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  • 1
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    [s.l.] : Nature Publishing Company
    Nature biotechnology 1 (1983), S. 725-725 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The U.S. Environmental Protection Agency (EPA) has made a bold move in announcing that it intends to regulate the release of genetically modified organisms into the environment (see BIO/TECHNOLOGY, 1983, 1:638). Despite the cost (approximately $10,000 to file) and the delay (at least 90 ...
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  • 2
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    Nature biotechnology 1 (1983), S. 725-725 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] It is inherently unfair to competing companies, especially small companies, for an institution to withhold licenses for the most basic tools of any technology. In cases like the Cohen-Boyer process patent and the Axel-Wigler patent granted to Columbia University for cotransformation of eukaryotic ...
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  • 3
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    Nature biotechnology 1 (1983), S. 730-731 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] SARASOTA, Florida—Many symposia at the Society for Industrial Microbiology meeting appeared aimed at the bioengineer rather than the industrial microbiologist. The need for cooperation and understanding between the two groups was a recurring theme of the meeting, which was held here in ...
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  • 4
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    Nature biotechnology 1 (1983), S. 734-735 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] NEW YORK, New York—As techniques for enzyme production, engineering, purification, and delivery improve, the range of enzyme applications to therapy is increasing. Doctors apply enzymes externally to burns and wounds, infuse enzymes into the bloodstream to promote or inhibit clotting, ...
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  • 5
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    Nature biotechnology 1 (1983), S. 732-734 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] WASHINGTON, D.C.—The U.S. Patent and Trademark Office (PTO) is considering changes in personnel, patent classification, and lines of authority to encompass the rapid growth and new technologies of genetic engineering, according to assistant commissioner for patents Rene Tegtmeyer. Several ...
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  • 6
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    Nature biotechnology 1 (1983), S. 736-740 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Top left: A calf “on line” at Bio-Response. Top right: A Celltech scientist demonstrates the scale of its new 100 liter fermentors. Bottom: Human hybridoma cells growing within Damon Biotech's capsules. NEW YORK, New York—Damon Biotech and Bio-Response plan to open new facilities ...
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  • 7
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    Nature biotechnology 1 (1983), S. 743-755 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Seeking a way to keep warm, the hobo thought he had discovered fuel oil when he opened the valve of the railroad tank car parked on a siding. Unfortunately, the car held not fuel oil but 21,000 gallons of a 50 percent formaldehyde solution. It gushed out of the tank, spilled over a stone railbed ...
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  • 8
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    Nature biotechnology 1 (1983), S. 676-676 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] One would hardly expect to find our planet's most grandiose biotechnology project in a nation whose inflation rate is 120 percent, whose massive debts threaten the fabric of international banking, and whose social discontent is such as to suggest violent upheavals, if not worse, in the near future. ...
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  • 9
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    Nature biotechnology 1 (1983), S. 709-709 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The Patent Cooperation Treaty, or PCT, gives inventors the option of reserving patent protection in 32 additional countries at the same time that they file in the U.S. Thirty-three countries ratified the 1978 treaty, under which a patent filed in one country forms the basis for protection in all ...
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  • 10
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    Nature biotechnology 1 (1983), S. 701-702 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Biochemical Engineering and Biotechnology Handbook. Edited by Bernard Aikens and Ferda Mavituna. Pp. 1119. ISBN 0 333 332741 (The Nature Press: New York). $97.00 The authors have assembled an impressive array of information, undoubtedly useful to workers in the field. The book is divided ...
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  • 11
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    Nature biotechnology 1 (1983), S. 537-538 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] KENSINGTON, Maryland—A technique for producing human monoclonal antibodies directed against tumor antigens associated with human colorectal cancers has been developed at Litton Bionetics, which says it has produced more than 20 of these cancer-reactive monoclonals since the beginning of the ...
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  • 12
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    Nature biotechnology 1 (1983), S. 543-543 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] STANFORD, California—Bacilli have a great track record in industry. More than a score of their secreted proteins (mostly cleaving enzymes) are successfully produced and widely employed by dozens of industries. But what about the future now that biotechnology has become something more than ...
