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  • Books  (5,535)
  • Firenze University Press  (3,086)
  • Frontiers Media SA  (2,449)
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  • 1
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: social-decision making ; animal behavior ; behavioral ecology ; animal collective behavior ; animal SDM ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 2
    Publication Date: 2024-04-09
    Description: The proposal is founded to reconversion the existing breakwaters and artificial nourishments with an artificial reef positioned on the “calm belt” for mimics the location of coral reef. This calm is characterized by the conversion of pulsing vertical wave offshore energy into inshore horizontal currents. The soft barrier, far from the storm surges, diminish water velocity with no erosion in excess and electric power generation. Moreover, the turbines have the impeller semi-submerged and close to an indifferent buoyancy, in order to favor the number of revolutions at minimum currents
    Keywords: Soft artificial reef ; Reconversion breakwater ; Erosion control ; Wave Energy Converter ; Beach recovery ; Posidonia nursery ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RN The environment
    Language: English
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  • 3
    Publication Date: 2024-04-05
    Description: After a quarter of century of rapid technological advances, research has revealed the complexity of cancer, a disease intimately related to the dynamic transformation of the genome. However, the full understanding of the molecular onset of this disease is still far from achieved and the search for mechanisms of treatment will follow closely. It is here that Nanotechnology enters the fray offering a wealth of tools to diagnose and treat cancer. In fact, the National Cancer Institute predicts that over the next years, nanotechnology will result in important advances in early detection, molecular imaging, targeted and multifunctional therapeutics, prevention and control of cancer. Nanotechnology offers numerous tools to diagnose and treat cancer, such as new imaging agents, multifunctional devices capable of overcome biological barriers to deliver therapeutic agents directly to cells and tissues involved in cancer growth and metastasis, and devices capable of predicting molecular changes to prevent action against precancerous cells. Nanomaterials-based delivery systems in Theranostics (Diagnostics & Therapy) provide better penetration of therapeutic and diagnostic substances within the body at a reduced risk in comparison to conventional therapies. At the present time, there is a growing need to enhance the capability of theranostics procedures where nanomaterials-based sensors may provide for the simultaneous detection of several gene-associated conditions and nanodevices with the ability to monitor real-time drug action. These innovative multifunctional nanocarriers for cancer theranostics may allow the development of diagnostics systems such as colorimetric and immunoassays, and in therapy approaches through gene therapy, drug delivery and tumor targeting systems in cancer. Some of the thousands and thousands of published nanosystems so far will most likely revolutionize our understanding of biological mechanisms and push forward the clinical practice through their integration in future diagnostics platforms. Nevertheless, despite the significant efforts towards the use of nanomaterials in biologically relevant research, more in vivo studies are needed to assess the applicability of these materials as delivery agents. In fact, only a few went through feasible clinical trials. Nanomaterials have to serve as the norm rather than an exception in the future conventional cancer treatments. Future in vivo work will need to carefully consider the correct choice of chemical modifications to incorporate into the multifunctional nanocarriers to avoid activation off-target, side effects and toxicity. Moreover the majority of studies on nanomaterials do not consider the final application to guide the design of nanomaterial. Instead, the focus is predominantly on engineering materials with specific physical or chemical properties. It is imperative to learn how advances in nanosystem’s capabilities are being used to identify new diagnostic and therapy tools driving the development of personalized medicine in oncology; discover how integrating cancer research and nanotechnology modeling can help patient diagnosis and treatment; recognize how to translate nanotheranostics data into an actionable clinical strategy; discuss with industry leaders how nanotheranostics is evolving and what the impact is on current research efforts; and last but not least, learn what approaches are proving fruitful in turning promising clinical data into treatment realities.
    Keywords: QD1-999 ; Q1-390 ; Nanoparticles ; Gene Therapy ; Immunotherapy ; bioimaging ; theranostics ; nanomaterials ; Drug delivery ; Nanomedicine ; Cancer ; Phototherapy ; thema EDItEUR::P Mathematics and Science::PN Chemistry
    Language: English
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  • 4
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    Firenze University Press
    Publication Date: 2022-09-22
    Description: Ukrainian, unlike other East Slavic languages, is characterized by the active use of significant lexical components derived from Romance, Germanic, and West Slavic languages. This article presents a brief overview of the presence of Romance language lexical elements in Ukrainian and lays the groundwork for further research on the Ukrainian alloglot lexis and the comparison of Ukrainian with Russian and Belarusian.
    Keywords: lexicology ; loan-words ; Ukrainian ; Romance languages ; East Slavic languages ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHB Sociology
    Language: Italian
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  • 5
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: omics ; epigenetics ; pharmacogenetics ; CYP ; risk prediction ; microbiota ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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  • 6
    Publication Date: 2024-04-11
    Description: It has become more evident that many microalgae respond very differently than land plants to diverse stimuli. Therefore, we cannot reduce microalgae biology to what we have learned from land plants biology. However, we are still at the beginning of a comprehensive understanding of microalgae biology. Microalgae have been posited several times as prime candidates for the development of sustainable energy platforms, making thus the in-depth understanding of their biological features an important objective. Thus, the knowledge related to the basics of microalgae biology must be acquired and shared rapidly, fostering the development of potential applications. Microalgae biology has been studied for more than forty years now and more intensely since the 1970’s, when genetics and molecular biology approaches were integrated into the research programs. Recently, studies on the molecular physiology of microalgae have provided evidences on the particularities of these organisms, mainly in model species, such as Chlamydomonas reinhardtii. Of note, cellular responses in microalgae produce very interesting phenotypes, such as high lipid content in nitrogen deprived cells, increased protein content in cells under high CO2 concentrations, the modification of flagella structure and motility in basal body mutant strains, the different ancient proteins that microalgae uses to dissipate the harmful excess of light energy, the hydrogen production in cells under sulfur deprivation, to mention just a few. Moreover, several research groups are using high-throughput and data-driven technologies, including “omics” approaches to investigate microalgae cellular responses at a system-wide level, revealing new features of microalgae biology, highlighting differences between microalgae and land plants. It has been amazing to observe the efforts towards the development and optimization of new technologies required for the proper study of microalgae, including methods that opened new paths to the investigation of important processes such as regulatory mechanisms, signaling crosstalk, chemotactic mechanisms, light responses, chloroplast controlled mechanisms, among others. This is an exciting moment in microalgae research when novel data are been produced and applied by research groups from different areas, such as bioprocesses and biotechnology. Moreover, there has been an increased amount of research groups focused in the study of microalgae as a sustainable source for bioremediation, synthesis of bioproducts and development of bioenergy. Innovative strategies are combining the knowledge of basic sciences on microalgae into their applied processes, resulting in the progression of many applications that hopefully, will achieve the necessary degree of optimization for economically feasible large-scale applications. Advances on the areas of basic microalgae biology and novelties on the essential cellular processes were revealed. Progress in the applied science showed the use of the basic science knowledge into fostering translational research, proposing novel strategies for a sustainable world scenario. In this present e-book, articles presented by research groups from different scientific areas showed, successfully, the increased development of the microalgae research. Herewith, you will find articles ranging from bioprospecting regional microalgae species, through advances in microalgae molecular physiology to the development of techniques for characterization of biomass and the use of biomass into agriculture and bioenergy production. This e-book is an excellent source of knowledge for those working with microalgae basic and applied sciences, and a great opportunity for researchers from both areas to have an overview of the amazing possibilities we have for building an environmentally sustainable future once the knowledge is translated into novel applications.
    Keywords: TA1-2040 ; TP248.13-248.65 ; QK1-989 ; Q1-390 ; Biotechnology ; biomass ; Hydrogen ; bioenergy ; Nutrients ; Lipids ; Microalgae ; Biofuels ; sustainability ; Carbon Dioxide ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: English
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  • 7
    Publication Date: 2022-06-02
    Description: The surge in public debt during the recent pandemic crisis has made high debt a prominent policy issue. Italy is an interesting case study since it has experienced high levels of debt for a significant part of its history. This article revisits the history of Italian public debts in the inter-war period. Italy emerged from WWI with public debt that peaked around 160 percent of GDP. In the mid-1920s a significant reduction of public debt occurred, in concomitance with a regime of fiscal austerity and two restructuring agreements that wiped more than 80 percent of Italian foreign debts. By the early 1930s, the US reaction to the Great Depression that opposed any form of international cooperation, led to an Italian default on war debts in 1934 and a move toward autarky.
    Keywords: Italy ; Public Debt ; Debt Restructuring ; Default
    Language: Italian
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  • 8
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    Firenze University Press
    Publication Date: 2024-03-24
    Description: Vulcano, Sicily 1964. After a meeting with him in Cortona, Helle Busacca, a poet and writer from Messina, began drafting an epistolary diary dedicated to Corrado Pavolini, a well-known intellectual and film director of Tuscan origins with whom she had been in love for over twenty years. Through the so far unpublished pages she dedicated to “una storia senza storia” (“a story without history"), the writer brings to life an incandescent theatre of the self, in which the dramatization of personal experience, the self-representative elaboration and the expression of a living and restless inner self combine in a mixture of strongly hybrid characters, which is conveyed by a disruptive communicative force. As the desperately pursued interlocutor becomes increasingly evanescent and unreachable, the voice of a modern tragic heroine emerges unmistakably between claim and confession.
    Keywords: thema EDItEUR::D Biography, Literature and Literary studies ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DS Literature: history and criticism
    Language: Italian
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  • 9
    Publication Date: 2024-04-01
    Description: After a long process, the reopening of Milanese canals has become one of the fundamental actions of the Town Plan approved in 2019. A strategic project that plans to reactivate the covered section of the Naviglio Martesana and the Cerchia Interna, reuniting Adda and Ticino rivers, and give new life to the great Renaissance project that Leonardo himself had worked on. In its methodological approach and in the specific outcome achieved, we can recognize elements of continuity with Leonardo’s thinking and contribute to a territorialist reflection on its current relevance.
    Keywords: Milan water city ; reopening Navigli ; Leonardo da Vinci ; thema EDItEUR::N History and Archaeology::NH History
    Language: Italian
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  • 10
    Publication Date: 2024-03-27
    Description: This volume contains the proceedings of the Conference on the Management of collections and co-operation in the hybrid library, which was organised in Florence on 13 October 2005 by the Italian Libraries Association (Tuscan Section and University and Research Committee). The contributions are dedicated in particular to grasping the opportunities and adaptations generated by Internet and the possibility of disseminating electronic documents, both in the development of the collections and the planning of services and in the study of new forms of communication between institutions.
    Description: Il volume raccoglie gli atti del convegno su Gestione delle raccolte e cooperazione nella biblioteca ibrida, organizzato a Firenze il 13 ottobre 2005 dall'Associazione Italiana Biblioteche (Sezione Toscana e Commissione Università e Ricerca). I contributi sono dedicati in particolare a cogliere le opportunità e le modifiche dovute ad Internet e alla possibilità di diffondere documenti elettronici sia nello sviluppo delle raccolte, sia nella pianificazione dei servizi, sia nello studio di nuove forme di cooperazione fra istituzioni.
