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  • Triticum aestivum  (861)
  • evolution  (752)
  • Springer  (1,545)
  • MDPI - Multidisciplinary Digital Publishing Institute  (63)
  • Springer Science + Business Media
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  • 1
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    Paleontology in the 21st Century (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-08-08
    Description: This Special Issue highlights fundamental changes to the questions that we can ask about both the recent past and deep time. Delve into the forefront of paleontological research with this Special Issue reprint. Renowned paleontologists from around the world share groundbreaking insights into ancient life on Earth. Discover the latest advances in fossil discovery, analytical techniques, interdisciplinary collaborations, and technological innovations that are shaping our understanding of evolution and the Earth's history. This collection of cutting-edge research is a must-read for scientists, researchers, and enthusiasts interested in the dynamic field of paleontology in the modern era.
    Keywords: REE ; Tyrannosaurus rex ; molecular paleontology ; geochemical taphonomy ; diagenesis ; bone ; protein ; collagen ; Hell Creek Formation ; cuticle ; Eocene ; Fur Formation ; insects ; melanin ; mo-clay ; pigment ; Stolleklint Clay ; structural coloration ; Ølst Formation ; fossil ; dinosaur ; paleoproteomics ; porphyrin ; keratin ; feather ; taphonomy ; degradation ; microbes ; CO2 ; apatite ; paleontology ; China ; history ; 20th century ; 21th century ; paleobiology ; history and philosophy of paleontology ; twenty-first-century paleontology ; paleobiological revolution ; technoscience and global issues ; fossil proteins ; rare earth elements ; soft-tissue preservation ; geochemistry ; soft tissues ; molecular preservation ; Hornerstown Formation ; shallow marine ; glauconite ; hybridization ; introgression ; ancient DNA (aDNA) ; hominin paleontology ; paleoanthropology ; Brachylophosaurus ; Judith River Formation ; ELISA ; RIA ; Venta Micena site ; VM-0 ; VM-1960 ; taxonomy ; morphometrics ; phylogeny ; evolution ; morphological clock ; molecular clock ; biodiversity ; palaeobiogeography ; macroevolution ; primates ; Cercopithecidae ; monkeys ; genotype:phenotype mapping ; dentition ; Equidae ; Equinae ; hipparionini ; protohippini ; equini ; paleoecology ; paleoclimatology ; biochronology ; steroids ; diet ; coprolites ; Gryphaea dilatata ; crystallographic texture ; pole figures ; neutron diffraction ; recrystallization ; thick-walled shells ; molecular taphonomy ; fossils ; preservation ; mass spectrometry ; dinosaurs ; Neanderthal ; Combe-Grenal ; juvenile ; mandible ; periodontitis ; tooth ; tartar ; SEM analysis ; n/a ; terrestrialization ; artrhopods ; Cambrian explosion ; molecular clocks ; palaeontology ; phylogenomics ; teeth ; enamel ; microanalysis ; Purussaurus ; Neoepiblema ; miocene ; ICP-MS ; MEV ; microscopy ; magnetic resonance imaging ; micro-computed tomography ; radiocarbon dating ; DNA barcoding ; synchrotron ; bone remodeling ; elemental analysis ; diagenetic alteration ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences
    Language: English
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  • 2
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    Left Versus Right Asymmetries of Brain and Behaviour (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2024-03-29
    Description: This book is a collection of papers written by leaders in the field of lateralized brain function and behaviour in non-human animals. The papers cover the asymmetry of brain mechanisms and behaviour in a wide range of both vertebrate and invertebrate species. Each paper focuses on one of the following topics: the link between population-level lateralization and social behaviour; the processes in the avian brain that permit one brain hemisphere to take control of behaviour; lateralized attention to predators and the common pattern of lateralization in vertebrate species; visual and auditory lateralization; influences that alter the development of lateralization—specifically, the effect of temperature on the development of lateralization in sharks; and the importance of understanding lateralization when considering both the training and welfare of dogs. Collectively, these studies address questions of why different species have asymmetry of brain and behaviour, how it develops, and how this is dealt with by these different species. The papers report on the lateralization of different types of behaviour, each going beyond merely reporting the presence of asymmetry and shedding light on its function and on the mechanisms involved in its expression.
