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  • pharmacokinetics  (2,025)
  • stability  (680)
  • Chemistry
  • Springer  (2,738)
  • Alliance for Coastal Technologies
  • 1
    Publication Date: 2020-11-12
    Description: Slope dynamics in volcanic environments comprise a wide spectrum of phenomena, from large lateral collapse to shallow debris remobilization, which may represent a major threat for human communities and infrastructures. Many volcanos built up from the ocean floor and large portions of the volcano edifice are submerged. In these settings, only the edifice’s summit can be investigated by terrestrial remote sensing and in-situ approaches. Growth and destruction, including tectonics and gravitational phenomena, affect entire volcano flanks and are not limited to the physical boundary of the sea level but could comprise their subaqueous parts.
    Description: Published
    Description: 2615–2618
    Description: 6V. Pericolosità vulcanica e contributi alla stima del rischio
    Description: JCR Journal
    Keywords: volcanoes ; flanks ; volcano-tectonics ; structure ; collapse ; stability ; 04.08. Volcanology ; 05.08. Risk
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 2
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    Alliance for Coastal Technologies | Solomons, MD
    In:  http://aquaticcommons.org/id/eprint/3114 | 130 | 2011-09-29 17:51:58 | 3114 | University of Maryland Center for Environmental Science. Chesapeake Biological Laboratory
    Publication Date: 2021-07-01
    Description: The Alliance for Coastal Technologies (ACT) convened a workshop on Evaluating Approaches and Technologies for Monitoring Organic Contaminants in the Aquatic Environment in Ann Arbor, MI on July 21-23, 2006. The primary objectives of this workshop were to: 1) identify the priority management information needs relative to organic contaminant loading; 2) explore themost appropriate approaches to estimating mass loading; and 3) evaluate the current status of thesensor technology. To meet these objectives, a mixture of leading research scientists, resourcemanagers, and industry representatives were brought together for a focused two-day workshop.The workshop featured four plenary talks followed by breakout sessions in which arranged groupsof participants where charged to respond to a series of focused discussion questions.At present, there are major concerns about the inadequacies in approaches and technologies forquantifying mass emissions and detection of organic contaminants for protecting municipal watersupplies and receiving waters. Managers use estimates of land-based contaminant loadings torivers, lakes, and oceans to assess relative risk among various contaminant sources, determinecompliance with regulatory standards, and define progress in source reduction. However, accuratelyquantifying contaminant loading remains a major challenge. Loading occurs over a range ofhydrologic conditions, requiring measurement technologies that can accommodate a broad rangeof ambient conditions. In addition, in situ chemical sensors that provide a means for acquiringcontinuous concentration measurements are still under development, particularly for organic contaminantsthat typically occur at low concentrations. Better approaches and strategies for estimatingcontaminant loading, including evaluations of both sampling design and sensor technologies,need to be identified. The following general recommendations were made in an effort to advancefuture organic contaminant monitoring:1. Improve the understanding of material balance in aquatic systems and the relationship betweenpotential surrogate measures (e.g., DOC, chlorophyll, particle size distribution) and target constituents.2. Develop continuous real-time sensors to be used by managers as screening measures and triggersfor more intensive monitoring.3. Pursue surrogate measures and indicators of organic pollutant contamination, such as CDOM,turbidity, or non-equilibrium partitioning.4. Develop continuous field-deployable sensors for PCBs, PAHs, pyrethroids, and emerging contaminantsof concern and develop strategies that couple sampling approaches with tools that incorporatesensor synergy (i.e., measure appropriate surrogates along with the dissolved organics toallow full mass emission estimation).[PDF contains 20 pages]
    Description: NOAA
    Description: Alliance for Coastal Technologies, CBL/UMCES
    Keywords: Engineering ; Earth Sciences ; Environment ; Chemistry
    Repository Name: AquaDocs
    Type: monograph
    Format: application/pdf
    Format: application/pdf
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  • 3
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    Alliance for Coastal Technologies | Solomons, MD
    In:  http://aquaticcommons.org/id/eprint/3110 | 130 | 2011-09-29 17:51:42 | 3110 | University of Maryland Center for Environmental Science. Chesapeake Biological Laboratory
    Publication Date: 2021-07-01
