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  • Books  (6,672)
  • De Gruyter  (3,026)
  • Frontiers Media SA  (2,449)
  • RAND Corporation  (1,197)
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  • 1
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    De Gruyter | JOVIS Verlag GmbH
    Publication Date: 2024-03-23
    Description: Infrastructures of Freedom sheds light on the impact of inadequate public lighting in self-built communities in Cape Town. In democratic South Africa, where infrastructure provision still reflects deeply embedded notions of citizenship, informal neighborhoods with minimal infrastructure provision face challenges beyond access to basic services and opportunities. Fear, the feeling of being forgotten, and living in undignified conditions are among the powerful experiences darkness brings about in these neighborhoods. The book not only reveals these experiences of everynight life, but takes a step further: it considers how the co-production of a solar public lighting project within a community improved everynight life and suggests ways for infrastructure to more successfully articulate citizenship.
    Keywords: post-Apartheid urban planning ; public light ; darkness ; Cape Town ; South Africa ; Khayelitsha light infrastructure ; citizenship ; urban segregation ; township action research ; bottom-up ; Apartheid ; southern urbanism ; thema EDItEUR::A The Arts::AM Architecture::AMD Architecture: professional practice ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RP Regional and area planning
    Language: English
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  • 2
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    De Gruyter
    Publication Date: 2024-04-14
    Description: This book is an introduction to the subjects of linked data, open data and open linked data, and to their specific relevance for libraries. It illustrates these concepts through detailed descriptions of actual data projects. The volume will be useful to individuals involved in library practice and those in library management who have not yet become familiarized with these important contemporary fields.
    Keywords: Z ; Q350-390 ; Libraries ; Internet ; hyperlinks ; thema EDItEUR::U Computing and Information Technology
    Language: German
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  • 3
    Publication Date: 2022-01-31
    Description: As records of the link between a manuscript and the texts it contains, paratexts document many aspects of a manuscript’s life: production, transmission, usage, and reception. Comprehensive studies of paratexts are still rare in the field of manuscript studies, and the universal categories of time and space are used to create a common frame for research and comparisons. Contributions in this volume span over three continents and one millennium.
    Keywords: PN1-6790 ; Genette ; Gérard ; Paratext
    Language: English
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  • 4
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: social-decision making ; animal behavior ; behavioral ecology ; animal collective behavior ; animal SDM ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 5
    Publication Date: 2024-04-02
    Description: As part of an effort to assist Chile in developing a strategic program to foster the development of the health information technology (health IT) sector over the next five to ten years, this report assesses the current state of health IT adoption and implementation in Chile, as well as the challenges and opportunities facing the sector over the coming years.
    Keywords: Health Sciences ; History ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas ; thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues ; thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBQ Medicolegal issues
    Language: English
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  • 6
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    De Gruyter
    Publication Date: 2024-04-08
    Description: The present volume is the seventeenth and last in this series of the Jerusalem Talmud. The four tractates of theSecond Order - Ta'aniot, Megillah, Hagigah, Mo'ed Qatan (Mašqin) - deal with different fasts and holidays as well as with the pilgrimage to the Temple. The texts are accompanied by an English translation and presented with full use of existing Genizah texts and with an extensive commentary explaining the Rabbinic background.
    Keywords: Talmud ; Jewish Studies ; Rabbinic Scripture ; bic Book Industry Communication::H Humanities::HR Religion & beliefs::HRJ Judaism ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRJ Judaism
    Language: English , Hebrew
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  • 7
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    De Gruyter | De Gruyter
    Publication Date: 2024-04-07
    Description: Dieser Sammelband widmet sich den römischen Epikern Lucan, Valerius Flaccus, Statius und Silius Italicus. Die Beiträge beleuchten den Kontrast zwischen Gattungstheorie und -praxis, das Zusammenspiel von Gattungsinterferenzen und Intertextualität sowie das Spannungsverhältnis zwischen Konvention und Innovation. Im Mittelpunkt steht das Verhältnis der nachaugusteischen Epik zur früheren Tradition, d. h. zu maßgeblichen Vorgängern wie Homer, Vergil und Ovid. Die Selbstpositionierung der späteren Dichter in Bezug zum Kanon geht häufig mit der Bemühung einher, traditionelle Elemente neu zu konfigurieren: Durch Aussparung, Variation oder Übersteigerung gattungstypischer Aspekte treten ihre Werke in einen Dialog mit den früheren Epen und unterwandern dabei permanent die Erwartungshorizonte des Publikums. Hierbei spielt die Einbindung gattungsfremder Diskurse eine zentrale Rolle: Moderne literaturwissenschaftliche Konzepte zur Analyse von Gattungsinterferenzen werden im Sammelband kritisch evaluiert und reflektiert in die Interpretation einbezogen. Die methodische Bandbreite und die innovativen Zugänge in diesem Band leisten einen wichtigen Beitrag zur Vertiefung und Erweiterung des aktuellen Forschungsstandes. ; Dieser Sammelband widmet sich den römischen Epikern Lucan, Valerius Flaccus, Statius und Silius Italicus. Die Beiträge beleuchten den Kontrast zwischen Gattungstheorie und -praxis, das Zusammenspiel von Gattungsinterferenzen und Intertextualität sowie das Spannungsverhältnis zwischen Konvention und Innovation. Im Mittelpunkt steht das Verhältnis der nachaugusteischen Epik zur früheren Tradition, d. h. zu maßgeblichen Vorgängern wie Homer, Vergil und Ovid. Die Selbstpositionierung der späteren Dichter in Bezug zum Kanon geht häufig mit der Bemühung einher, traditionelle Elemente neu zu konfigurieren: Durch Aussparung, Variation oder Übersteigerung gattungstypischer Aspekte treten ihre Werke in einen Dialog mit den früheren Epen und unterwandern dabei permanent die Erwartungshorizonte des Publikums. Hierbei spielt die Einbindung gattungsfremder Diskurse eine zentrale Rolle: Moderne literaturwissenschaftliche Konzepte zur Analyse von Gattungsinterferenzen werden im Sammelband kritisch evaluiert und reflektiert in die Interpretation einbezogen. Die methodische Bandbreite und die innovativen Zugänge in diesem Band leisten einen wichtigen Beitrag zur Vertiefung und Erweiterung des aktuellen Forschungsstandes. ; This anthology is dedicated to the Roman epic poets Lucan, Valerius Flaccus, Statius and Silius Italicus. The contributions examine the contrast between genre theory and practice, the interplay of genre interference and intertextuality, and the tension between convention and innovation. The focus is on the relationship of post-Augustan epic poetry to the earlier tradition, i.e. to authoritative predecessors such as Homer, Virgil and Ovid. The self-positioning of later poets in relation to the canon often goes hand in hand with an endeavour to reconfigure traditional elements: By omitting, varying or exaggerating aspects typical of the genre, their works enter into a dialogue with the earlier epics, permanently subverting the audience's horizons of expectation. The integration of non-genre discourses plays a central role here: modern literary concepts for analysing genre interference are critically evaluated in the anthology and incorporated into the interpretation in a reflective manner. The methodological range and innovative approaches in this volume make an important contribution to deepening and expanding the current state of research.
    Keywords: Epos ; Latein ; Antike ; Literaturtheorie ; Classical antiquity ; epic poetry ; Latin ; literature theory ; thema EDItEUR::D Biography, Literature and Literary studies::DB Ancient, classical and medieval texts ; thema EDItEUR::D Biography, Literature and Literary studies::DS Literature: history and criticism::DSB Literary studies: general::DSBB Literary studies: ancient, classical and medieval ; thema EDItEUR::N History and Archaeology::NH History::NHC Ancient history
    Language: German
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  • 8
    Publication Date: 2024-04-01
    Description: Modern popular culture came to the world from the stage. Even before film and radio had established themselves, popular theater had developed into a commercial and boundary-crossing entertainment industry that reached a mass audience. Tobias Becker compares the theater landscapes of London and Berlin and points out the cultural exchanges that took place between these metropolises during the long turn of the century (1880&#82111930).
    Keywords: D204-475 ; media history ; German-British history ; theater history ; urban history ; history of popular culture ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: German
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  • 9
    Publication Date: 2024-04-01
    Keywords: D204-475 ; DD1-905 ; JA1-92 ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: German
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  • 10
    Publication Date: 2024-04-05
    Description: After a quarter of century of rapid technological advances, research has revealed the complexity of cancer, a disease intimately related to the dynamic transformation of the genome. However, the full understanding of the molecular onset of this disease is still far from achieved and the search for mechanisms of treatment will follow closely. It is here that Nanotechnology enters the fray offering a wealth of tools to diagnose and treat cancer. In fact, the National Cancer Institute predicts that over the next years, nanotechnology will result in important advances in early detection, molecular imaging, targeted and multifunctional therapeutics, prevention and control of cancer. Nanotechnology offers numerous tools to diagnose and treat cancer, such as new imaging agents, multifunctional devices capable of overcome biological barriers to deliver therapeutic agents directly to cells and tissues involved in cancer growth and metastasis, and devices capable of predicting molecular changes to prevent action against precancerous cells. Nanomaterials-based delivery systems in Theranostics (Diagnostics & Therapy) provide better penetration of therapeutic and diagnostic substances within the body at a reduced risk in comparison to conventional therapies. At the present time, there is a growing need to enhance the capability of theranostics procedures where nanomaterials-based sensors may provide for the simultaneous detection of several gene-associated conditions and nanodevices with the ability to monitor real-time drug action. These innovative multifunctional nanocarriers for cancer theranostics may allow the development of diagnostics systems such as colorimetric and immunoassays, and in therapy approaches through gene therapy, drug delivery and tumor targeting systems in cancer. Some of the thousands and thousands of published nanosystems so far will most likely revolutionize our understanding of biological mechanisms and push forward the clinical practice through their integration in future diagnostics platforms. Nevertheless, despite the significant efforts towards the use of nanomaterials in biologically relevant research, more in vivo studies are needed to assess the applicability of these materials as delivery agents. In fact, only a few went through feasible clinical trials. Nanomaterials have to serve as the norm rather than an exception in the future conventional cancer treatments. Future in vivo work will need to carefully consider the correct choice of chemical modifications to incorporate into the multifunctional nanocarriers to avoid activation off-target, side effects and toxicity. Moreover the majority of studies on nanomaterials do not consider the final application to guide the design of nanomaterial. Instead, the focus is predominantly on engineering materials with specific physical or chemical properties. It is imperative to learn how advances in nanosystem’s capabilities are being used to identify new diagnostic and therapy tools driving the development of personalized medicine in oncology; discover how integrating cancer research and nanotechnology modeling can help patient diagnosis and treatment; recognize how to translate nanotheranostics data into an actionable clinical strategy; discuss with industry leaders how nanotheranostics is evolving and what the impact is on current research efforts; and last but not least, learn what approaches are proving fruitful in turning promising clinical data into treatment realities.
