicators. It is shown that the dynamics sensitivity depends on small variations in the inductive charge parameter, magnetic field parameter, energy, and angular momentum. Chaos occurs easily as each of the inductive charge parameter, magnetic field parameter, and energy increases but is weakened as the angular momentum increases. When the dragging effects of the spacetime increase, the chaotic properties are not always weakened under some circumstances.
    Electronic ISSN: 2218-1997
    Topics: Physics
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  • 17
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    A Novel Approach for the Design of Fast-Settling Amplifiers for Biosignal Detection (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-28
    Description: The most common method used to pick up biomedical signals is through metallic electrodes coupled to the input of high-gain, low-noise amplifiers. Unfortunately, electrodes, amongst other effects, introduce an undesired contact resistance and a contact potential. The contact potential needs to be rejected since it would otherwise cause the saturation of the input stage of the amplifiers, and this is almost always obtained by inserting a simple RC high-pass filter in the input signal path. The contact resistance needs to be estimated to ensure that it does not impair correct measurements. Methods exist for estimating the contact resistance by dynamically modifying the input network configuration, but because of the presence of the input RC filter, long transients are induced any time a switch occurs between different input configurations, so that the measurement time may become unacceptably long. In this paper, we propose a new topology for a DC removal network at the input of the differential signal amplifier that results in an AC filter whose time constant can be continuously changed by means of a control voltage. As such, we can speed up the recovery from transients by setting very short time constants (during the input resistance estimation process) while maintaining the ability to obtain very low cut-in frequencies by setting a much larger time constant during actual measurements. A prototype of the system was built and tested in order to demonstrate the advantage of the approach we propose in terms of reduced measurement time.
    Electronic ISSN: 2079-9292
    Topics: Electrical Engineering, Measurement and Control Technology
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  • 18
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    Labeling of Installed Heating Appliances in Residential Buildings: An Energy Labeling Methodology for Improving Consumers’ Awareness (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-28
    Description: In the EU 28, the installed heating appliance stock is quite old, with an actual replacement rate of 4%. This is directly reflected in the average efficiency of the installed heating systems, where around 60% of the stock is rated with an energy class of C or D (the lowest classes of the energy label scale). The European project HARP aims at raising consumers’ awareness of the planned replacement of their old and inefficient heating appliances with more efficient and renewable solutions. In this direction, an energy labeling methodology for old appliances has been developed to rate the installed stock before the introduction of the EU energy label. The methodology has been developed for space heating appliances and water heaters, targeting two types of users: end consumers and professional users. The validation considered about 4600 space heating appliances and 800 water heaters built between 1972 and 2019. Three heating appliances and two water heaters were tested in the laboratory, confirming the reliability of the proposed methodology. The expected impact of defining an energy labeling methodology for installed heating appliances increases the current replacement rate of these appliances in the EU from 4% to 5%.
    Electronic ISSN: 1996-1073
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by Molecular Diversity Preservation International
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  • 19
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    A Comprehensive Harmonic Analysis of Current-Mode Power Amplifiers (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-28
    Description: This work presents a comprehensive theoretical analysis of current-mode power amplifiers as a function of input power for different biasing classes under the common simplifying assumption of constant transconductance and hard current cut-off/saturation. Typically, the theoretical analysis of power amplifier performance and behavior are carried out only at maximum output power. However, to achieve high data-rates, modern telecommunication systems adopt signals characterized by a very high peak-to-average power ratio, thus it is useful to analyze the power amplifier behavior as a function of power back-off. Moreover, in many cases, to enhance the efficiency and/or to apply harmonic shaping techniques, a clipped drain-source current, which approaches a square wave, is required. The classical analysis can be extended to low power levels only under the assumption of power-independent conduction angle, which is true only for class-A and class-B amplifiers, and does not take into account possible waveform clipping at maximum current. This work presents a complete theoretical Fourier analysis of FET-based power amplifiers as a function of quiescent drain-source current at any input power level and accounting for the clipped current case, up to the square-wave limit, reorganizing and completing the material that can be found in classical textbooks in the field.
    Electronic ISSN: 1996-1073
    Topics: Energy, Environment Protection, Nuclear Power Engineering
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  • 20
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    Increased Post-Hypoxic Oxidative Stress and Activation of the PERK Branch of the UPR in Trap1-Deficient Drosophila melanogaster Is Abrogated by Metformin (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-28
    Description: Hypoxia is known to impair mitochondrial and endoplasmic reticulum (ER) homeostasis. Post-hypoxic perturbations of the ER proteostasis result in the accumulation of misfolded/unfolded proteins leading to the activation of the Unfolded Protein Response (UPR). Mitochondrial chaperone TNF receptor-associated protein 1 (TRAP1) is reported to preserve mitochondrial membrane potential and to impede reactive oxygen species (ROS) production thereby protecting cells from ER stress as well as oxidative stress. The first-line antidiabetic drug Metformin has been attributed a neuroprotective role after hypoxia. Interestingly, Metformin has been reported to rescue mitochondrial deficits in fibroblasts derived from a patient carrying a homozygous TRAP1 loss-of-function mutation. We sought to investigate a putative link between Metformin, TRAP1, and the UPR after hypoxia. We assessed post-hypoxic/reperfusion longevity, mortality, negative geotaxis, ROS production, metabolic activity, gene expression of antioxidant proteins, and activation of the UPR in Trap1-deficient flies. Following hypoxia, Trap1 deficiency caused higher mortality and greater impairments in negative geotaxis compared to controls. Similarly, post-hypoxic production of ROS and UPR activation was significantly higher in Trap1-deficient compared to control flies. Metformin counteracted the deleterious effects of hypoxia in Trap1-deficient flies but had no protective effect in wild-type flies. We provide evidence that TRAP1 is crucially involved in the post-hypoxic regulation of mitochondrial/ER stress and the activation of the UPR. Metformin appears to rescue Trap1-deficiency after hypoxia mitigating ROS production and downregulating the pro-apoptotic PERK (protein kinase R-like ER kinase) arm of the UPR.
