ALBERT

Notes: This paper examines the law and economics of informational regulation (IR) of environmental risks. Informational regulation here means regulation which provides to affected stakeholders information on the operations of regulated entities, usually with the expectation that such stakeholders will then exert pressure on these entities to comply with regulations in a manner which serves the interests of stakeholders. As such, IR reinforces and augments direct regulatory monitoring and enforcement through third-party monitoring and incentives. The paper provides two contrasting frameworks, from law and economics, to analyze the costs and benefits likely to arise from IR and concludes with a discussion of the appropriate scope of IR as a substitute for and complement of traditional environmental regulation and law.

Notes: Regulations under Section 112(r) of the 1990 Clean Air Act Amendments require fixed facilities having threshold quantities of materials on the U.S. Environmental Protection Agency's list of regulated substances to disclose to the general public the expected offsite consequences of worst-case accidental chemical releases. This paper describes the communication practices of small firms in Delaware and New Jersey and the practical problems these facilities might encounter complying with the proposed rule. The paper reports an interesting difference between the apprehension voiced by small firms required to report worst-case release information and the public's apparent lack of interest in such information. Unlike the difficulty expected by small firms in calculating and communicating worst-case chemical release information, this paper includes some observations on the ability of large chemical firms to comply with the proposed requirements.

Notes: EPA's rule of Risk Management Programs for Chemical Accidental Release Prevention applies to facilities that manufacture, process, use, store, or otherwise handle regulated substances at or above specified threshold quantities. EPA estimates that approximately 66,000 facilities nationwide will be regulated under the rule. This paper examines the use of a structured ISO 14000 mechanism as option-regulated facilities could elect for implementation of the rule. Under the ISO 14000 option, facilities would commit to additional obligations regarding information disclosure, discussions with potentially affected publics, and timely correction of deficiencies noted in annual ISO 14000 audits of their compliance with the Risk Management Program they submit to the EPA under the rule. In return, facilities would be granted significant relief in regard to both EPA audit frequency and the penalties that might be applied for any items of noncompliance with the rule noted during the course of implementing agency reviews of the facility. The paper concludes with a discussion of the advantages and disadvantages of this option to potentially affected stakeholders.

Notes: We present a critical assessment of the benchmark dose (BMD) method introduced by Crump(1) as an alternative method for setting a characteristic dose level for toxicant risk assessment. The no-observed-adverse-effect-level (NOAEL) method has been criticized because it does not use all of the data and because the characteristic dose level obtained depends on the dose levels and the statistical precision (sample sizes) of the study design. Defining the BMD in terms of a confidence bound on a point estimate results in a characteristic dose that also varies with the statistical precision and still depends on the study dose levels.(2) Indiscriminate choice of benchmark response level may result in a BMD that reflects little about the dose-response behavior available from using all of the data. Another concern is that the definition of the BMD for the quantal response case is different for the continuous response case. Specifically, defining the BMD for continuous data using a ratio of increased effect divided by the background response results in an arbitrary dependence on the natural background for the endpoint being studied, making comparison among endpoints less meaningful and standards more arbitrary. We define a modified benchmark dose as a point estimate using the ratio of increased effect divided by the full adverse response range which enables consistent placement of the benchmark response level and provides a BMD with a more consistent relationship to the dose-response curve shape.

Notes: Currently, there is a trend away from the use of single (often conservative) estimates of risk to summarize the results of risk analyses in favor of stochastic methods which provide a more complete characterization of risk. The use of such stochastic methods leads to a distribution of possible values of risk, taking into account both uncertainty and variability in all of the factors affecting risk. In this article, we propose a general framework for the analysis of uncertainty and variability for use in the commonly encountered case of multiplicative risk models, in which risk may be expressed as a product of two or more risk factors. Our analytical methods facilitate the evaluation of overall uncertainty and variability in risk assessment, as well as the contributions of individual risk factors to both uncertainty and variability which is cumbersome using Monte Carlo methods. The use of these methods is illustrated in the analysis of potential cancer risks due to the ingestion of radon in drinking water.

Notes: This paper describes the U.S. Environmental Protection Agency's assessment of potential health risks associated with the possible widespread use of a manganese (Mn)-based fuel additive, methylcyclopentadienyl manganese tricarbonyl (MMT). This assessment was significant in several respects and may be instructive in identifying certain methodological issues of general relevance to risk assessment. A major feature of the inhalation health risk assessment was the derivation of Mn inhalation reference concentration (RfC) estimates using various statistical approaches, including benchmark dose and Bayesian analyses. The exposure assessment component used data from the Particle Total Exposure Assessment Methodology (PTEAM) study and other sources to estimate personal exposure levels of particulate Mn attributable to the permitted use of MMT in leaded gasoline in Riverside, CA, at the time of the PTEAM study; on this basis it was then possible to predict a distribution of possible future exposure levels associated with the use of MMT in all unleaded gasoline. Qualitative as well as quantitative aspects of the risk characterization are summarized, along with inherent uncertainties due to data limitations.

Notes: Knowledge of the workforce's risk perceptions and attitudes to safety is necessary for the development of a safety culture, where each person accepts responsibility for working safely. The ACSNI Human Factors report stresses the importance of assessing workforce perceptions of risk to achieve a proper safety culture. Risk perception research has been criticized for insufficient analysis of the causal relationships between risk factors and perceived risk. The present study reports some of the factors which predicted risk perception in a sample of 622 employees from six UKCS offshore oil installations who completed a 15-section questionnaire. This paper focuses on the accuracy of workers’ risk perceptions and what underlying factors predict the perception of personal risk from both major and minor hazards.