    Keywords: BF1-990 ; spider monkey ; zebra finch ; starlings ; frequency-dependent selection ; monocular viewing ; welfare ; climate change ; song ; development ; social behavior ; social interactions ; physiology ; predator inspection ; scale-eater ; vision ; reaction time ; cross-predation ; auditory perception ; dog ; eye preference ; brain asymmetry ; asymmetry of brain function ; paw preference ; songbirds ; shelter ; hemisphere differences ; hemispheric interactions ; population-level ; birds ; color discrimination ; laterality ; general pattern of lateralisation ; lateralised behaviour ; individual-level ; lateral dimorphism ; temperature ; social interaction ; behavior ; ESS ; social networks ; evolution ; Campbell’s monkeys ; hemispheric specialisation ; lateralization ; elasmobranchs ; Perissodus ; attention ; risk ; bic Book Industry Communication::J Society & social sciences::JM Psychology ; thema EDItEUR::J Society and Social Sciences::JM Psychology
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  • 3
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    Regulation of Central Carbon and Amino Acid Metabolism in Plants (2022)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2024-03-28
    Description: Due to their lightweight and high specific strength, Mg-based alloys are considered as substitutes to their heavier counterparts in applications in which corrosion is non-relevant and weight saving is of importance. Furthermore, due to the biocompatibility of Mg, some alloys with controlled corrosion rates are used as degradable implant materials in the medical sector. The typical processing route of Mg parts incorporates a casting step and, subsequently, a thermo–mechanical treatment. In order to achieve the desired macroscopic properties and thus fulfill the service requirements, thorough knowledge of the relationship between the microstructure, the processing steps, and the resulting property profile is necessary. This Special Issue covers in situ and ex situ experimental and computational investigations of the behavior under thermo–mechanical load of Mg-based alloys utilizing modern characterization and simulation techniques. The papers cover investigations on the effect of rare earth additions on the mechanical properties of different Mg alloys, including the effect of long-period stacking-ordered (LPSO) structures, and the experimental and computational investigation of the effect of different processing routes
    Keywords: Arabidopsis ; abiotic stress response ; photosynthesis ; phosphoglycolate phosphatase ; photorespiration ; 2-phosphoglycolate ; Arabidopsis thaliana ; glycolate oxidase ; protein phosphorylation ; Zea mays ; Portulaca grandiflora ; C4 photosynthesis ; Crassulacean acid metabolism (CAM), evolution ; development ; PEP carboxylase ; Portulacaceae ; glycine decarboxylase ; metabolite signaling/acclimation ; TCA cycle ; Calvin–Benson cycle ; photoperiodic changes ; redox-regulation ; environmental adaptation ; Glycolate oxidase ; evolution ; Archaeplastida ; Cyanobacteria ; MCF ; oxidative phosphorylation ; mitochondrial carriers ; transporters ; energy balancing ; cyclic electron flux ; malate valve ; C3 cycle ; acclimation ; chlorophyll a fluorescence ; fluctuating light ; natural variation ; pyruvate kinase ; glycolysis ; respiratory metabolism ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
    Language: English
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  • 4
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    Cave Communities: From the Surface Border to the Deep Darkness (2024)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2024-01-08
    Description: From a biological perspective, the subterranean realm is one of the less studied, but at the same time, one of the most promising, theatres for new findings and research. Compared to those on the surface, the ecological conditions occurring in subterranean habitats are relatively simple, and this may be an optimal scenario for understanding the mechanisms allowing the colonization, adaptation, and evolution of species, as well as their interactions within local communities. Diversity in subterranean habitats is often overlooked, and few studies embrace whole communities or try to assess functional relationships between species. This Special Issue reprint comprises papers covering a wide range of aspects related to the distribution, composition, and roles of subterranean communities occurring in different typologies of subterranean habitats.