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  • 13
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    Nature biotechnology 1 (1983), S. 565-575 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The revolutionary advances of the early 1970's, such as rapid nucleic acid sequencing, restriction enzyme technology, and recombinant DNA techniques, have produced an information explosion in the field of molecular biology. Millions of base pairs of DNA sequences are now known and must be analyzed; ...
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  • 14
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    Nature biotechnology 1 (1983), S. 612-612 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Biotechnology Made Simple. PJB Publications ed. Pp. 1127. (PJB Publications: 1983) $150; £75,00 This large-format paperback is a dictionary of terms used in biology and biochemistry. Figures from basic texts are included. A chronology of the emerging biotechnology industry may be ...
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  • 15
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    Nature biotechnology 1 (1983), S. 615-616 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] This month the New Products section will feature products with applications in several areas of biotechnology. The section will review reagents and equipment for molecular biology, genetic engineering, and microbiological experimentation; the companies marketing these products will be exhibiting ...
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  • 16
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    Nature biotechnology 1 (1983), S. 613-614 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The American Type Culture Collection (ATCC), a non-profit organization located in Rockville, Maryland, recently made the following materials available for distribution to biotechnologists in industry and academia. These materials may be ordered from the Collection by using the ATCC® number. ...
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  • 17
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    Nature biotechnology 1 (1983), S. 480-483 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The Netherlands Organization for Applied Scientific Research (TNO) sponsored its second conference on “The Biology of the Interferon System” on 18–22 April 1983 in Rotterdam. Although it came only six months after the Third International Congress for Interferon Research, the ...
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  • 18
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    Nature biotechnology 1 (1983), S. 490-492 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Nothing said more about the subject of the first stream of sessions at Biotech 83, entitled The Climate for Biotechnology, than the simple fact that approximately 1000 delegates were prepared to pay as much as £400 a head to register for the meeting. Although a surprising number of speakers ...
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  • 19
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    Nature biotechnology 1 (1983), S. 507-508 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] TITLE: Dispersant and Biodegradant Formulations for Treating Hydrocarbon-Polluted Waters INVENTORS: Claude Gatellier, Boulogne, Andree Plessis, Le Vesinet, Patrick Gateau, Trappes, and Jean-Pierre Durand, Chatou, FR ASSIGNEE: Institut Francais du Petrole, Fueil-Malmaison, FR FILING & ...
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  • 20
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    Nature biotechnology 1 (1983), S. 388-389 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] BACTERIAL PLASTIC COMES TO MARKET LONDON, England—Despite its mixed experience with single-cell protein, Britain's ICI is determined to stay in the biotechnology business, and believes it may have found a new path to success. At the Biotech '83 conference and exhibition here ICI took one of ...
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  • 21
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    Nature biotechnology 1 (1983), S. 395-396 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] SAN CARLOS, California—The financially plagued International Plant Research Institute (IPRI) has avoided bankruptcy, at least for now. Bio Rad, a Richmond, CA, manufacturer of clinical diagnostics, research products and instrumentation, stepped in at the end of May and purchased IPRI ...
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  • 22
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    Nature biotechnology 1 (1983), S. 410-412 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Most appropriately, the first Keystone Conference on Plant Molecular Biology began with a keynote address by Josef Schell (Rijksuniversiteit, Gent and Max Planck Institut fur Zuchtungsforschung, Koln) on the “Prospects for Genetic Engineering in Higher Plants.” Dr. Schell reviewed the ...
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  • 23
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    Nature biotechnology 1 (1983), S. 439-440 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Since the major component of any large batch of media is water, its quality must be carefully monitored. Pyrogen content of the water is also a very important consideration. A variety of filtration systems, deionizers, distilled-deionizing systems, mixed-bed ion exchangers, and similar products are ...
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  • 24
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    Nature biotechnology 1 (1983), S. 448-448 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Biotechnology International Edited by Carmel Barnard. Three volumes. Vol. 1, 200 Pp., $400.00; Vol. 2, 252 Pp., $400.00; Vol. 3, 114 Pp., $400.00. $1000.00 for all three volumes. (IMS World Publications, Ltd., York House, 37 Queens Square, London WC1 N3BL, U.K.) 1982 ...