    Keywords: biblioteconomia ; biblioteche pubbliche ; biblioteconomy ; libraries ; atti di convegno ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GL Library and information sciences / Museology::GLC Library, archive and information management ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GL Library and information sciences / Museology::GLF IT, Internet and electronic resources in libraries
    Language: Italian
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  • 11
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: oligodendrocyte ; Schwann cell ; oligodendrocyte precursor cell ; myelin ; myelin repair ; axon physiology ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 12
    Publication Date: 2023-12-21
    Description: It is now well appreciated that the immune system, in addition to its traditional role in defending the organism against pathogens, communicate in a well-organized fashion with the brain to maintain homeostasis and regulate a set of neural functions. Perturbation in this brain-immune interactions due to inflammatory responses may lead to psychiatric and neurological disorders. Microglia are one of the essential cells involved in the brain-immune interactions. Microglial cells are now not simply regarded as resident tissue macrophages in the brain. These cells are derived from myeloid progenitor cells in the yolk sac in early gestation, travel to the brain parenchyma and interact actively with neurons during the critical period of neurogenesis. Microglia provide a trophic support to developing neurons and take part in the neural wiring through the activity-dependent synapse elimination via direct neuron-microglia interactions. Altered microglial functions including changes in the gene expression due to early life inflammatory events or psychological and environmental stressors can be causally related to neurodevelopmental diseases and mental health disorders. This type of alterations in the neural functions can occur in the absence of infiltration of inflammatory cells in the brain parenchyma or leptomeninges. In this sense, the pathogenetic state underlying a significant part of psychiatric and neurological diseases may be similar to “para-inflammation”, an intermediate state between homeostatic and classical inflammatory states as defined by Ruslan Medzhitov (Nature 454:428-35, 2008). Therefore, it is important to study how systemic inflammation affects brain health and how local peripheral inflammation induces changes in the brain microenvironment. Chronic pain is also induced by disturbance in otherwise well-organized multisystem interplay comprising of reciprocal neural, endocrine and immune interactions. Especially, early-life insults including exposure to immune challenges can alter the neuroanatomical components of nociception, which induces altered pain response later in life. Recently the discrete roles of microglia and blood monocyte-derived macrophages are being defined. The distinction may be further highlighted by disorders in which the brain parenchymal tissue is damaged. Therefore, studies investigating the dynamics of immune cells in traumatic brain injury and neurotropic viral infections including human immunodeficiency virus, etc. as well as neurodegenerative diseases such as amyotrophic lateral sclerosis are promising to clarify the interplay between the central nervous and immune systems. The understanding of the histological architecture providing the infrastructure of such neuro-immune interplay is also essential. This Frontiers research topic brings together fourteen articles and aims to create a platform for researchers in the field of psychoneuroimmunology to share the recent theories, hypotheses and future perspectives regarding open questions on the mechanisms of cell-cell interactions with chemical mediators among the nervous, immune and endocrine systems. We hope that this platform would reveal the relevance of the studies on multisystem interactions to enhance the understanding of the mechanisms underlying a wide variety of neurological and psychiatric disorders.
    Keywords: R5-920 ; RC346-429 ; RC581-607 ; brain-immune interaction ; fatigue ; pain ; HIV ; neuroinflammation ; traumatic brain injury ; depression ; microglia ; amyotrophic lateral sclerosis ; autism ; bic Book Industry Communication::M Medicine
    Language: English
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  • 13
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    Firenze University Press
    Publication Date: 2024-03-24
    Description: «With absolute honesty»: this is how Natalia Ginzburg worked in her editorial job at the Einaudi publishing house. Through documents from the Einaudi Archives in Turin and the Archivio del Novecento (Sapienza University), this book traces Ginzburg's editorial work in the postwar period, when she had major editorial responsibility and coordinated the translation of Proust’s Recherche. The correspondences with authors and translators restore a new profile of the writer, bringing to light the relevance of her intervention in narrative series, such as “Coralli” and “Gettoni”; the interaction between the professions of writer, editor and translator, from which recurring elements of poetics emerge; and the issues involved in being the only woman to have a decision-making role in the Einaudi editorial staff of the time.
    Keywords: Natalia Ginzburg ; Einaudi ; 20th century literature ; publishing ; translation ; thema EDItEUR::D Biography, Literature and Literary studies
    Language: Italian
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  • 14
    Publication Date: 2022-04-28
    Description: This book addresses the topic of entrepreneurial succession in the family business. This is a fundamental passage, frequently decisive in a type of enterprise that is extremely common in the Italian and European economic context. Consequently, it is evident that appropriate planning of this phase and a knowledge of the most pertinent strategic and operational alternatives are of crucial importance. After an initial overview of the specific features of the family business, the book addresses the typical problems related to the opening up of the corporate structure and the succession process from an entrepreneurial point of view. This is followed by an analysis of various tools for planning the succession and the principal operations deemed functional to the entrepreneurial succession process.
    Description: In questo volume si affronta il tema della successione imprenditoriale nell'impresa familiare. Si tratta di un passaggio fondamentale, spesso decisivo per la sopravvivenza di questo particolare tipo di imprese, peraltro molto diffuso nel contesto economico italiano ed europeo. Emerge dunque con forza l'importanza di un'adeguata pianificazione e conoscenza delle alternative strategiche ed operative ideali a realizzarla. Dopo una ricognizione delle peculiarità delle imprese familiari, vengono affrontate le problematiche tipiche dell'apertura della compagine sociale e della procedura successoria, in un'ottica imprenditoriale. Vengono quindi analizzati alcuni strumenti di pianificazione successoria e le principali operazioni ritenute utili al processo successorio-imprenditoriale.
    Keywords: economy ; gestione d'impresa ; business & management ; economia ; bic Book Industry Communication::K Economics, finance, business & management::KJ Business & management::KJC Business strategy
    Language: Italian
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  • 15
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    Firenze University Press
    Publication Date: 2024-03-24
    Description: In light of the dramatic events which have been shocking Ukraine since November 2013, this work’s itinerary aims at functioning as a basis for the formulation of new contact points, for a dialogue between traditions and cultures which nowadays are again being shaken by the events of history. The author examines the self-identification paths of the literary phenomenon of Russian language in Ukraine. With the help of interviews with important representatives of the Ukrainian Russian-speaking literary scene, made on the eve of the so-called 'Ukrainian crisis', the author shall closely observe the origins of the marginal nature of these 'post-Soviet hybrid narratives'.
    Keywords: thema EDItEUR::C Language and Linguistics::CF Linguistics ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DS Literature: history and criticism
    Language: Italian
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  • 16
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    Firenze University Press
    Publication Date: 2024-04-01
    Description: The paper presents a reasoned review of digital resources useful for historians and the teaching of public history. This review will not be limited only to the tools of search and treatment of sources on the web, but will be directed above all to provide a guidance framework - which will be by the very nature of the digital constantly evolving over time - of those tools, methods and narratives that make use of digital to enhance teaching and research.
    Keywords: public history ; digital history ; review ; teaching ; research ; thema EDItEUR::N History and Archaeology::NH History
    Language: Italian
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  • 17
    Publication Date: 2024-04-05
    Description: In the past two decades there have been significant advances made in understanding the cellular and molecular alterations that occur with brain ageing, as well as with our understanding of age-related brain diseases. Ageing is associated with a mid-life decline in many cognitive domains (eg. Attention, working memory, episodic memory) that progresses with advancing age and which may be potentiated by a variety of diseases. However, despite the breadth of attempts to explain it, the underlying basis for age-related memory impairment remains poorly understood. Both normal and “pathological” ageing (as in age-related neurodegenerative disorders such as Alzheimer’s disease) may be associated with overlapping and increased levels of “abnormal” pathology, and this may be a potential mediator of cognitive decline in both populations. An emerging hypothesis in this field is that metal ion dys/homeostasis may represent a primary unifying mechanism to explain age- and disease-associated memory impairment – either indirectly via an effect on disease pathogenesis, or by a direct effect on signaling pathways relevant to learning and memory. There remains a concerted worldwide effort to deliver an effective therapeutic treatment for cognitive decline associated with ageing and/or disease, which is currently an unmet need. There have been numerous clinical trials conducted specifically testing drugs to prevent cognitive decline and progression to dementia, but to date the results have been less than impressive, highlighting the urgent need for a greater understanding of the neurobiological basis of memory impairment in ageing and disease which can then drive the search for effective therapeutics.
    Keywords: RC321-571 ; Q1-390 ; Down Syndrome ; Amyotrophic Lateral Sclerosis ; Parkinson's disease ; aluminium ; Iron ; TBI ; Cognition ; Copper ; Alzheimer's disease ; Zinc ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 18
    Publication Date: 2024-04-04
    Description: Evolution of the horse has been an often-cited primary example of evolution, as well as one of the classic and important stories in paleontology for over a century and a half, due to their rich fossil record across 5 continents: North America, South America, Europe, Asia and Africa. The recent horse has served a profound role in human ancestry, including agriculture, commerce, sport, transport, warfare, and in prehistory, for the subsistence of humans. Many studies have examined the evolution of the Equidae and chronicled the striking changes in skulls, dentition, limbs, and body size which have long been perceived to be a response to environmental shifts through time. Most comprehensive studies heretofore have: (1) focused on the “Great Transformation”- changes that occurred in the early Miocene, (2) involved tracking long-term diversity or paleoecological trends on a single continent or within a geographical locality, or (3) concentrated on the 3-toed hipparions. The Plio–Pleistocene evolutionary stage of horse evolution is punctuated by the great climatic fluctuations of the Quaternary beginning 2.6 Ma which influenced Equus evolution, biogeographic dispersion and adaptation on a nearly global scale. The evolutionary biology of Equus evolution across its entire range remains relatively poorly understood and often highly controversial. Some of this lack of understanding is due to assumptions that have arisen because of the relatively derived craniodental and postcranial anatomy of Equus and its close relatives which has seemed to imply that that these forms occupied relatively homogenous and narrow dietary and locomotor niches - notions that have not been adequately addressed and rigorously tested. Other challenges have revolved around teasing apart environmentally-driven adaptation versus phylogenetically defined morphological change. Geochronologic age control of localities, geographic provinces and continents has improved, but in no way is absolute and can be reexamined in our proposed volume. Temporal resolution for paleodietary, paleohabitat and paleoecological interpretations are also challenging for understanding the evolution of Equus. Our proposed volume attempts to assemble a group of experts who will address multiple dimensions of Equus’ evolution in time and space.
    Keywords: Ecomorphology ; Equus ; Paleoecology ; Taxonomy ; Biogeography ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAF Ecological science, the Biosphere
    Language: English
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  • 19
    Publication Date: 2023-12-21
    Description: Poly-ADP ribose polymerase (PARP) proteins are critical mediators of DNA repair. Many traditional anti-cancer chemotherapy agents overwhelm a cell’s ability to repair DNA damage in order to kill proliferating malignant cells. Recent evidence suggests that cancers within and across tissue types have specific defects in DNA repair pathways, and that these defects may predispose for sensitivity and resistance to various classes of cytotoxic agents. Breast, ovarian and other cancers develop in the setting of inherited DNA repair deficiency, and these cancers may be more sensitive to cytotoxic agents that induce DNA strand breaks, as well as to inhibitors of PARP activity. A series of recent clinical trials has tested whether PARP inhibitors can achieve synthetic lethality in hereditary DNA repair-deficient tumors. At the current time, mutation of BRCA serves as a potential, but not comprehensive, biomarker to predict response to PARP inhibitor therapy. Mechanisms of resistance to PARP inhibitors are only recently being uncovered. Future studies seek to identify sporadic cancers that harbor genomic instability rendering susceptibility to PARP inhibitors that compound lethal DNA damage.