Notes: Many psychometric studies have investigated judgments concerning personal risks from technologies, activities or consumer products, but only a few studies have included judgments of risk to the environment. Thus, little is known about this aspect of environmental risk perception, and whether it differs from personal risk perception. This study investigates risk judgments for 30 consumer products of various types such as herbal remedies, mobile telephones, genetically engineered drugs, or garden pesticides. A survey was conducted in two German cities: Leipzig and West Berlin. In total, 408 subjects evaluated the consumer products with regard to personal and environmental risk (and other risk-related aspects) and whether they would recommend the product to others. The findings show statistically significant differences between the mean values of perceived personal risk and environmental risk for most products. Despite these differences, the rank order of mean personal risk and environmental risk judgments for the products is quite similar. However, separate analyses for each product reveal that correlations between perceived personal and environmental risk vary strongly across products. Multiple regression analyses with personal and environmental risk judgments as predictors and product recommendation as criterion, run separately for each consumer product, show that it is mainly the judgment of perceived personal risk that explains product recommendation. Perceived risk to the environment adds little explanatory power. The study also explores differences in judgments of personal and environmental risk with regard to two sociodemographic variables: location (former East Germany vs. West Germany) and gender. Differences in both types of risk judgments are found with regard to location but not for gender.

Notes: To assess the health benefits gained from the use of cleaner burning gasoline, an analysis was conducted of changes in the atmospheric concentration of eight VOCs: acetaldehyde, benzene, 1,3-butadiene, ethylbenzene, formaldehyde, POM, toluene, and xylenes resulting from the use of reformulated gasoline and oxyfuel containing the additive MTBE. Modeled ambient air concentrations of VOCs were used to assess three seasonally-based scenarios: baseline gasoline compared to (a) summer MTBE:RFG, (b) winter MTBE:RFG, and (c) MTBE oxyfuel. The model predicts that the addition of MTBE to RFG or oxyfuel will decrease acetaldehyde, benzene, 1,3-butadiene and POM, but increase formaldehyde tailpipe emissions. The increased formaldehyde emissions, however, will be offset by the reduction of formaldehyde formation in the atmosphere from other VOCs. Using a range of plausible risk estimates, the analysis predicts a positive health benefit, i.e., a decline in cancer incidence associated with use of MTBE:RFG and MTBE oxyfuel. Using EPA cancer risk estimates, reduction in 1,3-butadiene exposure accounts for the greatest health benefit while reduction of benzene exposure accounts for the greatest health benefits based on alternative risk estimates. An analysis of microenvironment monitoring data indicates that most exposures to VOCs are significantly below levels of concern based on established margin-of-safety standards. The analysis does suggest, however, that health effects associated with short-term exposures to acetaldehyde and benzene may warrant further investigation.

Notes: In some areas where oxygenated fuel programs have been implemented, there have been widespread complaints of non-specific health effects attributed to the gasoline. There are a number of hypotheses that can account for this apparent association. This paper examines the hypothesis that the use of oxy-fuel (either oxygenated gasoline or reformulated gasoline) results in exposure of the general population to one or more chemicals at concentrations that cause toxicologic injury. Although several oxygenates can be used in oxy-fuels, this analysis focuses on MTBE because it is the most widely used oxygenate and because the database of relevant toxicologic data is greatest for this oxygenate. The causal assessment is based on an evaluation of the qualitative and quantitative plausibility that oxygenated fuel-related exposures have toxicological effects, and the epidemiologic studies that directly test the hypothesis that the use of oxygenated fuels causes adverse health effects. The plausibility that chemical exposures related to oxy-fuel use cause toxicological effects is very low. This determination is based on consideration of the exposure-response and time-action profiles for relevant toxicological effects of MTBE in animals, experimental MTBE exposure studies in humans, and the possibility that the addition of MTBE to gasoline results in toxicologically significant qualitative and/or quantitative changes in gasoline-related exposures. Similarly, the epidemiologic studies of oxy-fuel exposed cohorts do not support a causal relationship between oxy-fuel use and adverse health effects. Although the data are insufficient to rule the possibility of unique sensitivity in a small segment of the population, the strength of the evidence and the availability of other more plausible explanations for the health complaints reported in association with oxy-fuels support a high degree of confidence in the conclusion that MTBE-containing oxygenated fuels are not the cause of acute toxicity in the general population.

Notes: Factors such as hazard type and source credibility have been identified as important in the establishment of effective strategies for risk communication. The elaboration likelihood model was adapted to investigate the potential impact of hazard type, information source, and persuasive content of information on individual engagement in elaborative, or thoughtful, cognitions about risk messages. One hundred sixty respondents were allocated to one of eight experimental groups, and the effects of source credibility, persuasive content of information and hazard type were systematically varied. The impact of the different factors on beliefs about the information and elaborative processing examined. Low credibility was particularly important in reducing risk perceptions, although persuasive content and hazard type were also influential in determining whether elaborative processing occurred.

Notes: A Score Comparison Method (SCM), for use in comparative risk projects, is described. It provides a degree of analytical guidance for those undertaking to integrate environmental issues which have been placed into separate, qualitative rankings according to different types of risk into a single, qualitative, integrated risk ranking. Its use in an actual case is shown.