    Keywords: QD1-999 ; Q1-390 ; Nanoparticles ; Gene Therapy ; Immunotherapy ; bioimaging ; theranostics ; nanomaterials ; Drug delivery ; Nanomedicine ; Cancer ; Phototherapy ; thema EDItEUR::P Mathematics and Science::PN Chemistry
    Language: English
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  • 11
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    De Gruyter
    Publication Date: 2024-04-01
    Description: Psychiatric disorders in adolescents are an important social problem relevant to almost all healthcare professionals. The prevalence of mood, anxiety, substance use and other psychiatric disorders among adolescents is high. However, medical professionals are not sufficiently trained about adolescent psychiatric disorders. Primary care providers correctly identify less than a fourth of youth with a depressive or anxiety disorder and many clinicians underestimate the importance of the problem of adolescent psychiatric illnesses and suicidal behavior. Multiple clinical, neurobiological, cultural and legal aspects of psychiatric disorders in adolescents are discussed in this book.
    Keywords: Medicine & Public Health ; Medicine ; Public Health ; Psychiatric disorders ; Adolescence ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKL Psychiatry
    Language: English
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  • 12
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    De Gruyter | De Gruyter
    Publication Date: 2024-04-02
    Description: The book offers an examination of issues, institutions and actors that have become central to Muslim life in the region. Focusing on leadership, authority, law, gender, media, aesthetics, radicalization and cooperation, it offers insights into processes that reshape power structures and the experience of being Muslim. It makes room for perspectives from the region in an academic world shaped by scholarship mostly from Europe and America.
    Keywords: Islam ; West Africa ; Muslim Life ; thema EDItEUR::N History and Archaeology::NH History::NHG Middle Eastern history ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRP Islam::QRPP Islamic life and practice
    Language: English , French
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  • 13
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    De Gruyter | De Gruyter Oldenbourg
    Publication Date: 2024-01-12
    Description: Nursery of Capitalism examines the relationship between children and money in the 18th and 19th centuries. In the modern era, money came to symbolize both a resource for rationalization and a morally dangerous object. The author reveals that this ambivalence surfaced particularly in educating children to become economic citizens, and thus extends the history of economic subjectivity to include the perspective of children.
    Keywords: Cultural history ; childhood ; money ; economics ; pedagogy ; bic Book Industry Communication::J Society & social sciences::JN Education::JNB History of education ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCZ Economic history ; bic Book Industry Communication::H Humanities::HB History::HBJ Regional & national history::HBJD European history::HBJD1 British & Irish history ; bic Book Industry Communication::H Humanities::HB History::HBT History: specific events & topics::HBTB Social & cultural history
    Language: German
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  • 14
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: omics ; epigenetics ; pharmacogenetics ; CYP ; risk prediction ; microbiota ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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  • 15
    Publication Date: 2024-04-11
    Description: It has become more evident that many microalgae respond very differently than land plants to diverse stimuli. Therefore, we cannot reduce microalgae biology to what we have learned from land plants biology. However, we are still at the beginning of a comprehensive understanding of microalgae biology. Microalgae have been posited several times as prime candidates for the development of sustainable energy platforms, making thus the in-depth understanding of their biological features an important objective. Thus, the knowledge related to the basics of microalgae biology must be acquired and shared rapidly, fostering the development of potential applications. Microalgae biology has been studied for more than forty years now and more intensely since the 1970’s, when genetics and molecular biology approaches were integrated into the research programs. Recently, studies on the molecular physiology of microalgae have provided evidences on the particularities of these organisms, mainly in model species, such as Chlamydomonas reinhardtii. Of note, cellular responses in microalgae produce very interesting phenotypes, such as high lipid content in nitrogen deprived cells, increased protein content in cells under high CO2 concentrations, the modification of flagella structure and motility in basal body mutant strains, the different ancient proteins that microalgae uses to dissipate the harmful excess of light energy, the hydrogen production in cells under sulfur deprivation, to mention just a few. Moreover, several research groups are using high-throughput and data-driven technologies, including “omics” approaches to investigate microalgae cellular responses at a system-wide level, revealing new features of microalgae biology, highlighting differences between microalgae and land plants. It has been amazing to observe the efforts towards the development and optimization of new technologies required for the proper study of microalgae, including methods that opened new paths to the investigation of important processes such as regulatory mechanisms, signaling crosstalk, chemotactic mechanisms, light responses, chloroplast controlled mechanisms, among others. This is an exciting moment in microalgae research when novel data are been produced and applied by research groups from different areas, such as bioprocesses and biotechnology. Moreover, there has been an increased amount of research groups focused in the study of microalgae as a sustainable source for bioremediation, synthesis of bioproducts and development of bioenergy. Innovative strategies are combining the knowledge of basic sciences on microalgae into their applied processes, resulting in the progression of many applications that hopefully, will achieve the necessary degree of optimization for economically feasible large-scale applications. Advances on the areas of basic microalgae biology and novelties on the essential cellular processes were revealed. Progress in the applied science showed the use of the basic science knowledge into fostering translational research, proposing novel strategies for a sustainable world scenario. In this present e-book, articles presented by research groups from different scientific areas showed, successfully, the increased development of the microalgae research. Herewith, you will find articles ranging from bioprospecting regional microalgae species, through advances in microalgae molecular physiology to the development of techniques for characterization of biomass and the use of biomass into agriculture and bioenergy production. This e-book is an excellent source of knowledge for those working with microalgae basic and applied sciences, and a great opportunity for researchers from both areas to have an overview of the amazing possibilities we have for building an environmentally sustainable future once the knowledge is translated into novel applications.
    Keywords: TA1-2040 ; TP248.13-248.65 ; QK1-989 ; Q1-390 ; Biotechnology ; biomass ; Hydrogen ; bioenergy ; Nutrients ; Lipids ; Microalgae ; Biofuels ; sustainability ; Carbon Dioxide ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: English
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  • 16
    Publication Date: 2024-04-04
    Description: This report shares an overview of the budget of the U.S. Department of Veterans Affairs (VA) and focuses particularly on health care spending and the Veterans Health Administration (VHA), including makeup of the veteran population, available health coverage, patterns of use, and potential areas of improvement.
    Keywords: History ; Health Sciences ; thema EDItEUR::N History and Archaeology::NH History::NHW Military history ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas ; thema EDItEUR::M Medicine and Nursing::MQ Nursing and ancillary services
    Language: English
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  • 17
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    De Gruyter
    Publication Date: 2022-05-02
    Description: The future of area studies lies in opening out into TransArea studies, which tie together area-connected competencies with transdisciplinary research practices. It is one of the loftiest and most urgent duties of philology to lift up this treasure in the awareness of the special relevance of literature, and to make it democratically available to the broadest possible sections of the population.
    Keywords: Modern Languages and Linguistics ; Area Studies ; Literary Studies ; Literature ; History of Globalization ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFF Social issues & processes::JFFS Globalization
    Language: English
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  • 18
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: oligodendrocyte ; Schwann cell ; oligodendrocyte precursor cell ; myelin ; myelin repair ; axon physiology ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 19
    Publication Date: 2023-12-21
    Description: It is now well appreciated that the immune system, in addition to its traditional role in defending the organism against pathogens, communicate in a well-organized fashion with the brain to maintain homeostasis and regulate a set of neural functions. Perturbation in this brain-immune interactions due to inflammatory responses may lead to psychiatric and neurological disorders. Microglia are one of the essential cells involved in the brain-immune interactions. Microglial cells are now not simply regarded as resident tissue macrophages in the brain. These cells are derived from myeloid progenitor cells in the yolk sac in early gestation, travel to the brain parenchyma and interact actively with neurons during the critical period of neurogenesis. Microglia provide a trophic support to developing neurons and take part in the neural wiring through the activity-dependent synapse elimination via direct neuron-microglia interactions. Altered microglial functions including changes in the gene expression due to early life inflammatory events or psychological and environmental stressors can be causally related to neurodevelopmental diseases and mental health disorders. This type of alterations in the neural functions can occur in the absence of infiltration of inflammatory cells in the brain parenchyma or leptomeninges. In this sense, the pathogenetic state underlying a significant part of psychiatric and neurological diseases may be similar to “para-inflammation”, an intermediate state between homeostatic and classical inflammatory states as defined by Ruslan Medzhitov (Nature 454:428-35, 2008). Therefore, it is important to study how systemic inflammation affects brain health and how local peripheral inflammation induces changes in the brain microenvironment. Chronic pain is also induced by disturbance in otherwise well-organized multisystem interplay comprising of reciprocal neural, endocrine and immune interactions. Especially, early-life insults including exposure to immune challenges can alter the neuroanatomical components of nociception, which induces altered pain response later in life. Recently the discrete roles of microglia and blood monocyte-derived macrophages are being defined. The distinction may be further highlighted by disorders in which the brain parenchymal tissue is damaged. Therefore, studies investigating the dynamics of immune cells in traumatic brain injury and neurotropic viral infections including human immunodeficiency virus, etc. as well as neurodegenerative diseases such as amyotrophic lateral sclerosis are promising to clarify the interplay between the central nervous and immune systems. The understanding of the histological architecture providing the infrastructure of such neuro-immune interplay is also essential. This Frontiers research topic brings together fourteen articles and aims to create a platform for researchers in the field of psychoneuroimmunology to share the recent theories, hypotheses and future perspectives regarding open questions on the mechanisms of cell-cell interactions with chemical mediators among the nervous, immune and endocrine systems. We hope that this platform would reveal the relevance of the studies on multisystem interactions to enhance the understanding of the mechanisms underlying a wide variety of neurological and psychiatric disorders.
    Keywords: R5-920 ; RC346-429 ; RC581-607 ; brain-immune interaction ; fatigue ; pain ; HIV ; neuroinflammation ; traumatic brain injury ; depression ; microglia ; amyotrophic lateral sclerosis ; autism ; bic Book Industry Communication::M Medicine
    Language: English
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  • 20
    Publication Date: 2024-04-05
    Description: Polymer Engineering focuses on the preparation and application of polymers in several hot topics such as artificial photosynthesis, water purification by membrane technologies, and biodiesel production from wastewater plants. The authors not only describe the latest developments in polymer science, but also support these experimental results by computational chemistry and modelling studies.
    Keywords: QD1-999 ; thema EDItEUR::P Mathematics and Science::PN Chemistry
    Language: English
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  • 21
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    De Gruyter | De Gruyter
    Publication Date: 2024-03-24
    Description: This volume examines the linguistic dimension of vigilance in different contexts. The focus is on the social potentials, normative and regulative effects of languages as well as their use for marking dangers and orienting attention. This shows that language can be both an object and an instrument of vigilance and can itself become a medium of reflection of vigilance.