    Keywords: R5-920 ; RC254-282 ; DNA reapir ; PARP inhibitor ; Homologous Recombination ; combination therapy ; DNA Damage ; Cancer ; bic Book Industry Communication::M Medicine
    Language: English
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  • 20
    Publication Date: 2024-04-05
    Description: Neuromorphic engineering has just reached its 25th year as a discipline. In the first two decades neuromorphic engineers focused on building models of sensors, such as silicon cochleas and retinas, and building blocks such as silicon neurons and synapses. These designs have honed our skills in implementing sensors and neural networks in VLSI using analog and mixed mode circuits. Over the last decade the address event representation has been used to interface devices and computers from different designers and even different groups. This facility has been essential for our ability to combine sensors, neural networks, and actuators into neuromorphic systems. More recently, several big projects have emerged to build very large scale neuromorphic systems. The Telluride Neuromorphic Engineering Workshop (since 1994) and the CapoCaccia Cognitive Neuromorphic Engineering Workshop (since 2009) have been instrumental not only in creating a strongly connected research community, but also in introducing different groups to each other’s hardware. Many neuromorphic systems are first created at one of these workshops. With this special research topic, we showcase the state-of-the-art in neuromorphic systems.
    Keywords: RC321-571 ; Q1-390 ; neuromorphic engineering ; Learning ; Floating gate ; Neural Network ; spike-based ; event-based ; simulation ; dynamic vision sensor ; network ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 21
    Publication Date: 2024-03-24
    Description: Starting with the last European discourse of David Sassoli, our intention is to reflect on Europe, specifically, on the concept of European literature as a factor of political integration.
    Keywords: Europe ; literature ; politics ; Sassoli ; thema EDItEUR::D Biography, Literature and Literary studies
    Language: Portuguese
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  • 22
    Publication Date: 2023-12-21
    Description: This e-book provides the insight into occupational health and safety problems, challenges and solutions of the dairy sector. Thirty-two authors have been sharing their results and knowledge reflecting the challenges from small scale farming up to industrial style. The worldwide trend of growing farm sizes and a reduction in numbers is one of the major drivers for the changes in the working environment. Musculoskeletal disorders are among the most prevalent health problems of people working on farms. Nevertheless mechanisation has not reduced the number of complaints, and new problems arise due to the changing working environment.
    Keywords: R5-920 ; RA1-1270 ; immigrant workers ; Dairy farming ; OHS ; MSS ; MSD ; bic Book Industry Communication::M Medicine
    Language: English
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  • 23
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    Frontiers Media SA
    Publication Date: 2024-04-05
    Description: Despite the importance of mathematics in our educational systems little is known about how abstract mathematical thinking emerges. Under the uniting thread of mathematical development, we hope to connect researchers from various backgrounds to provide an integrated view of abstract mathematical cognition. Much progress has been made in the last 20 years on how numeracy is acquired. Experimental psychology has brought to light the fact that numerical cognition stems from spatial cognition. The findings from neuroimaging and single cell recording experiments converge to show that numerical representations take place in the intraparietal sulcus. Further research has demonstrated that supplementary neural networks might be recruited to carry out subtasks; for example, the retrieval of arithmetic facts is done by the angular gyrus. Now that the neural networks in charge of basic mathematical cognition are identified, we can move onto the stage where we seek to understand how these basics skills are used to support the acquisition and use of abstract mathematical concepts.
    Keywords: RC321-571 ; Q1-390 ; Neuroimaging ; development ; numerosity ; gifted ; Mathematical Cognition ; algebra ; abstract ; Expertise ; Arithmetic ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 24
    Publication Date: 2024-04-03
    Description: The future has always been the destiny of men of action. We note the roots of the thought and fiction of the Portuguese socialist leader, Mário Soares, in the references of the political thought of Antero de Quental and the pedagogical of António Sérgio for the economic, social, cultural and mental well-being of the Portuguese people that we make coincide with humanity because western humanism movesus.
    Keywords: Humanis ; Socialism ; Pedagogy ; thema EDItEUR::J Society and Social Sciences
    Language: Portuguese
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  • 25
    Publication Date: 2023-12-21
    Description: Microglia are essential for the development and function of the adult brain. Their ontogeny, together with the absence of turnover from the periphery and the singular environment of the central nervous system (CNS), make microglia a unique cell population compared to other tissue-macrophages. The unique properties and functions of microglial cells, such as their role in synaptic pruning or the exceptional capacity to scan the brain parenchyma and rapidly react to its perturbations, have emerged in recent years. In the coming years, understanding how microglia acquire and maintain their unique profiles in order to fulfil distinct tasks in the healthy CNS and how these are altered in disease, will be essential to develop strategies to diagnose or treat CNS disorders with an immunological component. This Research Topic covers several aspects of microglial biology, ranging from their origin and the functional role of microglia during development and lifespan, their molecular properties compared with other brain and peripheral immune cells to microglial phenotypes and functional states in neurodegenerative diseases and brain tumours. In conclusion, the present Research Topic provides a comprehensive overview of our current understanding of several cellular and molecular mechanisms that make microglia a unique immune cell population within the healthy CNS as well as under inflammatory, neurodegenerative and tumorigenic processes.
    Keywords: R5-920 ; RC346-429 ; RC581-607 ; inflammation ; brain tumour ; neurodegeneration ; microglia ; ontogeny ; bic Book Industry Communication::M Medicine
    Language: English
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  • 26
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    Firenze University Press
    Publication Date: 2024-04-02
    Description: Consciously repressed by the current dominating culture, in Italy and Europe in the late mediaeval and early modern age death was addressed with greater confidence and awareness, and sometimes even with serenity. The modes of dying and of conceiving death – and the varied and rich religious and civil rituals that accompanied it – reflected the values and the choices of rich and poor, of kings and peasants, merchants and soldiers, nobles and churchmen, men and women. Several decades after the major studies that opened the road to these strands of research in Italy too (Ariès, Tenenti), this book offers a series of penetrating and suggestive explorations of a fascinating and complex theme which no reader can consider extraneous.
    Keywords: Morte ; Ritualità religiosa ; Storia ; Medioevo ; Italia ; thema EDItEUR::N History and Archaeology::NH History::NHB General and world history
    Language: Italian
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  • 27
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Exercise Science ; Performance ; Physiology ; Japan ; Olympics ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology
    Language: English
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  • 28
    Publication Date: 2022-06-02
    Description: In this work the central area of Corsica island was studied in order to reconstruct the tectono-metamorphic history of the continental and oceanic high pressure units that occupy the structurally deeper levels of the tectonic stacking of Alpine Corsica and their stratigraphic and structural relationship with the European margin (Hercynian Corsica). The study includes the geological mapping, the mesoscale and microscale structural analysis, the acquisition of chemical analyzes and micromaps with the microprobe, thermobarometric estimation through specific methodologies for metapelites, U-Th-Pb dating of zircons and allanites. The results obtained allows to reconstruct the geodynamic model of this sector of the Alpine belt from the Permian to the Burdigalian.
    Keywords: alpine orogeny in Corsica ; geological mapping ; thermobarometry on metapelites ; oceanic and continental subduction ; polyphase exhumation ; U-Pb dating ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RB Earth sciences::RBG Geology & the lithosphere
    Language: English
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  • 29
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: organohalide respiration ; Microbial reductive dehalogenation ; Dehalococcoides ; electron transport chain ; reductive dehalogenase ; Community composition and function ; bioremediation ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKF Pathology::MKFM Medical microbiology and virology ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical)
    Language: English
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  • 30
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: artificial reefs ; offshore oil and gas platforms ; coastal infrastructure ; aquaculture facilities ; anthropogenic influences ; ecological restoration ; marine conservation ; rigs-to-reef ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RB Earth sciences::RBK Hydrology and the hydrosphere::RBKC Oceanography (seas and oceans)
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  • 31
    Publication Date: 2023-12-21
    Description: The non-classical HLA class I molecule HLA-G is different from classical HLA class I molecules because of the low polymorphism in the coding region, the fact that HLA-G primary transcript is alternatively spliced in seven isoforms, and the inhibitory action on immune cells. Although HLA-G is low polymorphic, variants in both promoter and 3’ un-translated region (UTR) of HLA-G locus regulate its expression. In healthy conditions, a basal level of HLA-G gene transcription is observed in most cells and tissues; however, translation into HLA-G protein is restricted to trophoblasts in the placenta, where it participates in promoting tolerance at the fetal-maternal interface. HLA-G is also expressed by thymic epitelial, cornea, mesenchymal stem cells, nail matrix, pancreatic beta cells, erythroid, and endothelial precursors. HLA-G can be neo-expressed in adult tissues in pathological conditions, and its expression has been documented autoimmune disorders, viral infections, and cancer. In the latter setting de novo HLA-G expression is associated with the capability of tumor cells to evade the immune control. In the last decade it has become evident that HLA-G expression on T cells and antigenpresenting cells confers to these cells tolerogenic properties. This Research Topic focused on i) summarizing updated clinical and immunological evidences that HLA-G expression is associate with beneficial or detrimental tolerance, ii) gathering new insights into the mechanisms governing the expression of HLA-G in healthy and pathological conditions, such as pre-eclampsia, and iii) examining the mechanisms underlying HLA-G mediated tolerance.
    Keywords: R5-920 ; RC581-607 ; Pregnancy ; Autoimmunity ; Immuno-modulation ; Pre-Eclampsia ; Infections ; Exosomes ; HLA-G ; polymorphisms ; tolerance ; Cancer ; bic Book Industry Communication::M Medicine
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  • 32
    Publication Date: 2024-03-29
    Description: In the year 2013, ‘selfie’ was named word of the year by Oxford Dictionaries in recognition of dramatic changes in frequency, prominence, and register of the term. This drastic increase in selfie-taking was spurred by two factors. The first was the advent of smartphones equipped with front cameras and preview screens that made it easy to compose a photographic self-portrait by a process of deliberately exploring one’s image, choosing a pose, and finally taking the picture. The second key change contributing to the rise of the selfie age was the increasing availability of internet connections. It is estimated that about 50% of the world population has access to the internet today (2018; https://www.internetworldstats.com). At the end of the past century, this percentage was a mere 1%. The growth of the internet infrastructure simultaneously spurred the development of social network applications such as Facebook, Twitter, Snapchat, and Instagram, providing accessible media for sharing photographs including photographic self-portraits. However, despite their tremendous reach and popularity, selfies have so far received relatively little attention by the scientific community, especially within psychology. Thus, we proposed a Frontiers in Psychology Research Topic to expand empirical and theoretical work on the massively popular, yet scientifically unexplored, phenomenon of the selfie. The articles published in this eBook offer a multifaceted insight into current scholarly work on this topic.
    Keywords: BF1-990 ; Q1-390 ; group selfies ; self-esteem ; Human Computer Interaction (HCI) ; self-presentation ; selfie ; viewing perspective ; perception bias ; smartphones ; social media ; internet ; bic Book Industry Communication::J Society & social sciences::JM Psychology ; thema EDItEUR::J Society and Social Sciences::JM Psychology
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  • 33
    Publication Date: 2022-09-22
    Description: The analysis of origin-destination traffic flows may be useful in many contexts of application (e.g., urban planning, tourism economics) and have been commonly studied through the gravity model, which states that flows are proportional to ''masses" of both origin and destination, and inversely proportional to distance between them. Using data on the flow of mobile phone SIM among different aree di censimento, recorded hourly basis for several months and provided by FasterNet in the context of MoSoRe project, in this work we characterize and model the dynamic of such flows over the time in the strongly urbanized and flood-prone area of the Mandolossa (western outskirts of Brescia, northern Italy), with the aim of predicting the traffic flow during flood episodes. Whereas a traditional ”static” mass explanatory variable is represented by residential population (Pop), or by gross domestic product (GDP), here we propose to use a most accurate set of explanatory variables in order to better account for the dynamic over the time. First, we employ a time-varying mass variable represented by the number of city-users by area and by time period, which has been estimated from mobile phone data (provided by TIM) using functional data approach and already adopted to derive crowding maps for flood exposure. Secondly, we include in the model a proper set of factors such as areal and time dummies, and a novel set of indices related to (e.g.) the number and the type of streets, the number of offices, restaurants or cinemas, which may be retrieved from OpenStreetMap. The joint use of these two novel sets of explanatory variables should allow us to obtain a better linear fitting of the gravity model and a better traffic flow prediction for the flood risk evaluation.