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  • 25
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    Nature biotechnology 1 (1983), S. 309-310 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] COLOGNE, W. Germany—The branch of industry now most sensitively poised for a revolution triggered by recombinant DNA technology is plant breeding, judging from several papers given at the recent conference held by COGENE (the International Council of Scientific Unions' Committee on Genetic Ex ...
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  • 26
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    Nature biotechnology 1 (1983), S. 310-313 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] HUNTSVILLE, Alabama—A bioprocessing factory in space may not be too far in the future. One of the projects on the March space shuttle mission, the first flight of the Challenger, was a successful experiment in which National Aeronautics and Space Administration (NASA) astronauts operated ...
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  • 27
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    Nature biotechnology 1 (1983), S. 314-314 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] KEYSTONE, CO—Agrigenetics scientists announced expression of transferred foreign plant genes in plant cells at a meeting here late in April. At the same meeting, Monsanto scientists reported genetically engineering entire plants by transfer ring bacterial genes to plant cells, then ...
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  • 28
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    Nature biotechnology 1 (1983), S. 341-342 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] An old biotechnology, composting, has recently come into widespread use as a sewage sludge treatment process. (See Review Article, p. 347.) North American cities composting at least a sizeable portion of their sludge (or soon to do so) include Washing ton, DC; Philadelphia, PA; Camden, NJ; ...
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    Nature biotechnology 1 (1983), S. 344-345 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Although the food industry never fails to make the list of areas where the “biotechnology boom” will have a significant impact, few specific applications have as yet materialized. Several papers presented at the recent ASM seminar entitled “Biotechnology in the Food ...
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    Nature biotechnology 1 (1983), S. 346-346 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Acabal of biotechnologists and molecular biologists, gathered to mull over the future implications of their pioneering work, is hardly likely to become equally excited about studies carried out three decades ago by someone now in their eighties. But that is what happened recently at COGENE's latest ...
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    Nature biotechnology 1 (1983), S. 359-361 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Applied Genetic Engineering Future Trends and Problems. By Morris A. Levin, George M. Kidd, Robert H. Zaugg, and Jeffrey R. Swarz, pp. 191. ISBN 0-8155-0925-1 (Noyes Publications) $24.00 This book deals broadly with applied biology, including genetic engineering. The future trends promised ...
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    Nature biotechnology 1 (1983), S. 373-375 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] TITLE: Microbiological Production of Lower Aliphatic Carboxylic Acids INVENTORS: Marvin P. Bryant, and Barbara R. S. Genthner, both of Urbana, IL, US ASSIGNEE: University Patents, Inc., Norwalk, CT, US FILING & ISSUING DATA: U.S. Patent No.: 4,377,638 Date Issued: March 22, 1983 Lower ...
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  • 33
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    Nature biotechnology 1 (1983), S. 248-250 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Fundamental scientific inquiry in physics and mathematics over the past 50 years resulted in advances in man's ability to compute, to communicate, and to use energy in revolutionary ways. It is clear that each of these technologies has developed according to externally defined needs and objectives. ...
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    Nature biotechnology 1 (1983), S. 276-277 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Within the past decade the amount of newly published information relating to biotechnology has rapidly expanded. The growth in the number of biotechnology-related companies is far exceeded by the number of new books, journals, news sheets, and so on in the field. Many long-established publishing ...
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    Nature biotechnology 1 (1983), S. 277-277 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Biotech '83, the first world conference and exhibition on the commercial applications and implications of biotechnology is taking place this month in London. Accompanying the conference will be the first international biotechnology exhibition. Displays from many of the world's leading biotech ...
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    Nature biotechnology 1 (1983), S. 369-371 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] The following biotechnology-related grants were selected from a group of new awards recently announced by the Nation al Institutes of Health. The descriptions are excerpted from the technical abstracts accompanying the proposals. TITLE: Transposable genetic elements of maize INVESTIGATOR: ...
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    Nature biotechnology 1 (1983), S. 220-220 
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    Notes: [Auszug] NEW YORK, NY—Sci/Tech Holdings, the new international mutual fund specializing in technology stocks, completed its subscription period March 24 and began investing funds in April. Specializing in promising science and technology investments, including biotechnology, Sci/Tech hopes to ...