    Keywords: vigilance ; monitoring ; mindfulness ; thema EDItEUR::C Language and Linguistics::CF Linguistics::CFB Sociolinguistics ; thema EDItEUR::D Biography, Literature and Literary studies::DS Literature: history and criticism::DSB Literary studies: general ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GT Interdisciplinary studies::GTC Communication studies ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GT Interdisciplinary studies::GTD Semiotics / semiology ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTB Social and cultural history
    Language: English , German
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  • 22
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    De Gruyter | De Gruyter
    Publication Date: 2024-03-27
    Description: Within the scope of the Greek-Latin Alexander romance, the Res gestae Alexandri Macedonis by Julius Valerius (early fourth century CE) stand out due to their high literary and stylistic standards. The eleven contributions in this edited volume primarily focus on issues of narrative technique, linguistic design, and intertextuality, thereby illustrating the unique features and rank of this often-neglected work in literary history.
    Keywords: Alexander the Great ; Iulius Valerius ; Middle Latin ; Late Antiquity ; thema EDItEUR::D Biography, Literature and Literary studies::DS Literature: history and criticism::DSB Literary studies: general::DSBB Literary studies: ancient, classical and medieval ; thema EDItEUR::N History and Archaeology::NH History::NHC Ancient history ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3K CE period up to c 1500
    Language: German , English
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  • 23
    Publication Date: 2024-04-05
    Keywords: B1-5802 ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy
    Language: German
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  • 24
    Publication Date: 2024-04-04
    Description: The southeastern Land of Seven Rivers (Kazakhstan) – a small region in the Eurasian steppes – shows an enormous concentration of Bronze and early Iron Age archeological monuments, only a small fraction of which have been described by researchers. This study, the first comprehensive investigation of these monuments, also makes an important contribution to knowledge about the historical – cultural evolution of the region.
    Keywords: CC1-960 ; D51-90 ; Kurgans ; Scythians ; Kazakhstan ; thema EDItEUR::N History and Archaeology::NK Archaeology
    Language: German
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  • 25
    Publication Date: 2024-04-05
    Description: In the past two decades there have been significant advances made in understanding the cellular and molecular alterations that occur with brain ageing, as well as with our understanding of age-related brain diseases. Ageing is associated with a mid-life decline in many cognitive domains (eg. Attention, working memory, episodic memory) that progresses with advancing age and which may be potentiated by a variety of diseases. However, despite the breadth of attempts to explain it, the underlying basis for age-related memory impairment remains poorly understood. Both normal and “pathological” ageing (as in age-related neurodegenerative disorders such as Alzheimer’s disease) may be associated with overlapping and increased levels of “abnormal” pathology, and this may be a potential mediator of cognitive decline in both populations. An emerging hypothesis in this field is that metal ion dys/homeostasis may represent a primary unifying mechanism to explain age- and disease-associated memory impairment – either indirectly via an effect on disease pathogenesis, or by a direct effect on signaling pathways relevant to learning and memory. There remains a concerted worldwide effort to deliver an effective therapeutic treatment for cognitive decline associated with ageing and/or disease, which is currently an unmet need. There have been numerous clinical trials conducted specifically testing drugs to prevent cognitive decline and progression to dementia, but to date the results have been less than impressive, highlighting the urgent need for a greater understanding of the neurobiological basis of memory impairment in ageing and disease which can then drive the search for effective therapeutics.
    Keywords: RC321-571 ; Q1-390 ; Down Syndrome ; Amyotrophic Lateral Sclerosis ; Parkinson's disease ; aluminium ; Iron ; TBI ; Cognition ; Copper ; Alzheimer's disease ; Zinc ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 26
    Publication Date: 2024-04-04
    Description: Evolution of the horse has been an often-cited primary example of evolution, as well as one of the classic and important stories in paleontology for over a century and a half, due to their rich fossil record across 5 continents: North America, South America, Europe, Asia and Africa. The recent horse has served a profound role in human ancestry, including agriculture, commerce, sport, transport, warfare, and in prehistory, for the subsistence of humans. Many studies have examined the evolution of the Equidae and chronicled the striking changes in skulls, dentition, limbs, and body size which have long been perceived to be a response to environmental shifts through time. Most comprehensive studies heretofore have: (1) focused on the “Great Transformation”- changes that occurred in the early Miocene, (2) involved tracking long-term diversity or paleoecological trends on a single continent or within a geographical locality, or (3) concentrated on the 3-toed hipparions. The Plio–Pleistocene evolutionary stage of horse evolution is punctuated by the great climatic fluctuations of the Quaternary beginning 2.6 Ma which influenced Equus evolution, biogeographic dispersion and adaptation on a nearly global scale. The evolutionary biology of Equus evolution across its entire range remains relatively poorly understood and often highly controversial. Some of this lack of understanding is due to assumptions that have arisen because of the relatively derived craniodental and postcranial anatomy of Equus and its close relatives which has seemed to imply that that these forms occupied relatively homogenous and narrow dietary and locomotor niches - notions that have not been adequately addressed and rigorously tested. Other challenges have revolved around teasing apart environmentally-driven adaptation versus phylogenetically defined morphological change. Geochronologic age control of localities, geographic provinces and continents has improved, but in no way is absolute and can be reexamined in our proposed volume. Temporal resolution for paleodietary, paleohabitat and paleoecological interpretations are also challenging for understanding the evolution of Equus. Our proposed volume attempts to assemble a group of experts who will address multiple dimensions of Equus’ evolution in time and space.
    Keywords: Ecomorphology ; Equus ; Paleoecology ; Taxonomy ; Biogeography ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAF Ecological science, the Biosphere
    Language: English
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  • 27
    Publication Date: 2023-12-21
    Description: Poly-ADP ribose polymerase (PARP) proteins are critical mediators of DNA repair. Many traditional anti-cancer chemotherapy agents overwhelm a cell’s ability to repair DNA damage in order to kill proliferating malignant cells. Recent evidence suggests that cancers within and across tissue types have specific defects in DNA repair pathways, and that these defects may predispose for sensitivity and resistance to various classes of cytotoxic agents. Breast, ovarian and other cancers develop in the setting of inherited DNA repair deficiency, and these cancers may be more sensitive to cytotoxic agents that induce DNA strand breaks, as well as to inhibitors of PARP activity. A series of recent clinical trials has tested whether PARP inhibitors can achieve synthetic lethality in hereditary DNA repair-deficient tumors. At the current time, mutation of BRCA serves as a potential, but not comprehensive, biomarker to predict response to PARP inhibitor therapy. Mechanisms of resistance to PARP inhibitors are only recently being uncovered. Future studies seek to identify sporadic cancers that harbor genomic instability rendering susceptibility to PARP inhibitors that compound lethal DNA damage.
    Keywords: R5-920 ; RC254-282 ; DNA reapir ; PARP inhibitor ; Homologous Recombination ; combination therapy ; DNA Damage ; Cancer ; bic Book Industry Communication::M Medicine
    Language: English
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  • 28
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    De Gruyter | De Gruyter
    Publication Date: 2024-04-07
    Description: Terminologies present various challenges to their inventors and to their users, ranging from epistemic adequacy over linguistic concerns to matters of strategy and group construction. With respect to historical terminologies, however, research has been dominated by linguistic approaches. Breaking new ground, Coming to Terms collects eleven articles that combine an interest in the history of knowledge, mostly ancient Greek, with research on scientific terminologies. They all share an interest in terminological practices, that is, questions such as how and when to coin a term and then what to do with it. Among the fields discussed are astronomy, the Roman surveyors, Aristotelian science, Renaissance and modern biology, contemporary medicine, ancient Chinese philosophy, 20th-century physics, and colonial linguistics. Confronting ancient with modern terminologies, the collection intends to test integrative interpretive approaches. Thus, the collection documents how rich ancient (and modern) terminologies are and shows that they are, beyond lexicography, worth being studied per se. ; Terminologies present various challenges to their inventors and to their users, ranging from epistemic adequacy over linguistic concerns to matters of strategy and group construction. With respect to historical terminologies, however, research has been dominated by linguistic approaches. Breaking new ground, Coming to Terms collects eleven articles that combine an interest in the history of knowledge, mostly ancient Greek, with research on scientific terminologies. They all share an interest in terminological practices, that is, questions such as how and when to coin a term and then what to do with it. Among the fields discussed are astronomy, the Roman surveyors, Aristotelian science, Renaissance and modern biology, contemporary medicine, ancient Chinese philosophy, 20th-century physics, and colonial linguistics. Confronting ancient with modern terminologies, the collection intends to test integrative interpretive approaches. Thus, the collection documents how rich ancient (and modern) terminologies are and shows that they are, beyond lexicography, worth being studied per se.
    Keywords: Terminologie ; antike Wissenschaft ; Aristoteles ; terminology ; ancient science ; Aristotle ; thema EDItEUR::D Biography, Literature and Literary studies::DS Literature: history and criticism::DSB Literary studies: general::DSBB Literary studies: ancient, classical and medieval ; thema EDItEUR::P Mathematics and Science::PD Science: general issues::PDX History of science
    Language: English
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  • 29
    Publication Date: 2024-03-29
    Description: This study provides a quantitative and qualitative status report on the implementation of school-based management (SBM) in Indonesia, identifies factors associated with the successful practices of SBM, and assesses SBM effects on student achievement eight years after inception. They found that the implementation so far has produced limited success and provide recommendations to strengthen the nation’s SBM practices.
    Keywords: Education ; History ; bic Book Industry Communication::J Society & social sciences::JN Education::JNK Organization & management of education::JNKC Curriculum planning & development ; bic Book Industry Communication::J Society & social sciences::JN Education::JNK Organization & management of education::JNKD Examinations & assessment ; bic Book Industry Communication::J Society & social sciences::JN Education::JNS Teaching of specific groups & persons with special educational needs::JNSV Teaching of students with English as a second language (TESOL) ; bic Book Industry Communication::J Society & social sciences::JN Education::JNF Educational strategies & policy ; bic Book Industry Communication::H Humanities::HB History::HBJ Regional & national history::HBJF Asian history ; thema EDItEUR::J Society and Social Sciences::JN Education::JND Educational systems and structures::JNDG Curriculum planning and development ; thema EDItEUR::J Society and Social Sciences::JN Education::JND Educational systems and structures::JNDH Education: examinations and assessment ; thema EDItEUR::J Society and Social Sciences::JN Education::JNU Teaching of a specific subject ; thema EDItEUR::J Society and Social Sciences::JN Education::JNF Educational strategies and policy ; thema EDItEUR::N History and Archaeology::NH History::NHF Asian history
    Language: English
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  • 30
    Publication Date: 2024-04-05
    Description: Neuromorphic engineering has just reached its 25th year as a discipline. In the first two decades neuromorphic engineers focused on building models of sensors, such as silicon cochleas and retinas, and building blocks such as silicon neurons and synapses. These designs have honed our skills in implementing sensors and neural networks in VLSI using analog and mixed mode circuits. Over the last decade the address event representation has been used to interface devices and computers from different designers and even different groups. This facility has been essential for our ability to combine sensors, neural networks, and actuators into neuromorphic systems. More recently, several big projects have emerged to build very large scale neuromorphic systems. The Telluride Neuromorphic Engineering Workshop (since 1994) and the CapoCaccia Cognitive Neuromorphic Engineering Workshop (since 2009) have been instrumental not only in creating a strongly connected research community, but also in introducing different groups to each other’s hardware. Many neuromorphic systems are first created at one of these workshops. With this special research topic, we showcase the state-of-the-art in neuromorphic systems.