    Keywords: Mobile phone network ; Gravity model ; Origin-destination data ; Flooding risk ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHB Sociology::JHBC Social research & statistics
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  • 34
    Publication Date: 2022-06-02
    Description: Even today, Italians tend to adopt a double imagine of their national character, played on the contrast between an evolved and conscious minority (‘us’) and a backward and typically pre-modern majority (‘them’). As Giulio Bollati has shown better than any other in a famous essay, this self-representation draws its origins first of all from the period between the late Enlightenment and the early Napoleonic age, in which for the first time the Peninsula was called to deal with the models imposed by the great European modernization. The paper aims to reconstruct the process that led some of the most prominent political thinkers of this years (Baretti, Verri, Gioia, Botta, Cuoco) to adopt the image mentioned above - and this privileging the approach of the constitutional history.
    Keywords: National characters ; Italian identity
    Language: Italian
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  • 35
    Publication Date: 2022-06-02
    Description: The research aims to analyse and justifiably develop an innovative model for the internationalization of University social responsibility experiences through the international mobility of undergraduate students, with a combination of study and internships
    Keywords: university internationalization ; university social responsibility (third mission) ; internship abroad ; service learning
    Language: English
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  • 36
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    Firenze University Press
    Publication Date: 2022-06-02
    Description: Gender discrimination continues to be a reality in several parts of the world, also in Europe. The aim of this book is to provide an overview of both European Union’s (EU) gender policies and gender balance in EU institutions. It does so by looking at gender equality policies and the EU legal system concerning gender equality, women’s representation within diff erent institutions (and more particularly in the European External Action Service), gender rights as a type of human rights and the EU’s role in the external promotion of womens’ rights in third countries. The analysis shows that women’s representation in the EU institutions has increased in the last decades and that the EU has strengthened its att ention to gender rights in its external relations as well, however the results of both att empts are far from being fully satisfactory.
    Keywords: bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPA Political science & theory
    Language: English
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  • 37
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    Frontiers Media SA
    Publication Date: 2024-03-31
    Description: The main physiological actions of the biologically most active metabolite of vitamin D, 1a,25-dihydroxyvitamin D3(1a,25(OH)2D3), are calcium and phosphorus uptake and transport and thereby controlling bone formation. Other emergent areas of 1a,25(OH)2D3 action are in the control of immune functions, cellular growth and differentiation. This fits both with the widespread expression of the VDR and the above described consequences of vitamin D deficiency. Transcriptome-wide analysis indicated that per cell type between 200 and 600 genes are primary targets of vitamin D. Since most of these genes respond to vitamin D in a cell-specific fashion, the total number of vitamin D targets in the human genome is far higher than 1,000. This is supported by the genome-wide view on VDR binding sites in human lymphocytes, monocytes, colon and hepatic cells. All genomic actions of 1a,25(OH)2D3 are mediated by the transcription factor vitamin D receptor (VDR) that has been the subject of intense study since the 1980’s. Thus, vitamin D signaling primarily implies the molecular actions of the VDR. In this research topic, we present in 15 chapters different perspectives on the action of vitamin D and its receptor, such as the impact of the genomewide distribution of VDR binding loci, ii) the transcriptome- and proteome-wide effects of vitamin D, iii) the role of vitamin D in health, iv) tissue-specific functions of vitamin D and v) the involvement of vitamin D in different diseases, such as infections, autoimmune diseases, diabetes and different types of cancer.
    Keywords: QP1-981 ; Q1-390 ; Vitamin D ; Immune System ; Genomics ; vitamin D receptor ; Physiology ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology
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  • 38
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: resting-state fMRI ; fMRI denoising ; vascular modulation ; head motion ; arousal ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 39
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    Firenze University Press
    Publication Date: 2024-04-01
    Description: The Clinical-Scientific Report of the Meyer University Hospital is a precious tool for the sharing and dissemination of information that synthesises the method of working, the results and the paths for improvement to which particular efforts need to be devoted. It is therefore an evaluation tool aimed at both the interior and the exterior of the Hospital. It is a dynamic instrument, which ought to be refined in parallel with the improvements pursued by the Hospital itself.
    Keywords: thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKD Paediatric medicine ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKL Psychiatry ; thema EDItEUR::M Medicine and Nursing::MN Surgery ; thema EDItEUR::M Medicine and Nursing::MQ Nursing and ancillary services::MQC Nursing
    Language: Italian
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  • 40
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    Frontiers Media SA
    Publication Date: 2022-01-31
    Description: This research topic is focused on recent advances in our understanding of effects of mechanical loading on the skeleton, and research methods used in addressing these. Though it is well established that mechanical loading provides an essential stimulus for skeletal growth and maintenance, there have been major advances recently in terms of our understanding of the molecular pathways involved, which are thought to provide novel drug targets for treating osteoporosis. The articles included in this topic encompass the full spectrum of laboratory and clinical research, and range from review articles, editorials, hypothesis papers and original research articles. Together, they demonstrate how mechanical loading underpins many aspects of bone biology, including the pathogenesis and treatment of osteoporosis and other clinical disorders associated with skeletal fragility.
    Keywords: RC648-665 ; R5-920 ; mechanical loading ; bone architecture ; accelerometers ; osteoblast ; osteoporosis ; osteoclast ; fractures ; distraction osteogenesis
    Language: English
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  • 41
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    Frontiers Media SA
    Publication Date: 2024-04-05
    Description: Glial cells are no longer considered passive bystanders in neuronal brain circuits. Not only are they required for housekeeping and brain metabolism, they are active participants in regulating the physiological function and plasticity of brain circuits and the online control of behavior both in invertebrate and vertebrate model systems. In invertebrates, glial cells are essential for normal function of sensory organs (C. elegans) and necessary for the circadian regulation of locomotor activity (D. melanogaster). In the mamallian brain, astrocytes are implicated in the regulation of cortical brain rhythms and sleep homeostasis. Disruption of AMPA receptor function in a subset of glial cell types in mice shows behavioral deficits. Furthermore, genetic disruption of glial cell function can directly control behavioral output. Regulation of ionic gradients by glia can underlie bistability of neurons and can modulate the fidelity of synaptic transmission. Grafting of human glial progenitor cells in mouse forebrain results in human glial chimeric mice with enhanced plasticity and improved behavioral performance, suggesting that astrocytes have evolved to cope with information processing in more complex brains. Taken together, current evidence is strongly suggestive that glial cells are essential contributors to information processing in the brain. This Research Topic compiles recent research that shows how the molecular mechanisms underlying glial cell function can be dissected, reviews their impact on plasticity and behavior across species and presents novel approaches to further probe their function.
    Keywords: RC321-571 ; Q1-390 ; Cerebellum ; C. elegans ; Astrocytes ; DREADD ; Cortex ; plasticity ; Gq ; Behavior ; glia ; Hippocampus ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 42
    Publication Date: 2024-04-04
    Description: Assessing the structural integrity of unreinforced masonry structures is a complex and time-consuming process that necessitates the knowledge of various experts and meticulous cross-referencing of diverse data to achieve a comprehensive understanding of the building. In recent years, the Architecture and Construction Industry has witnessed a digital transformation, largely driven by Building Information Modeling (BIM). BIM has proven immensely valuable in the conservation of historic buildings. However, while it excels in new construction projects, its full potential is not fully realized when dealing with existing structures. A clear example of this limitation can be observed in the Industry Foundation Classes (IFC) format, which lacks instances necessary for accurately representing existing building features. This research contribution aims to advance the process of semantic enrichment of BIM for existing buildings, building upon findings from existing literature. Leveraging the Linked Data Approach and utilizing both existing ontologies and newly proposed domain ontologies, the objective is to facilitate the identification of vulnerabilities and potential local failure mechanisms. The geometric information of the building is represented in the IFC STEP format and enriched semantically by establishing new relationships between classes that are not present in the standard IFC. This approach is applied to a case study in the historical center of Castelnuovo di Porto, Italy. The results of this work demonstrate how the proposed model, enhancing the BIM representation of existing buildings and enabling better identification of potential weaknesses, contributes to improved preservation and seismic resilience of historic structures
    Keywords: BIM ; Linked Data ; Semantic Modeling ; Historic Constructions ; Structural Masonry ; thema EDItEUR::U Computing and Information Technology::UT Computer networking and communications::UTV Virtualization
    Language: English
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  • 43
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Thy-1 ; CD90 ; Signal Transduction ; cell-cell interaction ; Cell-matrix interaction ; Scaffold ; Nanodomains ; integrin ; Mechanotransduction ; Cancer ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Language: English
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  • 44
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    Firenze University Press
    Publication Date: 2022-06-02
    Description: The aim of the present study is to investigate some manifestations of language contact between Italian and Russian, and in particular lexical Italianisms acquired indirectly by passing from other European languages and then into Russian. Special attention is paid to methodological issues, in order to locate the study of lexical contact phenomena between Italian and Russian within the broader field of the study of Italianisms in other European languages.
    Keywords: Italianisms ; Language Contact ; Lexical Contact Phenomena ; Indirect Borrowings ; History of the Russian Language
    Language: Italian
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  • 45
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    Firenze University Press
    Publication Date: 2024-03-24
    Description: The 7th International Conference of the Gruppo di Studi sulla Comunicazione Parlata, dedicated to the memory of Claire Blanche-Benveniste, chose as its main theme Speech and Corpora. The wide international origin of the 235 authors from 21 countries and 95 institutions led to papers on many different languages. The 89 papers of this volume reflect the themes of the conference: spoken corpora compilation and annotation, with the technological connected fields; the relation between prosody and pragmatics; speech pathologies; and different papers on phonetics, speech and linguistic analysis, pragmatics and sociolinguistics. Many papers are also dedicated to speech and second language studies. The online publication with FUP allows direct access to sound and video linked to papers (when downloaded).
    Keywords: thema EDItEUR::C Language and Linguistics::CF Linguistics ; thema EDItEUR::C Language and Linguistics::CF Linguistics::CFF Historical and comparative linguistics ; thema EDItEUR::D Biography, Literature and Literary studies
    Language: English
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  • 46
    Publication Date: 2024-04-01
    Description: This essay considers a number of travellers’ writings about Africa which are reread to construct and deconstruct Italian colonial identity. It focuses on Cesare Cesari’s Viaggi africani di Pellegrino Matteucci (1932), which deems Matteucci a precursor of Fascist colonialism and contributor to Fascist “colonial science”. The essay then moves on to explore the more recent rereading by Angelo Del Boca and Igiaba Scego of respectively Indro Montanelli’s XX Battaglione Eritreo (1936) and Errico Emanuelli’s Settimana nera (1961). By bringing together and rereading these texts, the essay maps the transformations of Italianness from colonial to postcolonial times and reveals how colonial identity relied on a series of gender, racial and sexual tropes of exploration and conquest.
