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  • Articles  (31,016)
  • Molecular Diversity Preservation International  (29,087)
  • Nature America Inc.  (1,929)
  • Process Engineering, Biotechnology, Nutrition Technology  (31,016)
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  • Articles  (31,016)
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  • 1
    Electronic Resource
    Electronic Resource
    Hazardous CaMV promoter? (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 363-363 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: In your account (January 2000) of our prepublication manuscript, you quote the criticisms but ignore completely our full rebuttal, which was posted on the web last November. Our manuscript reviews and synthesizes the scientific literature on the 35S promoter of the cauliflower ...
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    URL: http://dx.doi.org/10.1038/74331
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  • 2
    Electronic Resource
    Electronic Resource
    Human genome bombshell (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 365-365 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] On March 14, US President Bill Clinton and UK Prime Minister Tony Blair released a joint statement exhorting industry to make public “raw, fundamental data on the human genome, including the human DNA sequence.“ Confusing White House statements and mistaken reporting led to the belief ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/74338
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  • 3
    Electronic Resource
    Electronic Resource
    Drosophila sequence “done” (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 365-365 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] At the annual meeting of the American Association for the Advancement of Science in February, researchers presented results that provide some validation of the “shotgun” genome-sequencing approach being pursued by Celera (Rockville, MD). Collaborating with scientists in the Berkeley ...
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    URL: http://dx.doi.org/10.1038/74340
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  • 4
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    Transatlantic biotech deal (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 366-366 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] At the start of March, Cambridge Antibody Technology (Cambridge, UK) announced a 10-year, $67 million agreement with genomics company Human Genome Sciences (Rockville, MD) to turn human genome data into human antibody-based therapies and diagnostics. Under terms of the deal, HGS will pay at ...
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    URL: http://dx.doi.org/10.1038/74346
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  • 5
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    Electronic Resource
    EPO admits patent mistake (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 366-366 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] In late February, the European Patent Office (EPO; Munich, Germany) admitted a mistake in a patent issued last December for a technology that could include cloning of humans. The English version of the patent, which was issued to Edinburgh University and biotech company Stem Cell Sciences (SCS; ...
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    URL: http://dx.doi.org/10.1038/74354
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  • 6
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    Elan buys Liposome (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 367-367 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Irish drug company Elan Corp. (Dublin) has announced that it is buying biopharmaceutical company Liposome (Princeton, NJ) in a $575 million stock swap. Liposome, which will operate as a wholly-owned subsidiary, is focused on liposomal formulations for improved delivery of drugs, particularly ...
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    URL: http://dx.doi.org/10.1038/74358
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  • 7
    Electronic Resource
    Electronic Resource
    Bionic shocker (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 368-368 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] A cleverly designed silicon chip developed by researchers at the University of California (Berkeley, CA) may soon give biologists precise control over cell electroporation. Using standard silicon fabrication techniques, the researchers created a chip with a microscopic hole capable of holding a ...
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    URL: http://dx.doi.org/10.1038/74371
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  • 8
    Electronic Resource
    Electronic Resource
    Artificial antigen presenting cells (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 370-370 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The infusion of large numbers of antigen-specific cytotoxic T lymphocytes (CTLs) is a promising therapeutic strategy in the fight against certain cancers and infectious diseases. This process currently involves the time-consuming differentiation or stimulation of natural antigen-presenting ...
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    URL: http://dx.doi.org/10.1038/74385
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  • 9
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    Electronic Resource
    Accessorizing biomaterials (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 371-371 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Fibrin is a natural biomaterial that has found uses in surgery and tissue engineering as a tissue sealant and matrix for cellular ingrowth. An important feature is its ability to be remodeled and replaced by the protease activities associated with cells during their migration and invasion. In ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/74397
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  • 10
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    Technical Reports (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 371-371 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The completion of the Human Genome Project has made possible the comprehensive analysis of gene expression using DNA microarrays. A limiting factor for these studies is the amount of RNA available, particularly if the sample is derived from a surgical specimen. In this issue, Marincola and ...
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    URL: http://dx.doi.org/10.1038/74405
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  • 11
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    Opinions evolve on Kauffman patent (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 373-373 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] In April, Applied Molecular Evolution (AME; San Diego, CA), a small, private biotechnology company currently developing novel protein therapeutics, is expected to unveil the terms of its much-anticipated licensing program for patent rights the company holds on directed evolution—a family ...