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    Nature biotechnology 1 (1983), S. 225-226 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] MALVERN, PA—Immunorex, the FMC Corp.-Centocor joint venture formed to produce pharmaceuticals using human monoclonal antibodies, is also planning to do immunoregulation research leading to the development of in vitro diagnostics. Although Immunorex is yet to market a product, FMC has agreed ...
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    Nature biotechnology 1 (1983), S. 228-235 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Leaching solution is sprayed by a sprinkler system on top of a copper-leaching dump. The recycled waste water, from which the copper sulfate has been removed, retains much ferrous iron and some sulfuric acid. Inset; Sulfolobus brierleyi. Scanning electron micrograph of the organism developing ...
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    Nature biotechnology 1 (1983), S. 239-239 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] One of the most rapidly progressing areas of biotechnology is plant molecular biology. Several re cent reports in BIO/TECHNOLOGY have focused on the manipulation of the Ti plasmid, a large plasmid found in Agrobacteria. Laboratories in the United States and Europe have announced successful ...
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    Notes: [Auszug] A set of broad host range cloning vectors has been constructed from the IncW plasmid pSa. These vectors have been constructed from the transfer defective deletion derivative pSa151, which encodes resistance to kanamycin and spectinomycin–streptomycin. Two of the vectors also contain the ...
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    Nature biotechnology 1 (1983), S. 280-280 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] A Wealth of Wild Species: Storehouse for Human Welfare. Norman Meyers. Pp. 274. ISBN 0-86531-132-3 (Western Press, Inc.: 1983). $27.00 This book is not specifically written for a business audience, but it is useful to those in the biotechnology industries. It offers a list of raw materials ...
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    Nature biotechnology 1 (1983), S. 291-294 
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    Notes: [Auszug] TITLE: Escherichia coli Bacteria Carrying Recombinant Plasmids and Their Use in the Fermentative Production of L-Tryptophan INVENTORS: David M. Anderson, Rockville, MD, Klaus M. Herrmann, and Ronald L. Somerville, West Lafayette, IN, US ASSIGNEE: Ajinomoto, Co., Inc., Tokyo, JP FILING & ...
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    Nature biotechnology 1 (1983), S. 146-147 
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    Notes: [Auszug] COLD SPRING HARBOR, New York—Several virus proteins that are normally anchored in a membrane have been genetically engineered to proteins that are exported from infected eukaryotic cells. The secreted proteins, which are biologically active, can be purified far more easily and quickly than ...
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    Nature biotechnology 1 (1983), S. 169-171 
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    Notes: [Auszug] Plant molecular genetics has finally come of age: the Miami Winter Symposium on the application of gene technology to agriculture drew more than 700 participants. While naturally occurring genetic variability among sexually compatible plants has long been exploited by plant breeders, it is now ...
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    Nature biotechnology 1 (1983), S. 181-188 
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    Notes: [Auszug] It is shown here how mass spectrometry (MS) can be used for on–line data acquisition in fermentation. MS was applied in this work to analyze gas and liquid phases. Gas phase analysis allows fast and accurate measurement of all gases of interest (O2, N2, CO2, Ar, He etc.). Liquid phase ...
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    Nature biotechnology 1 (1983), S. 195-196 
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    Notes: [Auszug] APRIL MEETINGS April 10–15. Cellular Responses to DNA Damage (1983 UCLA Symposium on Molecular and Cellular Biology). Keystone, CO. Info: UCLA Symposia, Molecular Biology Institute, University of California, Los Angeles, CA 90024 April 11. Meeting of the Recombi-nant DNA Advisory Committee. ...
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    Nature biotechnology 1 (1983), S. 205-205 
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    Notes: [Auszug] TITLE: Extrachromosomal Regulation of Expression INVENTORS: John J. Sninsky, Mountain View, CA, and Stanley N. Cohen, Portolla Valley, CA ASSIGNEE: The Board of Trustees of the Leland Stan ford Jr. University, Stanford, CA FILING AND ISSUING DATA: U.S. Patent No.: 4,374,927 Date Issued: ...
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    Nature biotechnology 1 (1983), S. 821-821 
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    Notes: [Auszug] BIO/TECHNOLOGY is very pleased to close its first volume with this December issue. A healthy circulation base and steadily increasing interest from advertisers testifies to the demand for this unique international publication. Independent surveys and conversations with our readers show that ...