    Keywords: Africa ; colonial identity ; race ; sex ; gender ; thema EDItEUR::N History and Archaeology::NH History
    Language: English
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  • 47
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: export ; secretion ; pathogens ; toxins ; macromolecular machineries ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCJ Infectious and contagious diseases
    Language: English
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  • 48
    Publication Date: 2023-12-21
    Description: Lymphocytes constantly survey the lymph nodes in search for potential infection by a pathogen. They enter the afferent lymphatic vessel that serves as a conduit to transport the motile lymphocytes to the draining lymph node. Lymphatic vessels (LVs) are present in most vascularized tissues. They are traditionally regarded as passive conduits for soluble antigens and leukocytes. Afferent LVs begin as blind ended capillaries, which give rise to collecting vessels that merge and connect with draining lymph nodes (dLNs). Initial lymphatic capillaries are composed of Lymphatic Endothelial Cells (LECs) connected by discontinuous cell junctions, which join to form larger collecting lymphatic vessels, and ultimately feed into the LN subcapsular sinus. Within the LN, LECs are localized to the subcapsular, cortical, and medullary sinuses, where they interact with incoming and exiting leukocytes. LECs, and in general LN stromal cells, have emerged in the recent years as active players in the immune response. In support to this,studies have shown that the immune response generated during inflammation and under pathologic conditions is accompanied by modeling of the LVs and generation of new lymphatics, a process known as lymphangiogenesis. These facts strongly suggest that LECs and stromal LN cells in general, are not inert players but rather are part of the immune response by organizing immune cells movement, exchanging information and supplying survival factors. The purpose of this research topic is to review the role of the LECs during immune homeostasis and cancer. Considering the critical role of lymphangiogenesis in many pathologies like chronic and acute inflammation, autoimmunity, wound healing, graft rejection, and tumor metastasis, it is important to understand the molecular mechanisms that govern the cross talks between the LECs and immune cells during homeostasis and inflammation.
    Keywords: R5-920 ; RC581-607 ; Liver Injury ; Lymphatic Vessels ; Lymphatic Vasculature ; Tumor Microenvironment ; PD-L1 ; Antigen Presenting Cells ; Lymphatic Endothelial Cells ; T cell trafficking ; T cells ; bic Book Industry Communication::M Medicine
    Language: English
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  • 49
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Heart Rate ; Heart rate variability ; Autonomic Nervous System ; infants ; Children ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology
    Language: English
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  • 50
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    Firenze University Press
    Publication Date: 2024-03-24
    Description: This book, the result of a lengthy labour of cataloguing and research, continues the indexing and recording of the unpublished epistolary material conserved in the Dessí fond, launched in 2003 by Chiara Andrei with the edition of the family correspondence (Firenze, FUP). Now, through 1,900 letters from friends and readers, Francesca Nencioni offers a different and more ample overview of the fundamental stages in the life and works of the writer, focusing above all on the years of his university training in Pisa. Of particular interest is the appendix of carefully annotated unpublished texts, which offers 19 letters from Dessí to friends and scholars, the complete two-way correspondence with Walter Binni, and the letters sent to the friend and disciple of the great historian, Delio Cantimori. Press reviews: 26/10/2009: Dessì e la voce "lontana e bianca" del 1955 12/2009: "L'immaginazione" n. 251
    Keywords: Epistolario ; Carteggi ; Biografia ; Letteratura italiana ; Giuseppe Dessì ; Novecento ; thema EDItEUR::D Biography, Literature and Literary studies ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DS Literature: history and criticism
    Language: Italian
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  • 51
    Publication Date: 2022-06-02
    Description: The contribution proposes a reflection on the greatest author of the 18th Century Italian theater who drew on the dramaturgical heritage of the siglos de oro. The main elements dealt with are: Carlo Gozzi's theoretical reflection on the characteristics of Spanish theater; the fundamental role in the repêchage that the actors of Antonio Sacco's company had in that theater, for which the author provided - according to him - a "voluntary friendly assistance"; finally, the most significant data that emerge, or could emerge, from the first National Edition of the works of Carlo Gozzi (launched in 2011).
    Keywords: Spanish theatre ; Carlo Gozzi ; Antonio Sacco theatrical ideas
    Language: Italian
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  • 52
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: NMDAR = N-methyl-d-aspartate receptor ; Enzymes - metabolism ; enzyme drug target ; d-serine ; L-serine ; thema EDItEUR::P Mathematics and Science::PD Science: general issues
    Language: English
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  • 53
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    Frontiers Media SA
    Publication Date: 2024-03-30
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: biobank ; samples ; data ; biobank network ; BBMRI
    Language: English
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  • 54
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    Firenze University Press
    Publication Date: 2024-04-01
    Description: The organisation of the territory is the outcome of strategies of varying scope, in which a number of agents interact to shape out the areas of operation. The Liguria reality is probed here through four different situations - separated in chronological terms but sharing the poor visibility and limited efficacy of the fortified settlements. These focus on Genoa, both in the definition of its hinterland between the tenth and the eleventh centuries, and in establishing the bulwarks of coastal territorial expansion in the twelfth; the powerful groups of feudal lords who remoulded the rural settlement layout in the thirteenth century; finally, a village of the hinterland explored right through to the modern age.
    Keywords: D111-203 ; Comuni medievali ; Open Access ; Storia ; Societ&agrave ; Liguria ; Signorie ; Medioevo ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3K CE period up to c 1500
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  • 55
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Microbial ; activity ; extracellular enzyme ; marine ; freshwater ; Metabolic potential ; function ; metabolic ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKF Pathology::MKFM Medical microbiology and virology ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical)
    Language: English
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  • 56
    Publication Date: 2022-06-02
    Description: In Europe, in the Middle Ages, ostrich feathers were used for the decoration of military headgear, as a representation of the high lineage of the possessor and his military virtues. They were imported from the coasts of West Africa, from Egypt and Syria into Italian and Spanish ports and from there exported to England and continental Europe. Venice, at the end of the fourteenth century, began to color feathers and soon the new fashion was spread throughout Europe. During the fifteenth century, even women began to use ostrich feathers on their hats or in their fans. When European ships reached America, Central Africa and the islands of the Indian Ocean, a huge amount of exotic bird feathers became available and ostrich feather fad spread through the population.
    Keywords: economic history ; international trade ; ostrich feathers ; africa ; europe
    Language: English
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  • 57
    Publication Date: 2022-06-02
    Description: This paper discuss the production of international textiles in statesponsored manufactures in Sweden-Finland between 1740 and 1810. The data set is based on the general summaries of manufacture output collected by municipal authorities during this period. The summaries include annual data on the production of the most important wool and silk textiles, wool and silk knitwear, as well as cotton and linen textiles. More specifically the paper analyze the type of fashion that was produced in Swedish textile manufactures during the period and how international influences affected the Swedish product range. In a subsequent forthcoming investigation I will discuss what the change in the Swedish textile production range towards the end of the eighteenth century says about Swedish and Nordic textile fashion in a European and international context.
    Keywords: manufactures
    Language: English
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  • 58
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: precise genome editing ; CRISPR ; HDR efficiency ; biallelic HDR targeting ; off-target effect ; animal model ; base editing ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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  • 59
    Publication Date: 2024-04-05
    Description: In this EBook, we highlight how newly emerging techniques for non-invasive manipulation of the human brain, combined with simultaneous recordings of neural activity, contribute to the understanding of brain functions and neural dynamics in humans. A growing body of evidence indicates that the neural dynamics (e.g., oscillations, synchrony) are important in mediating information processing and networking for various functions in the human brain. Most of previous studies on human brain dynamics, however, show correlative relationships between brain functions and patterns of neural dynamics measured by imaging methods such as electroencephalography (EEG), magnetoencephalography (MEG), near-infrared spectroscopy (NIRS), positron emission tomography (PET) and functional magnetic resonance imaging (fMRI). In contrast, manipulative approaches by non-invasive brain stimulation (NIBS) have been developed and extensively used. These approaches include transcranial magnetic stimulation (TMS) and transcranial electric stimulation (tES) such as transcranial direct current stimulation (tDCS), alternating current stimulation (tACS), and random noise stimulation (tRNS), which can directly manipulate neural dynamics in the intact human brain. Although the neural-correlate approach is a strong tool, we think that manipulative approaches have far greater potential to show causal roles of neural dynamics in human brain functions. There have been technical challenges with using manipulative methods together with imaging methods. However, thanks to recent technical developments, it has become possible to use combined methods such as TMS–EEG coregistration. We can now directly measure and manipulate neural dynamics and analyze functional consequences to show causal roles of neural dynamics in various brain functions. Moreover, these combined methods can probe brain excitability, plasticity and cortical networking associated with information processing in the intact human brain. The contributors to this EBook have succeeded in showcasing cutting-edge studies and demonstrate the huge impact of their approaches on many areas in human neuroscience and clinical applications.
    Keywords: RC321-571 ; Q1-390 ; non-invasive brain stimulation NIBS ; TMS-EEG ; Transcranial magnetic stimulation TMS ; transcranial electric stimulation tES ; Coregistration ; Near-infrared spectroscopy NIRS ; Functional magnetic resonance imaging fMRI ; transcranial direct current stimulation tDCS ; transcranial alternating current stimulation tACS ; transcranial random noise stimulation tRNS ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 60
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    Firenze University Press
    Publication Date: 2024-04-05
    Description: The volume traces the fundamental stages of the transition from wild roses to cultivated roses, taking as a starting point the systematics of the genus Rosa and linking it to a thousand stories concerning plant hunters, breeders, geographic explorations, the work of scholars and gardeners, enthusiasts, collectors. This book also offers some information on the use of the rose in gardening, cooking and medicine, as well as a large iconography created mostly in the Florence Botanical Garden, a glossary of technical terms and identification elements for horticultural roses.
    Keywords: thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PST Botany and plant sciences
    Language: Italian
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  • 61
    Publication Date: 2024-04-05
    Description: Bálint’s syndrome is named after the Hungarian physician who first reported a remarkable case of a man with complex visuospatial deficits following bilateral lesions within parietal and occipital cortex (Bálint, 1909). The syndrome has three primary symptoms: simultanagnosia (impaired spatial awareness of more than one object at time), optic ataxia (misreaching to visual targets) and ocular apraxia (described by Bálint as “psychic paralysis of gaze”). Balint’s patients not only cannot perceive more than one object at time and therefore show poor comprehension of multi-object visual scenes i.e. poor detection of all the objects present and difficulty in grasping the relationship between them; in addition they typically fail to reach towards location of the single object, which they can perceive. The deficit of the allocation of spatial attention in Balint’s syndrome has been linked to a problem in feature binding which results in illusory conjunctions. Patients with Balint’s syndrome also show deficits in global processing i.e. when integration of multiple local elements into global compound shapes is required. Consequently, Balint’s syndrome provides a unique opportunity to study the nature and neuroanatomy of human visuospatial processing, in particular multi-level object representation, spatial awareness and the distribution of visual attention. The studies collected here cover both the anatomical and the cognitive mechanisms of the different symptoms associated with the syndrome. Furthermore, the dissociations between the components of Bálints’ syndrome, in particular simultanagnosia and optic ataxia, can also co-occur with visual neglect and extinction and the different combinations of reported lesions raises a question about the status of the syndrome and whether it should be merely treated as a historical compilation of symptoms which may or may not coexist cohesively. This interesting argument is raised here.
    Keywords: RC321-571 ; Q1-390 ; posterior cortical atrophy ; Balints syndrome ; optic ataxia ; Posterior parietal cortex ; simultanagnosia ; ocular apraxia ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 62
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    Firenze University Press
    Publication Date: 2022-06-02
    Description: The book represents several contributions that guide the readers in the comprehension of the paradigmatic shift from adult/lifelong education, to adult/lifelong learning. At the same time it presents the contexts where adults learn: the organized contexts, such as the institutions and services, and the informal contexts. The book is one of a series dedicated to adult learning and education developed under the auspices of ESRALE (European Studies and Research in Adult Learning and Education) an EU supported project. Its companion books are Maria Slowey (ed.) Comparative Adult Education and Learning. Authors and Texts and Vanna Boffo, Paolo Federighi, Ekkehard Nuissl, Empirical Research Methodology in Adult Learning and Education. Authors and Texts.