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    URL: http://dx.doi.org/10.1038/74410
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  • 12
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    French genomics setup questioned (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 375-376 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] At the beginning of March, an initial request for projects went out for GenHomme, France's attempt to cash in on functional genomics. The program comes four years after public funds were spent to support the broadly criticized Bio Avenir program. Although efforts have been made to avoid the ...
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    URL: http://dx.doi.org/10.1038/74417
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  • 13
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    Validating a business model (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 378-378 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The merger of ValiGene (Paris) with Kimeragen (Newtown, PA) to create a new functional genomics company, ValiGen, is just the first step in the creation of a multi-technology company offering functional genomics services to the large company clients. The transaction, structured and implemented as a ...
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    URL: http://dx.doi.org/10.1038/74424
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  • 14
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    Creating molecular clues to uncover gene function (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 379-380 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Given a crime scene with scattered bodies and several suspects—but no smoking gun—the keen detective establishes a time line detailing who was where when. The indelible imprint each of the suspects makes on the environment through fingerprints, footprints, and the loss of hair, skin ...
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    URL: http://dx.doi.org/10.1038/74426
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  • 15
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    Scrutiny of gene therapy broadens, intensifies (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 377-377 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Officials at the US Food and Drug Administration (FDA; Rockville, MD) and National Institutes of Health (NIH; Bethesda, MD) have adopted several measures to improve the safety of participants in gene therapy clinical trials. Earlier in the month, members of the National Bioethics Advisory ...
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    URL: http://dx.doi.org/10.1038/74422
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  • 16
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    New tools for human developmental biology (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 381-382 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The establishment of immortal, pluripotent stem cell lines has given rise to a powerful tool for in vitro research of developmental processes at both cellular and organismal levels. These cells also offer tremendous potential for clinical application, serving as an unlimited source of cells for ...
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    URL: http://dx.doi.org/10.1038/74429
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  • 17
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    Identification of in vivo DNA targets of chromatin proteins using tethered Dam methyltransferase (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 424-428 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We have developed a novel technique, named DamID, for the identification of DNA loci that interact in vivo with specific nuclear proteins in eukaryotes. By tethering Escherichia coli DNA adenine methyltransferase (Dam) to a chromatin protein, Dam can be targeted in vivo to native binding sites ...
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    URL: http://dx.doi.org/10.1038/74487
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  • 18
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    A genetic system for detection of protein nuclear import and export (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 433-437 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We have developed a simple genetic assay to detect active nuclear localization (NLS) and export signals (NES) on the basis of their function within yeast cells. The bacterial LexA protein was modified (mLexA) to abolish its intrinsic NLS and fused to the activation domain of the yeast Gal4p ...
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    URL: http://dx.doi.org/10.1038/74500
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  • 19
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    Antifungal activity of a virally encoded gene in transgenic wheat (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 446-449 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The cDNA encoding the antifungal protein KP4 from Ustilago maydis-infecting virus was inserted behind the ubiquitin promoter of maize and genetically transferred to wheat varieties particularly susceptible to stinking smut (Tilletia tritici) disease. The transgene was integrated and inherited over ...
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    URL: http://dx.doi.org/10.1038/74521
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  • 20
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    Enhanced phosphorus uptake in transgenic tobacco plants that overproduce citrate (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 450-453 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Phosphorus (P) is one of the most important nutrients limiting agricultural production worldwide. In acid and alkaline soils, which make up over 70% of the world's arable land, P forms insoluble compounds that are not available for plant use. To reduce P deficiencies and ensure plant productivity, ...
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    URL: http://dx.doi.org/10.1038/74531
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  • 21
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    Analyzing the new written description guidelines (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 461-462 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] In order to streamline the patent prosecution process, on December 21, 1999, the United States Patent and Trademark Office (USPTO) issued two new directives: “Revised Utility Examination Guidelines” and “Revised Interim Guidelines for Examination of Patent Applications under 35 ...
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    URL: http://dx.doi.org/10.1038/74551
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  • 22
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    People (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 464-464 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] FeRx (San Diego, CA) has named Vicente Anido Jr. to its board of directors. Most recently, he was president and CEO of CombiChem, which was sold to DuPont Pharmaceuticals last year. Wolfgang Berthold has been appointed senior vice president of biopharmaceutical sciences at IDEC Pharmaceuticals ...