    Keywords: RC321-571 ; Q1-390 ; neuromorphic engineering ; Learning ; Floating gate ; Neural Network ; spike-based ; event-based ; simulation ; dynamic vision sensor ; network ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 31
    Publication Date: 2023-12-21
    Description: This e-book provides the insight into occupational health and safety problems, challenges and solutions of the dairy sector. Thirty-two authors have been sharing their results and knowledge reflecting the challenges from small scale farming up to industrial style. The worldwide trend of growing farm sizes and a reduction in numbers is one of the major drivers for the changes in the working environment. Musculoskeletal disorders are among the most prevalent health problems of people working on farms. Nevertheless mechanisation has not reduced the number of complaints, and new problems arise due to the changing working environment.
    Keywords: R5-920 ; RA1-1270 ; immigrant workers ; Dairy farming ; OHS ; MSS ; MSD ; bic Book Industry Communication::M Medicine
    Language: English
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  • 32
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    Frontiers Media SA
    Publication Date: 2024-04-05
    Description: Despite the importance of mathematics in our educational systems little is known about how abstract mathematical thinking emerges. Under the uniting thread of mathematical development, we hope to connect researchers from various backgrounds to provide an integrated view of abstract mathematical cognition. Much progress has been made in the last 20 years on how numeracy is acquired. Experimental psychology has brought to light the fact that numerical cognition stems from spatial cognition. The findings from neuroimaging and single cell recording experiments converge to show that numerical representations take place in the intraparietal sulcus. Further research has demonstrated that supplementary neural networks might be recruited to carry out subtasks; for example, the retrieval of arithmetic facts is done by the angular gyrus. Now that the neural networks in charge of basic mathematical cognition are identified, we can move onto the stage where we seek to understand how these basics skills are used to support the acquisition and use of abstract mathematical concepts.
    Keywords: RC321-571 ; Q1-390 ; Neuroimaging ; development ; numerosity ; gifted ; Mathematical Cognition ; algebra ; abstract ; Expertise ; Arithmetic ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 33
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    De Gruyter
    Publication Date: 2024-03-25
    Keywords: D1-2009 ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DN Biography and non-fiction prose
    Language: French , German
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  • 34
    Publication Date: 2024-04-01
    Keywords: D204-475 ; DD1-905 ; JA1-92 ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: German
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  • 35
    Publication Date: 2023-12-21
    Description: Microglia are essential for the development and function of the adult brain. Their ontogeny, together with the absence of turnover from the periphery and the singular environment of the central nervous system (CNS), make microglia a unique cell population compared to other tissue-macrophages. The unique properties and functions of microglial cells, such as their role in synaptic pruning or the exceptional capacity to scan the brain parenchyma and rapidly react to its perturbations, have emerged in recent years. In the coming years, understanding how microglia acquire and maintain their unique profiles in order to fulfil distinct tasks in the healthy CNS and how these are altered in disease, will be essential to develop strategies to diagnose or treat CNS disorders with an immunological component. This Research Topic covers several aspects of microglial biology, ranging from their origin and the functional role of microglia during development and lifespan, their molecular properties compared with other brain and peripheral immune cells to microglial phenotypes and functional states in neurodegenerative diseases and brain tumours. In conclusion, the present Research Topic provides a comprehensive overview of our current understanding of several cellular and molecular mechanisms that make microglia a unique immune cell population within the healthy CNS as well as under inflammatory, neurodegenerative and tumorigenic processes.
    Keywords: R5-920 ; RC346-429 ; RC581-607 ; inflammation ; brain tumour ; neurodegeneration ; microglia ; ontogeny ; bic Book Industry Communication::M Medicine
    Language: English
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  • 36
    Publication Date: 2023-10-05
    Description: This study examines the likely effects of the Affordable Care Act on average annual consumer health care spending and the risk of catastrophic medical costs. The analysis also considers how the decision to expand Medicaid would affect average annual consumer health spending and the risk of catastrophic medical costs for low-income individuals in two large states: Texas and Florida.
    Keywords: Health Sciences ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBQ Medicolegal issues ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBP Health systems & services::MBPR Medical insurance
    Language: English
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  • 37
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Exercise Science ; Performance ; Physiology ; Japan ; Olympics ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology
    Language: English
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  • 38
    Publication Date: 2022-01-31
    Keywords: DD1-905
    Language: German
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  • 39
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    De Gruyter | De Gruyter
    Publication Date: 2024-04-08
    Description: Funerary rituals and mortuary cults are classics of religious studies research in ancient Egypt. Still, we know little about how the living interacted with ancestors and gods in daily life. The case study of the city of Memphis and its Saqqara necropolis in the late 2nd mil. BCE focusses on lived ancient religion, and demonstrates the spectrum of religious practices and options to configure religion and sociality through commemorative practices.
    Keywords: Practices ; memory ; ancient Egypt Religion ; bic Book Industry Communication::H Humanities::HR Religion & beliefs ; bic Book Industry Communication::H Humanities::HR Religion & beliefs::HRA Religion: general ; bic Book Industry Communication::H Humanities::HR Religion & beliefs::HRA Religion: general::HRAX History of religion ; bic Book Industry Communication::H Humanities::HR Religion & beliefs::HRK Other non-Christian religions::HRKP Ancient religions & mythologies ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRA Religion: general ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRA Religion: general::QRAX History of religion ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRR Other religions and spiritual beliefs::QRRT Indigenous, ethnic and folk religions and spiritual beliefs::QRRT1 Indigenous religions, spiritual beliefs and mythologies of the Americas
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  • 40
    Publication Date: 2023-10-05
    Description: In this first of two reports, RAND researchers assess whether and how The Military Spouse Employment Partnership addresses its objectives in supporting the employment of military spouses and closing the wage gap between military and civilian spouses. This report documents the first phase of research to help meet the 2015 National Defense Authorization Act requirement for a “report evaluating the progress of military spouse employment programs."
    Keywords: Management & Organizational Behavior ; Law ; Finance ; bic Book Industry Communication::K Economics, finance, business & management::KF Finance & accounting::KFC Accounting ; bic Book Industry Communication::K Economics, finance, business & management::KJ Business & management::KJM Management & management techniques::KJMV Management of specific areas::KJMV2 Personnel & human resources management ; bic Book Industry Communication::L Law::LN Laws of Specific jurisdictions::LNH Employment & labour law
    Language: English
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  • 41
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: organohalide respiration ; Microbial reductive dehalogenation ; Dehalococcoides ; electron transport chain ; reductive dehalogenase ; Community composition and function ; bioremediation ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKF Pathology::MKFM Medical microbiology and virology ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical)
    Language: English
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  • 42
    Publication Date: 2024-03-29
    Description: The U.S. armed forces must be prepared to deploy to a wide range of locations and confront adversaries that span the threat spectrum. This report reviews selected findings from a study of Army and joint anti-access and area denial challenges and proposes a joint approach to countering these threats in future operations.
    Keywords: History ; Technology ; thema EDItEUR::J Society and Social Sciences::JW Warfare and defence::JWK Military and defence strategy ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TT Other technologies and applied sciences::TTM Military engineering
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  • 43
    Publication Date: 2024-04-08
    Description: As part of the German Jewish Cultural Heritage project, the expert contributors to this volume examine the cultural influence of the German-speaking Jewish intelligentsia around the world. This influence continues to be felt in many countries of origin and exile without being adequately reflected in collective consciousness. This volume makes a substantive contribution to the search for traces of German-speaking Jewish culture in the wake of emigration.
    Keywords: BM1-990 ; Emigration Judaism Jewish identity cultural heritage cultural history ; bic Book Industry Communication::H Humanities::HR Religion & beliefs::HRJ Judaism ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRJ Judaism
    Language: German
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  • 44
    Publication Date: 2024-03-25
    Description: In welcher Weise und in welchem Maß haben die Ergebnisse des Newtonschen Experiments der Farbbrechung Einfluss auf die Bildende Kunst des 18. und 19. Jahrhunderts genommen? Diese Fragen stehen im Zentrum der Beiträge, welche die Malpraxis, die Theoriebildung zur Farbe, die neuen graphischen Reproduktionstechniken, die steigende Sehkompetenz, die Materialität von Farbe, die Verfeinerung der Darstellungsdetails und die Rolle optischer Instrumente untersuchen. Die Irritation im 18. Jahrhundert entstand aus der nicht eindeutigen Trennung in Licht- und Pigmentfarben. Für die Künstler hatte die alte Farbtrias - Blau, Rot, Gelb - weiterhin Bestand. Nichtsdestotrotz ist eine Verfeinerung des Sehens zu konstatieren, wie zunehmende Differenzierungskompetenz, die nicht nur neue graphische Techniken hervorbrachte, die im 19. Jahrhundert zur Fotographie führen sollten, sondern auch die Ästhetisierung verstärkte. Beiträge von: Ulrike Boskamp, Werner Busch, Erna Fiorentini, John Gage, Bettina Gockel, Ursula Klein, Carolin Meister, Jutta Müller-Tamm, Annik Pietsch, H. Otto Sibum, Monika Wagner, Marc Wellmann.
    Keywords: D1-2009 ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DN Biography and non-fiction prose
    Language: German
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  • 45
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: artificial reefs ; offshore oil and gas platforms ; coastal infrastructure ; aquaculture facilities ; anthropogenic influences ; ecological restoration ; marine conservation ; rigs-to-reef ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RB Earth sciences::RBK Hydrology and the hydrosphere::RBKC Oceanography (seas and oceans)
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  • 46
    Publication Date: 2023-12-21
    Description: The non-classical HLA class I molecule HLA-G is different from classical HLA class I molecules because of the low polymorphism in the coding region, the fact that HLA-G primary transcript is alternatively spliced in seven isoforms, and the inhibitory action on immune cells. Although HLA-G is low polymorphic, variants in both promoter and 3’ un-translated region (UTR) of HLA-G locus regulate its expression. In healthy conditions, a basal level of HLA-G gene transcription is observed in most cells and tissues; however, translation into HLA-G protein is restricted to trophoblasts in the placenta, where it participates in promoting tolerance at the fetal-maternal interface. HLA-G is also expressed by thymic epitelial, cornea, mesenchymal stem cells, nail matrix, pancreatic beta cells, erythroid, and endothelial precursors. HLA-G can be neo-expressed in adult tissues in pathological conditions, and its expression has been documented autoimmune disorders, viral infections, and cancer. In the latter setting de novo HLA-G expression is associated with the capability of tumor cells to evade the immune control. In the last decade it has become evident that HLA-G expression on T cells and antigenpresenting cells confers to these cells tolerogenic properties. This Research Topic focused on i) summarizing updated clinical and immunological evidences that HLA-G expression is associate with beneficial or detrimental tolerance, ii) gathering new insights into the mechanisms governing the expression of HLA-G in healthy and pathological conditions, such as pre-eclampsia, and iii) examining the mechanisms underlying HLA-G mediated tolerance.