Notes: Recent reviews of epidemiological evidence on the relation between exposure to diesel exhaust (DE) and lung cancer risk have reached conflicting conclusions, ranging from belief that there is sufficient evidence to conclude that DE is a human lung carcinogen (California EPA, 1994) to conclusions that there is inadequate evidence to support a causal association between DE and human lung cancer (Muscat and Wynder, 1995). Individual studies also conflict, with both increases and decreases in relative risks of lung cancer mortality being cited with 95% statistical confidence. On balance, reports of elevated risk outnumber reports of reduced risk. This paper reexamines the evidence linking DE exposures to lung cancer risk. After briefly reviewing animal data and biological mechanisms, it surveys the relevant epidemiological literature and examines possible explanations for the discrepancies. These explanations emphasize the distinction between statistical associations, which have been found in many studies, and causal associations, which appear not to have been established. Methodological threats to valid causal inference are identified and new approaches for controlling them are proposed using recent techniques from artificial intelligence (AI) and computational statistics. These threats have not been adequately controlled for in previous epidemiological studies. They provide plausible noncausal explanations for the reported increases in relative risks, making it impossible to infer causality between DE exposure and lung cancer risk from these studies. A key contribution is to show how recent techniques developed in the AI-and-statistics literature can help clarify the causal interpretation of complex multivariate data sets used in epidemiological risk assessments. Applied to the key study of Garshick et al. (1988), these methods show that DE concentration has no positive causal association with occupational lung cancer mortality risk.

Notes: Book Review in this article:Petroleum Contaminated Soils, Vol. 1: Remediation Techniques, Environmental Fate, Risk Assessment Edited by Paul T. Kostecki and Edward J. Calabrese Chelsea, Michigan: Lewis Publishers, 1989 260 pp, $55.50 hbManaging Industrial Hazardous Waste: A Practical Handbook Gary Lindgren Chelsea, Michigan: Lewis Publishers, 1989 350 pp., $59.95 hbRisk Analysis Section, Oak Ridge National Laboratory, Chinn Building, MS-6492, Oak Ridge, Tennessee 37831.Health Effects of Drinking Water Treatment Technologies Drinking Water Health Effects Task Force Chelsea, Michigan: Lewis Publishers, 1989 145 pp., $37.50Chemical Hazards in the Workplace Ronald M. Scott Chelsea, Michigan: Lewis Publishers, 1989 196 pp., $39.95Environmental Chemistry and Toxicology of Aluminum Edited by Timothy E. Lewis Chelsea, Michigan: Lewis Publishers, 1989 344 pp., $59.95 hbLight Water Reactor Safety Bengt Pershagen New York: Pergamon Press, 1989 470 pp., $90.00Biologically Based Methods for Cancer Risk Assessment Edited by Curtis C. Travis New York: Plenum Press, 1989 355 pp.Social Decision Methodology for Technological Projects Edited by Charles Vlek and George Cvetkovich Boston: Kluwer Academic Publishers, 1989 343 pp., $87.00

Notes: The present study utilizes an operational model as well as simple empirical relationships for estimating hazard zones due to fire, explosion, and toxic vapor cloud dispersion. The empirical relationships are based on giving appropriate weightage to each of the parameters on which the hazard in question (viz. fire, explosion, toxic vapour dispersion) is dependent. Results from these two approaches [i.e., an operational model FLAMCALC of U.K. Health and Safety Executive (HSE) and an empirical model named FIREX] have been compared with the data obtained from the Mexico City disaster in 1984. In general, results from the empirical approach and FLAMCALC are comparable to the observed effects.

Notes: Annual concentrations of toxic air contaminants are of primary concern from the perspective of chronic human exposure assessment and risk analysis. Despite recent advances in air quality monitoring technology, resource and technical constraints often impose limitations on the availability of a sufficient number of ambient concentration measurements for performing environmental risk analysis. Therefore, sample size limitations, representativeness of data, and uncertainties in the estimated annual mean concentration must be examined before performing quantitative risk analysis. In this paper, we discuss several factors that need to be considered in designing field-sampling programs for toxic air contaminants and in verifying compliance with environmental regulations. Specifically, we examine the behavior of SO2, TSP, and CO data as surrogates for toxic air contaminants and as examples of point source, area source, and line source-dominated pollutants, respectively, from the standpoint of sampling design. We demonstrate the use of bootstrap resampling method and normal theory in estimating the annual mean concentration and its 95% confidence bounds from limited sampling data, and illustrate the application of operating characteristic (OC) curves to determine optimum sample size and other sampling strategies. We also outline a statistical procedure, based on a one-sided t-test, that utilizes the sampled concentration data for evaluating whether a sampling site is in compliance with relevant ambient guideline concentrations for toxic air contaminants.

Notes: Heavy gas dispersion models have been developed at IIT (hereinafter referred as IIT heavy gas models I and II) with a view to estimate vulnerable zones due to accidental (both instantaneous and continuous, respectively) release of dense toxic material in the atmosphere. The results obtained from IIT heavy gas models have been compared with those obtained from the DEGADIS model [Dense Gas Dispersion Model, developed by Havens and Spicer (1985) for the U.S. Coast Guard] as well as with the observed data collected during the Burro Series, Maplin Sands, and Thorney Island field trials. Both of these models include relevant features of dense gas dispersion, viz., gravity slumping, air entrainment, cloud heating, and transition to the passive phase, etc. The DEGADIS model has been considered for comparing the performance of IIT heavy gas models in this study because it incorporates most of the physical processes of dense gas dispersion in an elaborate manner, and has also been satisfactorily tested against field observations. The predictions from IIT heavy gas models indicate a fairly similar trend to the observed values from Thorney Island, Burro Series, and Maplin experiments with a tendency toward overprediction. There is a good agreement between the prediction of IIT heavy Gas models I and II with those from DEGADIS, except for the simulations of IIT heavy gas model-I pertaining to very large release quantities under highly stable atmospheric conditions. In summary, the performance of IIT heavy gas models have been found to be reasonably good both with respect to the limited field data available and various simulations (selected on the basis of relevant storages in the industries and prevalent meteorological conditions performed with DEGADIS). However, there is a scope of improvement in the IIT heavy gas models (viz., better formulation for entrainment, modification of coefficients, transition criteria, etc.).Further, isotons (nomograms) have been prepared by using IIT heavy gas models for chlorine, which provide safe distance for various storage amounts for 24 meteorological scenarios prevalent in the entire year. These nomograms are prepared such that a nonspecialist can use them easily for control and management in case of an emergency requiring the evacuation of people in the affected region. These results can also be useful for siting and limiting the storage quantities.