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    URL: http://dx.doi.org/10.1038/74556
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  • 23
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    Progress against AIDS (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 466-467 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] There is significant progress in the development of drugs against AIDS and AIDS-related conditions, with more than 100 new medicines currently being tested in various clinical trials. These medicines promise to enhance the pipeline of more than 60 drugs already in use against the disease. Despite ...
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    URL: http://dx.doi.org/10.1038/74566
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  • 24
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    Synchronizing expectations (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 239-239 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Lateness is the principle cause of time-keeping grouches, but not in biotechnology. In our every day lives, we are incensed by trains delays, offended by correspondence impromptly returned, inconvenienced by deadlines missed, deflated by unmet company projections, and chided for anniversaries ...
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    URL: http://dx.doi.org/10.1038/73582
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  • 25
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    Epigenomics (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 243-243 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: The commentary by Stephan Beck, Alexander Olek, and Jörn Walter (Nat. Biotechnol. 17, 1144, 1999) emphasizes the importance of epigenetic information in the human genome, and points out that a European alliance, the Human Epigenome Consortium (HEC), has been formed. This ...
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    URL: http://dx.doi.org/10.1038/73588
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  • 26
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    IBM joins SNP Consortium (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 245-245 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] IBM has become the second information technology company (the other being Motorola) to join the SNP Consortium, a two-year, $50 million initiative being led by 10 pharmaceutical companies and the Wellcome Trust to identify and analyze at least 300,000 single nucleotide polymorphisms (SNPs) ...
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  • 27
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    British Biotech: Still waiting (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 245-245 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] British Biotech (Oxford, UK) has suffered yet another disappointment related to its anticancer drug marimastat (Nat. Biotechnol., 17, 409, 1999). The company's most recent phase III clinical trial looked at the effect of the matrix metalloproteinase inhibitor on patients with advanced pancreatic ...
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  • 28
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    Japan okays stem cells (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 246-246 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The bioethics committee of Japan's Science and Technology Council (Tokyo) has approved research involving the use of embryonic stem cells, citing its potential applications in the development of therapeutics for such diseases as leukemia and Parkinson's disease. The decision and the speed at which ...
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  • 29
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    Artificial chromosomes for antibiotic-producing actinomycetes (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 343-345 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Bacteria belonging to the order Actinomycetales produce most microbial metabolites thus far described, several of which have found applications in medicine and agriculture. However, most strains were discovered by their ability to produce a given molecule and are, therefore, poorly characterized ...
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  • 30
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    Solid-state DNA computer (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 249-249 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] A team of scientists at the University of Wisconsin, Madison has shown that DNA computing is possible on a gold-plated chip no bigger than a ticket stub (Nature 403, 175– 179, 2000.) By encoding immobilized DNA strands to represent all possible solutions of a logical problem and serially ...
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  • 31
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    Tracking phosphorylation in live cells (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 250-250 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] On page 313, Nagai et al. describe a way of visualizing phosphorylation activity of cAMP-dependent protein kinase (PKA) as it occurs in living cells. They placed a well-characterized substrate of PKA between blue and green mutants of GFP Phosphorylation of this peptide by PKA resulted in a ...
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  • 32
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    Delivering PNAs to the nucleus (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 250-250 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Peptide nucleic acids (PNAs) are synthetic homologs of nucleic acids with the sugar-phosphate backbone replaced by an uncharged mimic of repeating 2-aminoethyl-glycine units. PNAs bind tightly to single-stranded complementary DNAs to form PNA–DNA hybrids, and would be promising anti-gene ...
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    Gone, butt not begotten (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 133-133 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Veterinarians may try to use nonreproductive cell-cloning methods to restore a type of recently extinct goat. The last known animal of a subspecies of Pyrenean mountain goat known as a bucardo was killed at the beginning of January when its head was crushed under a falling tree. Fortunately, ...
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  • 34
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    Testing Bt refuge strategies (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 251-251 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Crops expressing insecticidal proteins from Bacillus thuringiensis (“Bt crops”) are becoming increasingly popular with farmers as a way of increasing crop yield and reducing insecticide use. However, some fear that widespread cultivation of Bt crops will accelerate the rate at which ...
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  • 35
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    Slippery slopes? (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 1-1 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Once upon a time, or at least we like to imagine, the formal academic research paper served as a forum for free exchange of scientific data and ideas. There were no restraints on access to data or methodology. There were no page constraints or color charges for papers. Materials could be obtained ...