    Description: This Alliance for Coastal Technologies (ACT) workshop was convened to assess the availabilityand state of development of conductivity-temperature sensors that can meet the needs of coastalmonitoring and management communities. Rased on the discussion, there are presently a numberof commercial sensor options available, with a wide range of package configurations suitable fordeployment in a range of coastal environments. However, some of the central questions posedin the workshop planning documents were left somewhat unresolved. The workshop descriptionemphasized coastal management requirements and, in particular, whether less expensive, easilydeployed, lower-resolution instruments might serve many management needs. While several participantsexpressed interest in this class of conductivity-temperature sensors, based on input fromthe manufacturers, it is not clear that simply relaxing the present level of resolution of existing instrumentswill result in instruments of significantly lower unit cost. Conductivity-temperature sensorsare available near or under the $1,000 unit cost that was operationally defined at the workshopas a breakpoint for what might be considered to be a "low cost" sensor. For the manufacturers, akey consideration before undertaking the effort to develop lower cost sensors is whether there willbe a significant market. In terms of defining "low cost," it was also emphasized that the "life cyclecosts" for a given instrument must be considered (e.g., including personnel costs for deploymentand maintenance). An adequate market survey to demonstrate likely applications and a viablemarket for lower cost sensors is needed. Another topic for the workshop was the introductionto the proposed ACT verification for conductivity-temperature sensors. Following a summaryof the process as envisioned by ACT, initial feedback was solicited. Protocol development willbe pursued further in a workshop involving ACT personnel and conductivity-temperature sensormanufacturers.[PDF contains 28 pages]
    Description: NOAA
    Description: Alliance for Coastal Technologies, CBL/UMCES
    Keywords: Earth Sciences ; Environment ; Chemistry
    Repository Name: AquaDocs
    Type: monograph
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  • 4
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    Alliance for Coastal Technologies | Solomons, MD
    In:  http://aquaticcommons.org/id/eprint/3126 | 130 | 2011-09-29 17:52:50 | 3126
    Publication Date: 2021-06-25
    Description: The Alliance for Coastal Technologies (ACT) Workshop "Applications of in situ Fluorometers inNearshore Waters" was held in Cape Elizabeth, Maine, February 2-4,2005, with sponsorship bythe Gulf of Maine Ocean Observing System (GoMOOS), one of the ACT partner organization.The purpose of the workshop was to explore recent trends in fluorometry as it relates to resourcemanagement applications in nearshore environments. Participants included representatives fromstate and federal environmental management agencies as well as research institutions, many ofwhom are currently using this technology in their research and management applications.Manufacturers and developers of fluorometric measuring systems also attended the meeting.The Workshop attendees discussed the historical and present uses of fluorometry technology andidentified the great potential for its use by coastal managers to fulfill their regulatory andmanagement objectives. Participants also identified some of the challenges associated with thecorrect use of Fluorometers to estimate biomass and the rate of primary productivity. TheWorkshop concluded that in order to expand the existing use of fluorometers in both academicand resource management disciplines, several issues concerning data collection, instrumentcalibration, and data interpretation needed to be addressed. Participants identified twelverecommendations, the top five of which are listed below:Recommendations1) Develop a "Guide" that describes the most important aspects of fluorescencemeasurements. This guide should be written by an expert party, with both research andindustry input, and should be distributed by all manufacturers with theirinstrumentation. The guide should also be made available on the ACT website as wellas those of other relevant organizations. The guide should include discussions on thefollowing topics:The benefits of using fluorometers in research and resource managementapplications;What fluorometers can and cannot provide in terms of measurements;The necessary assumptions required before applying fluorometry;Characterization and calibration of fluorometers; (pdf contains 32 pages)
    Description: NOAA
    Description: Alliance for Coastal Technologies, CBL/UMCES
    Keywords: Environment ; Chemistry
    Repository Name: AquaDocs
    Type: monograph
    Format: application/pdf
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    The journal of Fourier analysis and applications 5 (1999), S. 105-125 
    ISSN: 1531-5851
    Keywords: 26B05 ; 42B10 ; 42C99 ; frame ; Gabor system ; Riesz basis ; stability ; wavelet
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract If the sequence of functions ϕj, k is a wavelet frame (Riesz basis) or Gabor frame (Riesz basis), we obtain its perturbation system ψj,k which is still a frame (Riesz basis) under very mild conditions. For example, we do not need to know that the support of ϕ or ψ $$(\hat \phi or\hat \psi )$$ is compact as in [14]. We also discuss the stability of irregular sampling problems. In order to arrive at some of our results, we set up a general multivariate version of Littlewood-Paley type inequality which was originally considered by Lemarié and Meyer [17], then by Chui and Shi [9], and Long [16].