    Keywords: R5-920 ; RC581-607 ; Pregnancy ; Autoimmunity ; Immuno-modulation ; Pre-Eclampsia ; Infections ; Exosomes ; HLA-G ; polymorphisms ; tolerance ; Cancer ; bic Book Industry Communication::M Medicine
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  • 47
    Publication Date: 2024-03-29
    Description: In the year 2013, ‘selfie’ was named word of the year by Oxford Dictionaries in recognition of dramatic changes in frequency, prominence, and register of the term. This drastic increase in selfie-taking was spurred by two factors. The first was the advent of smartphones equipped with front cameras and preview screens that made it easy to compose a photographic self-portrait by a process of deliberately exploring one’s image, choosing a pose, and finally taking the picture. The second key change contributing to the rise of the selfie age was the increasing availability of internet connections. It is estimated that about 50% of the world population has access to the internet today (2018; https://www.internetworldstats.com). At the end of the past century, this percentage was a mere 1%. The growth of the internet infrastructure simultaneously spurred the development of social network applications such as Facebook, Twitter, Snapchat, and Instagram, providing accessible media for sharing photographs including photographic self-portraits. However, despite their tremendous reach and popularity, selfies have so far received relatively little attention by the scientific community, especially within psychology. Thus, we proposed a Frontiers in Psychology Research Topic to expand empirical and theoretical work on the massively popular, yet scientifically unexplored, phenomenon of the selfie. The articles published in this eBook offer a multifaceted insight into current scholarly work on this topic.
    Keywords: BF1-990 ; Q1-390 ; group selfies ; self-esteem ; Human Computer Interaction (HCI) ; self-presentation ; selfie ; viewing perspective ; perception bias ; smartphones ; social media ; internet ; bic Book Industry Communication::J Society & social sciences::JM Psychology ; thema EDItEUR::J Society and Social Sciences::JM Psychology
    Language: English
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  • 48
    Publication Date: 2022-01-31
    Keywords: PT1-4897
    Language: German
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  • 49
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    De Gruyter | De Gruyter
    Publication Date: 2024-03-24
    Description: This volume seeks to shed light on the interdependencies between wordplay and language creativity. Contributions explore the most diverse genres and discourses throughout History —anagrams, medieval fatrasies, the works of Rabelais, children books, slam, riddles, and contemporary constrained writing—, trying to understand their theoretical, didactic and historical impact.
    Keywords: Semiotics ; Literature ; Linguistics ; Language creativity ; Constrained writing ; thema EDItEUR::C Language and Linguistics ; thema EDItEUR::C Language and Linguistics::CF Linguistics ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DS Literature: history and criticism ; thema EDItEUR::D Biography, Literature and Literary studies::DS Literature: history and criticism::DSB Literary studies: general
    Language: French
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  • 50
    Publication Date: 2024-04-08
    Description: This volume includes both historical treatments of differing German-Jewish understandings of their experience – their relations to their Judaism, general culture and to other Jews – and contemporary reflections and competing interpretations as to how to understand the overall experience of German Jewry.
    Keywords: BM1-990 ; DD1-905 ; German-Jewish Intellectuals Jewish Modernity ; bic Book Industry Communication::H Humanities::HR Religion & beliefs::HRJ Judaism ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRJ Judaism
    Language: English
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  • 51
    Publication Date: 2024-04-01
    Description: The year 2014 saw the 200th anniversary of Napoleon's downfall - and the restauration of the French monarchy under the house of Bourbon. With this as a starting point, Volker Sellin shows how the European monarchies restored and prolonged their reigns by giving their countries constitutions. This new angle results in an astonishing history of the 19th century in Europe from Spain to Russia.
    Keywords: D204-475 ; political legitimacy ; legal history ; constitutions ; Restauration ; monarchies ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: English
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  • 52
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    RAND Corporation
    Publication Date: 2024-03-29
    Description: This RAND report examines the U.S. Army role in Southeast Asia. Under current benign conditions, efforts should focus on supporting defense reform, addressing transnational threats, and balancing China. If the outlook deteriorates, the United States should increase security cooperation, conclude new regional basing agreements, expand disaster assistance, and create policies to encourage risk-averse Chinese behavior.
    Keywords: History ; thema EDItEUR::J Society and Social Sciences::JW Warfare and defence::JWK Military and defence strategy ; thema EDItEUR::N History and Archaeology::NH History::NHW Military history ; thema EDItEUR::N History and Archaeology::NH History::NHF Asian history
    Language: English
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    Publication Date: 2024-04-02
    Description: The Department of Defense (DoD) has developed new sensor technologies to support U.S. forces in Iraq and Afghanistan; these technologies are potentially useful for counterdrug operations along the southern U.S. border, but there are legal questions regarding how they may be used and how sensor information may be shared between federal agencies in domestic operations. This report examines federal law and DoD policy to answer these questions.
    Keywords: History ; Technology ; Political Science ; thema EDItEUR::N History and Archaeology::NH History::NHH African history ; thema EDItEUR::N History and Archaeology::NH History::NHF Asian history ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPS International relations::JPSD Diplomacy ; thema EDItEUR::J Society and Social Sciences::JK Social services and welfare, criminology::JKS Social welfare and social services::JKSW Emergency services::JKSW1 Police and security services ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TT Other technologies and applied sciences::TTM Military engineering
    Language: English
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    De Gruyter | De Gruyter
    Publication Date: 2024-03-23
    Description: This volume addresses interdependencies between the original and the copy while focusing on the latter. Going beyond established imperatives for innovation, the essays in this volume examine artistic repetition and concentrate on its specific forms, intentions, and contexts. The faithfulness of the copy is thus revealed as a productive category in its own right, even if—or perhaps precisely because—the aim is “creating nothing new.”
    Keywords: Copy ; thema EDItEUR::A The Arts::AB The arts: general topics ; thema EDItEUR::A The Arts::AB The arts: general topics::ABC Conservation, restoration and care of artworks
    Language: German , English
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    RAND Corporation
    Publication Date: 2024-03-29
    Description: U.S.-Turkish relations, long a vital element of U.S. policy, have seriously deteriorated in recent years. However, the arrival of a new U.S. administration offers an opportunity to repair recent fissures. Priority should be given to harmonizing policy toward Iraq and the Middle East as well as Central Asia and the Caucasus.
    Keywords: Political Science ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPS International relations ; thema EDItEUR::J Society and Social Sciences::JW Warfare and defence ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RN The environment::RND Environmental policy and protocols
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    Frontiers Media SA
    Publication Date: 2024-03-31
    Description: The main physiological actions of the biologically most active metabolite of vitamin D, 1a,25-dihydroxyvitamin D3(1a,25(OH)2D3), are calcium and phosphorus uptake and transport and thereby controlling bone formation. Other emergent areas of 1a,25(OH)2D3 action are in the control of immune functions, cellular growth and differentiation. This fits both with the widespread expression of the VDR and the above described consequences of vitamin D deficiency. Transcriptome-wide analysis indicated that per cell type between 200 and 600 genes are primary targets of vitamin D. Since most of these genes respond to vitamin D in a cell-specific fashion, the total number of vitamin D targets in the human genome is far higher than 1,000. This is supported by the genome-wide view on VDR binding sites in human lymphocytes, monocytes, colon and hepatic cells. All genomic actions of 1a,25(OH)2D3 are mediated by the transcription factor vitamin D receptor (VDR) that has been the subject of intense study since the 1980’s. Thus, vitamin D signaling primarily implies the molecular actions of the VDR. In this research topic, we present in 15 chapters different perspectives on the action of vitamin D and its receptor, such as the impact of the genomewide distribution of VDR binding loci, ii) the transcriptome- and proteome-wide effects of vitamin D, iii) the role of vitamin D in health, iv) tissue-specific functions of vitamin D and v) the involvement of vitamin D in different diseases, such as infections, autoimmune diseases, diabetes and different types of cancer.
    Keywords: QP1-981 ; Q1-390 ; Vitamin D ; Immune System ; Genomics ; vitamin D receptor ; Physiology ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: resting-state fMRI ; fMRI denoising ; vascular modulation ; head motion ; arousal ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 58
    Publication Date: 2024-04-02
    Description: The Kurdistan Region of Iraq needs policy-relevant data to help improve infrastructure, encourage the private sector, attract foreign investment, and foster economic growth. The Kurdistan Region Statistics Office needs to build capacity to collect the data. RAND worked closely with the Office to build capacity by preparing, conducting, and analyzing the first round of a survey of the regional labor force.
    Keywords: History ; Sociology ; Law ; thema EDItEUR::N History and Archaeology::NH History::NHG Middle Eastern history ; thema EDItEUR::L Law::LN Laws of specific jurisdictions and specific areas of law::LNH Employment and labour law: general ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHB Sociology::JHBC Social research and statistics
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    Frontiers Media SA
    Publication Date: 2022-01-31
    Description: This research topic is focused on recent advances in our understanding of effects of mechanical loading on the skeleton, and research methods used in addressing these. Though it is well established that mechanical loading provides an essential stimulus for skeletal growth and maintenance, there have been major advances recently in terms of our understanding of the molecular pathways involved, which are thought to provide novel drug targets for treating osteoporosis. The articles included in this topic encompass the full spectrum of laboratory and clinical research, and range from review articles, editorials, hypothesis papers and original research articles. Together, they demonstrate how mechanical loading underpins many aspects of bone biology, including the pathogenesis and treatment of osteoporosis and other clinical disorders associated with skeletal fragility.
    Keywords: RC648-665 ; R5-920 ; mechanical loading ; bone architecture ; accelerometers ; osteoblast ; osteoporosis ; osteoclast ; fractures ; distraction osteogenesis
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    Frontiers Media SA
    Publication Date: 2024-04-05
    Description: Glial cells are no longer considered passive bystanders in neuronal brain circuits. Not only are they required for housekeeping and brain metabolism, they are active participants in regulating the physiological function and plasticity of brain circuits and the online control of behavior both in invertebrate and vertebrate model systems. In invertebrates, glial cells are essential for normal function of sensory organs (C. elegans) and necessary for the circadian regulation of locomotor activity (D. melanogaster). In the mamallian brain, astrocytes are implicated in the regulation of cortical brain rhythms and sleep homeostasis. Disruption of AMPA receptor function in a subset of glial cell types in mice shows behavioral deficits. Furthermore, genetic disruption of glial cell function can directly control behavioral output. Regulation of ionic gradients by glia can underlie bistability of neurons and can modulate the fidelity of synaptic transmission. Grafting of human glial progenitor cells in mouse forebrain results in human glial chimeric mice with enhanced plasticity and improved behavioral performance, suggesting that astrocytes have evolved to cope with information processing in more complex brains. Taken together, current evidence is strongly suggestive that glial cells are essential contributors to information processing in the brain. This Research Topic compiles recent research that shows how the molecular mechanisms underlying glial cell function can be dissected, reviews their impact on plasticity and behavior across species and presents novel approaches to further probe their function.