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    GeneMedix sets sights on Southeast Asia (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 12-12 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Biogeneric manufacturer GeneMedix (Esher, UK) raised almost £20 million ($30 million) when it listed on the London and Singapore stock exchanges at the end of November. GeneMedix is the first biotechnology company to list in Singapore, attracted by the government's strong support of ...
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    EPA re-evaluates StarLink license (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 11-11 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] US regulatory officials continued to wrestle in December with a request from Aventis CropScience (Research Triangle Park, NC) to permit limited human consumption of its StarLink corn. Although the company has been removing products that contain StarLink from the food supply, Aventis representatives ...
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    Research collaborations (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 133-133 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
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    Comparative g enomics in development (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 136-136 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Before too long, the complete nucleotide sequence of a handful of vertebrate genomes will become available. Comparative sequence analyses should allow us to trace the molecular evolution of conserved genetic elements, such as coding regions, promoters, and repeated sequence elements. In this ...
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    A peptide mimetic of Herceptin (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 137-137 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Monoclonal antibodies that bind to the ectodomain of the p185HER2/neu oncoprotein have been shown to reduce the growth of certain kinds of tumors. Herceptin, a recombinant humanized form, now has been approved for use in humans. However, full-length antibodies can be costly to produce, limited ...
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    GM vines: focal point for EC power struggle (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 15-15 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] The European Parliament has approved a set of amendments to directive 68/193 covering the marketing of material for the vegetative propagation of the vine to include vines that are genetically modified. Although the draft doesn't mark any real change in European legislation with respect to GMOs, ...
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    EC study reveals an informed public (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 15-16 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] A European Commission-funded study of Public Perceptions of Agricultural Biotechnology in Europe (PABE) will be published this month. It finds that the public's reaction to GMOs has been influenced by the misassumption—on the parts of not only regulatory authorities, scientists, and industry, ...
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    New candidates for true antisense (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 17-18 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Over the past 15 years, antisense oligonucleotides have been widely used for artificially regulating gene expression through RNA targeting. One class of these, the phosphorothioate oligodeoxynucleotides, were originally developed as nuclease-resistant alternatives to phosphodiester oligomers, ...
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    Fungal pathogen protection in potato by expression of a plant defensin peptide (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 1307-1310 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Defensins are small cysteine-rich peptides with antimicrobial activity. We demonstrate that the alfalfa antifungal peptide (alfAFP) defensin isolated from seeds of Medicago sativa displays strong activity against the agronomically important fungal pathogen Verticillium dahliae. Expression of ...
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    Research Errata (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 1318-1318 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] On of the October 2000 issue, the ..Figure 5 caption of “Use of G-protein fusions to monitor integral membrane protein–protein interactions in yeast” by Kathleen N. Ehrhard, Jörg J. Jacoby, Xin-Yuan Fu, Reinhard Jahn, and Henrik G. Dohlman was not printed ...
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    Aneuploidy and cancer—the vintage wine revisited (2001)
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    Nature biotechnology 19 (2001), S. 22-23 
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    Notes: [Auszug] Twenty-five years ago, Peter Duesberg isolated and characterized the first viral oncogene—the principal base on which the predominant, current gene mutation theory of cancer rests. During the past five years, Duesberg has been applying a similar determination investigating an alternative ...
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    Biotech weighs up the options in obesity (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 25-28 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] In the past few decades, technological innovations have created a society where most forms of work are lighter, travel less strenuous, and lifestyles more sedentary. Add to this the overconsumption of food, in particular high-fat convenience foods, and you have the perfect recipe for a ...
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    GM crop data—agronomy and ecology in tandem (2001)
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    Nature biotechnology 19 (2001), S. 3-3 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] At a recent international gathering of biosafety researchers, a European scientist overheard our American dialects and commented dryly, “I didn't think you Yanks cared about this sort of thing [biosafety].” There is, unfortunately, a grain of truth in that statement. However, we do ...
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    Local endostatin treatment of gliomas administered by microencapsulated producer cells (2001)
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    Nature biotechnology 19 (2001), S. 29-34 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] We describe a technique for the treatment of malignant brain tumors based on local delivery of the anti-angiogenic protein endostatin from genetically engineered cells encapsulated in ultrapure sodium alginate. Alginate consists of L-guluronic and D-mannuronic acid, which in the presence of ...
