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  • thema EDItEUR::P Mathematics and Science::PS Biology, life sciences  (438)
  • Chemical Engineering
  • Organic Chemistry
  • MDPI - Multidisciplinary Digital Publishing Institute  (405)
  • Frontiers Media SA  (35)
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  • 1
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-05
    Description: DNA methylation, a modification found in most species, regulates chromatin functions in conjunction with other epigenome modifications, such as histone post-translational modifications and non-coding RNAs. In mammals, DNA methylation has an essential role in development by orchestrating the generation and maintenance of the phenotypic diversity of human cell types. Recent years have brought spectacular advances in our understanding of the mechanism, function and regulation of DNA methyltransferases through their interaction with other epigenome modifications, chromatin factors and post-translational modifications, which are described in this Special Issue of Genes. Manuscripts are specifically addressing describing the targeting and regulation of DNA methyltransferases by interacting factors and their roles in cellular differentiation and the development of diseases. Prof. Dr. Albert Jeltsch and Prof. Dr. Humaira Gowher, Guest Editors
    Keywords: QH301-705.5 ; Q1-390 ; DNMTs ; n/a ; histone modification ; TBRS ; DNA methyltransferases ; autoinhibition ; epigenetics ; DNMT ; cell identity ; embryogenesis ; dwarfism ; DNMT3B ; germ cells ; HSAN1E ; USP7 ; DNMT3A ; DNA methyltransferase ; gene expression ; DNMT1 ; de novo DNA methylation ; DNA methyltransferase structure ; UHRF1 ; DNA methyltransferase mechanism ; allosteric regulation ; rare diseases ; DNA Methylation ; maintenance DNA methylation ; DNA methylation ; ADCA-DN ; PCC/PGL ; ubiquitination ; TETs ; DNA methyltransferase function ; molecular epigenetics ; DNA methyltransferase regulation ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Language: English
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  • 2
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Thy-1 ; CD90 ; Signal Transduction ; cell-cell interaction ; Cell-matrix interaction ; Scaffold ; Nanodomains ; integrin ; Mechanotransduction ; Cancer ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Language: English
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  • 3
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-05
    Description: Recombinant viruses expressing reporter fluorescent or bioluminescent proteins are an excellent option to evaluate the dynamics of viral infection progression in both cultured cells and/or validated animal models of viral infection. Reporter proteins are valid surrogates for direct detection of infected cells in vitro and in vivo, without the use of secondary methodologies to identify infected cells. By eliminating the need of secondary labeling, tractable replicating-competent, reporter-expressing viruses provide an ideal approach to monitor viral infections in real time, representing a significant advance in the study of the biology of viruses, to evaluate vaccination approaches, and to identify new therapeutics against viral infections using high-throughput screening settings. In this Special Issue “Replication-Competent Reporter-Expressing Viruses” we review replication-competent, reporter-expressing viruses belonging to different families, methods of characterization, and applications to facilitate the study of in vitro and in vivo viral infections. We also seek to discuss disadvantages and limitations associated with these reporter-expressing viruses. Finally, we provide rational future perspectives and additional avenues for the development, characterization, and applications of recombinant, reporter-expressing, competent viruses.
    Keywords: QH301-705.5 ; luminescence ; virus rescue approaches ; fluorescence ; Recombinant viruses ; plasmid-based reverse genetics ; reporter genes ; replicating-competent reporter-expressing viruses ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Language: English
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  • 4
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: Introducing “A Feasible Approach for Natural Products to Treatment of Diseases”–an exploration of the therapeutic potential locked within nature’s abundant offerings. This comprehensive reprint delves into the fascinating realm of natural products, uncovering their inherent properties, mechanisms of action, and potential roles in effective disease management. Through extensive scientific research and reviews, the authors shed light on the immense potential of natural products as a viable approach to enhancing health and combating diseases. This reprint presents a diverse and multidimensional exploration, bridging the gap between traditional wisdom and contemporary scientific understanding and offering new avenues for healthcare professionals, researchers, and enthusiasts to harness the power of nature’s remarkable resources. As a catalyst for unlocking the healing potential of natural products, this reprint inspires further investigation and innovation, and drives us towards a future where their integration into mainstream healthcare becomes indispensable. Discover the possibilities and embark on a health and well-being journey with “A Feasible Approach for Natural Products to Treatment of Diseases”.