    Print ISSN: 1661-6596
    Electronic ISSN: 1422-0067
    Topics: Chemistry and Pharmacology
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    Identification of Reference Genes for Expression Studies in the Whole-Blood from Three Cattle Breeds under Two States of Livestock Weather Safety (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-28
    Description: Real-time PCR is widely used to study the relative abundance of mRNA due to its specificity, sensitivity, and repeatability quantification. However, relative quantification requires a reference gene, which should be stable in its expression, showing lower variation by experimental conditions or tissues. The aim of this study was to evaluate the stability of the expression of five commonly used reference genes (actb, ywhaz, b2m, sdha, and 18s rRNA) at different physiological stages (alert and emergency) in three different cattle breeds. In this study, five genes (actb, ywhaz, b2m, sdha, and 18s rRNA) were selected as candidate reference genes for expression studies in the whole blood from three cattle breeds (Romosinuano, Gyr, and Brahman) under heat stress conditions. The transcription stability of the candidate reference genes was evaluated using geNorm and NormFinder. The results showed that actb, 18SrRNA, and b2m expression were the most stable reference genes for whole blood of Gyr and Brahman breeds under two states of livestock weather safety (alert and emergency). Meanwhile, actb, b2m, and ywhaz were the most stable reference genes for the Romosinuano breed.
    Electronic ISSN: 2076-2615
    Topics: Biology , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
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  • 22
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    Poor Ventilation Habits in Nursing Homes Have Favoured a High Number of COVID-19 Infections (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-28
    Description: Residents of nursing homes have been significantly affected by COVID-19 in Spain. The factors that have contributed to the vulnerability of this population are very diverse. In this study, physical agents, chemical pollutants, population density and different capacities of residences were analysed to understand their influence on the number of elderly people who have died in geriatric centres in different autonomous communities (AACCs) of Spain. A statistical analysis was carried out on the variables observed. The results show that many residences with a larger number of deaths were private, with some exceptions. Physical agents and pollutants were found to be determining factors, especially for the communities of Extremadura and Castilla–La Mancha, although the large number of factors involved makes this study complicated. The compromise between air quality and energy efficiency is of great importance, especially when human health is at stake.
    Electronic ISSN: 2071-1050
    Topics: Energy, Environment Protection, Nuclear Power Engineering
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  • 23
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    Energy Self-Sufficient Livestock Farm as the Example of Agricultural Hybrid Off-Grid System (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-28
    Description: Contemporary agriculture has become very energy-intensive and mainly uses electricity, which is needed for technological processes on livestock farms. Livestock faeces are burdensome for the environment due to the release of methane into the atmosphere. This article presents the concept of a self-sufficient livestock farm as an off-grid energy circuit that is a part of the agricultural process. The key idea is to obtain an energy flow using the concept of a smart valve to achieve a self-sufficient energy process based on a biogas plant, renewable energy sources, and energy storage. During the production process, a livestock farm produces large amounts of waste in the form of grey and black manure. On the one hand, these products are highly harmful to the environment, but on the other, they are valuable input products for another process, i.e., methane production. The methane becomes the fuel for cogeneration generators that produce heat and electricity. Heat and electricity are partly returned to the main farming process and partly used by residents of the area. In this way, a livestock farm and the inhabitants of a village or town can become energy self-sufficient and independent of national grids. The idea described in this paper shows the process of energy production combining a biogas plant, renewable energy sources, and an energy storage unit that enable farmland to become fully self-sufficient through the energy flow between all constituents of the energy cycle being maintained by a smart valve.
    Electronic ISSN: 1996-1073
    Topics: Energy, Environment Protection, Nuclear Power Engineering
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  • 24
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    SCADA Data-Based Working Condition Classification for Condition Assessment of Wind Turbine Main Transmission System (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-28
    Description: Due to the complex and variable conditions under which wind turbines operate, existing working condition classification methods are inadequate for condition assessment of the main transmission system. Because working conditions are too few after classification, it cannot effectively describe the complex and variable working conditions of wind turbine. This can lead to high false-alarm rates in the condition monitoring, which affect normal operations. This paper proposes a working condition classification method for the main transmission system of wind turbines based on supervisory control and data acquisition (SCADA) data. Firstly, correlation analysis of SCADA data acquired by wind farm is used to select the parameters relevant to the main transmission system. Secondly, according to the wind turbine control principle, the working conditions are initially divided into four phases: shutdown, start-up, maximum wind energy tracking, and constant speed. The k-means clustering algorithm is used to subdivide the maximum wind energy-tracking phase and constant speed phase, which account for a larger proportion of the working conditions, to achieve better classification. Finally, a case study is used to demonstrate the calculation of alarm thresholds and alarm rates for each working condition. The results are compared with the direct use of k-means clustering for working condition classification. It is concluded that the proposed method can significantly reduce the false-alarm rate of the vibration detection process.