    Keywords: RC321-571 ; Q1-390 ; Cerebellum ; C. elegans ; Astrocytes ; DREADD ; Cortex ; plasticity ; Gq ; Behavior ; glia ; Hippocampus ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Thy-1 ; CD90 ; Signal Transduction ; cell-cell interaction ; Cell-matrix interaction ; Scaffold ; Nanodomains ; integrin ; Mechanotransduction ; Cancer ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: export ; secretion ; pathogens ; toxins ; macromolecular machineries ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCJ Infectious and contagious diseases
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  • 63
    Publication Date: 2023-12-21
    Description: Lymphocytes constantly survey the lymph nodes in search for potential infection by a pathogen. They enter the afferent lymphatic vessel that serves as a conduit to transport the motile lymphocytes to the draining lymph node. Lymphatic vessels (LVs) are present in most vascularized tissues. They are traditionally regarded as passive conduits for soluble antigens and leukocytes. Afferent LVs begin as blind ended capillaries, which give rise to collecting vessels that merge and connect with draining lymph nodes (dLNs). Initial lymphatic capillaries are composed of Lymphatic Endothelial Cells (LECs) connected by discontinuous cell junctions, which join to form larger collecting lymphatic vessels, and ultimately feed into the LN subcapsular sinus. Within the LN, LECs are localized to the subcapsular, cortical, and medullary sinuses, where they interact with incoming and exiting leukocytes. LECs, and in general LN stromal cells, have emerged in the recent years as active players in the immune response. In support to this,studies have shown that the immune response generated during inflammation and under pathologic conditions is accompanied by modeling of the LVs and generation of new lymphatics, a process known as lymphangiogenesis. These facts strongly suggest that LECs and stromal LN cells in general, are not inert players but rather are part of the immune response by organizing immune cells movement, exchanging information and supplying survival factors. The purpose of this research topic is to review the role of the LECs during immune homeostasis and cancer. Considering the critical role of lymphangiogenesis in many pathologies like chronic and acute inflammation, autoimmunity, wound healing, graft rejection, and tumor metastasis, it is important to understand the molecular mechanisms that govern the cross talks between the LECs and immune cells during homeostasis and inflammation.
    Keywords: R5-920 ; RC581-607 ; Liver Injury ; Lymphatic Vessels ; Lymphatic Vasculature ; Tumor Microenvironment ; PD-L1 ; Antigen Presenting Cells ; Lymphatic Endothelial Cells ; T cell trafficking ; T cells ; bic Book Industry Communication::M Medicine
    Language: English
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Heart Rate ; Heart rate variability ; Autonomic Nervous System ; infants ; Children ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology
    Language: English
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    De Gruyter
    Publication Date: 2024-03-27
    Description: To honor the 20th year of his reign, Emperor Constantine was given what may be the most precious gift of his lifetime: a codex of artistic panegyrics and odes dedicated to him by the poet Optatianus. Optatianus’ poems showcase the poetic talent of their creator and go beyond the classical confines of a panegyric: they form a literary invitation to an intellectual bond between laudator and laudandus.
    Keywords: Panegyric ; Visual poetry ; Late Antiquity ; Performativity ; thema EDItEUR::D Biography, Literature and Literary studies::DS Literature: history and criticism::DSB Literary studies: general::DSBB Literary studies: ancient, classical and medieval ; thema EDItEUR::N History and Archaeology::NH History::NHC Ancient history
    Language: German
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    De Gruyter | De Gruyter
    Publication Date: 2024-04-04
    Description: The contributions in this edited volume approach poetry, narrative, and drama from the perspective of Computational Stylistics. They exemplify methods of computational textual analysis and explore the possibility of computational generation of literary texts. The volume presents a range of computational and Natural Language Processing applications to literary studies, such as motif detection, network analysis, machine learning, and deep learning.
    Keywords: Digital Humanities ; stylistics poetry ; distant reading ; thema EDItEUR::D Biography, Literature and Literary studies ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DS Literature: history and criticism ; thema EDItEUR::D Biography, Literature and Literary studies::DS Literature: history and criticism::DSA Literary theory ; thema EDItEUR::D Biography, Literature and Literary studies::DS Literature: history and criticism::DSB Literary studies: general
    Language: English
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  • 67
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: NMDAR = N-methyl-d-aspartate receptor ; Enzymes - metabolism ; enzyme drug target ; d-serine ; L-serine ; thema EDItEUR::P Mathematics and Science::PD Science: general issues
    Language: English
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    Frontiers Media SA
    Publication Date: 2024-03-30
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: biobank ; samples ; data ; biobank network ; BBMRI
    Language: English
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  • 69
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Microbial ; activity ; extracellular enzyme ; marine ; freshwater ; Metabolic potential ; function ; metabolic ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKF Pathology::MKFM Medical microbiology and virology ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical)
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: precise genome editing ; CRISPR ; HDR efficiency ; biallelic HDR targeting ; off-target effect ; animal model ; base editing ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
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  • 71
    Publication Date: 2022-02-01
    Description: acques Derrida’s extensive early writings devoted considerable attention to “being as presence,” the reality underlying the history of metaphysics. In Derrida on Being as Presence: Questions and Quests, David A. White develops the intricate conceptual structure of this notion by close exegetical readings drawn from these writings. White discusses cardinal concepts in Derrida’s revamping of theoretical considerations pertaining to language–signification, context, negation, iterability–as these considerations depend on the structure of being as presence and also as they ground “deconstructive” reading. White’s appraisal raises questions invoking a range of problems. He deploys these questions in conjunction with thematically related quests that arise given Derrida’s conviction that the history of metaphysics, as variations on being as presence, has concealed and skewed vital elements of reality. White inflects this critical apparatus concerning being as presence with texts drawn from that history–e.g., by Plato, Aristotle, Bacon, Hume, Kant, Whitehead. The essay concludes with a speculative ensemble of provisional categories, or zones of specificity. Implementing these categories will ground the possibility that philosophy in general and metaphysics in particular can be pursued in ways which acknowledge the relevance of Derrida’s thought when integrated with the philosophical enterprise as traditionally understood.
    Keywords: BC1-199 ; B1-5802
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  • 72
    Publication Date: 2022-01-31
    Description: Despite the richness of its facets, the short religious epic has been largely neglected by scholars until now. This study explores this literary phenomenon using a multi-perspectival descriptive model. Extensive detailed case studies provide basic information and present the genre in its broader literary historical and systematic context.
    Keywords: PT1-4897 ; short epic ; classification of texts ; Middle High German literature ; religious literature
    Language: German
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    De Gruyter | De Gruyter
    Publication Date: 2024-03-26
    Description: This book analyzes, conceptualizes and historicizes the amateur translator figure as political and cultural agent in US-Latin American relations, from the end of the 19th century to the mid-20th century. Centered on the work of two US-American translators, Alice Stone Blackwell and Isaac Goldberg, it is the first study to offer a modern history of the amateur translator as subject of resistance and cultural mediator between the two regions.
    Keywords: Literary translation ; US-Latin American relations ; Stone Blackwell ; Alice ; Goldberg ; Isaac ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DS Literature: history and criticism ; thema EDItEUR::D Biography, Literature and Literary studies::DS Literature: history and criticism::DSB Literary studies: general::DSBH Literary studies: c 1900 to c 2000 ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBC Cultural and media studies::JBCT Media studies
    Language: Spanish
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    RAND Corporation
    Publication Date: 2024-04-14
    Description: This report discusses the information revolution in the Asia-Pacific region and its likely course over the next five to ten years. Key questions addressed in this report include the extent to which the information revolution has taken hold of markets in this region, the political implications of the information revolution for Asian governments, the variations between individual countries, and the prospects for further information-technology-related developments in the region.
    Keywords: Technology ; thema EDItEUR::U Computing and Information Technology::UY Computer science::UYZ Human–computer interaction::UYZM Information architecture ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
    Language: English
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    De Gruyter | De Gruyter
    Publication Date: 2024-04-06
    Description: Der Witwer. Die Gefährtin erscheint als 14. Band der – von Konstanze Fliedl herausgegebenen – historisch-kritischen Ausgabe von Arthur Schnitzlers Frühwerk. Ein Witwer erfährt aus Briefen vom Betrug seiner verstorbenen Gattin mit seinem besten Freund und Assistenten. Schnitzler widmete sich diesem Stoff zuerst in der Novelle Der Witwer und erarbeitete daraus schließlich das Drama Die Gefährtin. Die Texte verhandeln gesellschafts- und kulturpolitischen Kontexte der Zeit und zeigen ein Ringen um Ethik und Moral – vor allem in Hinblick auf die Institution ‚Ehe‘. Während erste Ansätze zu einer Aufbereitung der Entstehungsgeschichte bereits vorliegen (Höfflin-Grether 2021), veranschaulicht die vorliegende Ausgabe die Komplexität der Entstehung in vollem Umfang; faksimiliert die Handschriften, die sich großteils im Schnitzler-Nachlass an der Cambridge University Library befinden, versieht sie mit einer Umschrift und ediert die Typoskripte. Der Band zeichnet zudem die Druckgeschichte nach und bietet Lesetexte der Novelle und des Dramas nach dem Erstdruck bzw. der Erstausgabe. Versehen werden die Texte mit Kommentaren zu kulturhistorischen Kontexten, Austriazismen und veralteten, zum Teil fremdsprachlichen Ausdrücken. Die historisch-kritische Ausgabe bietet eine wissenschaftlich fundierte Grundlage für eine Auseinandersetzung mit dem Werk Arthur Schnitzlers. ; Der Witwer. Die Gefährtin erscheint als 14. Band der – von Konstanze Fliedl herausgegebenen – historisch-kritischen Ausgabe von Arthur Schnitzlers Frühwerk. Ein Witwer erfährt aus Briefen vom Betrug seiner verstorbenen Gattin mit seinem besten Freund und Assistenten. Schnitzler widmete sich diesem Stoff zuerst in der Novelle Der Witwer und erarbeitete daraus schließlich das Drama Die Gefährtin. Die Texte verhandeln gesellschafts- und kulturpolitischen Kontexte der Zeit und zeigen ein Ringen um Ethik und Moral – vor allem in Hinblick auf die Institution ‚Ehe‘. Während erste Ansätze zu einer Aufbereitung der Entstehungsgeschichte bereits vorliegen (Höfflin-Grether 2021), veranschaulicht die vorliegende Ausgabe die Komplexität der Entstehung in vollem Umfang; faksimiliert die Handschriften, die sich großteils im Schnitzler-Nachlass an der Cambridge University Library befinden, versieht sie mit einer Umschrift und ediert die Typoskripte. Der Band zeichnet zudem die Druckgeschichte nach und bietet Lesetexte der Novelle und des Dramas nach dem Erstdruck bzw. der Erstausgabe. Versehen werden die Texte mit Kommentaren zu kulturhistorischen Kontexten, Austriazismen und veralteten, zum Teil fremdsprachlichen Ausdrücken. Die historisch-kritische Ausgabe bietet eine wissenschaftlich fundierte Grundlage für eine Auseinandersetzung mit dem Werk Arthur Schnitzlers.