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    Continuous release of endostatin from microencapsulated engineered cells for tumor therapy (2001)
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    Nature biotechnology 19 (2001), S. 35-39 
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    Notes: [Auszug] Research studies suggest that tumor-related angiogenesis contributes to the phenotype of malignant gliomas. We assessed the effect of local delivery of the angiogenesis inhibitor endostatin on human glioma cell line (U-87MG) xenografts. Baby hamster kidney (BHK) cells were stably transfected ...
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    Phosphoramidate oligonucleotides as potent antisense molecules in cells and in vivo (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 40-44 
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    Notes: [Auszug] Antisense oligonucleotides are designed to specifically hybridize to a target messenger RNA (mRNA) and interfere with the synthesis of the encoded protein. Uniformly modified oligonucleotides containing N3′–P5′ phosphoramidate linkages exhibit (NP) extremely high-affinity ...
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    Scanning of guanine–guanine mismatches in DNA by synthetic ligands using surface plasmon resonance (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 51-55 
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    Notes: [Auszug] Here we have designed and synthesized ligands that specifically bind with high affinity (Kd = 53 nM) to the guanine (G)–guanine mismatch, one of four types of single-nucleotide polymorphism (SNP). Detection of the G-G mismatch was performed by a surface plasmon resonance ...
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    A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 45-50 
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    Notes: [Auszug] A large proportion of the 6,000 genes present in the genome of Saccharomyces cerevisiae, and of those sequenced in other organisms, encode proteins of unknown function. Many of these genes are “silent,” that is, they show no overt phenotype, in terms of growth rate or other fluxes, ...
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    Technical Reports (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 1233-1233 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] On page 1314, Zhang et al. describe a way to efficiently clone large target sequences in a single step. First an appropriate bacterial host containing a highly efficient phage recombination system is transformed with the target DNA along with a PCR-generated fragment that contains a replication ...
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    First Genetic Trust banks on genes (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 1236-1236 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Genes are money these days and, not before time, the depositors and borrowers of genetic information have their own commercial bank. The First Genetic Trust (Chicago, IL), formed in October, has put itself forward as “a third party intermediary among researchers, healthcare providers, and ...
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    GMO roundup (2001)
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    Nature biotechnology 19 (2001), S. 5-5 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] &cirf; UK civil servants prove themselves as adept as ever at handling potentially sensitive genetic modification issues. In the run up to the trial of four people accused of vandalizing crops in Scotland, Mae-Wan Ho of the Institute of Science in Society (London) announced at a press conference ...
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    FDA gene rules impractical (2001)
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    Nature biotechnology 19 (2001), S. 5-5 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Current US Food and Drug Administration guidelines for long term followup are unfeasible for trial sponsors and patients, especially individual investigators on five-year NIH grants and less well-financed biotechnology companies. So concluded the Biological Response Modifiers Advisory Committee ...
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    Blech settles with SEC (2001)
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    Nature biotechnology 19 (2001), S. 5-5 
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    Notes: [Auszug] US Federal officials have settled a civil lawsuit with David Blech, barring the former biotechnology financier from being associated with a broker or dealer. In the early 1990s, Blech bankrolled such startup firms as GeneMedicine (Woodlands, TX), Incyte Genomics (Palo Alto, CA), and Guilford ...
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    OGS/Glaxo biomarker deal (2001)
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    Nature biotechnology 19 (2001), S. 5-5 
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    Notes: [Auszug] Proteomics company Oxford GlycoSciences (Oxford, UK) has signed a deal with Glaxo Wellcome (Greenford, UK) to identify biomarkers—proteins whose expression change during illness. Biomarkers can be used not only to detect and monitor a disease, but also to improve the design and assessment of ...
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    Aventis to shed ag (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 5-5 
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    Notes: [Auszug] The supervisory board of Aventis SA (Strasbourg, France) revealed plans in November to divest the agricultural business Aventis CropScience (Lyon, France) by the end of 2001 in order to focus on pharmaceuticals, which accounts for 75% of the parent business. The divestment may take the form of an ...
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    Interference-based detection of nucleic acid targets on optically coated silicon (2001)
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    Nature biotechnology 19 (2001), S. 62-65 
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    Notes: [Auszug] Sequence-specific detection of polynucleotides typically requires modified reporter probes that are labeled with radioactive, fluorescent, or luminescent moieties. Although these detection methods are capable of high sensitivity, they require instrumentation for signal detection. In certain ...