    Electronic ISSN: 1996-1073
    Topics: Energy, Environment Protection, Nuclear Power Engineering
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    Land Use Change and Its Impact on Landscape Ecological Risk in Typical Areas of the Yellow River Basin in China (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-28
    Description: The basic premise of regional ecological construction would be to scientifically and effectively grasp the characteristics of land use change and its impact on landscape ecological risk. The research objects of this paper are the typical areas of the Yellow River Basin in China and “process-change-drive” as the logical main line. Moreover, this paper is based on multi-period land use remote sensing data from 2000 to 2020, the regional land use change process and influencing factors are identified, the temporal and spatial evolution and response process of landscape ecological risk are discussed, and the land use zoning control strategy to reduce ecological risk is put forward. The results indicated: (1) The scale and structure of land use show the characteristics of “many-to-one” and “one-to-many”; (2) the process of land use change is affected by the alternation of multiple factors. The natural environment and socio-economic factors dominate in the early stage and the location and policy factors have a significant impact in the later stage; (3) the overall landscape ecological risk level and conversion rate show a trend of “high in the southeast, low in the northwest”, shift from low to high and landscape ecological risks gradually increase; and (4) in order to improve the regional ecological safety and according to the characteristics of landscape ecological risk and spatial heterogeneity, we should adopt the management and control zoning method and set different levels of control intensity (from key intensity to strict intensity to general intensity), and develop differentiated land use control strategies.
    Print ISSN: 1661-7827
    Electronic ISSN: 1660-4601
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
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  • 26
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    Validation of the COVID-19 Transmission Misinformation Scale and Conditional Indirect Negative Effects on Wearing a Mask in Public (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-28
    Description: The SARS-CoV-2 (COVID-19) pandemic devastated the world economy. Global infections and deaths altered the behaviors of generations. The Internet acted as an incredible vehicle for communication but was also a source of unfounded rumors. Unfortunately, this freedom of information sharing and fear of COVID-19 fostered unfounded claims about transmission (e.g., 5G networks spread the disease). With negligible enforcement to stop the spread of rumors and government officials spouting unfounded claims, falsities became ubiquitous. Organizations, public health officials, researchers, and businesses spent limited resources addressing rumors instead of implementing policies to overcome challenges (e.g., speaking to defiant mask wearers versus safe reopening actions). The researchers defined COVID-19 transmission misinformation as false beliefs about the spread and prevention of contracting the disease. Design and validation of the 12-item COVID-19 Transmission Misinformation Scale (CTMS) provides a measure to identify transmission misinformation believers. Indirect COVID-19 transmission misinformation beliefs with a fear of COVID-19 decreased wearing a mask in public intentions. Callousness exacerbated COVID-19 transmission misinformation beliefs as a moderator.
    Print ISSN: 1661-7827
    Electronic ISSN: 1660-4601
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
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  • 27
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    Fattening of Polish Holstein-Friesian × Limousin Bulls under Two Production Systems and Its Effect on the Fatty Acid Profiles of Different Fat Depots (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-28
    Description: This study was designed to compare the fatty acid (FA) profiles of four types of fat depots from crossbred bulls (Polish Holstein-Friesian × Limousin, PHF × LM) fattened semi-intensively (SI) and intensively (I). Intramuscular fat was most abundant in total polyunsaturated fatty acids (PUFAs), n-3 and n-6 PUFAs, and functional fatty acids C 18:2, C 18:3, C 20:4 and C 20:5 in comparison with the remaining fat types. Furthermore, note that external fat was more abundant in conjugated linoleic acid (CLA) than other fat types. Grass silage fed to cattle during fattening had a beneficial influence on the FA profile of beef, and an increase in the amount of concentrate in the ration did not decrease beef quality.
    Electronic ISSN: 2076-2615
    Topics: Biology , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
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    Fracture Resistance and Failure Mode of Mandibular Molar Restored by Occlusal Veneer: Effect of Material Type and Dental Bonding Surface (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-28
    Description: This study assesses the effect of the material type (lithium disilicate, zirconia, and polymer-infiltrated ceramic) and dental bonding substrates (dentin, dentin with intra-coronal cavity, and dentin with composite filling) on the fracture resistance and failure mode of molars restored by occlusal veneers. Methods: Ninety occlusal veneers, fabricated from either lithium disilicate, zirconia, or polymer-infiltrated ceramic, were adhesively bonded to teeth prepared with either dentin, dentin with intra-coronal cavity, or dentin with composite filling. All specimens were thermally aged (5000 cycles), then load cycled (120,000 cycles). Each specimen was subjected to a compressive load through fracture, then was examined (×20) to identify the fracture type. Data were statistically analyzed. Results: Material type and dental substrate had no significant effect on the fracture resistance of adhesively retained occlusal veneer restorations. For each material, no significant differences were found between veneers bonded to dentin, dentin with intra-coronal cavity, and dentin with composite filling. Additionally, within each bonding substrate, there were no significant differences between lithium disilicate, zirconia, and polymer-infiltrated ceramic veneers. The adhesive failure was recorded mainly with zirconia occlusal veneer restorations. Conclusions: Considering the fracture results, lithium disilicate, zirconia, and polymer-infiltrated ceramic occlusal veneers perform well whatever the type of dental bonding surface. When the dental bonding surface varies, different occlusal veneer materials should be considered. Occlusal veneers bonded to dentin, dentin with composite filling, or dentin with an intra-coronal cavity exhibited a fracture resistance exceeding the average human masticatory forces in the molar area.