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    Nature biotechnology 1 (1983), S. 824-824 
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    Notes: [Auszug] BIO/TECHNOLOGY STOCK INDEX OF SPECIALTY FIRMS Price Oct. 15 Price Nov. 15 Percent Change 52 Week Hi-Low Market Capitalization in $ millions (stock price × number of shares outstanding) Companies Emphasizing Recombinant DNA Technology Amgen 71/2 63/4 −10 ...
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    Nature biotechnology 1 (1983), S. 847-856 
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    Notes: [Auszug] Discussions of the implementation of genetic engineering in industrial processes by means of fermentation in industrial reactors inevitably turn to problems of scale up. This term refers to the translation of small scale laboratory experiments into processes that can be used in an economically ...
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    Nature biotechnology 1 (1983), S. 837-837 
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    Notes: [Auszug] KALAMAZOO, Michigan—The Upjohn Company, the multinational pharmaceutical concern headquartered here, has formed a biotechnology unit. Since the firm was granted more than 20 biotechnology-related patents last year—easily more than Genentech, Genex, and Cetus combined—the move is a ...
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    Nature biotechnology 1 (1983), S. 879-882 
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    Notes: [Auszug] We have isolated bacillus strains highly productive for penicillin acylase using conventional mutagenesis and screening techniques. This report describes the isolation of a 2.7 kb chromosomal DNA fragment from Bacillus megaterium which, when inserted in a multi–copy vector and transferred ...
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    Nature biotechnology 1 (1983), S. 18-20 
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    Notes: [Auszug] THE HAGUE—The Ad Hoc Committee on Recombinant DNA Work in the Netherlands has proposed new guidelines for the use of genetically engineered microorganisms in cultures of 10 liters or more. Concluding that detailed regulations are neither necessary nor possible, the committee proposed that the ...
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    Nature biotechnology 1 (1983), S. 33-33 
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    Notes: [Auszug] The nuclear genomes of plants are typical of eukaryotes generally: large, complex, containing a variety of repeating sequences, probably transposons, and other elements. Genes, or at least cDNAs, for most of the major storage proteins, have been isolated, cloned, and mapped. These genes typically ...
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    Nature biotechnology 1 (1983), S. 43-44 
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    Notes: [Auszug] Worldwide agriculture production has increased greatly since World War II, due in part to post-war discoveries and the subsequent large-scale use of synthetic fertilizers and pesticides. Many organochlorine insecticides, including DDT, dieldrin, and heptachlor, which initially provided good ...
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    Nature biotechnology 1 (1983), S. 7-7 
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    Notes: [Auszug] The publication of this ambitious magazine/journal of industrial biology is similar in some respects to successful research and development projects in biotechnology. The seemingly endless planning, negotiating, hiring, and arduous work prior to the birth of BIO/TECHNOLOGY were conducted in ...
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    Nature biotechnology 1 (1983), S. 38-43 
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    Notes: [Auszug] On January 14–15, 1983, the International Society for Plant Molecular Biology (formerly the Plant Molecular Biology Association) held its first conference in Miami, Florida. The Conference focused on the higher plant and plant virus genomes. Because genomic variation is the source of improved ...
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    Nature biotechnology 1 (1983), S. 47-54 
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    Notes: [Auszug] Successful application of microorganisms in oil recovery will greatly increase well output. Most promising is the use of microbial products in the production of biosurfactants. Current efforts to develop research are hindered by the lode of in-depth databases. Microbial processes and products have ...
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    Notes: [Auszug] Antibody to human enteric bacterial isolates from sewage sludge dumped into the ocean has been demonstrated in several species of marine teleost. Antibody profiles of these bacteria gathered on commercial species can show what contact fish have had with potentially pathogenic microorganisms which ...
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    Notes: [Auszug] The use of a new strain of Bacillus thuringiensis has been successfully used in mosquito control in Israel. Toxicity tests with Culex pipiens and Aedes aegypti showed that the strain was effective in LD50 bioassays. Field trials with B. thuringiensis showed that several applications were needed and ...