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Risk analysis 19 (1999), S. 711-726 
    ISSN: 1539-6924
    Keywords: variability ; exposure ; susceptibility ; risk assessment ; pharmacokinetics ; pharmacodynamics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract This paper reviews existing data on the variability in parameters relevant for health risk analyses. We cover both exposure-related parameters and parameters related to individual susceptibility to toxicity. The toxicity/susceptibility data base under construction is part of a longer term research effort to lay the groundwork for quantitative distributional analyses of non-cancer toxic risks. These data are broken down into a variety of parameter types that encompass different portions of the pathway from external exposure to the production of biological responses. The discrete steps in this pathway, as we now conceive them, are: •Contact Rate (Breathing rates per body weight; fish consumption per body weight) •Uptake or Absorption as a Fraction of Intake or Contact Rate •General Systemic Availability Net of First Pass Elimination and Dilution via Distribution Volume (e.g., initial blood concentration per mg/kg of uptake) •Systemic Elimination (half life or clearance) •Active Site Concentration per Systemic Blood or Plasma Concentration •Physiological Parameter Change per Active Site Concentration (expressed as the dose required to make a given percentage change in different people, or the dose required to achieve some proportion of an individual's maximum response to the drug or toxicant) •Functional Reserve Capacity–Change in Baseline Physiological Parameter Needed to Produce a Biological Response or Pass a Criterion of Abnormal Function Comparison of the amounts of variability observed for the different parameter types suggests that appreciable variability is associated with the final step in the process–differences among people in “functional reserve capacity.” This has the implication that relevant information for estimating effective toxic susceptibility distributions may be gleaned by direct studies of the population distributions of key physiological parameters in people that are not exposed to the environmental and occupational toxicants that are thought to perturb those parameters. This is illustrated with some recent observations of the population distributions of Low Density Lipoprotein Cholesterol from the second and third National Health and Nutrition Examination Surveys.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1539-6924
    Keywords: MeHg ; pharmacokinetics ; PBPK model ; variability ; risk assessment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract An analysis of the uncertainty in guidelines for the ingestion of methylmercury (MeHg) due to human pharmacokinetic variability was conducted using a physiologically based pharmacokinetic (PBPK) model that describes MeHg kinetics in the pregnant human and fetus. Two alternative derivations of an ingestion guideline for MeHg were considered: the U.S. Environmental Protection Agency reference dose (RfD) of 0.1 μg/kg/day derived from studies of an Iraqi grain poisoning episode, and the Agency for Toxic Substances and Disease Registry chronic oral minimal risk level (MRL) of 0.5 μg/kg/day based on studies of a fish-eating population in the Seychelles Islands. Calculation of an ingestion guideline for MeHg from either of these epidemiological studies requires calculation of a dose conversion factor (DCF) relating a hair mercury concentration to a chronic MeHg ingestion rate. To evaluate the uncertainty in this DCF across the population of U.S. women of child-bearing age, Monte Carlo analyses were performed in which distributions for each of the parameters in the PBPK model were randomly sampled 1000 times. The 1st and 5th percentiles of the resulting distribution of DCFs were a factor of 1.8 and 1.5 below the median, respectively. This estimate of variability is consistent with, but somewhat less than, previous analyses performed with empirical, one-compartment pharmacokinetic models. The use of a consistent factor in both guidelines of 1.5 for pharmacokinetic variability in the DCF, and keeping all other aspects of the derivations unchanged, would result in an RfD of 0.2 μg/kg/day and an MRL of 0.3 μg/kg/day.