Notes: Benzene is one of the best studied of the known human carcinogens. It causes leukemia in humans and a variety of solid tumors in rats and mice. Decades of research on benzene metabolism, pharmacokinetics, cytotoxicity, genotoxicity, and carcinogenicity in vivo and in vitro are starting to converge on a small set of overlapping hypotheses about the most probable biological mechanisms of benzene toxicity and carcinogenicity. Although there is still room for surprises, it seems likely that the ultimate answer to the mystery of how benzene exerts its multiple effects will consist of elaborations and extensions of one or more of the current hypotheses. This paper reviews benzene health effects and biology, showing how various aspects of metabolism and cytotoxicity fit together with genotoxic and nongenotoxic effects to help explain how benzene may cause cancer. Its goals are: (i) to introduce the qualitative biological background needed for detailed quantitative dose-response modeling of benzene cancer risks; and (ii) to survey a rapidly evolving area of research that shows promise of producing fundamental insights into the mechanisms of toxicity and carcinogenesis for several chemicals–benzene and perhaps phenols, catechols, and other hydroxylated ring hydrocarbons–in the decade ahead.

Notes: ONGC's Hazira Gas-Processing Complex (HGPC) consists of facilities for receiving natural gas along with associated condensate from an off-shore field at a rate of 20 MMN M3 per day. After separating the condensate, which is processed in condensate fractionation units, the gas is processed through various steps to recover LPG and to reduce its dew point to less than 5°C in order to make it suitable for transportation over long distances. The acid gas recovered during the gas-sweetening step is processed to obtain sulphur. The major products manufactured at HGPC therefore are lean sweet gas, LPG, NGL, and sulphur. The Oil and Natural Gas Commission awarded the assignment on Hazard Study and Risk Analysis of their Hazira Gas-Processing Complex (HGPC) to the Council of Scientific and Industrial Research (CSIR) in association with the Netherlands Organisation for Applied Scientific Research (TNO). The scope of this assignment covered a number of closely related and fully defined activities normally encountered in this type of work. Identification of hazards through the most appropriate methods, assigning frequency of occurrence of major unwanted incidents, quantification and assessment of probable damage to plant equipment, environment, human and animal life due to an unexpected event, and evaluation of various methods for reducing risk, together constituted the methodology for this assignment. Detailed recommendations aimed at reducing risk and enhancing reliability of plant and machinery were made. This article gives an overview of the assignment.

Notes: McKone has recently proposed an innovative two-layer model for dermal uptake of organic chemicals from a soil matrix that explicitly includes variables for properties of the chemical, the soil, the skin, and the exposure. In this note, we investigate the joint time- and loading-dependencies implicit in the model by using MATHEMATICA to find and plot a closed-form function for the uptake fraction for six aromatic hydrocarbons.

Notes: Upperbound lifetime excess cancer risks were calculated for activities associated with asbestos abatement using a risk assessment framework developed for EPA's Superfund program. It was found that removals were associated with cancer risks to workers which were often greater than the commonly accepted cancer risk of 1 × 10−6, although lower than occupational exposure limits associated with risks of 1 × 10−3. Removals had little effect in reducing risk to school populations. Risks to teachers and students in school buildings containing asbestos were approximately the same as risks associated with exposure to ambient asbestos by the general public and were below the levels typically of concern to regulatory agencies. During abatement, however, there were increased risks to both workers and nearby individuals. Careless, everyday building maintenance generated the greatest risk to workers followed by removals and encapsulation. If asbestos abatement was judged by the risk criteria applied to EPA's Superfund program, the no-action alternative would likely be selected in preference to removal in a majority of cases. These conclusions should only be interpreted within the context of an overall asbestos risk management program, which includes consideration of specific fiber types and sizes, sampling and analytical limitations, physical condition of asbestos-containing material, episodic peak exposures, and the number of people potentially exposed.

Notes: The effects of exposure to two carcinogens are explored within the context of the two-stage clonal expansion model of carcinogenesis. This biologically based model provides a useful framework for the quantitative description of carcinogenesis, and for defining carcinogenic agents that act as initiators, promoters, and completers. This paper addresses the combined effects of simultaneous lifetime exposure to two carcinogens as well as nonoverlapping partial lifetime exposure to each agent. Whereas the age-specific relative risk for exposure to two initiators or two completers is additive, a multiplicative relative risk model holds for exposure to an initiator and a completer, or to a promoter and a completer. Exposure to two promoters yields supra-multiplicative relative risk. Exposure to an initiator and promoter leads to multiplicative and supra-multiplicative relative risks for simultaneous lifetime and nonoverlapping partial lifetime exposures, respectively. Although departures from the additive relative risk model may thus occur at moderate to high doses, conditions are identified under which additivity will provide a good approximation to the joint risk at low doses. The methods of analysis used in this paper can also be used to determine the joint effects of exposure to two carcinogens which may affect more than one stage (initiation, promotion, completion) of the process of carcinogenesis. In general, the joint effects of exposure to such agents depends on the relative magnitude of the effects on individual stages.