    Electronic ISSN: 1996-1944
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
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    Urban Rehabilitation, Social Innovation, and New Working Spaces in Lisbon (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-28
    Description: This study brings together three subjects: urban rehabilitation, social innovation, and new working spaces, envisaging an intersectoral viewpoint, focusing on a European city, Lisbon, arguing that the public sector holds the capacity to consistently drive positive achievements in this respect. This study involves analyzing policy, governance, and urban planning documents in force, observation and spatial analysis using open-source databases, and stakeholder interviews. The result is in line with the primary research plea applied to the case study, and conclusions show that public intervention, whenever applied systematically from the city vision to local plans, resorting to close bonds between the sites and the communities in a participatory and collaborative way, may lead to urban rehabilitation and social innovation through the inception and development of new working spaces. The study was designed while researching as a member of COST CA18214 (The Geography of New Working Spaces and the Impact on the Periphery).
    Electronic ISSN: 2071-1050
    Topics: Energy, Environment Protection, Nuclear Power Engineering
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  • 30
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    A Low-Cost, Portable, and Wireless In-Shoe System Based on a Flexible Porous Graphene Pressure Sensor (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-28
    Description: Monitoring gait patterns in daily life will provide a lot of biological information related to human health. At present, common gait pressure analysis systems, such as pressure platforms and in-shoe systems, adopt rigid sensors and are wired and uncomfortable. In this paper, a biomimetic porous graphene–SBR (styrene-butadiene rubber) pressure sensor (PGSPS) with high flexibility, sensitivity (1.05 kPa−1), and a wide measuring range (0–150 kPa) is designed and integrated into an insole system to collect, process, transmit, and display plantar pressure data for gait analysis in real-time via a smartphone. The system consists of 16 PGSPSs that were used to analyze different gait signals, including walking, running, and jumping, to verify its daily application range. After comparing the test results with a high-precision digital multimeter, the system is proven to be more portable and suitable for daily use, and the accuracy of the waveform meets the judgment requirements. The system can play an important role in monitoring the safety of the elderly, which is very helpful in today’s society with an increasingly aging population. Furthermore, an intelligent gait diagnosis algorithm can be added to realize a smart gait monitoring system.
    Electronic ISSN: 1996-1944
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
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    The Impact of Bacillus subtilis PB6 and Chromium Propionate on the Performance, Egg Quality and Nutrient Metabolizability of Layer Breeders (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-28
    Description: The objective of this study was to evaluate the effects of Bacillus subtillis PB6, chromium propionate or a combination of the two on the performance, egg and eggshell quality, nutrient metabolizability and serum biochemistry of layer breeders. White Plymouth Rock and Red Rhodes Island breeder hens at 55 weeks of age were allocated in individual cages using a completely randomized block design with 16 replicates. Hens were fed control, control + probiotic (500 g/ton of Bacillus subtilis PB6), control + CrProp (50 g/ton of chromium propionate) and control + probiotic + CrProp diets from 55 to 70 weeks of age. Productive parameters and eggshell quality as well as cortisol and blood biochemistry were grouped each 28 d as well as for the overall period. The metabolizability of nutrients and energy was determined at 70 weeks of age. In the overall period, hens fed the control + probiotic or control + probiotic + CrProp diets had significantly higher egg production, egg mass, shell percentage, thickness and shell strength. The metabolizability of dry matter, nitrogen and energy increased in hens that were fed the control + probiotic + CrProp diet. In conclusion, diets supplemented with Bacillus subtillis PB6 and chromium propionate resulted in improved productive performance, eggshell quality and nutrient metabolizability of layer breeders, without modifying serum cortisol, albumin and triglycerides.
    Electronic ISSN: 2076-2615
    Topics: Biology , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
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    A Study of the Effects of Geological Conditions on Korean Tunnel Construction Time Using the Updated NTNU Drill and Blast Prediction Model (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-28
    Description: This paper analyses the construction time and advance rate of a 3 km long drill and blast tunnel under various geological conditions using an upgraded NTNU drill and blast prediction model. The analysis was carried out for the five types of Korean tunnel supports according to the rock mass quality (from Type 1, meaning a very good rock mass quality; to Type 5, meaning a very poor rock mass quality). Four kinds of rock properties, as well as the rock mass quality, for each tunnel support type were applied to simulate different geological conditions based on previous studies and the NTNU model. The construction time was classified into five categories: basic, standard, gross, tunnel and total, according to the operation characteristics to more effectively analyse the time. In addition, to consider the actual geological conditions in tunnelling, the construction times for the three mixed geological cases were analysed. It was found that total construction time of a tunnel covering all the operations and site preparations with a very poor rock mass quality was more than twice that of a tunnel with a very good rock mass quality for the same tunnel length. It is thought that this study can be a useful approach to estimating the construction time and advance rate in the planning or design stage of a drill and blast tunnel.
    Electronic ISSN: 2076-3417
    Topics: Natural Sciences in General
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    Cross-Hedging Portfolios in Emerging Stock Markets: Evidence for the LATIBEX Index (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-28
    Description: We consider alternative possibilities for hedging spot positions on the FTSE LATIBEX Index, the index of the only international market exclusively for Latin American firms that is denominated by the euro. Since there is not a futures market on the index, it is unclear whether a relatively successful hedge can be found. We explore the plausibility of employing futures on four stock market indices: EUROSTOXX 50, S&P500, BOVESPA, and IPC, and simulate the results that could be obtained by a hedge position based on either unconditional or conditional second order moments estimated from different asymmetric GARCH models. Several criteria for hedging effectiveness suggest that futures contracts on BOVESPA should be preferred, and that a salient reduction in risk can be achieved over the unhedged LATIBEX portfolio. The evidence in favor of a better performance of conditional moments is very clear, without significant differences among the alternative GARCH specifications.