    Keywords: cancer immunotherapy ; fructan ; FT-IR ; mass spectrometry ; young green barley ; COVID-19 ; β-glucans ; immunomodulation ; anti-inflammation ; anti-oxidant ; ACE2 regulation ; impedance ; ECIS ; antitumor activity ; anticancer properties ; betulin ; betulinic acid ; Amadori rearrangement compounds ; barley ; anti-obesity ; arginyl-fructose ; adipogenic ; ergosta-5,7,22,24(28)-tetraenol (ERGT) ; cholesta-5,7,22,24-tetraenol (CHT) ; ergosterol biosynthesis ; antimetabolite ; suicide substrate ; Trypanosoma brucei ; coronavirus SARS-CoV-2 ; main protease ; Saussurea costus ; molecular docking ; GC-MS profiling ; Molineria recurvata ; diabetic nephropathy ; urinary biomarkers ; inflammation ; oxidative stress ; walnut ; Juglans regia ; high-fat diet ; insulin resistance ; cognitive function ; JNK/NFκB pathway ; Citri Reticulatae Pericarpium ; flavonoids ; anticancer ; mechanism ; phenotype ; Angelica sinensis polysaccharide ; Astragalus membranaceus polysaccharide ; hexokinase 2 ; glycolysis ; JAK2/STAT3 pathway ; liver regeneration ; Holoptelea integrifolia ; MMP-9 ; wound healing ; friedelin ; oxalactam A ; macrolactam ; anti-Rhizoctonia solani ; Penicillium oxalicum ; molecular dynamics ; non-alcoholic fatty liver disease (NAFLD) ; natural products ; terpenoids ; mechanisms ; treatment ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry
    Language: English
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  • 5
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-05
    Description: Several epidemiological studies have demonstrated that oxidative stress is associated with a number of health disorders, including cardiovascular malfunction, certain types of cancer, diabetes mellitus, many other auto-immune diseases, and even ageing. The body possesses multiple mechanisms to counteract oxidative stress, which employ antioxidant compounds that are either naturally generated in situ (endogenous antioxidants) or externally supplied through food (exogenous antioxidants). These antioxidants are able to counteract oxidative stress, thanks to their ability to neutralize excess free radicals and protect the cellular lipids, proteins, and DNA from molecular damage. Exogenous antioxidants from the diet are of increasing interest because of their beneficial role in maintaining good health and in preventing chronic diseases. Indeed, a diet rich in dietary antioxidants, especially from fruits and vegetables, has been correlated with a successful prevention and lower incidence of several degenerative pathologies, including obesity, diabetes, cardiovascular diseases, and cancer. This Special Issue of Nutrients welcomes the submission of manuscripts, either describing original research or reviewing scientific literature, examining the role of diets rich in antioxidant compounds in the prevention of chronic diseases and the characteristics of the antioxidants included in such diets.
    Keywords: QH301-705.5 ; antioxidants ; chronic diseases ; dietary supplementation ; human health ; prevention ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Language: English
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  • 6
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-05
    Description: Diet and nutrition are key tools in promoting health and reducing the comorbidities of chronic diseases. There are thousands of biomolecules in fruits, vegetables, wild and medicinal plants, other land and marine organisms, which can exert functional and health-promoting effects through bioactivity beyond nutrition. From the enormous amount of knowledge generated from different natural bioactive ingredients present in foods, we are aiming to bring together experts working in different fields of food, nutrition, and health, in order to work on this Special Issue, with a comprehensive collection of papers to gain insight into the most promising bioactive compounds in different foods, to improve the preservation of bioactivity during the food processing chain, and to provide scientific evidence of the efficacy of key bioactives in foods in preventing disease and improving health and wellbeing.