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    Nature biotechnology 1 (1983), S. 79-80 
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    Notes: [Auszug] Legal Protection For Microbiological And Genetic Engineering Inventions. By Roman Saliwanchik. Pp. 256. ISBN 0-201-10938-7. (Addison-Wesley: 1982.) $34.95. Technological breakthroughs in the biosciences during the past decade have created wide-ranging commercial possibilities. Among these ...
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    Nature biotechnology 1 (1983), S. 7-7 
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    Notes: [Auszug] The United States has yet to form a consistent set of policies which addresses both the problems and the economic potential of biotechnology. Despite the fact that federal money continues to support excellent research, and that corporations have begun manufacturing the first generation of ...
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    Nature biotechnology 18 (2000), S. 363-363 
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    Notes: [Auszug] To the editor: In your account (January 2000) of our prepublication manuscript, you quote the criticisms but ignore completely our full rebuttal, which was posted on the web last November. Our manuscript reviews and synthesizes the scientific literature on the 35S promoter of the cauliflower ...
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    Nature biotechnology 18 (2000), S. 365-365 
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    Notes: [Auszug] On March 14, US President Bill Clinton and UK Prime Minister Tony Blair released a joint statement exhorting industry to make public “raw, fundamental data on the human genome, including the human DNA sequence.“ Confusing White House statements and mistaken reporting led to the belief ...
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    Nature biotechnology 18 (2000), S. 365-365 
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    Notes: [Auszug] At the annual meeting of the American Association for the Advancement of Science in February, researchers presented results that provide some validation of the “shotgun” genome-sequencing approach being pursued by Celera (Rockville, MD). Collaborating with scientists in the Berkeley ...
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    Nature biotechnology 18 (2000), S. 366-366 
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    Notes: [Auszug] At the start of March, Cambridge Antibody Technology (Cambridge, UK) announced a 10-year, $67 million agreement with genomics company Human Genome Sciences (Rockville, MD) to turn human genome data into human antibody-based therapies and diagnostics. Under terms of the deal, HGS will pay at ...
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    Nature biotechnology 18 (2000), S. 366-366 
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    Notes: [Auszug] In late February, the European Patent Office (EPO; Munich, Germany) admitted a mistake in a patent issued last December for a technology that could include cloning of humans. The English version of the patent, which was issued to Edinburgh University and biotech company Stem Cell Sciences (SCS; ...
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    Nature biotechnology 18 (2000), S. 367-367 
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    Notes: [Auszug] Irish drug company Elan Corp. (Dublin) has announced that it is buying biopharmaceutical company Liposome (Princeton, NJ) in a $575 million stock swap. Liposome, which will operate as a wholly-owned subsidiary, is focused on liposomal formulations for improved delivery of drugs, particularly ...
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    Nature biotechnology 18 (2000), S. 368-368 
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    Notes: [Auszug] A cleverly designed silicon chip developed by researchers at the University of California (Berkeley, CA) may soon give biologists precise control over cell electroporation. Using standard silicon fabrication techniques, the researchers created a chip with a microscopic hole capable of holding a ...
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    Nature biotechnology 18 (2000), S. 370-370 
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    Notes: [Auszug] The infusion of large numbers of antigen-specific cytotoxic T lymphocytes (CTLs) is a promising therapeutic strategy in the fight against certain cancers and infectious diseases. This process currently involves the time-consuming differentiation or stimulation of natural antigen-presenting ...
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    Nature biotechnology 18 (2000), S. 371-371 
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    Notes: [Auszug] Fibrin is a natural biomaterial that has found uses in surgery and tissue engineering as a tissue sealant and matrix for cellular ingrowth. An important feature is its ability to be remodeled and replaced by the protease activities associated with cells during their migration and invasion. In ...
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    Nature biotechnology 18 (2000), S. 371-371 
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    Notes: [Auszug] The completion of the Human Genome Project has made possible the comprehensive analysis of gene expression using DNA microarrays. A limiting factor for these studies is the amount of RNA available, particularly if the sample is derived from a surgical specimen. In this issue, Marincola and ...