    Electronic ISSN: 2227-7390
    Topics: Mathematics
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    Gene Mapping, Cloning and Association Analysis for Salt Tolerance in Rice (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-28
    Description: Soil salinization caused by the accumulation of sodium can decrease rice yield and quality. Identification of rice salt tolerance genes and their molecular mechanisms could help breeders genetically improve salt tolerance. We studied QTL mapping of populations for rice salt tolerance, period and method of salt tolerance identification, salt tolerance evaluation parameters, identification of salt tolerance QTLs, and fine-mapping and map cloning of salt tolerance QTLs. We discuss our findings as they relate to other genetic studies of salt tolerance association.
    Print ISSN: 1661-6596
    Electronic ISSN: 1422-0067
    Topics: Chemistry and Pharmacology
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    Predictive Machine Learning of Objective Boundaries for Solving COPs (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-28
    Description: Solving Constraint Optimization Problems (COPs) can be dramatically simplified by boundary estimation, that is providing tight boundaries of cost functions. By feeding a supervised Machine Learning (ML) model with data composed of the known boundaries and extracted features of COPs, it is possible to train the model to estimate the boundaries of a new COP instance. In this paper, we first give an overview of the existing body of knowledge on ML for Constraint Programming (CP), which learns from problem instances. Second, we introduce a boundary estimation framework that is applied as a tool to support a CP solver. Within this framework, different ML models are discussed and evaluated regarding their suitability for boundary estimation, and countermeasures to avoid unfeasible estimations that avoid the solver finding an optimal solution are shown. Third, we present an experimental study with distinct CP solvers on seven COPs. Our results show that near-optimal boundaries can be learned for these COPs with only little overhead. These estimated boundaries reduce the objective domain size by 60-88% and can help the solver find near-optimal solutions early during the search.
    Electronic ISSN: 2673-2688
    Topics: Computer Science
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    Histone Modification in NSCLC: Molecular Mechanisms and Therapeutic Targets (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-28
    Description: Lung cancer is the leading cause of cancer mortality in both genders, with non-small cell lung cancer (NSCLC) accounting for about 85% of all lung cancers. At the time of diagnosis, the tumour is usually locally advanced or metastatic, shaping a poor disease outcome. NSCLC includes adenocarcinoma, squamous cell carcinoma, and large cell lung carcinoma. Searching for novel therapeutic targets is mandated due to the modest effect of platinum-based therapy as well as the targeted therapies developed in the last decade. The latter is mainly due to the lack of mutation detection in around half of all NSCLC cases. New therapeutic modalities are also required to enhance the effect of immunotherapy in NSCLC. Identifying the molecular signature of NSCLC subtypes, including genetics and epigenetic variation, is crucial for selecting the appropriate therapy or combination of therapies. Epigenetic dysregulation has a key role in the tumourigenicity, tumour heterogeneity, and tumour resistance to conventional anti-cancer therapy. Epigenomic modulation is a potential therapeutic strategy in NSCLC that was suggested a long time ago and recently starting to attract further attention. Histone acetylation and deacetylation are the most frequently studied patterns of epigenetic modification. Several histone deacetylase (HDAC) inhibitors (HDIs), such as vorinostat and panobinostat, have shown promise in preclinical and clinical investigations on NSCLC. However, further research on HDIs in NSCLC is needed to assess their anti-tumour impact. Another modification, histone methylation, is one of the most well recognized patterns of histone modification. It can either promote or inhibit transcription at different gene loci, thus playing a rather complex role in lung cancer. Some histone methylation modifiers have demonstrated altered activities, suggesting their oncogenic or tumour-suppressive roles. In this review, patterns of histone modifications in NSCLC will be discussed, focusing on the molecular mechanisms of epigenetic modifications in tumour progression and metastasis, as well as in developing drug resistance. Then, we will explore the therapeutic targets emerging from studying the NSCLC epigenome, referring to the completed and ongoing clinical trials on those medications.
    Print ISSN: 1661-6596
    Electronic ISSN: 1422-0067
    Topics: Chemistry and Pharmacology
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    Towards Understanding the Chemical Structure Modification of EVA Copolymer upon MAPLE Processing of Thin Films (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-28
    Description: A series of coatings from poly(ethylene-co-vinyl acetate) (EVA) were obtained using the matrix-assisted pulsed laser evaporation (MAPLE) technique. By changing the process parameters, i.e., laser fluence and EVA co-polymer concentration in the target, coatings with various morphologies and topographies were produced. The evaluation of the film structure was based on an analysis of optical and atomic force microscopy and profilometry measurements. A detailed chemical structure investigation, conducted based on Fourier transform infrared (FTIR) and X-ray photoelectron spectroscopy (XPS) spectra, revealed that although the general structure was preserved, some alterations of ethylene (Et) and vinyl acetate (VAc) blocks took place. The most noticeable change was in the ester group that was transformed into ketone and carboxyl groups; nevertheless, some changes in the aliphatic main chain were also present. The chemical structure changes in EVA coatings took place regardless of the process parameters used. The use of chloroform as a solvent to dissolve the EVA copolymer was indicated as a possible reason of the changes as well as the tendency of EVA macromolecules to form clusters. Nevertheless, due to low level of structure alteration, it has been shown that the MAPLE technique can be successfully used to obtain coatings from polymers with more complex structures, which are soluble in a limited number of solvents.