Notes: A conceptual framework is developed for the prescriptive evaluation of health and safety risks to an individual. This framework allows one to compare chronic vs. acute health risks, accidents vs. illness, and physical vs. psychological impacts. To do this, value judgments are necessary to quantify one's health state in terms of both physical and psychological well-being. Probabilities are necessary to describe implications of activities such as skiing or smoking and conditions such as cancer or third-degree bums in terms of these health states. Suggestions are made to operationalize and use the framework to evaluate and compare very different individual health and safety risks. Essentially, all existing measures of individual risk can be derived as special cases of the proposed framework.

Notes: A quantitative structure-activity relationship (QSAR) model has been developed to estimate maximum tolerated doses (MTD) from structural features of chemicals and the corresponding oral acute lethal doses (LD50) as determined in male rats. The model is based on a set of 269 diverse chemicals which have been tested under the National Cancer Institute/National Toxicology Program (NCI/NTP) protocols. The rat oral LD50 value was the strongest predictor. Additionally, 22 structural descriptors comprising nine substructural MOLSTAC(c) keys, three molecular connectivity indices, and sigma charges on 10 molecular fragments were identified as endpoint predictors. The model explains 76% of the variance and is significant (F= 35.7) at p 〈 0.0001 with a standard error of the estimate of 0.40 in the log(1/mol) units used in Hansch-type equations. Cross-validation showed that the difference between the average deleted residual square (0.179) and the model residual square (0.160) was not significant (t= 0.98).

Notes: Mathematical models of carcinogenesis are one tool used for research into the mechanisms of carcinogenesis and for assessing risks from exposure to carcinogenic agents. Recent research into carcinogenic mechanisms has focused on the role of cell replication in fixing damage to cellular DNA and increasing the incidence of malignancies. The most commonly used multistage model of carcinogenesis does not explicitly account for DNA damage and the contribution of cell replication rates on the transformation of cells through the various stages. In this manuscript, a generalized multistage model of carcinogenesis is developed in which DNA damage, cell replication, and DNA repair are explicitly included.

Notes: This study develops a theoretical model for accident evolutions and how they can be arrested. The model describes the interaction between technical and human-organizational systems which may lead to an accident. The analytic tool provided by the model gives equal weight to both these types of systems and necessitates simultaneous and interactive accident analysis by engineers and human factors specialists. It can be used in predictive safety analyses as well as in post hoc incident analyses. To illustrate this, the AEB model is applied to an incident reported by the nuclear industry in Sweden. In general, application of the model will indicate where and how safety can be improved, and it also raises questions about issues such as the cost, feasibility, and effectiveness of different ways of increasing safety.

Notes: The use of critical effects in the determination of occupational exposure limits (OELs) in Sweden is subjected to a statistical study. Many of the present OELs are high in relation to known noeffect levels and effect levels, and the degree of protection has a surprisingly weak correlation with the seriousness of the adverse effect. Several proposals for improved procedures are put forward. One of these is to supplement the concept of critical effects with that of dominant effects. A dominant effect of a substance is a health effect that is at some concentration the most serious health effect.

Notes: A purely stochastic Monte Carlo model is used to compare the relative midair collision course probabilities and mean closing velocities of four systems of rules for aircraft cruising altitudes as a function of altitude error: (1) current U.S. federal rules, (2) random altitudes, and (3) two proposed alternatives to the current rules. This model increments error while: (1) counting collisions among cruising pairs of aircraft following the four rules being tested on random headings between randomly placed airports, and (2) calculating mean closing velocities for each rule. The calculations verify that: (1) federal rules increase collision course probabilities by about four times more than for a chaotic system of aircraft cruising at randomly selected altitudes, (2) risk is directly proportional to the level of compliance, and (3) mean closing velocities resulting from the current rule are slightly less than for random altitudes, while being almost twice as high as for the proposed rules. High closing velocities are shown to increase the collision probability.

Notes: The dependence of the radiological consequences of the “Demokritos” research reactor on the operating schedule of the reactor is assessed in this paper. The 5 MW reactor is located within the limits of Athens city, a large population center with over 3 million inhabitants. The consequences examined would be due to the occurrence of a postulated accident, a 20% core melt loss of coolant accident, that is also considered as the design basis accident of the reactor. Three operating schedules are taken into account: (a) a continuous operation schedule; (b) a 16 hr/day, 5 days/week schedule; and (c) the present 8 hr/day, 5 days/week operating schedule. The assessment of the source term emerges from a conservative estimation of fission product releases to the reactor operating floor, and further under the conservative assumptions of no filter mitigation, and a ground release to the environment. The results of the analysis indicate that there is a direct relation between consequences and duration of operation, the former becoming appreciable as the continuous operation limit is approached. In all cases examined, the thyroid dose and the latent thyroid health effects would be the limiting consequences.

Notes: A survey has been conducted among decision-makers from the urban area of Lyon (France). It aimed at elicitating attitudes toward industrial risk, with an emphasis on major hazards. The sample was quite small (23 individuals), but most of the actual decision-makers of the area belonged to it. A questionnaire allowed to look at the weights that are given to “catastrophic accidents,” when compared to more usual ones. It showed that decision-makers are strongly “adverse to catastrophes.” The findings support many risk management approaches that are based on assigning an “extra weight” to potential accidents that may cause a high number of casualties.