    Keywords: Schnitzler, Arthur ; Wiener Moderne ; Novelle ; Novella ; Schnitzler ; Arthur ; Viennese Modernism ; thema EDItEUR::D Biography, Literature and Literary studies::DS Literature: history and criticism::DSB Literary studies: general::DSBH Literary studies: c 1900 to c 2000 ; thema EDItEUR::D Biography, Literature and Literary studies::DS Literature: history and criticism::DSG Literary studies: plays and playwrights ; thema EDItEUR::D Biography, Literature and Literary studies::DS Literature: history and criticism::DSK Literary studies: fiction, novelists and prose writers
    Language: German
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    Publication Date: 2024-04-05
    Description: In this EBook, we highlight how newly emerging techniques for non-invasive manipulation of the human brain, combined with simultaneous recordings of neural activity, contribute to the understanding of brain functions and neural dynamics in humans. A growing body of evidence indicates that the neural dynamics (e.g., oscillations, synchrony) are important in mediating information processing and networking for various functions in the human brain. Most of previous studies on human brain dynamics, however, show correlative relationships between brain functions and patterns of neural dynamics measured by imaging methods such as electroencephalography (EEG), magnetoencephalography (MEG), near-infrared spectroscopy (NIRS), positron emission tomography (PET) and functional magnetic resonance imaging (fMRI). In contrast, manipulative approaches by non-invasive brain stimulation (NIBS) have been developed and extensively used. These approaches include transcranial magnetic stimulation (TMS) and transcranial electric stimulation (tES) such as transcranial direct current stimulation (tDCS), alternating current stimulation (tACS), and random noise stimulation (tRNS), which can directly manipulate neural dynamics in the intact human brain. Although the neural-correlate approach is a strong tool, we think that manipulative approaches have far greater potential to show causal roles of neural dynamics in human brain functions. There have been technical challenges with using manipulative methods together with imaging methods. However, thanks to recent technical developments, it has become possible to use combined methods such as TMS–EEG coregistration. We can now directly measure and manipulate neural dynamics and analyze functional consequences to show causal roles of neural dynamics in various brain functions. Moreover, these combined methods can probe brain excitability, plasticity and cortical networking associated with information processing in the intact human brain. The contributors to this EBook have succeeded in showcasing cutting-edge studies and demonstrate the huge impact of their approaches on many areas in human neuroscience and clinical applications.
    Keywords: RC321-571 ; Q1-390 ; non-invasive brain stimulation NIBS ; TMS-EEG ; Transcranial magnetic stimulation TMS ; transcranial electric stimulation tES ; Coregistration ; Near-infrared spectroscopy NIRS ; Functional magnetic resonance imaging fMRI ; transcranial direct current stimulation tDCS ; transcranial alternating current stimulation tACS ; transcranial random noise stimulation tRNS ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 77
    Publication Date: 2024-04-05
    Description: Bálint’s syndrome is named after the Hungarian physician who first reported a remarkable case of a man with complex visuospatial deficits following bilateral lesions within parietal and occipital cortex (Bálint, 1909). The syndrome has three primary symptoms: simultanagnosia (impaired spatial awareness of more than one object at time), optic ataxia (misreaching to visual targets) and ocular apraxia (described by Bálint as “psychic paralysis of gaze”). Balint’s patients not only cannot perceive more than one object at time and therefore show poor comprehension of multi-object visual scenes i.e. poor detection of all the objects present and difficulty in grasping the relationship between them; in addition they typically fail to reach towards location of the single object, which they can perceive. The deficit of the allocation of spatial attention in Balint’s syndrome has been linked to a problem in feature binding which results in illusory conjunctions. Patients with Balint’s syndrome also show deficits in global processing i.e. when integration of multiple local elements into global compound shapes is required. Consequently, Balint’s syndrome provides a unique opportunity to study the nature and neuroanatomy of human visuospatial processing, in particular multi-level object representation, spatial awareness and the distribution of visual attention. The studies collected here cover both the anatomical and the cognitive mechanisms of the different symptoms associated with the syndrome. Furthermore, the dissociations between the components of Bálints’ syndrome, in particular simultanagnosia and optic ataxia, can also co-occur with visual neglect and extinction and the different combinations of reported lesions raises a question about the status of the syndrome and whether it should be merely treated as a historical compilation of symptoms which may or may not coexist cohesively. This interesting argument is raised here.
    Keywords: RC321-571 ; Q1-390 ; posterior cortical atrophy ; Balints syndrome ; optic ataxia ; Posterior parietal cortex ; simultanagnosia ; ocular apraxia ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 78
    Publication Date: 2023-10-05
    Description: This book examines the Army's role in the war on terrorism; the Army's homeland security needs; the implications of increased emphasis on Asia; the Army's role in coalition operations; the unfinished business of jointness-the lessons learned from operations and how to prepare for the future; the Army's deployability, logistical, and personnel challenges; and whether the Army can afford its Transformation. These examinations are bracketed by an introduction, a description of the Army's place in the new national security strategy, and a summary of the authors' conclusions.
    Keywords: Political Science ; Management & Organizational Behavior ; bic Book Industry Communication::K Economics, finance, business & management::KJ Business & management::KJM Management & management techniques::KJMV Management of specific areas::KJMV2 Personnel & human resources management ; bic Book Industry Communication::J Society & social sciences::JW Warfare & defence
    Language: English
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  • 79
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    De Gruyter
    Publication Date: 2024-04-04
    Description: An increasing complexity of models used to predict real-world systems leads to the need for algorithms to replace complex models with far simpler ones, while preserving the accuracy of the predictions. This two-volume handbook covers methods as well as applications. This second volume focuses on applications in engineering, biomedical engineering, computational physics and computer science.
    Keywords: Applied mathematics ; PROM ; thema EDItEUR::P Mathematics and Science::PB Mathematics::PBK Calculus and mathematical analysis::PBKS Numerical analysis ; thema EDItEUR::P Mathematics and Science::PB Mathematics::PBW Applied mathematics ; thema EDItEUR::P Mathematics and Science::PH Physics::PHU Mathematical physics ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGP Production and industrial engineering
    Language: English
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  • 80
    Publication Date: 2023-10-05
    Description: An investigation of the effects of having symptoms of post-traumatic stress disorder (PTSD) on the labor market earnings of reservists in the years following deployment.
    Keywords: Law ; Psychology ; Technology ; Business ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCF Labour economics ; bic Book Industry Communication::J Society & social sciences::JM Psychology::JMP Abnormal psychology
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  • 81
    Publication Date: 2022-02-01
    Description: Zentrales Thema des Sammelbandes ist der Begriff der Verfestigung bzw. der formalen Stabilität im Deutschen und im Sprachvergleich, der die Aktualität der neueren lexikographischen und phraseologischen Forschung besonders prägt. Die hier versammelten 23 Beiträge reihen sich thematisch in diese Aktualität ein und behandeln diskursive Aspekte der Verfestigungs- bzw. Stabilitätsproblematik im Diskurs. Arbeiten und Forschungsergebnisse ausgewiesener internationaler Experten werden hier zusammengefu?hrt, die sich der Schnittstelle zwischen Pragmatik und Morphologie/Syntax widmen und vor allem das Deutsche oder den Sprachvergleich betreffende Fragestellungen im Zusammenhang mit Grammatikalisierungs-, Lexikalisierungs- und/oder Phraseologisierungsphänomenen diskutieren. Hiermit verbunden wird u.a. der Frage nachgegangen, wie verfestigte Strukturen zu Argumentationszwecken im Diskurs eingesetzt werden. Der vier thematische Bereiche umfassende Band zeigt damit, wie facettenreich der Verfestigungsbegriff im Diskurs sein kann und bietet zugleich Impulse fu?r die ku?nftige Forschung in diesem Bereich.
    Keywords: P1-1091 ; Discourse ; Phraseology ; Lexicalization ; Grammaticalization
    Language: German
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  • 82
    Publication Date: 2024-04-05
    Description: The tale of cyclic GMP has been astonishing. Having overcome an initial disbelief, cyclic GMP has risen to its present eminence as a premium cellular signal transduction messenger of not only hormonal extracellular but also of the intracellular signals. This research topic focuses on the pathways and functions of membrane guanylate cyclases in different tissues of the body and their interplay with intracellular sensory signals where in many cases, cyclic GMP along with Ca2+ have taken on roles as synarchic co-messengers.
    Keywords: RC321-571 ; Q1-390 ; Glaucoma ; Visceral Pain ; Calcium ; membrane guanylate cyclase ; ANF-RGC ; Gene Therapy ; Cyclic GMP ; synaptic plasticity ; trafficking ; ROS-GC ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 83
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Microbial communities ; Pollutants ; Environmental risk assessment ; Bioindication ; Biodegradation ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKF Pathology::MKFM Medical microbiology and virology ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical)
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  • 84
    Publication Date: 2023-10-05
    Description: Describes the response of state and local health departments to outbreaks of Severe Acute Respiratory Syndrome (SARS), monkeypox, West Nile virus, and hepatitis A that took place from 1999 to 2003. In general, public health agencies demonstrated a robust ability to implement the major components of response to a public health emergency. Researchers found that the most pervasive problem involved communication difficulties within public health agencies and with public health partners.
    Keywords: Health Sciences ; Sociology ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBN Public health & preventive medicine::MBNS Epidemiology & medical statistics ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBN Public health & preventive medicine ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFF Social issues & processes::JFFH Illness & addiction: social aspects
    Language: English
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  • 85
    Publication Date: 2024-04-02
    Description: California’s Juvenile Justice Crime Prevention Act provides funds for counties to offer evidence-based programs for high-need juvenile probationers and at-risk youth. This report, based on the annual report to the state legislature, outlines the program’s success for six outcome measures (completion of probation, restitution, and community service; arrests; probation violations; and incarcerations) and county-required supplemental outcomes.