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    Nature biotechnology 18 (2000), S. 373-373 
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    Notes: [Auszug] In April, Applied Molecular Evolution (AME; San Diego, CA), a small, private biotechnology company currently developing novel protein therapeutics, is expected to unveil the terms of its much-anticipated licensing program for patent rights the company holds on directed evolution—a family ...
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    Nature biotechnology 18 (2000), S. 375-376 
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    Notes: [Auszug] At the beginning of March, an initial request for projects went out for GenHomme, France's attempt to cash in on functional genomics. The program comes four years after public funds were spent to support the broadly criticized Bio Avenir program. Although efforts have been made to avoid the ...
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    Nature biotechnology 18 (2000), S. 378-378 
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    Notes: [Auszug] The merger of ValiGene (Paris) with Kimeragen (Newtown, PA) to create a new functional genomics company, ValiGen, is just the first step in the creation of a multi-technology company offering functional genomics services to the large company clients. The transaction, structured and implemented as a ...
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    Nature biotechnology 18 (2000), S. 379-380 
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    Notes: [Auszug] Given a crime scene with scattered bodies and several suspects—but no smoking gun—the keen detective establishes a time line detailing who was where when. The indelible imprint each of the suspects makes on the environment through fingerprints, footprints, and the loss of hair, skin ...
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    Nature biotechnology 18 (2000), S. 377-377 
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    Notes: [Auszug] Officials at the US Food and Drug Administration (FDA; Rockville, MD) and National Institutes of Health (NIH; Bethesda, MD) have adopted several measures to improve the safety of participants in gene therapy clinical trials. Earlier in the month, members of the National Bioethics Advisory ...
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    Nature biotechnology 18 (2000), S. 381-382 
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    Notes: [Auszug] The establishment of immortal, pluripotent stem cell lines has given rise to a powerful tool for in vitro research of developmental processes at both cellular and organismal levels. These cells also offer tremendous potential for clinical application, serving as an unlimited source of cells for ...
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    Nature biotechnology 18 (2000), S. 424-428 
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    Notes: [Auszug] We have developed a novel technique, named DamID, for the identification of DNA loci that interact in vivo with specific nuclear proteins in eukaryotes. By tethering Escherichia coli DNA adenine methyltransferase (Dam) to a chromatin protein, Dam can be targeted in vivo to native binding sites ...
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    Nature biotechnology 18 (2000), S. 433-437 
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    Notes: [Auszug] We have developed a simple genetic assay to detect active nuclear localization (NLS) and export signals (NES) on the basis of their function within yeast cells. The bacterial LexA protein was modified (mLexA) to abolish its intrinsic NLS and fused to the activation domain of the yeast Gal4p ...
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    Nature biotechnology 18 (2000), S. 446-449 
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    Notes: [Auszug] The cDNA encoding the antifungal protein KP4 from Ustilago maydis-infecting virus was inserted behind the ubiquitin promoter of maize and genetically transferred to wheat varieties particularly susceptible to stinking smut (Tilletia tritici) disease. The transgene was integrated and inherited over ...
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    Notes: [Auszug] Phosphorus (P) is one of the most important nutrients limiting agricultural production worldwide. In acid and alkaline soils, which make up over 70% of the world's arable land, P forms insoluble compounds that are not available for plant use. To reduce P deficiencies and ensure plant productivity, ...
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    Nature biotechnology 18 (2000), S. 461-462 
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    Notes: [Auszug] In order to streamline the patent prosecution process, on December 21, 1999, the United States Patent and Trademark Office (USPTO) issued two new directives: “Revised Utility Examination Guidelines” and “Revised Interim Guidelines for Examination of Patent Applications under 35 ...
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    Nature biotechnology 18 (2000), S. 464-464 
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    Notes: [Auszug] FeRx (San Diego, CA) has named Vicente Anido Jr. to its board of directors. Most recently, he was president and CEO of CombiChem, which was sold to DuPont Pharmaceuticals last year. Wolfgang Berthold has been appointed senior vice president of biopharmaceutical sciences at IDEC Pharmaceuticals ...
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    Nature biotechnology 18 (2000), S. 466-467 
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    Notes: [Auszug] There is significant progress in the development of drugs against AIDS and AIDS-related conditions, with more than 100 new medicines currently being tested in various clinical trials. These medicines promise to enhance the pipeline of more than 60 drugs already in use against the disease. Despite ...