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Circuits, systems and signal processing 19 (2000), S. 423-435 
    ISSN: 1531-5878
    Keywords: Time-varying autoregressive models ; stability ; smoothness priors ; Tihkonov regularization ; constrained optimization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: Abstract The stability of time-varying autoregressive (AR) models is an important issue in such applications as time-varying spectrum estimation and electroencephalography simulation and estimation. In some cases, such as time-varying spectrum estimation, the models that exhibit roots near unit moduli are difficult to use. Thus a tighter stability condition such as stability with a positive margin is needed. A time-varying AR model is stable with a positive margin if the moduli of the roots of the time-varying characteristic polynomial are somewhat less than unity for every time instant. Recently, a new method for the estimation of the time-varying AR models was introduced. This method is based on the interpretation of the underdetermined time-varying prediction equations as an ill-posed inverse problem that is solved by Tikhonov regularization. The method is referred to as the deterministic regression smoothness priors (DRSP) scheme. In this paper, a stabilization method in which the DRSP scheme is augmented with nonlinear stability constrainst is proposed. The problem is formulated so that stability with a positive margin can also be achieved. The problem is solved iteratively with an exterior point algorithm. The performance of the algorithm is studied with a simulation. It is shown that the proposed approach is well suited to stable modeling of signals containing narrowband transitions.
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Circuits, systems and signal processing 19 (2000), S. 13-25 
    ISSN: 1531-5878
    Keywords: Singular systems ; delay ; consistency condition ; stability ; instability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: Abstract In this paper, the general class of singular systems with delay and linear constant coefficient singular systems with delay are discussed. First, several definitions of stability are presented for singular systems with delay, and general sufficient stability conditions and instability conditions are obtained. Second, stability and instability are analyzed for linear constant coefficient singular systems with delay.
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Computing 24 (1980), S. 341-347 
    ISSN: 1436-5057
    Keywords: Numerical analysis ; Volterra integral equations of the second kind ; stability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Description / Table of Contents: Zusammenfassung Ziel dieser Arbeit ist es, die Stabilitätseigenschaften einer Klasse Volterrascher Integralgleichungen zweiter Art zu untersuchen. Unsere Behandlung ist der üblichen Stabilitätsanalyse ähnlich, in der die Kernfunktionen zu einer im voraus beschränkten Klasse von Testfunktionen gehören. Wir haben die Klasse der “endlich zerlegbaren” Kerne betrachtet. Stabilitätsbedingungen werden abgeleitet und verglichen mit den Bedingungen für die einfache Testgleichung. Es zeigt sich, daß die neuen Kriteria einschränkender sind als die konventionellen Bedingungen. Der praktische Wert wird getestet durch numerische Experimente mit der Trapezregel.
    Notes: Abstract The purpose of this paper is to analyse the stability properties of a class of multistep methods for second kind Volterra integral equations. Our approach follows the usual analysis in which the kernel function is a priori restricted to a special class of test functions. We consider the class of finitely decomposable kernels. Stability conditions will be derived and compared with those obtained with the simple test equation. It turns out that the new criteria are more severe than the conventional conditions. The practical value is tested by numerical experiments with the trapezoidal rule.
    Type of Medium: Electronic Resource
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