    Keywords: bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::J Society & social sciences::JN Education::JNA Philosophy & theory of education
    Language: English
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  • 63
    Publication Date: 2022-06-02
    Description: Social media are nowadays fertile ground for debates that are often rich in arguments of persuasive value. In the present writing, we hypothesize that emotions play a significant role in determining the success of arguments on social media. In order to validate the hypothesis, we analyzed Change My View, an Internet forum on Reddit where the persuasiveness of the discussions among participants is explicit and regulated by specific norms. Our analysis revealed that arguments enjoying a higher degree of success were characterized by two particular emotions: anticipation and joy, which we interpret as belonging to engagement, a more general emotional dimension that includes them both. Such characteristics of successful arguments lead us to consider the persuasive experience on social media as analogous to a playful experience. Like in a game, in order to successfully take part in such a persuasive experience, certain requirements are needed: commitment and respect for the rules as well as joyful participation.
    Keywords: Online Debate ; Emotions ; Argumentation Theory
    Language: Italian
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  • 64
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    Firenze University Press
    Publication Date: 2024-03-24
    Description: The volume collects the proceedings of the conference “Firenze e la lingua italiana tra nazione ed Europa” (Florence and the Italian language between nation and Europe), which was held from on May 27 and 28 2004 in the Aula Magna of the University of Florence and the Accademia della Crusca. As known, Florence played a central role in the process of national linguistic unification and thanks to its international vocation the city has promoted the spread and knowledge of the Italian language and culture all over Europe and in the world. Beyond any celebratory enthusiasm, the conference has been an occasion of open discussion on the cultural identity of the city in the contemporary context, through a critical reflection on its history (in particular on some significant moments of the Florentine culture between the nineteenth and twentieth centuries) and on its linguistic primacy.
    Keywords: Lingua italiana ; Linguistica ; Storia ; Atti di convegno ; Firenze ; Europa ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: Italian
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  • 65
    Publication Date: 2022-09-22
    Description: The importance of the Word of Mouth is growing day by day in many topics. This phenomenon is evident in everyday life, e.g., the rise of influencers and social media managers. If more people positively debate specific products, then even more people are encouraged to buy them and vice versa. This effect is directly affected by the relationship between the potential customer and the reviewer. Moreover, considering the negative reporting bias is evident in how the Word of Mouth analysis is of absolute interest in many fields. We propose an algorithm to extract the sentiment from a natural language text corpus. The combined approach of Neural Networks, with high predictive power but more challenging interpretation, with more simple but informative models, allows us to quantify a sentiment with a numeric value and to predict if a sentence has a positive (negative) sentiment. The assessment of an objective quantity improves the interpretation of the results in many fields. For example, it is possible to identify crucial specific sectors that require intervention, improving the company's services whilst finding the strengths of the company himself (useful for advertising campaigns). Moreover, considering that the time information is usually available in textual data with a web origin, to analyze trends on macro/micro topics. After showing how to properly reduce the dimensionality of the textual data with a data-cleaning phase, we show how to combine: WordEmbedding, K-Means clustering, SentiWordNet, and the Threshold-based Naïve Bayes classifier. We apply this method to Booking.com and TripAdvisor.com data, analyzing the sentiment of people who discuss a particular issue, providing an example of customer satisfaction.
    Keywords: GSD ; WoM ; Threshold-based Naïve ; Bayes ; NLP ; Sentiment Analysis ; Customer Satisfaction ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHB Sociology::JHBC Social research & statistics
    Language: English
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  • 66
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    Firenze University Press
    Publication Date: 2024-04-05
    Description: This volume takes up part of the content of the one published on the occasion of the 40th anniversary of the foundation of the Faculty of Engineering of the University of Florence and constitutes, after 10 years, only for the first and second part of that volume, the natural continuation with all the necessary updates, while the third part will be resumed in a new volume. These 10 years have been characterized by a reform of the University which has significantly changed its structure with the abolition of the Faculties and the transfer of teaching organization to the Departments which, as it is well known, were originally constituted only as research bodies. This evolution will be discussed in the new volume.
    Keywords: Florence School of Engineering ; History of Engineering in Florencem ; Alumni of the School of Engineering in Florence ; Santa Marta in Florence ; Villa Cristina in Florence ; thema EDItEUR::P Mathematics and Science::PH Physics::PHK Electricity, electromagnetism and magnetism ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TJ Electronics and communications engineering::TJF Electronics engineering
    Language: Italian
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  • 67
    Publication Date: 2024-04-05
    Description: The tale of cyclic GMP has been astonishing. Having overcome an initial disbelief, cyclic GMP has risen to its present eminence as a premium cellular signal transduction messenger of not only hormonal extracellular but also of the intracellular signals. This research topic focuses on the pathways and functions of membrane guanylate cyclases in different tissues of the body and their interplay with intracellular sensory signals where in many cases, cyclic GMP along with Ca2+ have taken on roles as synarchic co-messengers.
    Keywords: RC321-571 ; Q1-390 ; Glaucoma ; Visceral Pain ; Calcium ; membrane guanylate cyclase ; ANF-RGC ; Gene Therapy ; Cyclic GMP ; synaptic plasticity ; trafficking ; ROS-GC ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 68
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    Firenze University Press
    Publication Date: 2024-04-11
    Description: The AXMEDIS International Conference series aims to explore all subjects and topics related to cross-media and digital-media content production, processing, management, standards, representation, sharing, protection and rights management, to address the latest developments and future trends of the technologies and their applications, impacts and exploitation. The AXMEDIS events offer venues for exchanging concepts, requirements, prototypes, research ideas, and findings which could contribute to academic research and also benefit business and industrial communities. In the Internet as well as in the digital era, cross-media production and distribution represent key developments and innovations that are fostered by emergent technologies to ensure better value for money while optimising productivity and market coverage.
    Keywords: thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TJ Electronics and communications engineering::TJF Electronics engineering ; thema EDItEUR::U Computing and Information Technology::UM Computer programming / software engineering::UMZ Software Engineering ; thema EDItEUR::U Computing and Information Technology::UT Computer networking and communications
    Language: English
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  • 69
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Microbial communities ; Pollutants ; Environmental risk assessment ; Bioindication ; Biodegradation ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKF Pathology::MKFM Medical microbiology and virology ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical)
    Language: English
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  • 70
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    Firenze University Press
    Publication Date: 2022-06-02
    Description: Following Fernand Braudel’s Méditerranée, historians interpreted the Mediterranean, Baltic, Atlantic, Indian Ocean or Pacific as closed maritime systems, consisting of multiple micro-environments. This essay seeks to overcome these limited perspectives and to examine, how the various seas and oceans were connected by the Vikings, the Cairo Genizah merchants and the Italian trading companies of the Middle Ages. The second part of my article “Connected Seas” examines the perception and memory of the seas as an element of maritime connectivity. It introduces the concept of realm of memory (lieu de mémoire) into maritime history and tests it in four case studies on the Sound, the Straits of Gibraltar, the Dardanelles and the Straits of Malacca.
    Keywords: Vikings ; Genizah ; merchants ; maritime straits ; lieu de mémoire
    Language: Italian
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  • 71
    Publication Date: 2023-05-02
    Description: The Region of Tuscany, has developed a process/methodology to foster autonomy and accompany to work disadvantaged people and people with disability. The approach adopted consists of an integrated methodology that sees the recipients adhere to a customized project, prepared together with the Social Services, the local Employment Centers and public and private entities active in the field of interventions to combat poverty and social exclusion. Third Sector Entities play a key role in this framework.
    Keywords: Fragility ; Guidance ; Inclusion ; Job Placement ; Work Placement ; bic Book Industry Communication::J Society & social sciences
    Language: Italian
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  • 72
    Publication Date: 2024-03-29
    Description: Umberto Gori has held the first chair of International Relations in Italy and has been the first scholar to address a series of central topics in the analysis of foreign policy and international politics. Those who browse, even if only rapidly, his rich bibliography cannot but be struck by the great variety of the topics examined: from the first works of a predominantly legal nature, we move on to studies centered on methodological and epistemological issues, relations between states, analysis of foreign policy in general and Italian foreign policy in particular, Peace Research, strategic affairs, intelligence, and finally the impact of the information and digital revolution on international politics and contemporary strategy. What holds together so many different issues is, firstly, a constant attention to methodology and, secondly, a clear preference for a predominantly operational approach, in the belief that knowledge must always be functional to decision and action. These basic attitudes are reflected not only in his strongly characterized research agenda, but also in the twofold nature of his teaching commitment: on the one hand, Gori taught outside the university classrooms, at military and governmental institutions, for decades; on the other hand, he introduced issues traditionally reserved to diplomacy and security institutions into the Italian academic context. Such a propensity to build bridges between different worlds - academic, military, technological, diplomatic, financial - and a research vocation that has never failed make Umberto Gori a figure indissolubly linked to the birth and development of International Relations in Italy.
    Keywords: Umberto Gori ; Relazioni Internazionali in Italia ; Centro Analisi Relazioni Internazionali ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPA Political science & theory ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPA Political science and theory
    Language: Italian
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  • 73
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    Firenze University Press
    Publication Date: 2022-01-31
    Description: 〈i〉Automi, realtà virtuale e formiche〈/i〉 (“Automata, virtual reality and ants”) proposes an analysis of the complexity of the war phenomenon through three different approaches: in the microphysics of the individual action, in simulated reality and in a metaphor with the biological environment. The investigation into the nature of the interactions between man and machine presents the attempt to dominate the Clausewitzian uncertainty of the battle through an automated, post-human system. This seems to be resolved in the Omega Point, which the theologian de Chardin had identified as a point of escape from entropy and from the disorder of reality. There is neither a scientific solution, nor a theological fate. Intelligence is shared through the semantics of the satellite, of the drone and through the information passing from machine to machine. While the warriors will act as a swarm, by sharing a huge amount of data, each one of them on the exocrine glands of the machine, St. Basil was right when he warned that whoever claims to speak on the nature of things (and therefore on war) should first of be able to speak of the nature of the ant.
    Keywords: JA1-92
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  • 74
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Alzheimer's disease ; Neurodegeneration ; Peptides ; cognitive ; model ; Parkinson's disease ; database ; transgenic ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 75
    Publication Date: 2022-06-02
    Description: In the stem-derivational perfective-imperfective opposition of Slavic the role of prefixes and suffixes has to be assessed jointly. The article evaluates the diachronic backdrop and parameters appropriate for classificatory categories. Special attention is paid to the criteria applied by aspectologists to determine aspect pairs and to aspect triplets. The assessment ends up with a paradox resulting from Maslov’s criteria of ‘trivial pairednessʼ, which require not only identical lexical meaning, but an ontology for which telic events are the sole basis in the derivation of aspect pairs.
    Keywords: Slavic aspect ; classificatory categories ; stem derivation ; aspectual pairedness ; aspect triples
    Language: Russian
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  • 76
    Publication Date: 2024-04-14
    Description: This volume explores the issues of using e-learning in university and of developing and using a “blended learning” teaching method for the course of Computer Science from the first year of the the Medicine and Surgery Degree of the University of Florence. This course was used as a trial for the peer-review teaching method, which can be useful in classes with a high number of students; this publication also includes a selection of the best works produced by the students. The results of the trial prove the advantages of using the peer-review teaching method for other university courses, and the students' works on e-health give current medical practitioners insights on how to use ICT in their practice with skill and care.