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    FDA withholds xeno data (2001)
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    Nature biotechnology 19 (2001), S. 6-6 
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    Notes: [Auszug] The Campaign for Responsible Transplantation (CRT; New York) filed a lawsuit late in November against the FDA claiming officials are withholding information on xenotransplantation research. Following Freedom of Information Act requests that began last March, CRT director Alix Fano has been leading ...
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    French ethics law revised (2001)
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    Nature biotechnology 19 (2001), S. 6-6 
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    Notes: [Auszug] The French government has proposed changes to its 1994 Bioethics law to allow research on human embryos and facilitate the development of new therapies from work on embryonic stem cells (ESCs). Under the amended law, researchers will be able to derive stem cells from “spare” embryos ...
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    Breeding of retroviruses by DNA shuffling for improved stability and processing yields (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 1279-1282 
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    Notes: [Auszug] Manufacturing of retroviral vectors for gene therapy is complicated by the sensitivity of these viruses to stress forces during purification and concentration. To isolate viruses that are resistant to these manufacturing processes, we performed breeding of six ecotropic murine leukemia virus ...
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    Tobacco ribosomal DNA spacer element stimulates amplification and expression of heterologous genes (2000)
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    Nature biotechnology 18 (2000), S. 1303-1306 
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    Notes: [Auszug] Here we show that the cis-acting genetic element aps (amplification-promoting sequence), isolated from the nontranscribed spacer region of tobacco ribosomal DNA (rDNA), increases the level of expression of recombinant proteins. Transgenic tobacco plants, transformed with expression cassettes ...
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    Research Corrigendum (2000)
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    Nature biotechnology 18 (2000), S. 1318-1318 
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    Notes: [Auszug] In the November research article, “A T-cell-selective interleukin 2 mutein exhibits potent antitumor activity and is well tolerated in vivo,” by A.B. Shanafelt et al., the black and the white circle labels were reversed in the first sentence of the legends for Figures 2 through 6. In ...
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    Overexpression of the Bt cry 2Aa2 operon in chloroplasts leads to formation of insecticidal crystals (2001)
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    Nature biotechnology 19 (2001), S. 71-74 
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    Notes: [Auszug] In nuclear transgenic plants, expression of multiple genes requires introduction of individual genes and time-consuming subsequent backcrosses to reconstitute multi-subunit proteins or pathways, a problem that is compounded by variable expression levels. In order to accomplish expression of ...
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    A helper phage to improve single-chain antibody presentation in phage display (2001)
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    Nature biotechnology 19 (2001), S. 75-78 
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    Notes: [Auszug] We show here that the number of single-chain antibody fragments (scFv) presented on filamentous phage particles generated with antibody display phagemids can be increased by more than two orders of magnitude by using a newly developed helper phage (hyperphage). Hyperphage have a wild-type pIII ...
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    Blood into brains (2001)
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    Nature biotechnology 19 (2001), S. 7-7 
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    Notes: [Auszug] Cells generated from bone marrow transplants can migrate from the circulation into the brain and differentiate into neurons, according to a report in Science (290, 1779–1782, 2000). Spurred on by evidence that bone marrow cells can transform into glial cells, Éva Mezey and her ...
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    Counting alleles reveals a connection between chromosome 18q loss and vascular invasion (2001)
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    Nature biotechnology 19 (2001), S. 78-81 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The analysis of loss of heterozygosity (LOH) is perhaps the most widely used technique in cancer genetics. In primary tumors, however, the analysis of LOH is fraught with technical problems that have limited its reproducibility and interpretation. In particular, tumors are mixtures of neoplastic ...
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    Arabidopsis sequenced (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 7-7 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The first complete sequence of a plant genome was published last month, bringing to an end a four-year effort by the Arabidopsis sequencing consortium. Last month's Nature (408, 816–826, 2000) provides the genome sequences of chromosomes 1, 3, and 5 of thale cress (Arabidopsis thaliana), ...
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    Catalytic DNA lead probe (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 7-7 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Nanomolar concentrations of lead can be harmful to health, but current forms of detection are relatively insensitive and require sophisticated off-site analysis. Now, Jing Li and colleague Yi Lu have developed a DNA-based lead “probe” that can detect levels of the toxic metal ion ...
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    Chlorobenzene degrader (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 7-7 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Scientists have traditionally relied on consortia of bacteria to degrade nasty mixtures of chlorinated hydrocarbons that often are recalcitrant environmental contaminants. Now, a team of German researchers has isolated a bacterium that is capable of degrading chlorobenzenes in isolation (Nature ...