Notes: In 1982 the Council of the European Communities issued a Directive on the Major Accident Hazards of Certain Industrial Activities, commonly known as the Seveso Directive. Besides other requirements, the Directive specifies that members of the public liable to be affected by a major accident from certain industrial activities must be informed of safety measures and how they should behave in the event of an accident. The Directive was subsequently amended in an extensive way. Upon the transposition of the Seveso Directive and its amendments into national legislations, the 12 European Member States are faced with the task of “appropriately and effectively” informing the public about major accident hazards. Delays are observed throughout the community, both in transposing the Directives and implementing public information. A pilot study on “Risk Information Needs” was commissioned and carried out at two Seveso sites in Italy in order to begin to resolve some of the problems involved in the provision of public information and to suggest appropriate guidelines. One hundred subjects answered an experimental protocol designed to assess their “information needs.” This article presents the theoretical background, the pragmatic aims, and the design of the study. It also summarizes its most relevant findings and suggests some recommendations for the provision of information to the public.

Notes: Waste management has become a major environmental issue in Germany. The siting of waste incineration especially arouses strong local opposition. The study presented here is related to such a case (i.e., a planned waste incineration facility in a small West German village). The study is based on a telephone survey aimed at the information needs of the residents. Two topics are stressed: (1) the thematic relevance of the siting project as seen by the public; and (2) the residents’information needs. The results show that a majority of residents are concerned about the planned facility, and the most important topics of their information needs refer to the risks and the safety systems of the planned facility, as well as information about waste management alternatives. Furthermore, the information needs depend on the personal relevance of the issue and the perceived knowledge deficit about it. Conclusions are drawn with regard to the design of a risk communication program. Here, four groups of residents are distinguished in terms of knowledge and motivation and, thus, need to be approached in different ways.

Notes: In recent years a large number of conflicts associated with environmental risks have arisen in Hungary. The case study described here is related to the siting of a hazardous waste incinerator in Dorog. First, the history of the siting procedure is outlined in terms of the multiparty, multiattribute decision framework. Subsequently, the case reveals how stakeholder groups can be identified in the structure of decision-making, how they think about the object causing the conflict, about the conflict itself, and the possibilities of resolving it. In investigating the conflict, a combination of analytical tools were applied. The multiple-perspective model of Linstone and the argumentation analysis of Toulmin provided the frame for analyzing the information collected by interviews in the affected town, Dorog, and two other towns affected to different degrees in environmental problems.

Notes: Many problems arise in connection with the communication of risk information. In this article the content of the information communicated is taken as a starting-point for analyzing the risk communication process. We studied the way in which authorities communicated health risks to local residents in Dutch soil pollution situations and found that communication problems were characterized more by misunderstanding and conflict between parties with different views and interests than by a lack of understanding. Therefore, it is important to look more closely at the way the communicators of information (in our cases, officials) select risk information from risk assessments, and to study the effects that the information selected has on the receivers (in our cases, residents). Both the process of selection by the officials and the process of interpretation by the residents will be shown to be influenced by the different institutional backgrounds. The article presents a new approach to risk communication. Both the risk information presented by the authorities and the public reactions to this risk information are considered to reflect the institutional background of authorities and residents, and can be analyzed in these terms. Such an approach has consequences for the study of risk communication and the manner in which it is practiced.

Notes: Risk communication is seen as an important adjunct to the process of siting locally noxious facilities. To understand how risk communication might function in such a process, one needs to understand the political context that gives rise to public opposition to such facilities in the first place. This analysis draws on a variety of data to describe the decline of deference, a situation in which a hostile and alienated public is mobilized primarily through ad hoc voluntary organizations, and is increasingly reluctant to defer important decisions to institutional elites. Risk communication programs must be designed to offset the trends that result in the decline of deference. This conclusion differs markedly from the conventional wisdom that risk communication is merely a device for providing information to citizens so sthat they may make more rational decisions.

Notes: Any personal or societal activity, besides bringing us benefits, also carries some risk. Energy production and use are no exceptions. In order to judge these risks, they must be quantified, and the risks of all alternative methods of producing this energy must then be compared among each other. These risks originate in many parts of the energy cycle; they are diverse in character and involve different parts of the population. It is therefore necessary to discriminate between many aspects of risk so that only reasonably comparable categories are compared. The results of a critical analysis of the international risk literature are presented, which are applicable to power production plants as they could be built today in central European countries. This review pays special attention to the possibility of severe accidents occurring, which attract so much attention in our modern societies. It turns out that the health risks of routine nuclear energy production are lower than the risks of other energy options, particularly for the general public. The probability of a severe accident occurring is far higher for all conventional energy options. Only the renewable systems utilizing the energy of the sun and the wind are not susceptible to severe accidents.

Notes: Risk perception studies show that individuals tend to underestimate significant risks, overestimate negligible ones, and distrust authorities. They also rely on a variety of strategies or heuristics to reach decisions regarding their risk-taking behavior. We report on a survey of fishermen and crabbers engaged in recreational and subsistence fishing in a Puerto Rican estuary (near Humacao), which has been declared a “Superfund site” because of suspected contamination by mercury, and at ecologically similar control sites. Nearly everyone interviewed at the Humacao site was aware of the mercury contamination, but either denied its importance, believed the contamination was restricted to a distant part of the estuary, or assumed that the estuary would be closed by the authorities if the threat was real. All site-users consumed the fish and crabs they caught. At Humacao, the average catch was 7 fish per fishermen (mostly tilapia, Tilapia mossambica, and tarpon, Megalops atlantica) and 13 crabs per crabber (all blue crabs, Callinectes sapidus). On average, the site-users returned to the lagoons about 3-4 times per month. At control sites, fewer fish were eaten. The worst case consumption of tarpon, a species which concentrated mercury at Eastern Puerto Rico, provided an exposure exceeding the EPA reference dose, whereas consumption of one tarpon per week did not entail excess exposure. Fortunately, few individuals caught tarpon exclusively. Unlike counterparts in the northeastern United States, they trusted authorities and indicated that they would have heeded warnings of mercury contamination posted where they fished.