    Keywords: Law ; History ; Political Science ; Sociology ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas ; thema EDItEUR::L Law::LN Laws of specific jurisdictions and specific areas of law::LNF Criminal law: procedure and offences::LNFQ Juvenile criminal law ; thema EDItEUR::J Society and Social Sciences::JK Social services and welfare, criminology::JKS Social welfare and social services::JKSW Emergency services::JKSW1 Police and security services ; thema EDItEUR::J Society and Social Sciences::JK Social services and welfare, criminology::JKV Crime and criminology
    Language: English
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  • 86
    Publication Date: 2024-04-14
    Description: In 2010, 15 percent of Americans older than age 70 had dementia. By 2050, the number of new dementia cases among those 65 and older is expected to double. This blueprint outlines policy options to help decisionmakers improve dementia long-term services and supports (LTSS) by promoting earlier detection, improving access to LTSS, promoting person- and caregiver-centered care, supporting caregivers, and reducing dementia LTSS costs.
    Keywords: Public Health ; Psychology ; Health Sciences ; thema EDItEUR::V Health, Relationships and Personal development::VF Family and health::VFJ Coping with / advice about personal, social and health topics::VFJB Coping with / advice about illness and specific health conditions ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKN Geriatric medicine ; thema EDItEUR::J Society and Social Sciences::JM Psychology::JMC Child, developmental and lifespan psychology
    Language: English
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  • 87
    Publication Date: 2024-04-02
    Description: Drawing from 140 recently declassified documents, this report comprehensively examines the organization, territorial designs, management, personnel policies, and finances of the Islamic State of Iraq (ISI) and al-Qa‘ida in Iraq. Analysis of the Islamic State predecessor groups is more than a historical recounting. It provides significant understanding of how ISI evolved into the present-day Islamic State and how to combat the group.
    Keywords: Political Science ; History ; thema EDItEUR::N History and Archaeology::NH History::NHG Middle Eastern history ; thema EDItEUR::J Society and Social Sciences::JP Politics and government ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPW Political activism / Political engagement::JPWL Terrorism, armed struggle
    Language: English
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  • 88
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    De Gruyter | De Gruyter
    Publication Date: 2024-03-25
    Description: This book engages the Chester Beatty Biblical Papyri, one of the most important collections of early manuscripts of Jewish scripture and the New Testament, by placing them within larger conversations relating to ancient literature and its interpretation, papyrology, and the ethics of collecting and scholarship. Ninety years after Beatty acquired these manuscripts, their value for scholarship and culture remains largely unexplored.
    Keywords: Philology ; Colonialism ; Social history ; Manuscripts ; thema EDItEUR::D Biography, Literature and Literary studies::DB Ancient, classical and medieval texts ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTR National liberation and independence ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRM Christianity::QRMF Christianity: sacred texts and revered writings::QRMF1 Bibles::QRMF13 New Testaments
    Language: English
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  • 89
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    De Gruyter | De Gruyter Oldenbourg
    Publication Date: 2024-04-02
    Description: While the economic involvement of early modern Germany in slavery and the slave trade is increasingly receiving attention, the direct participation of Germans in human trafficking remains a blind spot in historiography. This edited volume focuses on practices of enslavement taking place within German territories in the early modern period as well as on the people of African, Asian, and Native American descent caught up in them.
    Keywords: Slavery ; Germany ; Atlantic history ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHB General and world history ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTQ Colonialism and imperialism ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTR National liberation and independence ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTS Slavery and abolition of slavery
    Language: English
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  • 90
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Alzheimer's disease ; Neurodegeneration ; Peptides ; cognitive ; model ; Parkinson's disease ; database ; transgenic ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 91
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    RAND Corporation
    Publication Date: 2024-03-29
    Description: On September 11, 2001, the United States was without a plan for military operations in Afghanistan. One was quickly created by the Defense Department and operations began October 7. The Taliban was toppled in less than two months. This report describes preparations at CENTCOM and elsewhere, Army operations and support activities, building a coalition, and civil-military operations in Afghanistan from October 2001 through June 2002.
    Keywords: History ; Political Science ; thema EDItEUR::J Society and Social Sciences::JW Warfare and defence::JWK Military and defence strategy ; thema EDItEUR::N History and Archaeology::NH History::NHF Asian history ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPS International relations
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  • 92
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Sport ; performance ; physiology ; kinesiology ; biomechanics ; health ; exercise ; physical activity ; athletes ; training ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::S Sports and Active outdoor recreation ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKW Sports injuries and medicine
    Language: English
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  • 93
    Publication Date: 2023-12-20
    Description: This volume contains presentations and discussions from the Conference of the Association of German Constitutional Lawyers, which was held in Düsseldorf from 1 to 4 October 2014.
    Keywords: K1-7720 ; constitutional law ; fundamental rights ; democracy ; bic Book Industry Communication::L Law
    Language: German
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  • 94
    Publication Date: 2024-04-05
    Description: In the search for simple explanations of the natural world, its complicated textures are often filed down to a smoothened surface of our liking. The impetus for this Research Topic was borne out of a need to re-ignite interest in the complex – in this case in the context of ion channels in the nervous system. Ion channels are the large proteins that form regulated pores in the membranes of cells and, in the brain, are essential for the transfer, processing and storage of information. These pores full of twists and turns themselves are not just barren bridges into cells. More and more we are beginning to understand that ion channels are like bustling medieval bridges (packed with apartments and shops) rather than the more sleek modern variety – they are dynamic hubs connected with many structures facilitating associated activities. Our understanding of these networks continues to expand as our investigative tools advance. Together these articles highlight how the complexity of ion channel signaling nexuses is critical to the proper functioning of the nervous system.
    Keywords: RC321-571 ; Q1-390 ; Nervous System ; Ion Channels ; Interactome ; cellular signaling ; Protein complexes ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 95
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Brainstem monoamine neurons ; locus coeruleus ; emotion ; pain ; morphometry ; amphetamine derivatives ; sleep ; gaze ; trigeminal nerve ; microglia. ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 96
    Publication Date: 2024-04-05
    Description: Genome-wide association studies (GWAS) for complex disorders with large case-control populations have been performed on hundreds of traits in more than 1200 published studies (http://www.genome.gov/gwastudies/) but the variants detected by GWAS account for little of the heritability of these traits, leading to an increasing interest in using family based designs. While GWAS studies are designed to find common variants with low to moderate attributable risks, family based studies are expected to find rare variants with high attributable risk. Because family-based designs can better control both genetic and environmental background, this study design is robust to heterogeneity and population stratification. Moreover, in family-based analysis, the background genetic variation can be modeled to control the residual variance which could increase the power to identify disease associated rare variants. Analysis of families can also help us gain knowledge about disease transmission and inheritance patterns. Although a family-based design has the advantage of being robust to false positives, novel and powerful methods to analyze families in genetic epidemiology continue to be needed, especially for the interaction between genetic and environmental factors associated with disease. Moreover, with the rapid development of sequencing technology, advances in approaches to the design and analysis of sequencing data in families are also greatly needed. The 11 articles in this book all introduce new methodology and, using family data, substantial new findings are presented in the areas of infectious diseases, diabetes, eye traits, autism spectrum disorder and prostate cancer.
    Keywords: QH426-470 ; Q1-390 ; Regional heritability ; prostate cancer ; infectious diseases ; MCMC ; combining studies screening ; conditional-logistic linkage ; Informatics ; autism ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical)
    Language: English
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  • 97
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    De Gruyter | De Gruyter
    Publication Date: 2024-04-03
    Description: Society begins at the local level. This interdisciplinary volume analyzes different kinds of local self-organization against the backdrop of the rather limited states of Antiquity and the Global South of the present. By collaborating across different periods of time the contributors get a better grasp of the mechanisms by which local governance succeeds, and advance the theoretical debate on state and society.
    Keywords: civil society ; collective identity ; global history ; limited statehood ; thema EDItEUR::D Biography, Literature and Literary studies::DB Ancient, classical and medieval texts ; thema EDItEUR::N History and Archaeology::NH History::NHA History: theory and methods ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHH African history ; thema EDItEUR::N History and Archaeology::NH History::NHB General and world history ; thema EDItEUR::N History and Archaeology::NH History::NHC Ancient history ; thema EDItEUR::N History and Archaeology::NK Archaeology::NKD Archaeology by period / region ; thema EDItEUR::1 Place qualifiers::1Q Other geographical groupings: Oceans and seas, historical, political etc::1QB Historical states, empires, territories and regions::1QBA Ancient World ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPR Regional, state and other local government
    Language: English
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  • 98
    Publication Date: 2023-12-21
    Description: It is long known that many cells can shed extracellular vesicles, small membrane-enclosed cell fragments. Although the existence of extracellular vesicles has been recognized for many years, researchers are only beginning to understand their physiologic significance. Several recent studies have demonstrated that extracellular vesicles released from cells serve as a mode of cellular communication. They can carry diverse molecular payload (e.g. nucleic acids, bioactive lipids and proteins) to distal organs and recipient cells. Extracellular vesicles can be classified into three major groups: exosomes, microvesicles, and apoptotic bodies. All these types of extracellular vesicles can be found in a variety of biologic specimen and their numbers, distribution and composition may serve as biomarkers for various disorders, including cardiovascular disease. Although extracellular vesicle-mediated processes are currently best characterized in the fields of cancer biology and neurobiology, evidence is accumulating that extracellular vesicles play a key role in the pathophysiology of diabetes, thrombosis, inflammation and cardiovascular calcification. In this Research Topic, we invited review and methodological articles that advance our understanding of extracellular vesicle-related processes in vascular biology.
    Keywords: R5-920 ; Angiogenesis ; Atherosclerosis ; Extracellular vesicles ; Calcification ; Biomarkers ; Cardiovascular disease ; Inflammation ; Exosomes ; Platelets ; Heart valve ; bic Book Industry Communication::M Medicine
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  • 99
    Publication Date: 2024-03-29
    Description: The composition of Air Force active and reserve forces is often contentious, especially during a force drawdown. This document seeks to inform force composition decisions by clarifying issues that affect the suitability of missions for assignment to the reserve components.
    Keywords: History ; Technology ; thema EDItEUR::J Society and Social Sciences::JW Warfare and defence::JWK Military and defence strategy ; thema EDItEUR::J Society and Social Sciences::JW Warfare and defence::JWC Military forces and sectors::JWCM Air forces and warfare ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TT Other technologies and applied sciences::TTM Military engineering
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  • 100
    Publication Date: 2024-04-14
    Description: This report discusses how policy-makers might address the challenges and risks in respect of the security, privacy and trust aspects of cloud computing that could undermine the attainment of broader economic and societal objectives across Europe.
    Keywords: Technology ; Law ; thema EDItEUR::U Computing and Information Technology::UD Digital Lifestyle and online world: consumer and user guides ; thema EDItEUR::L Law::LN Laws of specific jurisdictions and specific areas of law::LNC Company, commercial and competition law: general::LNCD Company law
    Language: English
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