    Keywords: thema EDItEUR::U Computing and Information Technology
    Language: Italian
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  • 77
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Sport ; performance ; physiology ; kinesiology ; biomechanics ; health ; exercise ; physical activity ; athletes ; training ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::S Sports and Active outdoor recreation ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKW Sports injuries and medicine
    Language: English
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  • 78
    Publication Date: 2024-04-05
    Description: In the search for simple explanations of the natural world, its complicated textures are often filed down to a smoothened surface of our liking. The impetus for this Research Topic was borne out of a need to re-ignite interest in the complex – in this case in the context of ion channels in the nervous system. Ion channels are the large proteins that form regulated pores in the membranes of cells and, in the brain, are essential for the transfer, processing and storage of information. These pores full of twists and turns themselves are not just barren bridges into cells. More and more we are beginning to understand that ion channels are like bustling medieval bridges (packed with apartments and shops) rather than the more sleek modern variety – they are dynamic hubs connected with many structures facilitating associated activities. Our understanding of these networks continues to expand as our investigative tools advance. Together these articles highlight how the complexity of ion channel signaling nexuses is critical to the proper functioning of the nervous system.
    Keywords: RC321-571 ; Q1-390 ; Nervous System ; Ion Channels ; Interactome ; cellular signaling ; Protein complexes ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 79
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    Firenze University Press
    Publication Date: 2022-06-02
    Description: Medicine has coined the concept of 'disease', but individual patients frequently present complicated cases marked by the coexistence of several conditions or syndromes. The doctor needs to reflect on this complexity because, in his daily practice, he has to address and resolve it for a correct management of the patient. This is why we must, with genuine humility, seek to share a journey in which there are no major landmarks. The authority of the various colleagues who have contributed the different chapters can offer elements of guidance that are useful in a series based on the leitmotif of the cornerstone concepts of complexity. My thanks to those who have accepted this challenge, in the sincere hope that it may enrich us – even just a little and by slow degrees – with an enhanced capacity to address the daily issue of the complexity of the sick.
    Keywords: Medicina ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine
    Language: Italian
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  • 80
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    Unknown
    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Brainstem monoamine neurons ; locus coeruleus ; emotion ; pain ; morphometry ; amphetamine derivatives ; sleep ; gaze ; trigeminal nerve ; microglia. ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 81
    Publication Date: 2024-04-05
    Description: Genome-wide association studies (GWAS) for complex disorders with large case-control populations have been performed on hundreds of traits in more than 1200 published studies (http://www.genome.gov/gwastudies/) but the variants detected by GWAS account for little of the heritability of these traits, leading to an increasing interest in using family based designs. While GWAS studies are designed to find common variants with low to moderate attributable risks, family based studies are expected to find rare variants with high attributable risk. Because family-based designs can better control both genetic and environmental background, this study design is robust to heterogeneity and population stratification. Moreover, in family-based analysis, the background genetic variation can be modeled to control the residual variance which could increase the power to identify disease associated rare variants. Analysis of families can also help us gain knowledge about disease transmission and inheritance patterns. Although a family-based design has the advantage of being robust to false positives, novel and powerful methods to analyze families in genetic epidemiology continue to be needed, especially for the interaction between genetic and environmental factors associated with disease. Moreover, with the rapid development of sequencing technology, advances in approaches to the design and analysis of sequencing data in families are also greatly needed. The 11 articles in this book all introduce new methodology and, using family data, substantial new findings are presented in the areas of infectious diseases, diabetes, eye traits, autism spectrum disorder and prostate cancer.
    Keywords: QH426-470 ; Q1-390 ; Regional heritability ; prostate cancer ; infectious diseases ; MCMC ; combining studies screening ; conditional-logistic linkage ; Informatics ; autism ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical)
    Language: English
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  • 82
    Publication Date: 2023-12-21
    Description: It is long known that many cells can shed extracellular vesicles, small membrane-enclosed cell fragments. Although the existence of extracellular vesicles has been recognized for many years, researchers are only beginning to understand their physiologic significance. Several recent studies have demonstrated that extracellular vesicles released from cells serve as a mode of cellular communication. They can carry diverse molecular payload (e.g. nucleic acids, bioactive lipids and proteins) to distal organs and recipient cells. Extracellular vesicles can be classified into three major groups: exosomes, microvesicles, and apoptotic bodies. All these types of extracellular vesicles can be found in a variety of biologic specimen and their numbers, distribution and composition may serve as biomarkers for various disorders, including cardiovascular disease. Although extracellular vesicle-mediated processes are currently best characterized in the fields of cancer biology and neurobiology, evidence is accumulating that extracellular vesicles play a key role in the pathophysiology of diabetes, thrombosis, inflammation and cardiovascular calcification. In this Research Topic, we invited review and methodological articles that advance our understanding of extracellular vesicle-related processes in vascular biology.
    Keywords: R5-920 ; Angiogenesis ; Atherosclerosis ; Extracellular vesicles ; Calcification ; Biomarkers ; Cardiovascular disease ; Inflammation ; Exosomes ; Platelets ; Heart valve ; bic Book Industry Communication::M Medicine
    Language: English
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  • 83
    Publication Date: 2022-01-31
    Description: This eBook presents illustrative examples of genetic chaperonopathies affecting primarily nerves and muscles and discusses molecular mechanisms and treatment targeting chaperones, i.e., chaperonotherapy.
    Keywords: Q1-390 ; small-Hsp ; Hsp60/CCT/BBS ; Indirect/Secondary Chaperonopathies ; Genetic Chaperonopathies ; Hsp40/DnaJ ; chaperonotherapy
    Language: English
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  • 84
    Publication Date: 2022-06-02
    Description: In recent years, the Italian national institute of statistics (Istat), together with most National Statistical Institutes, is progressively moving from traditional production models based on the use of primary source of information - represented by direct surveys - to new production strategies based on the combined use of different primary and secondary sources of information. As result, new multisource statistical processes have been built, that guarantee a major improvement of both amount and quality of information about several phenomena of public interest. In this context, the Total Process Error (TPE) framework has been recently proposed in literature for assessing the quality of multisource processes. The TPE framework represents an evolution of the Zhang’s two-phase life-cycle approach and it additionally includes an operational tool to connect the steps of the multisource production process to the phases of the quality evaluation framework. TPE framework can be used both to support a multisource process design and to monitor an entire production process, in order to provide key elements to assess the quality of both the processes and their statistical outputs. In the present work, we describe as a case study in the new context of Istat production of official statistics the use of the TPE framework to support the process design of the Register for Public Administrations.
    Keywords: quality assessment ; total error ; multisource processes ; statistical registers
    Language: English
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  • 85
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    Firenze University Press
    Publication Date: 2024-03-24
    Description: Ancient linguistic reflection in India was able to combine the analysis of Sanskrit with the awareness that the language through which this analysis is conducted (Sanskrit) is different from the object it examines. Although this language-tool finds its dimension in the artificial Sanskrit of the sütras - the aphorisms of Påñini's grammar - metalinguistic discourse is not restricted to specialized discourse: common speech abounds in metalinguistic notations. The present work focuses on the testimonies of the grammatical school of Pâininian origin, by trying to retrace the course by which metalanguage left the field of naive linguistics to become an object of the school.
    Keywords: Lingua sanscrita ; Linguistica ; Cultura indiana ; India ; thema EDItEUR::C Language and Linguistics::CF Linguistics ; thema EDItEUR::N History and Archaeology::NH History::NHB General and world history ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDH Philosophical traditions and schools of thought ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs
    Language: Italian
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  • 86
    Publication Date: 2024-04-05
    Description: Virus-caused asthma, we now call a phenotype of asthma. Regardless of the significance and popularity of this disease, the etiology of the virus-induced asthma have not well understood. In addition, a few effective vaccines have been applied to prevent respiratory virus infection. To solve the issues, it is essential to clarify and delineate both aspects of the virus and host defense systems including acute/chronic inflammation and airway tissue remodeling. To deeply review and discuss pathophysiology and epidemiology of virus-induced asthma, this topics includes new findings of the host immunity, pathology, epidemiology, and virology of asthma/chronic obstructive pulmonary disease (COPD). We believe that these works are well summarized and informative to glimpse the field of virus- associated asthma and COPD, and may help understanding the basic and clinical aspects of the diseases.
    Keywords: QR1-502 ; QK1-989 ; Q1-390 ; virus-induced asthma ; Pathology ; respiratory virus ; human immunity ; Epidemiology ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical)
    Language: English
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  • 87
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    Firenze University Press
    Publication Date: 2022-06-02
    Description: This essay examines the figures of Jung and Beneduce. From the very beginning of their careers, until the crucial 30's, when the first one was appointed Ministry of Finance and the second one, confidential trustee of Mussolini. For both, the testbed was their work experience at IRI, where they helped create the Italian model of the government intervention in the economy and the nationalisation of the Banca Commerciale Italiana, Credito Italiano e Banco di Roma.
    Keywords: Iri ; Jung ; Beneduce ; Governement Intervention in the economy
    Language: Italian
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  • 88
    Publication Date: 2023-12-21
    Description: Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is widely used in the treatment of haematological malignancies as a form of immunotherapy acting through a graft-versus-leukemia (GvL) reaction. This curative allogeneic response can be associated with severe drawbacks, such as frequent and severe graft-versus-host disease (GvHD) and a long-lasting immunodeficiency, especially now with the development of innovative strategies such as umbilical cord blood transplantation or transplants from haplo-identical family donors (Haplo-HSCT). In the long-term follow-up of these patients, severe post-transplant infections, relapse or secondary malignancies may be directly related to persistent immune defects.Reconstitution of the different lymphocyte populations (B, T, NK, NKT) and antigen presenting cells of myeloid origin (monocytes, macrophages and dendritic cells) should be considered not only quantitatively but especially qualitatively, in terms of functional subsets. Immune deficiency leading to an increased susceptibility to infections lasts for more than a year. Although infections that occur in the first month mostly result from a deficiency in both granulocytes and mononuclear cells (MNC), later post-engraftment infections are due to a deficiency in MNC subsets, primarily CD4 T-cells and B-cells. T-cell reconstitution has been extensively studied because of the central role of T-cells in mediating both GvHD, evidenced by the reduced incidence of this complication following T-Cell depletion, and a GvL effect as shown by DLI. In the recent years there has been renewed interest in the role of NK-cells, especially in the context of Haplo-HSCT, and in B-cell reconstitution.This Frontiers Research Topic will provide state of the art knowledge of the mechanisms of immune reconstitution in an allogeneic environment, in order to improve monitoring and therapeutic intervention in allo-HSCT patients.
    Keywords: R5-920 ; RC581-607 ; cell therapy ; Immune reconstitution ; Haplo-SCT ; HSCT ; Thymic function ; bic Book Industry Communication::M Medicine
    Language: English
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  • 89
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    Firenze University Press
    Publication Date: 2024-04-02
    Description: The exhibition: “La Fisica ad Arcetri. Dalla nascita della Regia Università alle leggi raziali” was organized by the Department of Physics and Astronomy of the University of Florence and by the Florence Section of the Italian National Institute of Nuclear Physics, in collaboration with the Historical Archive of the Municipality of Florence, the Physical Science and Natural Mathematics Library of the University of Florence, the Science and Technology Foundation, and the “Galileo” Museum of Florence. It was held from May to September 2016 in the Exhibition Hall of the Municipal Historical Archive in via dell'Oriuolo, Florence. The time covered by the exhibition ranges from the birth of the Royal University of Florence (1924) to the enactment of racial laws in Italy by Benito Mussolini’s government (1938). The exhibited material comes from the Municipality's Historical Archive, the Garbasso Archive, the Della Corte Fund, the Department of Physics and Astronomy, the Science and Technology Foundation and from private collections. The catalogue is published as the third volume of the series of publications associated with the magazine «Il Colle di Galileo».