Notes: The primary mission of search and rescue (SAR) is the saving of lives. To assess SAR operations from a planning perspective, one must draw a connection between operations and the number of lives saved. Our approach is to model the probability that an incident results in at least one fatality, given the response time between the time of incident occurrence and time of rescue. We show that incidents involving air crashes, capsizing, foundering, grounding and other/unknown types of incidents tended to have higher probabilities of fatalities as the response time became higher. However, other emergency types did not exhibit the same overall tendency as these did. These statistical results do not prove causality between faster response times and lower fatality incidence for the above-mentioned emergency types. They can be used, however, for estimating the average number of fatalities for a given distribution of response time, and ultimately the marginal savings in lives for a change in the mix of resources and locations.

Notes: A common mental response to risk is worry. Though generally associated with fear and anxiety, worry is primarily a cognitive activity that can, under some circumstances, be beneficial for developing coping strategies to deal with stressful events. The present study reports an assessment of worry done both before and after the reactor accident at Three Mile Island (TMI). Worries over nuclear risks were assessed in the context of central life concerns such as financial, physical, and interpersonal well-being. The TMI incident elevated nuclear energy worries to a level near those of central life concerns. The productive value of worry is discussed in terms of its relationship with opportunities for personal control.

Notes: An unusual questionnaire was used to explore what risks concern laypeople. It asked respondents to list, in their own words, as many risks of personal concern as they could. They then selected the five risks of greatest concern and answered a set of specific questions about each. A coding scheme was developed for categorizing these responses and was shown to have good reliability. The questionnaire was administered to a heterogeneous convenience sample of subjects. They reported a very broad range of risks of concern, which differed in plausible ways as a function of their gender and age. Females and student-age subjects were generally more concerned about the environment, whereas males and older subjects were more likely to mention health and safety risks. Both the extent of the risk-reduction actions that they reported and their expressed willingness to pay for future risk reductions were greater for risk that presented a direct personal threat (e.g., health risks) than for risks that posed a diffuse threat to the environment or to people in general (e.g., pollution). Respondents perceived themselves as bearing primary responsibility for managing threats to their own health, but generally saw government as bearing a heavier responsibility for managing environmental risks (especially for pollutants) and war. The questionnaire instrument and coding structure developed for this work are well-suited to a variety of future research applications. They provide a way to identify the risks that concern lay groups, as well as to track the evolution of those concerns over time.

Notes: Existing approaches to routing hazardous material shipments by rail recognize that track condition is an important influence, but have not included it in the risk assessment and routing models. This note explores the influence of track condition based on predictions of internal defects in the rail. The method developed predicts the expected frequency of accidents and subsequent consequences in terms of the expected number of fatalities accounting for one aspect of track condition—internal defects. It is intended to indicate the magnitude and impact of track condition. The formulation integrates models of consequences and the risk of a hazardous spill found in the literature with the frequency of accidents as a function of the number of defects. The number of defects may be based on observations or predicted as a function of the cumulative traffic. The models are used to calculate the expected number of fatalities per year for a particular route. Application of the methodology to a hypothetical route shows that the risk associated with the transportation of hazardous material shipments varies significantly with the expected number of defects in the track. Therefore, risk not only varies from route to route but over time for any section of track as the condition deteriorates.

Notes: Mathematical expressions are derived, under different dosing patterns, for the number and size of premalignant clones within the framework of a two-mutation model for carcinogenesis, which has previously been shown to be consistent with a large body of epidemiologic and experimental data.

Notes: Five years of the annual Health Interview Survey, conducted by the National Center for Health Statistics, are used to estimate the effects of air pollution, smoking, and environmental tobacco smoke on respiratory restrictions in activity for adults, and bed disability for children. After adjusting for several socioeconomic factors, the multiple regression estimates indicate that an independent and statistically significant association exists between these three forms of air pollution and respiratory morbidity. The comparative risks of these exposures are computed and the plausibility of the relative risks is examined by comparing the equivalent doses with actual measurements of exposure taken in the homes of smokers. The results indicate that: (1) smokers will have a 55–75% excess in days with respiratory conditions severe enough to cause reductions in normal activity; (2) a 1 μg increase in fine particulate matter air pollution is associated with a 3% excess in acute respiratory disease; and (3) a pack-a-day smoker will increase respiratory restricted days for a nonsmoking spouse by 20% and increase the number of bed disability days for young children living in the household by 20%. The results also indicate that the estimates of the effects of secondhand smoking on children are improved when the mother's work status is known and incorporated into the exposure estimate.

Notes: The authors present results of a February 1987 survey on judged frequency of mortality causes and risk perception of technologies in a representative sample of the French population. Although the French context is very different, and the impact of public controversies have been very limited on technological choices such as the nuclear energy program, strong similarities in risk perception of technologies are observed with results from U.S. surveys. Results, which could be worthwhile for other countries, suggest that risk perception is influenced by two different types of components. The first influence is the global feeling of “security” that society procures to its members. Such feeling depends on the individual's socioeconomic status, subjective state of health, and personal discomfort in daily life, and explains individual aversion to risk independently of the mortality causes or technologies involved. The second influence is the degree of perceived social legitimization of the activities involving risks. Risks of medical and transportation activities are strongly opposed to illegitimate risky behaviors (smoking, drugs, alcohol); technologies which have been an object of public debate (nuclear plants, the chemical industry, lead in gasoline) have an intermediate position reflecting the remaining uncertainties of public opinion about their risk–benefit balancing. Tentative conclusions for risk communication are proposed.