    Print ISSN: 1661-6596
    Electronic ISSN: 1422-0067
    Topics: Chemistry and Pharmacology
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    X-ray Structure Determination, Antioxidant Voltammetry Studies of Butein and 2′,4′-Dihydroxy-3,4-dimethoxychalcone. Computational Studies of 4 Structurally Related 2′,4′-diOH Chalcones to Examine Their Antimalarial Activity by Binding to Falcipain-2 (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-28
    Description: Malaria is a huge global health burden with resistance to currently available medicines resulting in the search for newer antimalarial compounds from traditional medicinal plants in malaria-endemic regions. Previous studies on two chalcones, homobutein and 5-prenylbutein, present in E. abyssinica, have shown moderate antiplasmodial activity. Here, we describe results from experimental and computational investigations of four structurally related chalcones, butein, 2′,4′-dihydroxy-3,4-dimethoxychalcone (DHDM), homobutein and 5-prenylbutein to elucidate possible molecular mechanisms by which these compounds clear malaria parasites. The crystal structures of butein and DHDM show that butein engages in more hydrogen bonding and consequently, more intermolecular interactions than DHDM. Rotating ring-disk electrode (RRDE) voltammetry results show that butein has a higher antioxidant activity towards the superoxide radical anion compared to DHDM. Computational docking experiments were conducted to examine the inhibitory potential of all four compounds on falcipain-2, a cysteine protease that is involved in the degradation of hemoglobin in plasmodium-infected red blood cells of the host. Overall, this work suggests butein as a better antimalarial compound due to its structural features which allow it to have greater intermolecular interactions, higher antioxidant activity and to create a covalent complex at the active site of falcipain-2.
    Electronic ISSN: 1420-3049
    Topics: Chemistry and Pharmacology
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    SAP-Net: A Simple and Robust 3D Point Cloud Registration Network Based on Local Shape Features (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-28
    Description: Point cloud registration is a key step in the reconstruction of 3D data models. The traditional ICP registration algorithm depends on the initial position of the point cloud. Otherwise, it may get trapped into local optima. In addition, the registration method based on the feature learning of PointNet cannot directly or effectively extract local features. To solve these two problems, this paper proposes SAP-Net, inspired by CorsNet and PointNet++, as an optimized CorsNet. To be more specific, SAP-Net firstly uses the set abstraction layer in PointNet++ as the feature extraction layer and then combines the global features with the initial template point cloud. Finally, PointNet is used as the transform prediction layer to obtain the six parameters required for point cloud registration directly, namely the rotation matrix and the translation vector. Experiments on the ModelNet40 dataset and real data show that SAP-Net not only outperforms ICP and CorsNet on both seen and unseen categories of the point cloud but also has stronger robustness.
    Electronic ISSN: 1424-8220
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
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  • 40
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    Numerical Simulation and Experimental Validation of Melt Flow in the Naturally Pressurized Gating System (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-28
    Description: The main problem during the production of castings from aluminium alloys is the presence of the reoxidation, which negatively affects the final casting quality. Liquid metal surface reacts with the surrounding atmosphere and oxide layer of Al2O3 is formed on its surface. The problem occurs when the oxide layer is entrained to the internal volume of the melt by turbulence and double oxide layers are formed, also known as “bifilms”. Its formation is related to the melt velocity and gating system design. In paper, naturally pressurized gating system was calculated and designed. Effect of the filter media and vortex element on the melt velocity, amount of oxides, mechanical properties, and porosity were observed. Designs with 10 ppi and 20 ppi foam filters and vortex element were compared with design without filters to prove the positive (or negative) effect of filter media on melt velocity and thus on final casting quality. The melt velocity and amount of oxides were observed with the aid of simulation software. Mechanical properties, quantity of pores, bifilm index and EDX analysis were evaluated after experimental casts. It was proven that by using 20 ppi foam filter in combination with vortex element, the best results were achieved.
    Electronic ISSN: 2227-9717
    Topics: Biology , Chemistry and Pharmacology
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    Constructing a Precise Fuzzy Feedforward Neural Network Using an Independent Fuzzification Approach (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-28
    Description: This study discusses how to fuzzify a feedforward neural network (FNN) to generate a fuzzy forecast that contains the actual value, while minimizing the average range of fuzzy forecasts. This topic has rarely been investigated in past studies but is an essential step to constructing a precise fuzzy FNN (FFNN). Existing methods fuzzify all parameters at the same time, which results in a nonlinear programming (NLP) problem that is not easy to solve. In contrast, in this study, the parameters of a FNN are fuzzified independently. In this way, the optimal values of fuzzy parameters can be derived theoretically. An illustrative example is used to illustrate the applicability of the proposed methodology. According to experimental results, fuzzyifying some parameters may not guarantee that all fuzzy forecasts contain the corresponding actual values. In addition, fuzzifying parameters closer to the output node is more likely to achieve a 100% hit rate. The results lay a foundation for establishing a precise deep FFNN in the future.
    Electronic ISSN: 2075-1680
    Topics: Mathematics
    Published by Molecular Diversity Preservation International
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    Gamification in E-Learning and Sustainability: A Theoretical Framework (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-28
    Description: Progress in communication technologies and social isolation caused by the COVID-19 pandemic have supported the acceptance of e-learning. In the e-learning context, gamification has been identified as one of the most promising trends. Many researchers believe in the game elements’ capacity to drive learning, skills acquisition, and changes for more sustainable behavior. However, the literature on the subject is dispersed, addressing behavioral attitudes and elements in an isolated and fragmented way. This study aims to present a framework relating game elements to behavioral attitudes to promote sustainability and ensure quality of learning. The methodology is based on a systematic literature review using the PRISMA protocol, covering the content analysis of 130 articles indexed in the Web of Science database. For the framework construction, the following were identified: behavioral attitudes stimulated by gamification; main game elements and how they relate to each other. Based on this, a framework called 7GOALS (Gamification-Oriented Active Learning Steps) associated with the PDCA (Plan, Do, Check, Act) was established. The proposed structure is multidisciplinary and can be used in any knowledge field that uses gamification. With this, themes such as sustainability can be widely disseminated and leverage changes towards more sustainable behaviors that adhere to the real world.