    Keywords: QH301-705.5 ; TX341-641 ; Health ; Bioactives ; Nutrition and Metabolism ; Nutrients ; Bioavailability ; Food ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Language: English
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  • 7
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: The diversity of wood and non-wood forest products is enormous and reflected in their anatomical, physical and chemical properties as well as their potential applications. Special attention should be given to lesser-known species and even to invasive species, which may be profitable when properly managed, thereby decreasing the overexploitation of threatened species. Besides the market importance of stem wood, other tree components and non-wood forest products, often regarded simply as forest residual materials, are valuable forest resources with various potential applications that can strengthen the circular economy. Assessing the characteristics of these diverse materials, such as their structure and anatomy as well as their physical and chemical properties, is fundamental for evaluating their potential and increasing high-quality end-uses. This knowledge will also contribute to sustainable forest management with enhanced forest diversity and species conservation in addition to the reinforcement of certification and environmental policies.
    Keywords: Calamus zollingeri ; Calamus ornatus ; dynamic vapor sorption ; basic density ; volumetric swelling ; white rot ; mold ; Quercus suber L. ; seasonal variation ; cuticular waxes ; leaves ; new species ; morphology ; wood ; properties ; chemical composition ; spectroscopy ; chemometrics ; unconventional species ; Quercus suber ; cork borer ; cork ; phenolics ; tropical species ; wood anatomy ; wood density ; wood color ; multivariate analysis ; species diversity ; dark-brown zone ; lenticular filling tissue ; quantitative anatomical characteristics ; Quercus variabilis ; reproduction cork ; scanning electron microscopy ; sclereid ; virgin cork ; Cytisus scoparius ; liquefied ; optimization ; eco-valorization ; agro-industrial residues ; Asparagaceae ; lignocellulose ; crystalline cellulose ; syringyl/guaiacyl ; anatomy ; Tilia amurensis Rupr. ; Tilia mandshurica Rupr. & Maxim. ; branch ; wood properties ; papermaking material ; tropical timber ; color parameters ; mid-infrared spectroscopy ; FTIR ratios ; environmental factors ; West African Sahel ; Cupressus funebris Endl. wood ; wood knots ; physical properties ; wood color properties ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences ; thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KNA Agribusiness and primary industries::KNAL Forestry industry
    Language: English
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  • 8
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-05
    Description: “Personalised Nutrition” represents any initiative that attempts to provide tailor-made healthy eating advice based on the nutritional needs of each individual, as these are dictated by the individual’s behaviour, phenotype and/or genotype, and their interactions. This Special Issue of Nutrients is dedicated to the development, implementation and assessment of the effectiveness of evidence-based “Personalised Nutrition” strategies. In this regard, a selection of reviews and original research manuscripts will bring together the latest evidence on how lifestyle habits, physiology, nutraceuticals, gut microbiome and genetics can be integrated into nutritional solutions, specific to the needs of each individual, for maintaining health and preventing diseases.
    Keywords: QH301-705.5 ; Q1-390 ; TX341-641 ; n/a ; gene-based ; taste ; postprandial leptin ; children ; personalised ; obesity ; macronutrient composition ; gastrointestinal symptoms ; postprandial adiponectin ; formula diet ; avoidance diet ; weight loss ; weight ; omega-3 fatty acids ; microbiome ; genotype ; nutrition ; direct-to-consumer test ; intervention ; clinical nutrition ; postprandial total ghrelin ; dietary intervention ; microbiota ; low-carbohydrate diet ; insulin ; FADS polymorphism ; adults ; genetics ; diet ; healthcare professionals ; HbA1c ; PROX1 gene ; phenotype ; high-fat meal ; glucose ; personalised nutrition ; irritable bowel syndrome ; dietary recommendation ; postprandial metabolic fingerprinting ; type 2 diabetes mellitus risk ; high-carbohydrate meal ; health ; ultra-high performance liquid chromatography ; food allergy ; normo-carbohydrate meal ; nutrimetabolomics ; type 2 diabetes ; nutrigenetics ; gene–diet interaction ; personalized nutrition ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
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  • 9
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: New scientific advances in different areas have allowed the design of more precise strategies for the prevention and treatment of metabolic disorders through nutrition. In this context emerges the term Precision Nutrition, a new approach that takes advantage of scientific knowledge about the interaction of internal and external environmental factors to develop dynamic and precise nutritional recommendations. Therefore, Precision Nutrition includes personalized advice based on genetics and well-documented gene–nutrient–phenotype interactions, as well as other factors such as individual metabolome, transcriptome, and microbiota profile; food behavior; and dietary, physical activity, and life-style habits; and the resulting interactomes. Precision Nutrition should be based at least on three sequential steps: conventional nutritional approaches (considering age, gender, and physiological states); the incorporation of nutritional and health status information (e.g., metabolites, physical and nutritional behavior); and the genetic baggage including multiomics functional integration.