Notes: The following situation has been considered: during an accident sequence, a crew has to do a proper set of actions within a finite time window in order to achieve a specific goal. The operator actions are considered independent, they are lined up in series, and a single failure leads to mission failure. This paper proposes a general methodology for assessing the crew response (or success) probability, through a convolution integral formulation. This method is general and can be applied to any response probability model; an application to the Human Cognitive Reliability model is given.

Notes: This paper critiques the Environmental Protection Agency's assessment of risk for hazardous waste incineration at sea. It reviews operational and transportation risks and considers alternative approaches for managing chlorinated organic hazardous wastes. It concludes that depending on the scale of the program, ocean incineration will either contribute little to the overall management of this waste stream or else it will engender significant risks, especially in the coastal environment. Furthermore, past assessments on the part of EPA have tended to understate the risks of incineration at sea while simultaneously holding out the promise of the technology as a commercial-scale management option. Finally, this paper observes that the Western European countries that pioneered incineration in the North Sea are now finding practical alternatives. It is recommended that waste reuse, on-site treatment, and techniques of waste reduction provide viable alternatives and obviate the need for incineration at sea.

Notes: The most recent U.S. Nuclear Regulatory Commission (NRC) statement of safety goal policy is a significant advance over previous versions. However, some areas of the policy are still in need of refinement, and the resolution of several key questions was deferred pending further review. To clarify some of these issues, this paper presents a critical review of the NRC safety goal policy to date.

Notes: Studies often note the wide differences that exist in costs per death avoided across U.S. federal programs and regulatory contexts. This paper explores two new, related explanations for these differences. First, it argues that the patterns of revealed preferences (public allocations) may be related to public values, which are measured here through subjects' expressed preference responses to a contingent valuation survey regarding risk reduction. Subjects' expressed values are compared to actual (and proposed) costs of safety regulations for a similar set of hazards. We discover strong congruence in the ranking of expressed values and actual values. Second, the paper presents the results of a subsequent survey that investigates why the patterns observed in the first survey might occur. It suggests that one reason for the observed similarities between revealed and expressed preferences may be in how choices are framed. The paper hypothesizes that both subjects and decision makers may frame valuation decisions in the same way: as percentage changes from the reference point provided by the base rate of deaths for that hazard.

Notes: When high-dose tumor data are extrapolated to low doses, it is typically assumed that the dose of a carcinogen delivered to target cells is proportional to the dose administered to test animals, even at exposure levels below the experimental range. Since pharmacokinetic data are becoming available that in some cases question the validity of this assumption, risk assessors must decide whether to maintain the standard assumption. A pilot study of formaldehyde is reported that was undertaken to demonstrate how expert scientific judgment can help guide a controversial risk assessment where pharmacokinetic data are considered inconclusive. Eight experts on pharmacokinetic data were selected by a formal procedure, and each was interviewed personally using a structured interview protocol. The results suggest that expert scientific opinion is polarized in this case, a situation that risk assessors can respond to with a range of risk characterizations considered biologically plausible by the experts. Convergence of expert opinion is likely in this case if several specific research strategies are executed in a competent fashion. Elicitation of expert scientific judgment is a promising vehicle for evaluating the quality of pharmacokinetic data, expressing uncertainty in risk assessment, and fashioning a research agenda that offers possible forging of scientific consensus.

Notes: DETECT is an inexpensive, easy to use, general-purpose, Monte Carlo simulation program for IBM and compatible personal computers. It can be used to quickly analyze fault trees or functions of random variables. DETECT provides a wide variety of input distributions to choose from and a dependency (correlation) option. The result of the analysis is a probability distribution over the variable of interest. We look forward to further improvements (e.g., graphics, full-screen editing, ability to inspect intermediate results) that will make DETECT even more useful and attractive.

Notes: In many animal model systems for carcinogenesis, well characterized putative premalignant lesions are observed. A much studied example is provided by the enzyme altered foci in rodent hepatocarcinogenesis experiments. In a recent paper, we proposed a method for the quantitative analysis of such premalignant lesions. The model used in that paper assumed that the mean growth of premalignant clones is exponential. However, it has been suggested that such a model is oversimplified. In this paper, we relax the assumption of exponential mean growth. The new model contains one extra parameter that measures departures from exponentiality. Use of the model is illustrated by analysis of ATPase deficient foci in the liver of rats given NNM (N-nitrosomorpholine) in their drinking water. The analysis suggests that the clonal growth of altered cells is significantly accelerated (superexponential) for nontoxic doses of NNM. Finally, the hazard function of the two-mutation model for carcinogenesis is briefly discussed under nonexponential (mean) growth of intermediate cells.

Notes: Book Reviewed in this article: Transportation for the Nuclear Industry Edited by D. G. Walton and S. M. Blackburn Reproductive Health Hazards in the Workplace Office of Technology Assessment Task Force Philadelphia: J.B. Lippincott Co. Metal Speciation: Theory, Analysis and Application Edited by James R. Kramer and Herbert E. Allen Chelsea Environmental Hazards: Communicating Risks as a Social Process By Sheldon Krimsky and Alonzo Plough The Risk Ranking Technique in Decision Making By John C. Chicken and Michael R. Hayns Drinking Water and Health: Selected Issues in Risk Assessment, Vol. 9 Safe Drinking Water Committee, Board on Environmental Studies and Toxicology Risk Analysis: A Guide to Principles and Methods for Analyzing Health and Environmental Risks By John J. Cohrssen and Vincent T. Covello Film Badge Dosimetry in Atmospheric Nuclear Tests Committee on Film Badge Dosimetry in Atmospheric Nuclear Tests