    Keywords: cave biology ; subterranean habitats ; vertebrates ; invertebrates ; community dynamics ; biospeleology ; hypogean ; conservation ; biodiversity ; troglobite ; troglophile ; trogloxene ; extreme environment ; niche ; epikarst ; classification trees ; Copepoda ; random forests ; Diptera ; Limonia ; Limonia nubeculosa ; Neolimonia ; Trichoceridea ; cave community ; prey ; food resources ; occupancy ; abundance ; Astyanax ; Spelaeomysis ; Troglomexicanus ; Speocirolana ; Toro cave ; Sierra de El Abra ; troglomorphy ; stygobite ; fieldwork ; wild fish ; comparative biology ; behavior ; troglomorphism ; olfactory test ; infrared movies ; amino acids ; chondroitin ; plasticity ; cybernetics ; ecology ; cavefish ; dissolved oxygen ; cave evolution ; Astyanax mexicanus ; Ostracoda ; Yucatán Peninsula ; cenotes ; mitochondrial marker ; geometric morphometrics ; population ecology ; growth ; movements ; São Domingos karst area ; subterranean fishes ; evolution ; origin of troglobites ; Brazil ; subterranean biology ; environmental science ; biogeography ; distribution records ; groundwater ; underwater caves ; cenote ; mysid ; stygobiont ; bioindicator ; accidental cave visitors ; Arachnida ; Araneae ; arid ; levant ; Mediterranean ; species diversity ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSV Zoology & animal sciences
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  • 5
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    Major Histocompatibility Complex (MHC) in Health and Disease (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2024-04-05
    Description: The major histocompatibility complex (MHC) is a highly polymorphic and diverse multigene locus in all jawed vertebrate species that has an integral role in adaptive/innate immune systems, transplantation, and infectious and autoimmune diseases. The MHC supra-locus in mammalian vertebrates is usually partitioned into three distinct regions, known as classes I, II, and III, which, to varying extents, can be found conserved in nonmammalian jawed vertebrates, such as bony fish, amphibians, and bird lineages. The MHC gene region is characterized particularly by the expression of class I and class II glycoproteins that bind peptides derived from intracellular or extracellular antigens to circulating T-cells. While this expressed antigenic specificity remains the predominant interest with respect to MHC function and polymorphism in a population, a broader concept has emerged that examines the MHC as a multifunctional polymorphic controller that facilitates and regulates genome diversity with a much greater array of functions and effects than just MHC-restricted antigen recognition. This volume of 19 reprints presented by various experts and collected from the Special Issue of Cells on “MHC in Health and Disease” covers a broad range of topics on the genomic diversity of the MHC regulatory system in various vertebrate species, including MHC class I, II, and III genes; innate and adaptive immunity; neurology; transplantation; haplotypes; infectious and autoimmune diseases; fecundity; conservation; allelic lineages; and evolution. Taken together, these articles demonstrate the immense complexity and diversity of the MHC structure and function within and between different vertebrate species.
    Keywords: QH301-705.5 ; Q1-390 ; HCP5 ; n/a ; camels ; MHC ; STK19 ; major histocompatibility complex ; human papillomavirus (HPV) ; T-cell receptor ; T1DGC ; bottleneck ; micro-mini-pigs ; life history ; computational analysis ; hepatocellular carcinoma ; phase ; Bactrian camel ; NSDK ; melanoma ; antigen ; autoimmune disease ; RD ; selection ; disease resistance ; autoimmunity ; ancestral haplotype ; Ski complex ; DXO ; high-throughput sequencing ; conservation genetics ; SVA ; lncRNA ; ankylosing spondylitis ; MHC genes ; viral peptides ; competing endogenous RNA (ceRNA) ; astrogliosis ; birds ; long-fragment super haplotype ; SNP ; RLR ; HLA polymorphism ; 5??3? RNA decay ; expression ; 3??5? mRNA turnover ; orthology ; long-read sequencing ; disease association ; dromedary ; polyomavirus ; MHC-II-associated sperm-egg recognition ; experimental medicine ; single nucleotide polymorphism (SNP) ; fish ; SKIV2L ; production trait ; molecular dynamics simulation ; Macaca fascicularis ; human endogenous retrovirus (HERV) ; concerted evolution ; polymorphism ; Old World camels ; MHC polymorphism ; protocol ; nonclassical ; gene duplication ; microglial reaction ; human leukocyte antigen-E ; SKI2W ; quantitative trait loci (QTL) studies ; antiviral immunity ; human immunodeficiency virus (HIV) ; founder effect ; giant panda ; domain movements ; BK virus ; promoter-proximal transcriptional pause ; type 1 diabetes (T1D) ; RP1 ; miR1236 ; KIR ; synaptic covering ; swine leukocyte antigen ; cynomolgus macaque ; HLA ; kidney transplantation ; ?2m knockout mice ; DOM3Z ; interferon ? ; ethnic populations in China ; ecology ; KIR–HLA pairs ; exosomes ; major histocompatibility complex (MHC) ; MHC-I-based mother-fetus recognition ; RNA quality control ; autoimmune diseases ; NELF-E ; haplotype ; genetic drift ; evolution ; nonhuman primate models ; HLA-B27 ; PNS/CNS interface ; risk genes ; pedigree ; MHC-I- and MHC-II-dependent inter-individual recognition ; regulation ; crested ibis ; reproductive performance ; nephropathy ; cancer ; nuclear kinase ; trichohepatoenteric syndrome ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
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  • 6
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    Advances in Plant Taxonomy and Systematics (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-08-08
    Description: This reprint of the Special Issue "Advances in Plant Taxonomy and Systematics", includes an Editorial and fifteen high-quality papers published between April 2022 and April 2023 by global researchers. This collection addresses scholars and students interested in current progresses in taxonomy and systematics, which are crucial for all plant applications.
    Keywords: alpine species ; chromosome number ; Irano-Turanian region ; biogeography ; rapid radiation ; Veronica ; endemism ; morphometrics ; image analysis ; molecular analysis ; niche similarity ; nomenclature ; Magnoliaceae ; chloroplast genome ; phylogenomics ; intergeneric relationship ; Crassula ; Crassulaceae ; plastome ; codon usage ; codon aversion ; DNA barcoding ; evolutionary rates ; phylogeny ; Adonanthe ; molecular phylogeny ; taxonomy ; steppic plant ; demographic systematics ; ethology ; evolution ; natural selection ; next-generation sequencing ; ordination ; reproductive isolation ; sexual deceit ; speciation ; species circumscription ; Astragalus subgenus Hypoglottis ; Leguminosae ; Iran ; rapid diversification ; section Hypoglottidei ; section Stereothrix ; Australia ; carnivorous plants ; non-core Caryophyllales ; Nepenthales ; sundews ; typification ; Adelieae ; Argythamnia ; Caperonia ; Caperonieae ; Chiropetalum ; Ditaxeae ; Ditaxis ; phylogenetics ; Philyra ; Arecaceae ; Bentinckia ; biogeographic analysis ; karyomorphology ; Asteraceae ; ecology ; ddRADseq ; geography ; leaf morphology ; polyploidy ; chromosome numbers ; Crocus heuffelianus group ; Crocus series Verni ; dysploidy ; genome size ; genotyping-by-sequencing (GBS) ; morphometry ; apomixis ; hybridisation ; multiple origins ; Sorbus austriaca ; genomics ; geometric morphometrics ; Ranunculus auricomus ; taxonomically complex groups (TCGs) ; arid lands ; Cactaceae ; colonization ; Mammillaria ; Mexican Plateau ; Miocene ; Pleistocene ; recent diversification ; n/a ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PST Botany & plant sciences
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  • 7
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    Brain Asymmetry in Evolution (2022)
    MDPI - Multidisciplinary Digital Publishing Institute
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    Publication Date: 2022-02-01
    Description: In higher mammals, including primates and carnivores, the asymmetrical aspects of brain morphology and function have been shown to be species-related, sex-related, and subject to individual diversity, and are associated with cognition, emotion, language, preference of hand/paw use, and numerous other aspects. Disturbance of the brain lateralization is involved in human neurodevelopmental disorders with cognitive impairments, social deficits, and/or specific language impairments. Asymmetric development may be essential to the evolution of the brain in acquiring higher and/or more diverse functions. The purpose of this Special Issue on “Brain Asymmetry in Evolution” is to highlight morphological and functional lateralization of the brain in various species of mammals toward understanding the evolution of the brain.