    Keywords: thema EDItEUR::N History and Archaeology::NH History::NHB General and world history ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics ; thema EDItEUR::P Mathematics and Science::PD Science: general issues::PDN Scientific equipment, experiments and techniques ; thema EDItEUR::P Mathematics and Science::PH Physics ; thema EDItEUR::P Mathematics and Science::PH Physics::PHK Electricity, electromagnetism and magnetism ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TJ Electronics and communications engineering::TJF Electronics engineering
    Language: Italian
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  • 90
    Publication Date: 2024-04-01
    Description: The article analyses the morphological means used by the Slovenian dialects of Friuli in adapting loan verbs to their aspectual system in comparison to the traditional means of expressing verbal aspect in the indigenous Slavic lexicon. In relation to verbs of Slavic origin, the formation of aspectual pairs was mainly realised by means of prefixation to the base verb (thereby perfectivising it), whereas with loans from the adjacent Romance varieties (Friulian, Italian, Venetian) suffixation proves more productive (yielding imperfectivisation). The analysis is carried out on the dialect of Resia as well as those from the Torre and Natisone Valleys. Despite some differences, in all three dialects there is generally a strong tendency to integrate loan verbs into the aspectual systems of these varieties. Biaspectual verbs, on the other hand, are relatively rare except for the particular case of the verbs in -inat in Resian.
    Keywords: Slovene dialects of Friuli ; language contact ; loan verbs ; suffixation ; prefixation ; aspectual pairs ; biaspectuality ; thema EDItEUR::N History and Archaeology::NH History
    Language: Italian
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  • 91
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    Frontiers Media SA
    Publication Date: 2024-04-05
    Description: Transfer cells are anatomically specialized cells optimized to support high levels of nutrient transport in plants. These cells trans-differentiate from existing cell types by developing extensive and localized wall ingrowth labyrinths to amplify plasma membrane surface area which in turn supports high densities of membrane transporters. Unsurprisingly, therefore, transfer cells are found at key anatomical sites for nutrient acquisition, distribution and exchange. Transfer cells are involved in delivery of nutrients between generations and in the development of reproductive organs and also facilitate the exchange of nutrients that characterize symbiotic associations. Transfer cells occur across all taxonomic groups in higher plants and also in algae and fungi. Deposition of wall ingrowth-like structures are also seen in “syncytia” and “giant cells” which function as feeding sites for cyst and root-knot nematodes, respectively, following their infection of roots. Consequently, the formation of highly localized wall ingrowth structures in diverse cell types appears to be an ancient anatomical adaption to facilitate enhanced rates of apoplasmic transport of nutrients in plants. In some systems a role for transfer cells in the formation of an anti-pathogen protective barrier at these symplastic discontinuities has been inferred. Remarkably, the extent of cell wall ingrowth development at a particular site can show high plasticity, suggesting that transfer cell differentiation might be a dynamic process adapted to the transport requirements of each physiological condition. Recent studies exploiting different experimental systems to investigate transfer cell biology have identified signaling pathways inducing transfer cell development and genes/gene networks that define transfer cell identity and/or are involved in building the wall ingrowth labyrinths themselves. Further studies have defined the structure and composition of wall ingrowths in different systems, leading in many instances to the conclusion that this process may involve previously uncharacterized mechanisms for localized wall deposition in plants. Since transfer cells play important roles in plant development and productivity, the latter being relevant to crop yield, especially so in major agricultural species such as wheat, barley, soybean and maize, understanding the molecular and cellular events leading to wall ingrowth deposition holds exciting promise to develop new strategies to improve plant performance, a key imperative in addressing global food security. This Research Topic presents a timely and comprehensive treatise on transfer cell biology to help define critical questions for future research and thereby generating a deeper understanding of these fascinating and important cells in plant biology.
    Keywords: QK1-989 ; Q1-390 ; Wall ingrowth ; Arabidopsis thaliana ; synctial cells ; Zea mays ; transfer cells ; endosperm transfer cells ; Giant Cells ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PST Botany and plant sciences
    Language: English
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  • 92
    Publication Date: 2024-04-05
    Description: Research during the past decade highlights the strong link between appetitive feeding behavior, reward and motivation. Interestingly, stress levels can affect feeding behavior by manipulating hypothalamic circuits and brain dopaminergic reward pathways. Indeed, animals and people will increase or decrease their feeding responses when stressed. In many cases acute stress leads to a decrease in food intake, yet chronic social stressors are associated to increases in caloric intake and adiposity. Interestingly, mood disorders and the treatments used to manage these disorders are also associated with changes in appetite and body weight. These data suggest a strong interaction between the systems that regulate feeding and metabolism and those that regulate mood. This Research Topic aims to illustrate how hormonal mechanisms regulate the nexus between feeding behavior and stress. It focuses on the hormonal regulation of hypothalamic circuits and/or brain dopaminergic systems, as the potential sites controlling the converging pathways between feeding behavior and stress.
    Keywords: RC321-571 ; Q1-390 ; stress ; Obesity ; Dopamine ; Ghrelin ; Leptin ; Seasonal regulation ; feeding ; HPA axis ; Hypothalamus ; circadian rhythms ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 93
    Publication Date: 2022-06-02
    Description: An accurate definition of memory would embarrass any serious scholar. Briefly, memory could be defined as a wonderful mechanism, a way to transport us back in time. Memory is therefore a mental activity that binds us over time, it is what gives meaning to the existence. Self-narration or autobiography means first of all asking oneself about the status of one's own identity, it means communication, communicating to ourselves and to others who we are; it means transforming the interior monologue into dialogue with otherness; it means marking and regulating our emotions through the representation of the events of our life.
    Keywords: Pedagogia ; Psicologia ; Autobiografia ; Università ; bic Book Industry Communication::J Society & social sciences::JM Psychology
    Language: Italian
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  • 94
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    Firenze University Press
    Publication Date: 2022-06-02
    Description: The evolution of the Italian health system, which went from the establishment of the National Health Service in 1978 to the corporate management introduced with the reforms of the 1990s, requires a thorough knowledge of the effects of organizational change on the medical profession. Starting from this consideration, this volume focuses on the results of the corporatising process in terms of professional identity. The research, conducted among medical specialists operating in the territorial structures of two Tuscan Health Authorities, shows a transitioning figure, which hints at a new form of medical professionalism.
    Keywords: bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHB Sociology ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics
    Language: Italian
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  • 95
    Publication Date: 2024-04-05
    Description: euromodulation is among the fastest-growing areas of medicine, involving many diverse specialties and affecting hundreds of thousands of patients with numerous disorders worldwide. It can briefly be described as the science of how electrical, chemical, and mechanical interventions can modulate the nervous system function. A prominent example of neuromodulation is deep brain stimulation (DBS), an intervention that reflects a fundamental shift in the understanding of neurological and psychiatric diseases: namely as resulting from a dysfunctional activity pattern in a defined neuronal network that can be normalized by targeted stimulation. The application of DBS has grown remarkably and more than 130,000 patients worldwide have obtained a DBS intervention in the past 30 years—most of them for treating movement disorders. This Frontiers Research Topics provides an overview on the current discussion beyond basic research in DBS and other brain stimulation technologies. Researchers from various disciplines, who are working on broader clinical, ethical and social issues related to DBS and related neuromodulation technologies, have contributed to this research topic.
    Keywords: RC321-571 ; Q1-390 ; Informed Consent ; Deep Brain Stimulation ; Depression ; Neurosurgery ; Movement Disorders ; Neuromodulation ; Enhancement ; Neuroethics ; Philosophy ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 96
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    Firenze University Press
    Publication Date: 2023-08-05
    Description: undefined
    Keywords: Knowledge economy ; middle ages ; early modern age ; modern age ; economic growth ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHB Sociology
    Language: Italian
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  • 97
    Publication Date: 2024-03-29
    Description: The integration of multisensory information is an essential mechanism in perception and in controlling actions. Research in multisensory integration is concerned with how the information from the different sensory modalities, such as the senses of vision, hearing, smell, taste, touch, and proprioception, are integrated to a coherent representation of objects. Multisensory integration is central for action control. For instance, when you grasp for a rubber duck, you can see its size and hear the sound it produces. Moreover, identical physical properties of an object can be provided by different senses. You can both see and feel the size of the rubber duck. Even when you grasp for the rubber duck with a tool (e.g. with tongs), the information from the hand, from the effect points of the tool and from the eyes are integrated in a manner to act successfully. Over the recent decade a surge of interest in multisensory integration and action control has been witnessed, especially in connection with the idea that multiple sensory sources are integrated in an optimized way. For this perspective to mature, it will be helpful to delve deeper into the information processing mechanisms and their neural correlates, asking about the range and constraints of this mechanisms, about its localization and involved networks.
    Keywords: BF1-990 ; Q1-390 ; recalibration ; haptic ; Human Information Processing ; Vision ; Perception ; reference frame ; Acoustics ; Tool Use ; bic Book Industry Communication::J Society & social sciences::JM Psychology ; thema EDItEUR::J Society and Social Sciences::JM Psychology
    Language: English
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  • 98
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    Firenze University Press
    Publication Date: 2022-06-02
    Description: undefined
    Language: Italian
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  • 99
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    Firenze University Press
    Publication Date: 2022-06-02
    Description: This volume gives theoretical and practical insights in international and comparative research in the field of adult and continuing education. The 16 contributions of this volume give three perspectives on international and comparative adult education. The first perspective focuses on the question how internationalisation and comparative adult and continuing education can be taught. The second perspective gives insights into the results of comparative research that has been conducted throughout a two-week Winter School that took place in February 2019 in Würzburg. The third perspective complements the two perspectives with insights into international projects and practices in adult and continuing education. The authors of this volume are contributing to the transnational Winter School International and comparative studies in adult and continuing education in Würzburg, Germany since 2014.
    Keywords: comparative studies ; adult education ; continuing education ; good practices ; international adult education ; bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::J Society & social sciences::JN Education::JNA Philosophy & theory of education
    Language: English
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  • 100
    Publication Date: 2024-04-05
    Description: Volume I, entitled “Augmentation of Brain Functions: Brain-Machine Interfaces”, is a collection of articles on neuroprosthetic technologies that utilize brain-machine interfaces (BMIs). BMIs strive to augment the brain by linking neural activity, recorded invasively or noninvasively, to external devices, such as arm prostheses, exoskeletons that enable bipedal walking, means of communication and technologies that augment attention. In addition to many practical applications, BMIs provide useful research tools for basic science. Several articles cover challenges and controversies in this rapidly developing field, such as ways to improve information transfer rate. BMIs can be applied to the awake state of the brain and to the sleep state, as well. BMIs can augment action planning and decision making. Importantly, BMI operations evoke brain plasticity, which can have long-lasting effects. Advanced neural decoding algorithms that utilize optimal feedback controllers are key to the BMI performance. BMI approach can be combined with the other augmentation methods; such systems are called hybrid BMIs. Overall, it appears that BMI will lead to many powerful and practical brain-augmenting technologies in the future.
    Keywords: RC321-571 ; Q1-390 ; microcircuits ; Brain machine interface (BMI) ; nootropics ; tDCStranscranial direct current stimulation ; neural networks ; neuroprosthesis ; TMS ; implants ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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