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    Insulin mimics (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 7-7 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] A new gene therapy approach may overcome the problem of cleavage of proinsulin into active insulin for treatment of autoimmune type I diabetes. Researchers from Korea and Canada have engineered a liver-targeting recombinant adeno-associated virus (rAAV) that expresses a single-chain insulin analog ...
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    Patenting biotechnology inventions in China (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 83-84 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] China is the most populous country in the world, with over 1.2 billion people—a staggering consumer market for pharmaceutical and biotechnology products. With a fast-growing economy based on the government's drive for economic reform and modernization, China has in recent years twice revised ...
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    Recent patents in vaccines (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 85-85 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] There is a box assoicated with this article, available ...
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    The Nature Biotechnology 2001 New Year quiz (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 86-87 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] 1. Getting it together. Test your memory of events in mergers and acquisitions: (a) What business did Celltech (Leatherhead, UK) get from Medeva (Leatherhead, UK) and then pass on to PowderJect Pharmaceuticals (Oxford, UK) before it got people hopping mad in October? (b) Abgenix (Fremont, CA) ...
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    Promotions, advancements (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 88-88 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Dynavax Technologies (Berkeley, CA) has named three new vice presidents: Robert Lee Coffman as vice president and chief scientific officer (CSO); Stephen F. Tuck as vice president, biopharmaceutical development; and Gary Van Nest as vice president, preclinical research. Dr. Coffman was most ...
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    New Products (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 89-89 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Antibodies Cancer antigens Zymed offers eight monoclonal antibodies against cancer antigens CA 15-3 for breast cancer, CA 19-9 for colorectal and pancreatic cancer, CA 125 for non-mucinous ovarian cancer, and CA 72.4 for a variety of human adenocarcinomas. The Mabs are relatively tumor-specific ...
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    Tried and true antisense (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 8-8 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] On page 40, Faria et al. establish the mechanism of action of N3′-P5′ phosphoramidate (NP) oligonucleotides, which belong to a new generation of antisense reagents that have considerable promise as therapeutic reagents, as shown in a number of in vivo studies. Their extremely high ...
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    Got milk? (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 8-8 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Mastitis, a kind of infection of mammary tissue, costs the US dairy industry billions annually, and extracts an uncalculable cost in animal suffering. On page 66, Kerr et al. demonstrate a possible biotechnology solution: transgenic mice that secrete in their own milk a potent antibacterial ...
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    SNP detection made simpler? (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 8-8 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] High-throughput technologies for detecting SNPs require knowledge of sequence information, and alternatives for scanning without such information rely on cumbersome, gel-based methods. On page 51, Nakatani et al. provide an alternative. They have isolated small molecules called dimeric ...
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    Silent genes find a voice (2001)
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    Nature biotechnology 19 (2001), S. 8-8 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Of the many thousands of genes encoding proteins of unknown function, the most enigmatic are the “silent” ones—those that exhibit no detectable phenotype when deleted from the genome. On page 45, Raamsdonk et al. show that, at least in yeast, gene function can be accurately ...
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    Technical Reports (2001)
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    Nature biotechnology 19 (2001), S. 8-8 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Phage display of antibody libraries is an undeniably powerful technique for isolating highly specific antibodies. However, in the most widely used systems only a small percentage of the phage population carries an antibody, so the libraries are large and unwieldy to screen. On page 75, Rondot et ...
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    Technical Reports (2001)
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    Nature biotechnology 19 (2001), S. 8-8 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] On page 78, Zhou et al. describe a technique for scoring loss of heterozygosity in tumors. They used fluorescent molecular beacons and “digital PCR” to detect SNP loci for which the patient was heterozygous, and applied likelihood techniques to ask whether the markers were lost through ...
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    Endostatin encapsulated (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 8-8 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] In this issue two groups, Read et al. (see p. 29) and Joki et al. (see p. 35) describe a strategy for sustained delivery of the anti-angiogenic agent, endostatin, to tumors. Both groups engineered cells to express endostatin and then encapsulated them in sodium alginate, forming beads, an ...
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    Chloroplast engineering with operons (2001)
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    Nature biotechnology 19 (2001), S. 9-9 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Most agronomic traits result from the action of several genes, so efficient strategies to express multiple genes in transgenic plants are sorely needed, and not at all trivial undertakings. In this issue, Daniell and colleagues show a way to stably integrate into the chloroplast genome the entire ...