    Electronic ISSN: 2071-1050
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by Molecular Diversity Preservation International
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    Marine Polymer-Gels’ Relevance in the Atmosphere as Aerosols and CCN (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-28
    Description: Marine polymer gels play a critical role in regulating ocean basin scale biogeochemical dynamics. This brief review introduces the crucial role of marine gels as a source of aerosol particles and cloud condensation nuclei (CCN) in cloud formation processes, emphasizing Arctic marine microgels. We review the gel’s composition and relation to aerosols, their emergent properties, and physico-chemical processes that explain their change in size spectra, specifically in relation to aerosols and CCN. Understanding organic aerosols and CCN in this context provides clear benefits to quantifying the role of marine nanogel/microgel in microphysical processes leading to cloud formation. This review emphasizes the DOC-marine gel/aerosolized gel-cloud link, critical to developing accurate climate models.
    Electronic ISSN: 2310-2861
    Topics: Physics
    Published by Molecular Diversity Preservation International
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  • 44
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    On PSO-Based Simulations of Fuzzy Dynamical Systems Induced by One-Dimensional Ones (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-28
    Description: Zadeh’s extension principle is one of the elementary tools in fuzzy set theory, and among other things, it provides a natural extension of a real-valued continuous self-map to a self-map having fuzzy sets as its arguments. The purpose of this paper is to introduce a new algorithm that can be used for simulations of fuzzy dynamical systems induced by interval maps. The core of the proposed algorithm is based on calculations including piecewise linear maps, and consequently, an implementation of an optimization algorithm (in our case, particle swarm optimization) was prepared to obtain necessary piecewise linear approximations. For all parts of this algorithm, we provide detailed testing and numerous examples.
    Electronic ISSN: 2227-7390
    Topics: Mathematics
    Published by Molecular Diversity Preservation International
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  • 45
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    Evaluation of the Usability of a Low-Cost 3D Printer in a Tissue Engineering Approach for External Ear Reconstruction (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-28
    Description: The use of alloplastic materials instead of autologous cartilage grafts offers a new perspective in craniofacial reconstructive surgery. Particularly for regenerative approaches, customized implants enable the surgeon to restore the cartilaginous framework of the ear without donor site morbidity. However, high development and production costs of commercially available implants impede clinical translation. For this reason, the usability of a low-cost 3D printer (Ultimaker 2+) as an inhouse-production tool for cheap surgical implants was investigated. The open software architecture of the 3D printer was modified in order to enable printing of biocompatible and biologically degradable polycaprolactone (PCL). Firstly, the printing accuracy and limitations of a PCL implant were compared to reference materials acrylonitrile butadiene styrene (ABS) and polylactic acid (PLA). Then the self-made PCL-scaffold was seeded with adipose-tissue derived stem cells (ASCs), and biocompatibility was compared to a commercially available PCL-scaffold using a cell viability staining (FDA/PI) and a dsDNA quantification assay (PicoGreen). Secondly, porous and solid patient-customized ear constructs were manufactured from mirrored CT-imagining data using a computer-assisted design (CAD) and computer-assisted manufacturing (CAM) approach to evaluate printing accuracy and reproducibility. The results show that printing of a porous PCL scaffolds was possible, with an accuracy equivalent to the reference materials at an edge length of 10 mm and a pore size of 0.67 mm. Cell viability, adhesion, and proliferation of the ASCs were equivalent on self-made and the commercially available PCL-scaffolds. Patient-customized ear constructs could be produced well in solid form and with limited accuracy in porous form from all three thermoplastic materials. Printing dimensions and quality of the modified low-cost 3D printer are sufficient for selected tissue engineering applications, and the manufacturing of personalized ear models for surgical simulation at manufacturing costs of EUR 0.04 per cell culture scaffold and EUR 0.90 (0.56) per solid (porous) ear construct made from PCL. Therefore, in-house production of PCL-based tissue engineering scaffolds and surgical implants should be further investigated to facilitate the use of new materials and 3D printing in daily clinical routine.
    Print ISSN: 1661-6596
    Electronic ISSN: 1422-0067
    Topics: Chemistry and Pharmacology
    Published by Molecular Diversity Preservation International
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  • 46
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    Residual Stress and Tribological Performance of ZrN Coatings Produced by Reactive Bipolar Pulsed Magnetron Sputtering (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-28
    Description: In the past few decades, ZrN thin films have been identified as wear resistant coatings for tribological applications. The mechanical and tribological properties of ZrN thin layers depend on internal stress induced by the adopted deposition techniques and deposition parameters such as pressure, temperature, and growth rate. In sputtering deposition processes, the selected target voltage waveform and the plasma characteristics also play a crucial influence on physical properties of produced coatings. In present work, ZrN thin films, obtained setting different values of duty cycle in a reactive bipolar pulsed dual magnetron sputtering plant, were investigated to evaluate their residual stress through the substrate curvature method. A considerable progressive increase of residual stress values was measured at decreasing duty cycle, attesting the significant role of voltage waveform in stress development. An evident correlation was also highlighted between the values of the duty cycle and those of wear factor. The performed analysis attested an advantageous effect of internal stress, having the samples with high compressive stress, higher wear resistance. A downward trend for wear rate with the increase of internal residual stress was observed. The choice of suitable values of duty cycle allowed to produce ceramic coatings with improved tribological performance.