    Keywords: dietary parameters ; carbohydrate intake ; obesity ; single nucleotide polymorphism ; CLOCK gene ; rs3749474 ; sodium intake ; hypertension ; single-nucleotide polymorphism ; personalized nutrition ; dietary vitamin A ; body fat ; UCP ; retinoic acid ; PBMC ; genetic variant ; weight loss ; nutrigenomics ; dietary intervention ; FTO gene ; dietary protein ; dietary carbohydrates ; dietary fat ; macronutrients ; gene-diet interaction ; glucose homeostasis ; glaucoma ; polygenetic-risk scores ; gene-gene interaction ; gene-nutrient interaction ; precision medicine ; childhood ; insulin resistance ; adipokine ; metabolomics ; biomarkers ; ELOVL ; metabolic alterations ; Mexican population ; Single Nucleotide Polymorphisms ; pediatrics ; cardiometabolic risk factors ; precision nutrition ; eating behavior ; nutrigenetics ; microbiota ; metabolic syndrome ; Mediterranean diet ; genetic risk score ; HELENA ; adolescents ; sex ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBC Cultural and media studies::JBCC Cultural studies::JBCC4 Cultural studies: food and society
    Language: English
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  • 10
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-05
    Description: The Hippo pathway is a highly dynamic cellular signaling nexus that plays central roles in multiple cell types and regulates regeneration, metabolism, and development. The Hippo pathway integrates mechanotransduction, cell polarity, inflammation, and numerous types of paracrine signaling. If not tightly regulated, dysregulated Hippo pathway signaling drives the onset and progression of a range of diseases, including fibrosis and cancer. The molecular understanding of the Hippo pathway is rapidly evolving. This Special Issue contains ten articles contributed by established and up-and-coming Hippo pathway experts that, as a whole, provides an up-to-date overview of how dysregulated Hippo pathway activity is a common driver of specific diseases. The articles have a particular focus on the underlying molecular and cellular mechanisms that cause the Hippo pathway to go awry, and especially how this drives disease. The articles analyze disease-specific as well as common themes, which provides valuable insights into the fundamental molecular mechanisms in the dysfunctioning Hippo pathway, and thereby offer practical insights into potential future therapeutic intervention strategies.
    Keywords: QH301-705.5 ; Q1-390 ; STRIPAK ; skin cancer ; n/a ; Lats2 ; transcription ; myofibroblast ; epigenetic ; Hippo ; cancer immunity ; TAZ ; Taz ; TAZ (transcriptional co-activator with PDZ-binding motif) ; adaptive immunity ; fibroblasts ; innate immunity ; LATS ; MST (mammalian STE20-like protein kinase) ; phosphorylation ; stem cells ; wound healing ; signal transduction ; angiogenesis ; LATS1/2 ; EMT ; protein-protein interactions ; structure biology ; Hippo pathway ; hippo pathway ; autoimmunity ; Mps one binder ; YAP/TAZ ; GPCR ; fibrosis ; MST1/2 ; YAP (yes-associated protein) ; YAP ; Yap ; protein kinase ; LATS (large tumor suppressor kinase) ; peripheral nerve sheath tumor ; signal cross-talk ; stem cell ; skin development ; STK38 ; tumorigenesis ; NDR ; schwannoma ; G protein-coupled receptor ; anti-cancer therapy ; feedback loops ; vascular mimicry ; castration resistance ; chromatin ; Hippo signalling ; ECM ; MST ; prostate cancer ; TEAD ; cancer ; zebrafish ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Language: English
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