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    Nature biotechnology 18 (2000), S. 239-239 
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    Notes: [Auszug] Lateness is the principle cause of time-keeping grouches, but not in biotechnology. In our every day lives, we are incensed by trains delays, offended by correspondence impromptly returned, inconvenienced by deadlines missed, deflated by unmet company projections, and chided for anniversaries ...
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    Nature biotechnology 18 (2000), S. 243-243 
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    Notes: [Auszug] To the editor: The commentary by Stephan Beck, Alexander Olek, and Jörn Walter (Nat. Biotechnol. 17, 1144, 1999) emphasizes the importance of epigenetic information in the human genome, and points out that a European alliance, the Human Epigenome Consortium (HEC), has been formed. This ...
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    Nature biotechnology 18 (2000), S. 245-245 
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    Notes: [Auszug] IBM has become the second information technology company (the other being Motorola) to join the SNP Consortium, a two-year, $50 million initiative being led by 10 pharmaceutical companies and the Wellcome Trust to identify and analyze at least 300,000 single nucleotide polymorphisms (SNPs) ...
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    Notes: [Auszug] British Biotech (Oxford, UK) has suffered yet another disappointment related to its anticancer drug marimastat (Nat. Biotechnol., 17, 409, 1999). The company's most recent phase III clinical trial looked at the effect of the matrix metalloproteinase inhibitor on patients with advanced pancreatic ...
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    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 246-246 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The bioethics committee of Japan's Science and Technology Council (Tokyo) has approved research involving the use of embryonic stem cells, citing its potential applications in the development of therapeutics for such diseases as leukemia and Parkinson's disease. The decision and the speed at which ...
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    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 343-345 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Bacteria belonging to the order Actinomycetales produce most microbial metabolites thus far described, several of which have found applications in medicine and agriculture. However, most strains were discovered by their ability to produce a given molecule and are, therefore, poorly characterized ...
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    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 249-249 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] A team of scientists at the University of Wisconsin, Madison has shown that DNA computing is possible on a gold-plated chip no bigger than a ticket stub (Nature 403, 175– 179, 2000.) By encoding immobilized DNA strands to represent all possible solutions of a logical problem and serially ...
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    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 250-250 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] On page 313, Nagai et al. describe a way of visualizing phosphorylation activity of cAMP-dependent protein kinase (PKA) as it occurs in living cells. They placed a well-characterized substrate of PKA between blue and green mutants of GFP Phosphorylation of this peptide by PKA resulted in a ...
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    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 250-250 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Peptide nucleic acids (PNAs) are synthetic homologs of nucleic acids with the sugar-phosphate backbone replaced by an uncharged mimic of repeating 2-aminoethyl-glycine units. PNAs bind tightly to single-stranded complementary DNAs to form PNA–DNA hybrids, and would be promising anti-gene ...
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    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 133-133 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Veterinarians may try to use nonreproductive cell-cloning methods to restore a type of recently extinct goat. The last known animal of a subspecies of Pyrenean mountain goat known as a bucardo was killed at the beginning of January when its head was crushed under a falling tree. Fortunately, ...
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    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 251-251 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Crops expressing insecticidal proteins from Bacillus thuringiensis (“Bt crops”) are becoming increasingly popular with farmers as a way of increasing crop yield and reducing insecticide use. However, some fear that widespread cultivation of Bt crops will accelerate the rate at which ...
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    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 1-1 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Once upon a time, or at least we like to imagine, the formal academic research paper served as a forum for free exchange of scientific data and ideas. There were no restraints on access to data or methodology. There were no page constraints or color charges for papers. Materials could be obtained ...
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    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 12-12 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Biogeneric manufacturer GeneMedix (Esher, UK) raised almost £20 million ($30 million) when it listed on the London and Singapore stock exchanges at the end of November. GeneMedix is the first biotechnology company to list in Singapore, attracted by the government's strong support of ...
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    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 11-11 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] US regulatory officials continued to wrestle in December with a request from Aventis CropScience (Research Triangle Park, NC) to permit limited human consumption of its StarLink corn. Although the company has been removing products that contain StarLink from the food supply, Aventis representatives ...
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