    Electronic ISSN: 1996-1944
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by Molecular Diversity Preservation International
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    Genomic Analysis of Prophages from Klebsiella pneumoniae Clinical Isolates (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-28
    Description: Klebsiella pneumoniae is an increasing threat to public health and represents one of the most concerning pathogens involved in life-threatening infections. The resistant and virulence determinants are coded by mobile genetic elements which can easily spread between bacteria populations and co-evolve with its genomic host. In this study, we present the full genomic sequences, insertion sites and phylogenetic analysis of 150 prophages found in 40 K. pneumoniae clinical isolates obtained from an outbreak in a Portuguese hospital. All strains harbored at least one prophage and we identified 104 intact prophages (69.3%). The prophage size ranges from 29.7 to 50.6 kbp, coding between 32 and 78 putative genes. The prophage GC content is 51.2%, lower than the average GC content of 57.1% in K. pneumoniae. Complete prophages were classified into three families in the order Caudolovirales: Myoviridae (59.6%), Siphoviridae (38.5%) and Podoviridae (1.9%). In addition, an alignment and phylogenetic analysis revealed nine distinct clusters. Evidence of recombination was detected within the genome of some prophages but, in most cases, proteins involved in viral structure, transcription, replication and regulation (lysogenic/lysis) were maintained. These results support the knowledge that prophages are diverse and widely disseminated in K. pneumoniae genomes, contributing to the evolution of this species and conferring additional phenotypes. Moreover, we identified K. pneumoniae prophages in a set of endolysin genes, which were found to code for proteins with lysozyme activity, cleaving the β-1,4 linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in the peptidoglycan network and thus representing genes with the potential for lysin phage therapy.
    Electronic ISSN: 2076-2607
    Topics: Biology
    Published by Molecular Diversity Preservation International
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    Development of a Visual Servo System for Robotic Fruit Harvesting (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-28
    Description: One of the challenges in the future of food production, amidst increasing population and decreasing resources, is developing a sustainable food production system. It is anticipated that robotics will play a significant role in maintaining the food production system, specifically in labor-intensive operations. Therefore, the main goal of this project is to develop a robotic fruit harvesting system, initially focused on the harvesting of apples. The robotic harvesting system is composed of a six-degrees-of-freedom (DOF) robotic manipulator, a two-fingered gripper, a color camera, a depth sensor, and a personal computer. This paper details the development and performance of a visual servo system that can be used for fruit harvesting. Initial test evaluations were conducted in an indoor laboratory using plastic fruit and artificial trees. Subsequently, the system was tested outdoors in a commercial fruit orchard. Evaluation parameters included fruit detection performance, response time of the visual servo, and physical time to harvest a fruit. Results of the evaluation showed that the developed visual servo system has the potential to guide the robot for fruit harvesting.
    Electronic ISSN: 2624-7402
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by Molecular Diversity Preservation International
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    Multifunctional Optical Device with a Continuous Tunability over 500 nm Spectral Range Using Polymerized Cholesteric Liquid Crystals (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-28
    Description: We report that polymerization makes a robust, practically applicable multifunctional optical device with a continuous wavelength tunable over 500 nm spectral range using UV-polymerizable cholesteric liquid crystals (CLCs). It can be used as a circular polarizer generating an extremely high degree of circularly polarized light with |g| = 1.85~2.00. It can also be used for optical notch filters, bandwidth-variable (from ~28 nm to ~93 nm) bandpass filters, mirrors, and intensity-variable beam splitters. Furthermore, this CLC device shows excellent stability owing to the polymerization of CLC cells. Its performance remains constant for a long time (~2 years) after a high-temperature exposure (170 °C for 1 h) and an extremely high laser beam intensity exposure (~143 W/cm2 of CW 532 nm diode laser and ~2.98 MW/cm2 of Nd: YAG pulse laser operation for two hours, respectively). The optical properties of polymerized CLC were theoretically analyzed by Berreman’s 4 × 4 matrix method. The characteristics of this device were significantly improved by introducing an anti-reflection layer on the device. This wavelength-tunable and multifunctional device could dramatically increase optical research efficiency in various spectroscopic works. It could be applied to many instruments using visible and near-infrared wavelengths.
    Electronic ISSN: 2073-4360
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Process Engineering, Biotechnology, Nutrition Technology
    Published by Molecular Diversity Preservation International
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    Geographic Graph Hybrid Network for Robust Inversion of Particulate Matters (2021)
    Molecular Diversity Preservation International
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    Publication Date: 2021-10-28
    Description: Although remote sensors have been increasingly providing dense data and deriving reanalysis data for inversion of particulate matters, the use of these data is considerably limited by the ground monitoring samples and conventional machine learning models. As regional criteria air pollutants, particulate matters present a strong spatial correlation of long range. Conventional machine learning cannot or can only model such spatial pattern in a limited way. Here, we propose a method of a geographic graph hybrid network to encode a spatial neighborhood feature to make robust estimation of coarse and fine particulate matters (PM10 and PM2.5). Based on Tobler’s First Law of Geography and graph convolutions, we constructed the architecture of a geographic graph hybrid network, in which full residual deep layers were connected with graph convolutions to reduce over-smoothing, subject to the PM10–PM2.5 relationship constraint. In the site-based independent test in mainland China (2015–2018), our method achieved much better generalization than typical state-of-the-art methods (improvement in R2: 8–78%, decrease in RMSE: 14–48%). This study shows that the proposed method can encode the neighborhood information and can make an important contribution to improvement in generalization and extrapolation of geo-features with strong spatial correlation, such as PM2.5 and PM10.
    Electronic ISSN: 2072-4292
    Topics: Architecture, Civil Engineering, Surveying , Geography
    Published by Molecular Diversity Preservation International
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