    Keywords: oxyhemoglobin level ; state anxiety ; task performance ; heart rate ; human ; asymmetry ; sex difference ; MRI ; volumetry ; cerebellum ; ferret ; lateralization ; side bias ; fish ; methodological artefacts ; symmetry ; non-human primate ; Old World monkey ; evolution ; evolutionary expansion ; gyrification ; structural asymmetry ; language laterality ; topological data analysis ; persistent homology ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 8
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    Evolution, Composition and Regulation of Supernumerary B Chromosomes (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2024-04-05
    Description: Supernumerary B chromosomes (Bs) are dispensable genetic elements found in thousands of species of plants and animals, and some fungi. Since their discovery more than a century ago, they have been a source of puzzlement, as they only occur in some members of a population and are absent from others. When they do occur, they are often harmful, and in the absence of “selfishness”, based on mechanisms of mitotic and meiotic drive, there appears to be no obvious reason for their existence. Cytogeneticists have long wrestled with questions about the biological existence of these enigmatic elements, including their lack of any adaptive properties, apparent absence of functional genes, their origin, sequence organization, and co-evolution as nuclear parasites. Emerging new technologies are now enabling researchers to step up a gear, to look enthusiastically beyond the previous limits of the horizon, and to uncover the secrets of these “silent” chromosomes. This book provides a comprehensive guide to theoretical advancements in the field of B chromosome research in both animal and plant systems.
    Keywords: QH301-705.5 ; Q1-390 ; parent-of-origin effects ; fluorescent in situ hybridization ; coverage ratio analysis ; n/a ; ribosomal DNA ; reactivation ; cytogenetics ; epigenetics ; heterochromatin ; interphase nucleus ; whole genome resequencing ; transmission ; grasshoppers ; genome instability ; dot-like (micro) Bs ; ?s ; B chromosome ; supernumerary elements ; transcription of heterochromatin ; maternal X chromosome ; supernumerary chromosome ; population analysis ; supernumerary ; repeat clusters ; extra chromosomes ; genes ; tandem repeats ; B morphotypes ; repetitive DNA ; repetitive elements ; DNA copy number variation ; chromosome polymorphism ; satellite DNA ; mammals ; maize B chromosome ; additional chromosomes ; inactivation ; drive ; B chromosomes ; FISH (fluorescence in situ hybridisation) ; organelle DNA ; Orthoptera ; origin ; supernumerary chromosomes ; karyotype evolution ; GISH (genomic in situ hybridisation) ; DNA composition ; de novo centromere formation ; genomics ; paternal X chromosome ; euchromatin degradation ; supernumerary chromosomal segments (SCS) evolution ; centromere ; sSMC ; Prospero autumnale complex ; next-generation sequencing ; Drosophila ; host/parasite interaction ; Apodemus peninsulae ; genome evolution ; evolution ; teleost ; chromosome evolution ; microdissected DNA probes ; controlling element ; mobile element ; RNA-Seq ; karyotypes ; karyotypic characteristics ; RepeatExplorer ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
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  • 9
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    Hurdles for Phage Therapy (PT) to Become a Reality (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2024-04-05
    Description: Alternative treatment modes for antibiotic-resistant bacterial pathogens have become a public health priority. Bacteriophages are bacterial viruses that infect and lyse bacterial cells. Since bacteriophages are frequently bacterial host species-specific and can often also infect antibiotic-resistant bacterial cells, they could represent ideal antimicrobials for fighting the antibiotic resistance crisis. The medical use of bacteriophages has become known as phage therapy. It is widely used in Russia, where phage cocktails are sold in pharmacies as an over-the-counter drug. However, no phage product has been registered for medical purposes outside of the former Soviet Union. The current Special Issue of Viruses contains a collection of papers from opinion leaders in the field who explore hurdles to the introduction of phage therapy in western countries. The articles cover diverse topics ranging from patent to regulatory issues, the targeting of suitable bacterial infections, and the selection and characterization of safe and efficient phage cocktails. Phage resistance is discussed, and gaps in our knowledge of phage–bacterium interactions in the mammalian body are revealed, while other articles explore the use of phages in food production and processing.