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    An ultra-sensitive nucleic acid sensor? (2001)
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    Nature biotechnology 19 (2001), S. 9-9 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] On page 62, Jenison et al. describe a biosensor for detecting nucleic acid targets present at only attomolar concentrations. The detector comprises a set of oligonucleotide probes bound to a silicon-based surface that can hybridize to specific nucleic acid targets. Bound nucleic acids are then ...
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    A screen for ribozyme inhibitors (2001)
    [s.l.] : Nature America Inc.
    Nature biotechnology 19 (2001), S. 9-9 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Catalytic RNA is increasingly viewed as a promising drug target, particularly in that some catalyze activities specific to microorganisms and viruses. On page 56, Jenne et al. describe a fluorescence-based assay to find inhibitors of such catalytic RNA. They used a high-throughput FRET-based assay ...
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    Loss-of-heterozygosity analysis of small-cell lung carcinomas using single-nucleotide polymorphism arrays (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 1001-1005 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Human cancers arise by a combination of discrete mutations and chromosomal alterations. Loss of heterozygosity (LOH) of chromosomal regions bearing mutated tumor suppressor genes is a key event in the evolution of epithelial and mesenchymal tumors. Global patterns of LOH can be understood through ...
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    When the Human Genome Project and State Street collide (2000)
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    Nature biotechnology 18 (2000), S. 1009-1010 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Biotechnology patent litigation, always complex, is about to become even more challenging. With the ever-growing mountain of genomic data needing to be managed by more and more sophisticated information systems, fields such as bioinformatics are booming, and with the boom has come a new class of ...
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    Simultaneous stochastic sensing of divalent metal ions (2000)
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    Nature biotechnology 18 (2000), S. 1005-1007 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Stochastic sensing is an emerging analytical technique that relies upon single-molecule detection. Transmembrane pores, into which binding sites for analytes have been placed by genetic engineering, have been developed as stochastic sensing elements. Reversible occupation of an engineered binding ...
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    The ultimate piggybank (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 1011-1011 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Xeno offers both scientific and lay readers a lively, cogent, and comprehensive account of the scientific and ethical issues surrounding the use of animal organs and tissues for human transplantation. Written by two researchers who are deeply involved in xenotransplantation and therefore have a ...
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    People (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 1012-1012 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] MetaMorphix (Baltimore, MD) has announced that John R. Block and Gerald Welch have joined the company's board of directors. Mr. Block is president of Food Distributors International and was formerly US Secretary of Agriculture from 1981 to 1986. Mr. Welch was an executive vice president with ...
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    New Products (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 1013-1013 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Microarrays Seeing spots BioDiscovery's (Los Angeles, CA) AutoGene Microarray Image Analysis System is a powerful image analysis tool for high-throughput gene expression microarray and high-density membrane data analysis. AutoGene eliminates human intervention in grid placement and spot ...
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    The shape shifting business (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 905-905 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Structural genomics is biotechnology's newest thing, apparently—we said as much as far back as June 1998 (Nat. Biotechnol. 16, 595), and Nat. Struct. Biol. is devoting an entire supplement to it in November. Private investors have now caught on: they recently gave US startup Structural ...
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    Reasons to be cheerful (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 905-905 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] This issue contains four features (pp. 935–947) on public attitudes to biotechnology. Although not directly comparable, they provide valuable snapshots from Europe, Canada, the US, and Japan of what we are always being told is a highly important influence on the development of the life ...
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    Should companies set up databases in Europe? (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 907-907 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Companies that are in the biological data business should think about establishing databases in the European Union (EU). Many EU countries have implemented laws following the 1996 directive (96/9/EC) on the legal protection of databases (“Database Directive”). These give database ...
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    Making or breaking a deal (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 909-909 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor In their recent article “Deals that make sense,” Moscho et al. propose a model for valuing the respective contributions of licensor and licensee for biotechnology product deals. They seem to move from their model based on industry average valuations (which are ...
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    USDA's terminator talks (2000)
    [s.l.] : Nature America Inc.
    Nature biotechnology 18 (2000), S. 911-911 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Members of the US Department of Agriculture (USDA; Washington, DC) Advisory Committee on Agricultural Biotechnology (ACAB) played host in July to another round in the hot debate over the “terminator” technology, which is patented jointly by USDA and the seed company, Delta & Pine ...
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