    Keywords: QH301-705.5 ; QR1-502 ; Q1-390 ; alginate ; abortive infection ; n/a ; bacterial resistance ; bacteriophages ; ATMP ; MALDI-MS ; adaptation ; Bacteriophage ; horizontal gene transfer ; adaptive immunity ; co-evolution ; Listeria ivanovii ; personalised medicines ; pH stability ; phage-human host interaction ; vB_SauM-fRuSau02 ; antimicrobial resistance ; phagodisinfection ; biofilm ; capsule depolymerase ; animal model ; phage cocktails ; Enterococcus ; cases report ; zoonosis ; resistance ; magistral formula ; experimental therapy ; Belgium ; phage therapy ; E. faecalis ; nontraditional antibacterial ; industrial phage application ; Democratic Republic of the Congo ; OrthoMCL ; Germany ; high-throughput sequencing ; antimicrobial ; infection ; antibiotic therapy ; Kayvirus ; phages ; Twortlikevirus ; bacterial disease ; human host ; Pseudomonas aeruginosa ; phage ; multidrug-resistant bacteria ; bacterial infection ; Salmonella Typhi ; rhamnopolysaccharide ; compassionate use ; crop production ; compounding pharmacy ; antimicrobial resistance (AMR) ; best practices ; bacteriophage efficacy ; phage sensitivity ; antibiotic-resistance ; antibiotic ; lysins ; PTMP ; Escherichia coli ; typhoid fever ; patent landscape ; phage preparation ; innate immunity ; anti-phage antibodies ; immunology ; Staphylococcus aureus ; global health ; clinical trial ; adsorption ; Brussels ; phage-resistance ; Galleria mellonella ; science communication ; history of science ; virus–host interactions ; foodborne illness ; prophage ; resistance management ; biofilms ; IND ; immunomodulation ; frequency of resistance ; capsule ; gastrointestinal tract ; phage-host interactions ; disinfection ; production ; bacteriophage therapy ; bacteriophage ; Staphylococcus ; magistral preparation ; extended-spectrum beta lactamases (ESBL) ; Viral proteins ; antibiotic resistance ; genomics ; phage biocontrol ; therapy ; target selection ; viral genomes ; evolution ; pharmaceutical paradigm shift ; personalized medicine ; pharmaceutical legislation ; food safety ; regulation ; virulence ; developing countries ; infectious disease ; regulatory framework ; sustainable agriculture ; Klebsiella pneumoniae ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
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  • 10
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    The Structural and Functional Study of Efflux Pumps Belonging to the RND Transporters Family from Gram-Negative Bacteria (2022)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2022-05-06
    Description: Antimicrobial-resistant bacterial infections are a major and costly public health concern. Several pathogens are already pan-resistant, representing a major cause of mortality in patients suffering from nosocomial infections. Drug efflux pumps, which remove compounds from the bacterial cell, thereby lowering the antimicrobial concentration to sub-toxic levels, play a major role in multidrug resistance. In this Special Issue, we present up-to-date knowledge of the mechanism of RND efflux pumps, the identification and characterization of efflux pumps from emerging pathogens and their role in antimicrobial resistance, and progress made on the development of specific inhibitors. This collection of data could serve as a basis for antimicrobial drug discovery aimed at inhibiting drug efflux pumps to reverse resistance in some of the most resistant pathogens.
    Keywords: MdtF (YhiV) ; multidrug resistance ; RND-type efflux pump ; dye accumulation ; real-time efflux ; pathogens ; RND ; evolution ; efflux pump ; adaptation ; Aliarcobacter butzleri ; RND efflux pumps ; virulence ; resistance ; RND pump ; dominant negative effect ; assembly ; protein-protein interaction ; mutation ; drug resistance ; cystic fibrosis ; prevalence of efflux resistance mechanisms ; hospital acquired infections ; antibiotic resistance ; allostery ; antimicrobial resistance ; conformational changes ; energetic transition ; gram-negative bacteria ; pump activation ; n/a ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSG Microbiology (non-medical)
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